Drug Delivery and Biophysics of Biopharmaceuticals

Research output

Research output per year 1995 2015 2016 2018 2019 2020 2021 2022 2023 2024 2025

• 225 Journal article
• 14 Review
• 11 Book chapter
• 8 Conference abstract for conference
• 20 More
  • 4 Poster
  • 3 Comment/debate
  • 3 Conference abstract in journal
  • 3 Letter
  • 2 Editorial
  • 2 Preprint
  • 1 Ph.D. thesis
  • 1 Conference article
  • 1 Patent

Research output per year

Research output per year

Search results

• 2025

  A low-complexity linker as a driver of intra- and intermolecular interactions in DNAJB chaperones

  Hobbs, B., Limmer, N., Ossa, F., Knupling, E., Lenton, S., Fodera, V., Kalverda, A. P. & Karamanos, T. K., 2025, In: Nature Communications. 16, 1, 14 p., 5070.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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• Branched penetratin and penetramax display enhanced intestinal insulin delivery potency compared to their linear counterparts

  Diedrichsen, R. G., Mishra, N. K., Fredholt, F., Heade, J., Sørensen, K. K., Jensen, K. J. & Nielsen, H. M., 2025, In: Journal of Controlled Release. 380, p. 1031-1042

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  12 Downloads (Pure)

• Determination and exposure assessment of mycotoxins in Polygonati Rhizoma (Liliaceae)–An edible plant

  Wang, W., Rui, Y., Yuan, Y., Ma, Y., Luo, C., Yuan, L. & He, L., 2025, In: Journal of Food Composition and Analysis. 140, 107269.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Disassembly and in vitro cell compatibility of α-lactalbumin particulates under physiologically relevant conditions

  Stie, M. B., Fennema Galparsoro, D., Zhou, X. & Foderà, V., 2025, In: European Journal of Pharmaceutical Sciences. 204, 7 p., 106962.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  3 Citations (Scopus)

  5 Downloads (Pure)

• Hierarchy in regulator interactions with distant transcriptional activation domains empowers rheostatic regulation

  Due, A. D., Davey, N. E., Thomasen, F. E., Morffy, N., Prestel, A., Brakti, I., O'Shea, C., Strader, L. C., Lindorff-Larsen, K., Skriver, K. & Kragelund, B. B., 2025, In: Protein Science. 34, 6, 18 p., e70142.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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• Insulin amyloid morphology is encoded in H-bonds and electrostatics interactions ruling protein phase separation

  Lenton, S., Chaaban, H., Khaled, M., van de Weert, M., Strodel, B. & Foderà, V., 2025, In: Journal of Colloid and Interface Science. 683, p. 1175-1187

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Downloads (Pure)

• Intraoral Novel Drug Delivery Systems

  Mortazavi, S. M., Sayed-Tabatabaei, L., Tabatabaei, M. S. & Moghaddam, A. V., 2025, Novel Drug Delivery Systems: Fundamentals and Applications. Wiley, p. 67-102

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Low-frequency Raman spectroscopy as a new tool for understanding the behaviour of ionisable compounds in dispersed mesophases

  Krog, L. S., Kihara, S., Mota-Santiago, P., Foderà, V., Bērziņš, K. & Boyd, B. J., 2025, In: Journal of Colloid and Interface Science. 683, p. 210-220

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  1 Citation (Scopus)

  10 Downloads (Pure)

• Modulation of insulin aggregation by betaine and proline directly observed via real-time super-resolution microscopy

  Bender, S. W. B., Kaestel-Hansen, J., Fodera, V., Hatzakis, N. S. & Zhang, M., 2025, In: Protein Science. 34, 6, 9 p., e70149.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  1 Downloads (Pure)

• Nanogel encapsulation improves pharmacokinetics and biodistribution of antimicrobial peptide LL37 upon lung deposition: In vivo evaluation by SPECT/CT

  Kłodzińska, S. N., Esposito, T. V. F., Agnoletti, M., Rodríguez-Rodríguez, C., Blackadar, C., Wu, L., Thakur, A., Nahrstedt, J., Rades, T., Saatchi, K., Häfeli, U. O. & Mørck Nielsen, H., 2025, In: Journal of Controlled Release. 383, 13 p., 113817.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Downloads (Pure)

• Nanostructured lipid carriers as a strategy to enhance oral levosulpiride delivery: An in vitro and ex vivo assessment

  Arif, S. T., Khan, M. A., Frøslev, P., Zaman, S. U., Panou, D. A., Nielsen, H. M. & Heade, J., 2025, In: International Journal of Pharmaceutics. 669, 10 p., 125047.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  30 Downloads (Pure)

• Non-Invasive structural analysis of packaged pharmaceuticals using different variants of spatially offset low-frequency Raman spectroscopy

  Bērziņš, K., Krog, L. S. & Boyd, B. J., 2025, In: Measurement: Journal of the International Measurement Confederation. 252, 9 p., 117360.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  1 Downloads (Pure)

• Ocular Novel Drug Delivery Systems

  Khazaeli, P., Tabatabaei, M. S., Sayed-Tabatabaei, L. & Estabragh, M. A. R., 2025, Novel Drug Delivery Systems: Fundamentals and Applications. Wiley, p. 393-418

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Recent Advances and Challenges in the Development and Delivery of Antiprotozoal Agents Against Trichomoniasis

  Jaromin, A., Zagórska, A., Moraes, J. D. & Boyd, B. J., 2025, (E-pub ahead of print) In: Transboundary and Emerging Diseases. 1051460.

  Research output: Contribution to journal › Review › peer-review

  Open Access

• Time-Resolved In Situ Small-Angle X-ray Scattering to Determine the Kinetics of Formation of Liquid Crystalline Structure in the Core of Polymeric Nanoparticles during and after Turbulent Mixing

  Dasaro, S. R., Johnson, L. D., Salim, M., He, V., Amelemah, D., Ponsonby-Thomas, E., Barber, B., Fong, W.-K., Caukwell, J., Peach, E., Li, B., Manni, L. S., Kirby, N., Warr, G. G., Prud'homme, R. K., Boyd, B. J. & Ristroph, K., 2025, In: Nano Letters. 25, 17, p. 7075–7080

  Research output: Contribution to journal › Journal article › Research › peer-review

• To conjugate or not to conjugate? evaluating the potential use of cell-penetrating peptides for conjugation or complexation with oligonucleotides by surface plasmon resonance

  Dueholm, R., Ewald, J., Zosel, F., Heljo, P., Premdjee, B., Davies, A., Buckley, S. T., Hovgaard, L. & Nielsen, H. M., 2025, In: International Journal of Pharmaceutics. 671, 8 p., 125198.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  2 Downloads (Pure)
• 2024

  A head-to-head comparison of polymer interaction with mucin from porcine stomach and bovine submaxillary glands

  Stie, M. B., Cunha, C., Huang, Z., Kirkensgaard, J. J. K., Tuelung, P. S., Wan, F., Nielsen, H. M., Foderà, V. & Rønholt, S., 2024, In: Scientific Reports. 14, 1, 11 p., 21350.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  3 Citations (Scopus)

  21 Downloads (Pure)

• Amino acids as stabilizers for lysozyme during the spray-drying process and storage

  Zhang, C., Jørgensen, F. S., van de Weert, M., Bjerregaard, S., Rantanen, J. & Yang, M., 2024, In: International Journal of Pharmaceutics. 659, 124217.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  4 Citations (Scopus)

  18 Downloads (Pure)

• Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches

  Zhuo, X., Foderà, V., Larsson, P., Schaal, Z., Bergström, C. A. S., Löbmann, K. & Kabedev, A., 2024, In: European Journal of Pharmaceutical Sciences. 192, 13 p., 106639.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  9 Citations (Scopus)

  36 Downloads (Pure)

• Are membrane-interacting peptides viable as excipients for non-injectable peptide delivery?

  Nielsen, H. M., 2024, In: Expert Opinion on Drug Delivery. 21, 12, p. 1715-1718

  Research output: Contribution to journal › Editorial › Research › peer-review

• Biodistribution of Native and Nanoformulated Innate Defense Regulator Peptide 1002

  Esposito, T. V. F., Blackadar, C., Wu, L., Rodríguez-Rodríguez, C., Haney, E. F., Pletzer, D., Saatchi, K., Hancock, R. E. W. & Häfeli, U. O., 2024, In: Molecular Pharmaceutics. 21, 6, p. 2751-2766

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)

• Biodistribution of the cationic host defense peptide LL-37 using SPECT/CT

  Esposito, T. V. F., Rodríguez-Rodríguez, C., Blackadar, C., Kłodzińska, S., Mørck Nielsen, H., Saatchi, K. & Häfeli, U. O., 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 202, 9 p., 114398.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Defect engineering to tailor structure-activity relationship in biodegradable nanozymes for tumor therapy by dual-channel death strategies

  Su, Y., Lv, M., Huang, Z., An, N., Chen, Y., Wang, H., Li, Z., Wu, S., Ye, F., Shen, J. & Li, A., 2024, In: Journal of Controlled Release. 367, p. 557-571

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Development of a ^99mTc-labeled tetrazine for pretargeted SPECT imaging using an alendronic acid-based bone targeting model

  Bohrmann, L., Poulie, C. B. M., Rodríguez-Rodríguez, C., Karagiozov, S., Saatchi, K., Herth, M. M. & Häfeli, U. O., 2024, In: PLoS ONE. 19, 4, 18 p., e0300466.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  18 Downloads (Pure)

• Development of an immunosuppressed orthotopic hepatocellular carcinoma rat model for the evaluation of chemo- and radioembolization therapies

  Charles, L., Sekar, S., Osooly, M., Javed, S., Williams, K. C., Welch, I., Barta, I., Saatchi, K. & Häfeli, U. O., 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 196, 9 p., 114180.

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)

• Eco-Friendly Electrospun Nanofibers Based on Plant Proteins as Tunable and Sustainable Biomaterials

  Kalouta, K., Stie, M. B., Sun, X., Foderà, V. & Vetri, V., 2024, In: A C S Sustainable Chemistry & Engineering. 12, 27, p. 10118–10129

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Exploring the effect of protein secondary structure on the solid state and physical stability of protein-based amorphous solid dispersions

  Zhuo, X., Ochner, J., Leng, D., Foderà, V. & Löbmann, K., 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 198, 8 p., 114274.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  3 Citations (Scopus)

  28 Downloads (Pure)

• Investigating the influence of protein secondary structure on the dissolution behavior of β-lactoglobulin-based amorphous solid dispersions

  Zhuo, X., Tozzetti, M., Arnous, A., Leng, D., Foderà, V. & Löbmann, K., 2024, In: International Journal of Pharmaceutics. 653, 8 p., 123887.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  4 Citations (Scopus)

  24 Downloads (Pure)

• Leucine as a Moisture-Protective Excipient in Spray-Dried Protein/Trehalose Formulation

  Zhang, C., van de Weert, M., Bjerregaard, S., Rantanen, J. & Yang, M., 2024, In: Journal of Pharmaceutical Sciences. 113, 9, p. 2764-2774

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Ligand binding to proteins: When flawed fluorescence quenching methodology and interpretation become the new norm

  van de Weert, M. & Schönbeck, C., 2024, In: European Journal of Pharmaceutical Sciences. 203, 6 p., 106930.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

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  5 Downloads (Pure)

• Nanogel delivery systems for cationic peptides: More than a ‘One Size Fits All’ solution

  Kłodzińska, S. N., Wang, Q., Molchanova, N., Mahmoudi, N., Vallooran, J. J., Hansen, P. R., Jenssen, H. & Mørck Nielsen, H., 2024, In: Journal of Colloid and Interface Science. 663, p. 449-457

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Neo-Glycolipid Oximes as Intestinal Permeation Enhancers for Peptide Hormone PYY_3-36

  Kalomoiri, P., Mortensen, J. S., Christensen, N. J., Sørensen, K. K., Nielsen, H. M., Jensen, K. J. & Thygesen, M. B., 2024, In: Chemistry: A European Journal. 30, 72, 17 p., e202401887.

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)

• Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation

  Mortensen, J. S., Bohr, S. S. R., Krog, L. S., Bøtker, J. P., Kapousidou, V., Saaby, L., Hatzakis, N. S., Mørck Nielsen, H., Nguyen, D. N. & Rønholt, S., 2024, In: Scientific Reports. 14, 1, 17 p., 7665.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  2 Citations (Scopus)

  42 Downloads (Pure)

• Pea Protein Isolate-Based Nanofibers for Delivery of Clotrimazole

  Kalouta, K., Stie, M. B., Vetri, V. & Foderà, V., 2024, In: ACS Applied Nano Materials. 7, 23, p. 27736–27744

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)

• Prodrug Nanomedicine for Synovium Targeted Therapy of Inflammatory Arthritis: Insights from Animal Model and Human Synovial Joint Fluid

  Nosrati, Z., Chen, Y. A., Bergamo, M., Rodríguez-Rodríguez, C., Chan, J., Shojania, K., Kherani, R. B., Chin, C., Kelsall, J. T., Dehghan, N., Colwill, A. M., Collins, D., Saatchi, K. & Häfeli, U. O., 2024, In: Advanced Healthcare Materials. 13, 30, 2401936.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

  1 Downloads (Pure)

• Risk assessment of exposure to 12 kinds of mycotoxins through consumption of Pericarpium Citri Reticulatae collected from Three Gorges Reservoir area of China

  Wang, W., Yuan, Y., Ma, Y., Wu, R., He, S. & He, L., 2024, In: Toxicon. 243, 107745.

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)

• Time-resolved scattering methods for biological samples at the CoSAXS beamline, MAX IV Laboratory

  Herranz-Trillo, F., Sørensen, H. V., Dicko, C., Pérez, J., Lenton, S., Foderà, V., Fornell, A., Skepö, M., Plivelic, T. S., Berntsson, O., Andersson, M., Magkakis, K., Orädd, F., Ahn, B., Appio, R., Da Silva, J., Da Silva, V., Lerato, M. & Terry, A. E., 2024, In: Methods in Enzymology. 709, p. 245-296

  Research output: Contribution to journal › Journal article › Research › peer-review

• Versatile Mechanically Tunable Hydrogels for Therapeutic Delivery Applications

  Sun, Q., Tao, S., Bovone, G., Han, G., Deshmukh, D., Tibbitt, M. W., Ren, Q., Bertsch, P., Siqueira, G. & Fischer, P., 2024, In: Advanced Healthcare Materials. 13, 18, 10 p., 2304287.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  10 Citations (Scopus)

  13 Downloads (Pure)
• 2023

  Application of Low-Frequency Raman Spectroscopy to Probe Dynamics of Lipid Mesophase Transformations upon Hydration

  Krog, L. S., Kirkensgaard, J. J. K., Foderà, V., Boyd, B. J. & Be̅rziņš, K., 2023, In: Journal of Physical Chemistry B. 127, 14, p. 3223-3230

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  4 Citations (Scopus)

  2 Downloads (Pure)

• Ca²⁺-Responsive Glyco-insulin

  Wu, S., Østergaard, M., Fredholt, F., Christensen, N. J., Sørensen, K. K., Mishra, N. K., Nielsen, H. M. & Jensen, K. J., 2023, In: Bioconjugate Chemistry. 34, 3, p. 518–528

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  1 Citation (Scopus)

  1 Downloads (Pure)

• Carrier peptide interactions with liposome membranes induce reversible clustering by surface adsorption and shape deformation

  Diedrichsen, R. G., Vetri, V., Prévost, S., Foderà, V. & Nielsen, H. M., 2023, In: Journal of Colloid and Interface Science. 650, Part B, p. 1821-1832

  Research output: Contribution to journal › Journal article › Research › peer-review

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  5 Citations (Scopus)

  60 Downloads (Pure)

• Cell-Penetrating Peptides as Tools to Facilitate Oral Delivery of Biopharmaceuticals

  Asgreen, C. J., Fredholt, F., Nielsen, H. M. & Kristensen, M., 2023, Cell-Penetrating Peptides: Design, Development and Applications. Oba, M. & Demizu , Y. (eds.). Wiley-VCH, p. 331-354

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Corrigendum to "Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites" [J. Colloid Interface Sci. 606(Part 2) (2022) 1928-1939]

  Zhou, X., Galparsoro, D. F., Madsen, A. Ø., Vetri, V., van de Weert, M., Nielsen, H. M. & Foderà, V., 2023, In: Journal of Colloid and Interface Science. 640, p. 917

  Research output: Contribution to journal › Journal article › Communication

  Open Access

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  1 Downloads (Pure)

• Editorial: Microbe-nanoparticle interactions: a mechanistic approach

  Kumari, M., Klodzinska, S. N. & Chifiriuc, M. C., 2023, In: Frontiers in Microbiology. 14, 2 p., 1273364.

  Research output: Contribution to journal › Editorial › Research › peer-review

  Open Access

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  3 Citations (Scopus)

  20 Downloads (Pure)

• Effects of prophylactic antibiotics administration on barrier properties of intestinal mucosa and mucus from preterm born piglets

  Mortensen, J. S., Nguyen, D. N., Mørck Nielsen, H. & Harloff-Helleberg, S., 2023, In: Drug Delivery and Translational Research. 13, p. 1456–1469

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

  4 Downloads (Pure)

• Encapsulation in oleyl-modified hyaluronic acid nanogels substantially improves the clinical potential of the antimicrobial peptides SAAP-148 and Ab-Cath

  van Gent, M. E., Klodzinska, S. N., Drijfhout, J. W., Nielsen, H. M. & Nibbering, P. H., 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 193, p. 254-261

  Research output: Contribution to journal › Journal article › Research › peer-review

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  7 Citations (Scopus)

  24 Downloads (Pure)

• Encapsulation into hyaluronic acid-based nanogels improves the selectivity index of the snake cathelicidin Ab-Cath

  van Gent, M. E., Kłodzińska, S. N., Severin, M., Ali, M., van Doodewaerd, B. R., Bos, E., Koning, R. I., Drijfhout, J. W., Nielsen, H. M. & Nibbering, P. H., 2023, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 52, 11 p., 102694.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  8 Citations (Scopus)

  24 Downloads (Pure)

• Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections

  van Gent, M. E., van Baaren, T., Kłodzińska, S. N., Ali, M., Dolezal, N., van Doodewaerd, B. R., Bos, E., de Waal, A. M., Koning, R. I., Drijfhout, J. W., Nielsen, H. M. & Nibbering, P. H., 2023, In: Pharmaceutics. 15, 2, 20 p., 429.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  9 Citations (Scopus)

  28 Downloads (Pure)

• Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison

  Panou, D. A., Pedersen, S. H. F., Kristensen, M. & Nielsen, H. M., 2023, In: Frontiers in Drug Delivery. 3, 16 p., 1221628.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  5 Citations (Scopus)

  42 Downloads (Pure)

• From dilute to concentrated solutions of intrinsically disordered proteins: Interpretation and analysis of collected data

  Lenton, S., Fagerberg, E., Tully, M. & Skepö, M., 2023, In: Methods in Enzymology. 678, p. 299-330

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)