Research output per year
Research output per year
Personal profile
Primary fields of research
The focus of our lab is to understand the mechanisms that regulate differentiation of skeletal stem cells to osteoblast and adipocyte lineages, and to investigate the relevance of these regulatory mechanisms to pathogenesis of bone loss in the context of inflammation, cancer, and aging.
Current research
- Regulatory mechanisms of skeletal (mesenchymal) stem cell (MSC) fate specification
- Role of lysosomal proteases in regulation of bone and systemic energy homeostasis
- Role of MSC-secreted factors in pathogenesis of bone loss in the context of aging, cancer, and inflammation
- Role of bone marrow adipose tissue in regulation of skeletal homeostasis
Teaching
Our group has been engaged in teaching activities at different levels (medical students, bachelor, Master, PhD programs) and research training of post docs and international researchers.
Keywords
- Faculty of Health and Medical Sciences
- Mesenchymal (Skeletal) Stem Cell
- Osteoblast
- Adipocyte
- bone marrow adipose tissue
- cancer/inflammation/age-related bone loss
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Bone marrow adipocytes provide early sign for progression from MGUS to multiple myeloma
El-Masri, B. M., Leka, B., Mustapha, F., Gundesen, M. T., Hinge, M., Lund, T., Andersen, T. L., Diaz-delCastillo, M. & Jafari, A., 2024, In: OncoTarget. 15, p. 20-26 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)20 Downloads (Pure) -
Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer
Bagger, M. M., Sjölund, J., Kim, J., Kohler, K. T., Villadsen, R., Jafari, A., Kassem, M., Pietras, K., Rønnov-Jessen, L. & Petersen, O. W., 2024, In: Breast Cancer Research. 26, 1, 19 p., 11.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)17 Downloads (Pure) -
Legumain is a paracrine regulator of osteoblast differentiation and mediates the inhibitory effect of TGF-β1 on osteoblast maturation
Forbord, K. M., Lunde, N. N., Bosnjak-Olsen, T., Johansen, H. T., Solberg, R. & Jafari, A., 2024, In: Frontiers in Endocrinology. 15, 11 p., 1445049.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile -
The Cysteine Protease Legumain Is Upregulated by Vitamin D and Is a Regulator of Vitamin D Metabolism in Mice
Forbord, K. M., Okla, M., Lunde, N. N., Bosnjak-Olsen, T., Arnekleiv, G., Hesselson, D., Johansen, H. T., Tang, J. C. Y., Kassem, M., Solberg, R. & Jafari, A., 2024, In: Cells. 13, 1, 16 p., 36.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Downloads (Pure) -
Disturbed bone marrow adiposity in patients with Cushing’s syndrome and glucocorticoid- and postmenopausal- induced osteoporosis
Sørensen, N. N., Andreasen, C. M., Jensen, P. R., Hauge, E. M., Bollerslev, J., Delaissé, J. M., Kassem, M., Jafari, A., Diaz-delCastillo, M. & Andersen, T. L., 2023, In: Frontiers in Endocrinology. 14, 14 p., 1232574.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)13 Downloads (Pure) -
Interplay between Cultured Human Osteoblastic and Skeletal Muscle Cells: Effects of Conditioned Media on Glucose and Fatty Acid Metabolism
Lunde, N. N., Osoble, N. M. M., Fernandez, A. D., Antobreh, A. S., Jafari, A., Singh, S., Nyman, T. A., Rustan, A. C., Solberg, R. & Thoresen, G. H., 2023, In: Biomedicines. 11, 11, 20 p., 2908.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Downloads (Pure) -
TNIK is a conserved regulator of glucose and lipid metabolism in obesity
Pham, T. C. P., Dollet, L., Ali, M. S., Raun, S. H., Møller, L. L. V., Jafari, A., Ditzel, N., Andersen, N. R., Fritzen, A. M., Gerhart-Hines, Z., Kiens, B., Suomalainen, A., Simpson, S. J., Salling Olsen, M., Kieser, A., Schjerling, P., Nieminen, A. I., Richter, E. A., Havula, E. & Sylow, L., 2023, In: Science Advances. 9, 32, 18 p., eadf7119.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile7 Citations (Scopus)38 Downloads (Pure) -
The Mammalian Cysteine Protease Legumain in Health and Disease
Solberg, R., Lunde, N. N., Forbord, K. M., Okla, M., Kassem, M. & Jafari, A., 2022, In: International Journal of Molecular Sciences. 23, 24, 15983.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile21 Citations (Scopus)17 Downloads (Pure)