CNS Drug Delivery and Barrier Modelling

Research output

Research output per year 1995 2018 2020 2021 2022 2023 2024

• 48 Journal article
• 4 Book chapter
• 3 Review
• 2 Conference abstract in journal
• 4 More
  • 2 Preprint
  • 1 Poster
  • 1 Contribution to newspaper - Newspaper article

Research output per year

Research output per year

Search results

• 2024

  Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution

  Langthaler, K., Jones, C. R., Saaby, L., Bundgaard, C. & Brodin, B., 2024, In: Fluids and Barriers of the CNS. 21, 1, 15 p., 11.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  24 Downloads (Pure)

• Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus

  Nielsen, A. K. R., Lilieholm-Røngren, L., Schmid, B., Holst, B., Brodin, B. & Saaby, L., 2024, In: Stem Cell Research. 76, 5 p., 103348.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  18 Downloads (Pure)

• Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation

  Mortensen, J. S., Bohr, S. S. R., Krog, L. S., Bøtker, J. P., Kapousidou, V., Saaby, L., Hatzakis, N. S., Mørck Nielsen, H., Nguyen, D. N. & Rønholt, S., 2024, In: Scientific Reports. 14, 1, 17 p., 7665.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  20 Downloads (Pure)

• The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

  Svane, N. I., Pedersen, A. B. V., Rodenberg, A., Ozgür, B., Saaby, L., Bundgaard, C., Kristensen, M., Tfelt-Hansen, P. & Larsen, B. B., 2024, In: Fluids and Barriers of the CNS. 21, 19 p., 39.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  12 Downloads (Pure)

• The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

  Kurtyka, M., Wessely, F., Bau, S., Ifie, E., He, L., de Wit, N. M., Pedersen, A. B. V., Keller, M., Webber, C., de Vries, H. E., Ansorge, O., Betsholtz, C., De Bock, M., Chaves, C., Brodin, B., Nielsen, M. S., Neuhaus, W., Bell, R. D., Letoha, T., Meyer, A. H. & 7 others, Leparc, G., Lenter, M., Lesuisse, D., Cader, Z. M., Buckley, S. T., Loryan, I. & Pietrzik, C. U., 2024, In: European Journal of Cell Biology. 103, 2, 14 p., 151406.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  11 Downloads (Pure)
• 2023

  Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

  Nielsen, S. S. E., Holst, M. R., Langthaler, K., Bruun, E. H., Brodin, B. & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 2.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  6 Citations (Scopus)

  33 Downloads (Pure)

• Assessing extent of brain penetration in vivo (K_p,uu,brain) in Göttingen minipig using a diverse set of reference drugs

  Langthaler, K., Jones, C. R., Brodin, B. & Bundgaard, C., 2023, In: European Journal of Pharmaceutical Sciences. 190, 11 p., 106554.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  15 Downloads (Pure)

• Cell-Penetrating Peptides as Tools to Facilitate Oral Delivery of Biopharmaceuticals

  Asgreen, C. J., Fredholt, F., Nielsen, H. M. & Kristensen, M., 2023, Cell-Penetrating Peptides: Design, Development and Applications. Oba, M. & Demizu, Y. (eds.). Wiley-VCH, p. 331-354

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line

  Ozgür, B., Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V., Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, M., Auriola, S., Jensen, A., Fricker, G., Nielsen, M. S., Neuhaus, W. & Brodin, B., 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 96.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  25 Downloads (Pure)

• Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison

  Panou, D. A., Pedersen, S. H. F., Kristensen, M. & Nielsen, H. M., 2023, In: Frontiers in Drug Delivery. 3, 16 p., 1221628.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  20 Downloads (Pure)

• Iron Oxide Nanoparticles as a Contrast Agent for Synchrotron Imaging of Sperm

  Lindhøj, M. B., Cooper, S. R., Anker, A. S., Bonnin, A., Kristensen, M., Qvortrup, K., Almstrup, K., Jensen, K. M. Ø., Dyrby, T. B. & Sporring, J., 2023, arxiv.org, 21 p.

  Research output: Working paper › Preprint › Research

  Open Access

  File
  13 Downloads (Pure)

• Selenomethionine as alternative label to the fluorophore TAMRA when exploiting cell-penetrating peptides as blood-brain barrier shuttles to better mimic the physicochemical properties of the non-labelled peptides

  Ýr Þorgeirsdóttir, D., Hofman Andersen, J., Perch-Nielsen, M., Møller, L. H., Grønbæk-Thorsen, F., Kolberg, H. G., Gammelgaard, B. & Kristensen, M., 2023, In: European Journal of Pharmaceutical Sciences. 183, 10 p., 106400.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  37 Downloads (Pure)

• Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

  Holst, M. R., de Wit, N. M., Ozgür, B., Brachner, A., Hyldig, K., Appelt-Menzel, A., Sleven, H., Cader, Z., de Vries, H. E., Neuhaus, W., Jensen, A., Brodin, B. & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 17 p., 82.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  1 Citation (Scopus)

  17 Downloads (Pure)
• 2022

  Barrier properties of ex vivo porcine intestinal mucus are highly independent of isolation and storage conditions

  Støvring Mortensen, J., Saaby, L., Harloff-Helleberg, S. & Mørck Nielsen, H., 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 174, p. 106-110

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  6 Citations (Scopus)

  78 Downloads (Pure)

• Cell-Penetrating Peptides as Carriers for Transepithelial Drug Delivery

  Panou, D. A., Diedrichsen, R. G., Kristensen, M. & Nielsen, H. M., 2022, Cell Penetrating Peptides: Methods and Protocols. Langel, Ü. (ed.). Springer, p. 371-384 (Methods in Molecular Biology, Vol. 2383).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  3 Citations (Scopus)

• Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies

  Langthaler, K., Jones, C. R., Christensen, R. B., Eneberg, E., Brodin, B. & Bundgaard, C., 2022, In: Xenobiotica. 52, 6, p. 591-607

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  24 Downloads (Pure)

• En af hjernens forsvarsmure: Blod-hjerne-barrieren

  Ozgür, B., 2022, In: Pharma. 2022, 4, p. 15-17

  Research output: Contribution to journal › Contribution to newspaper - Newspaper article › Communication

  Open Access

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  21 Downloads (Pure)

• Generation of transient and tunable oxygen gradients in microfluidic channels utilizing the oxygen scavenging properties of thiol-ene polymers

  Yuan, Z., Sticker, D., Helms, H. C. C. & Kutter, J. P., 2022, In: Microfluidics and Nanofluidics. 26, 6, 10 p., 42.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model

  Frøslev, P., Franzyk, H., Ozgür, B., Larsen, B. B. & Kristensen, M., 2022, In: European Journal of Pharmaceutical Sciences. 168, 10 p., 106054.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  113 Downloads (Pure)

• Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers

  Ozgür, B., Helms, H. C. C., Tornabene, E. & Larsen, B. B., 2022, In: Fluids and Barriers of the CNS. 19, 1, 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  24 Downloads (Pure)

• Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)

  Mortensen, J. S., Bohr, S. S. R., Harloff-Helleberg, S., Hatzakis, N. S., Saaby, L. & Nielsen, H. M., 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  70 Downloads (Pure)

• Sortilin regulates blood-brain barrier integrity

  Toth, A. E., Helms, H. C., Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J., Klepe, A., Lipka, D. V., Møller, P. L., Andresen, T. L., Nyegaard, M., Moos, T., Brodin, B. & Nielsen, M. S., 2022, In: The FEBS Journal. 289, 4, p. 1062-1079

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  9 Downloads (Pure)

• Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions

  Imbernon, M., Saponaro, C., Helms, H. C. C., Duquenne, M., Fernandois, D., Deligia, E., Denis, R. G. P., Chao, D. H. M., Rasika, S., Staels, B., Pattou, F., Pfrieger, F. W., Brodin, B., Luquet, S., Bonner, C. & Prevot, V., 2022, In: Cell Metabolism. 34, 7, p. 1054-1063.e7

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  7 Downloads (Pure)

• The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo

  Lisa Al Humaidan, E., Lund Pedersen, S., Burkhart, A., Laurfelt Munch Rasmussen, C., Moos, T., Fuchs, P., Alves Fernandes, E. F., Ozgür, B., Strømgaard, K., Bach, A., Larsen, B. B. & Kristensen, M., 2022, In: Frontiers in Drug Delivery - CNS Drug Delivery. 2, 17 p., 854703.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  82 Downloads (Pure)
• 2021

  ATP induces contraction of cultured brain capillary pericytes, via activation of P2Y type purinergic receptors

  Hørlyck, S., Cai, C., Helms, H. C., Lauritzen, M. & Brodin, B., 2021, In: American Journal of Physiology: Heart and Circulatory Physiology. 320, p. H699–H712 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Brain endothelial cells metabolize glutamate via glutamate dehydrogenase to replenish TCA-intermediates and produce ATP under hypoglycemic conditions

  Hinca, S. B., Salcedo, C., Wagner, A., Goldeman, C., Sadat, E., Aibar, M. M. D., Maechler, P., Brodin, B., Aldana, B. I. & Helms, H. C. C., 2021, In: Journal of Neurochemistry. 157, 6, p. 1861-1875

  Research output: Contribution to journal › Journal article › Research › peer-review

• Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease

  Pultz, I. S., Hill, M., Vitanza, J. M., Wolf, C., Saaby, L., Liu, T., Winkle, P. & Leffler, D. A., Jul 2021, In: Gastroenterology. 161, 1, p. 81-93.e3

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  43 Citations (Scopus)

  11 Downloads (Pure)

• Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)

  Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, N., Ozgür, B., Holst, B., Shusta, E., Hall, V. J., Saaby, L., Hyttel, P. & Brodin, B., 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion

  Zambach, S. A., Cai, C., Helms, H. C. C., Hald, B. O., Dong, Y., Fordsmann, J. C., Nielsen, R. M., Hu, J., Lønstrup, M., Brodin, B. & Lauritzen, M. J., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 26, e2023749118.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  47 Citations (Scopus)

• Revealing the importance of carrier-cargo association in delivery of insulin and lipidated insulin

  Diedrichsen, R. G., Harloff-Helleberg, S., Werner, U., Besenius, M., Leberer, E., Kristensen, M. & Nielsen, H. M., 2021, In: Journal of Controlled Release. 338, p. 8-21

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  18 Citations (Scopus)

  100 Downloads (Pure)

• Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

  Ozgür, B., Saaby, L., Janfelt, C., Langthaler, K., Eneberg, E., Jacobsen, A-M., Badolo, L., Montanari, D. & Larsen, B. B., 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  44 Downloads (Pure)

• Tanycytes Control the Hypothalamic Uptake and Metabolic Actions of Liraglutide

  Imbernon, M., Saponaro, C., Helms, H. C. C., Zubiaga, L., Bitsi, S., Duquenne, M., Tomas, A., Chen, S., Salem, V., Deligia, E., Gmyr, V., Denis, R., Kerr-Conte, J., Chao, D. H. M., Beiroa, D., Steals, B., Pattou, F., Pfrieger, F., Brodin, B., Jones, B. & 3 others, Luquet, S., Bonner, C. & Prevot, V., Jul 2021, In: Glia. 69, S1, p. E237-E237

  Research output: Contribution to journal › Conference abstract in journal › Research

• Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins

  Winkler, L., Blasig, R., Breitkreuz-Korff, O., Berndt, P., Dithmer, S., Helms, H. C., Puchkov, D., Devraj, K., Kaya, M., Qin, Z., Liebner, S., Wolburg, H., Andjelkovic, A. V., Rex, A., Blasig, I. E. & Haseloff, R. F., 2021, In: Journal of Cerebral Blood Flow and Metabolism. 41, 1, p. 132-145

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  11 Citations (Scopus)

• Transendothelial electrical resistance measurement across the blood–brain barrier: A critical review of methods

  Vigh, J. P., Kincses, A., Ozgür, B., Walter, F. R., Santa-Maria, A. R., Valkai, S., Vastag, M., Neuhaus, W., Brodin, B., Dér, A. & Deli, M. A., 2021, In: Micromachines. 12, 6, 18 p., 685.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  1 Citation (Scopus)

  31 Downloads (Pure)
• 2020

  A novel derivative of thioridazine shows low toxicity and efficient activity against gram‐positive pathogens

  Jørgensen, N. S., Saaby, L., Andersson, A. M., Kromann, S., Sheikhsamani, E., Permin, A., Ronco, T., Svenningsen, S. W., Christensen, J. B. & Olsen, R. H., 2020, In: Antibiotics. 9, 6, 11 p., 327.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Citations (Scopus)

  78 Downloads (Pure)

• Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation

  Kristensen, M., Kucharz, K., Felipe Alves Fernandes, E., Strømgaard, K., Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, A., Ulrikkaholm Tofte-Hansen, M., Irene Aldana Garcia, B., Lauritzen, M. & Brodin, B., 2020, In: Pharmaceutics. 12, 7, 24 p., 661.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  3 Citations (Scopus)

  35 Downloads (Pure)

• Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells

  Goldeman, C., Ozgür, B. & Brodin, B., 22 Apr 2020, In: Fluids and Barriers of the CNS. 17, 32, 12 p., 32.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  3 Citations (Scopus)

  95 Downloads (Pure)

• Culture of brain capillary pericytes for cytosolic calcium measurements and calcium imaging studies

  Hørlyck, S., Helms, H. C. C. & Brodin, B., May 2020, In: Journal of Visualized Experiments. 159, p. 1-9 9 p., e61253.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB)

  Helms, H. C. C., Kristensen, M., Saaby, L., Fricker, G. & Brodin, B., 2020, Handbook of Experimental Pharmacology. Springer, Vol. 273. p. 151-183

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
  12 Citations (Scopus)

• Increased Carrier Peptide Stability through pH Adjustment Improves Insulin and PTH(1-34) Delivery In Vitro and In Vivo Rather than by Enforced Carrier Peptide-Cargo Complexation

  Kristensen, M., Diedrichsen, R. G., Vetri, V., Foderà, V. & Nielsen, H. M., 2020, In: Pharmaceutics. 12, 10, 18 p., 993.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  13 Citations (Scopus)

  75 Downloads (Pure)

• IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

  Saaby, L., Trasborg, J., Rasmussen, M. A., Holst, B. & Brodin, B., 17 Jul 2020, In: Pharmaceutics. 12, 7, 17 p., 673.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  1 Citation (Scopus)

  69 Downloads (Pure)

• Nitric oxide, KATP channels and endothelin-1 modulate brain pericyte function, vascular tone and neurovascular coupling

  Zambach, S. A., Cai, C., Helms, H. C. C., Hald, B. O., Fordsmann, J. C., Nielsen, R. M., Lønstrup, M., Brodin, B. & Lauritzen, M. J., 8 Jun 2020, bioRxiv, 43 p.

  Research output: Working paper › Preprint

  File
  28 Downloads (Pure)

• The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

  Ambjørner, S. E. B., Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, M., Saaby, L., Brodin, B., Rump, S., Weigt, H., Brünner, N. & Stenvang, J., 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  187 Downloads (Pure)
• 2019

  Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures

  Tornabene, E., Helms, H. C. C., Pedersen, S. F. & Brodin, B., 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  12 Citations (Scopus)

  126 Downloads (Pure)

• Evaluating the involvement of cerebral microvascular endothelial Na⁺/K⁺-ATPase and Na⁺-K⁺-2Cl^- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration

  Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, T. L., Tritsaris, K., Vilhardt, F., Brodin, B. & MacAulay, N., 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  10 Citations (Scopus)

• Two-photon fluorescence imaging: a platform to investigate cell-penetrating peptides and liposome-based nanocarriers for drug delivery across the heterogeneous BBB in vivo

  Kucharz, K., Kristensen, K., Kristensen, M., Lund, M., Andresen, T., Brodin, B. & Lauritzen, M., 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, p. 60 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
• 2018

  Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH

  Kristensen, M., Nielsen, L. H., Zor, K., Boisen, A., Christensen, M. V., Berthelsen, J. & Nielsen, H. M., 2018, In: Bioconjugate Chemistry. 29, 2, p. 371-381

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates

  Ozgür, B., Saaby, L., Langthaler, K. & Brodin, B., 2018, In: European Journal of Pharmaceutical Sciences. 112, p. 112-121 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Clinical and Regulatory Aspects of Companion Diagnostic Development in Oncology

  Jorgensen, J. T. & Hersom, M., Jun 2018, In: Clinical Pharmacology & Therapeutics. 103, 6, p. 999-1008

  Research output: Contribution to journal › Review › Research › peer-review
  29 Citations (Scopus)

• Companion and Complementary Diagnostics-Focus on PD-L1 Expression Assays for PD-1/PD-L1 Checkpoint Inhibitors in Non-Small Cell Lung Cancer

  Hersom, M. & Jorgensen, J. T., Feb 2018, In: Therapeutic Drug Monitoring. 40, 1, p. 9-16

  Research output: Contribution to journal › Review › Research › peer-review
  81 Citations (Scopus)