Research output per year
Research output per year
Personal profile
Short presentation
Clinical Professor of Muscle Physiology and Regeneration after Traumatic Soft-tissue Injury
Full list of publications and metrics:
Current research
Skeletal muscle produces the forces required for movement of the human body. To perform this function, each muscle fibre is dependent on neural input to inititate contraction, and a strong attachment to the skeleton for force transmission. The overall aim of our group is to understand how these components of physical function are affected by injury and during the ageing process, and how physical activity can help to slow the decline. Specifically we focus on muscle regeneration, muscle fibre denervation, and the myotendinous junction.
Possible conflicts of interest
Funding received from:
Lundbeck Foundation
Novo Nordisk Foundation
Independent Research Fund Denmark
Ministry of Culture Denmark
A.P. Møller Foundation
The Danish Rheumatism Association
Nordea Foundation (Healthy Aging Grant)
CV
PhD student supervision
2022, Casper Søndenbroe, Maintaining Muscle Innervation Through Exercise
2022, Jonathan Jetsmark Bjerre-Bastos, A novel clinical model for evaluating acute joint tissue turnover in osteoarthritis drug development
2019, Cecilie Jæger Leidesdorff Bechshøft, The role of ageing in the interplay between satellite cells and interstitial cells in skeletal muscle at rest and in response to exercise
2018, Anders Karlsen, The maintenance and improvement of skeletal muscle mass and function in healthy elderly individuals and hospitalized patients
2018, Mette Flindt Heisterberg, Can angiotensin II receptor blockers improve the response to heavy resistance exercise in elderly human muscle?
Education/Academic qualification
DMSc, Faculty of Health and Medical Science, University of Copenhagen, Denmark.
Award Date: 1 Feb 2022
PhD, University of Limerick
Award Date: 9 Sep 2003
Sport and Exercise Science, BSc, University of Limerick
Award Date: 16 Sep 1998
Keywords
- Faculty of Health and Medical Sciences
- Human experiments
- Satellite cells
- Skeletal muscle
- Myotendinous junction
- Extracellular matrix
- Muscle regeneration
- Muscle injury
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
-
Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise‐dependent manner
Soendenbroe, C., Schjerling, P., Bechshøft, C. J. L., Svensson, R. B., Schaeffer, L., Kjaer, M., Chazaud, B., Jacquier, A. & Mackey, A. L., 2024, (E-pub ahead of print) In: Aging Cell.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access -
Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration
Højfeldt, G., Sorenson, T., Gonzales, A., Kjaer, M., Andersen, J. L. & Mackey, A. L., 12 Aug 2023, In: Skeletal Muscle. 13, 1, p. 1-14 13.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile41 Downloads (Pure) -
Distinct myofibre domains of the human myotendinous junction revealed by single-nucleus RNA sequencing
Karlsen, A., Yeung, C-Y. C., Schjerling, P., Denz, L., Hoegsbjerg, C., Jakobsen, J. R., Krogsgaard, M., Koch, M., Schiaffino, S., Kjaer, M. & Mackey, A., 2023, In: Journal of Cell Science. 136, 8, 14 p., jcs260913.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile14 Citations (Scopus)95 Downloads (Pure) -
Enhancing muscle and brain resilience: The role of prehabilitative exercise in mitigating disuse effects
Soendenbroe, C., Boraxbekk, C-J. & Mackey, A. L., 6 Jan 2025, (E-pub ahead of print) In: The Journal of Physiology. 14 p.Research output: Contribution to journal › Review › Research › peer-review
-
Bone remodeling in survivors of pediatric hematopoietic stem cell transplantation: Impact of heavy resistance training
Krogh, L. M., Nissen, A., Weischendorff, S., Hartmann, B., Andersen, J. L., Holst, J. J., Sørensen, K., Fridh, M. K., Mackey, A. L. & Müller, K., 2024, In: Medical and Pediatric Oncology. Supplement. 71, 9, 10 p., e31159.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)6 Downloads (Pure) -
Fibre type differences in the organisation of mononuclear cells and myonuclei at the tips of human myofibres
Hoegsbjerg, C., Moebjerg, A., Yeung, C-Y. C., Schjerling, P., Krogsgaard, M. R., Koch, M., Kjaer, M., Keudell, A. G. V. & Mackey, A. L., 2024, (E-pub ahead of print) In: Journal of Cell Science.Research output: Contribution to journal › Journal article › Research › peer-review
10 Downloads (Pure) -
Insulin‐like growth factor‐1 infusion in preterm piglets does not affect growth parameters of skeletal muscle or tendon tissue
Tangbjerg, M., Damgaard, A., Karlsen, A., Svensson, R. B., Schjerling, P., Gelabert-Rebato, M., Pankratova, S., Sangild, P. T., Kjaer, M. & Mackey, A. L., 2024, In: Experimental Physiology. 109, 9, p. 1529-1544Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Downloads (Pure) -
Marked irregular myofiber shape is a hallmark of human skeletal muscle ageing and is reversed by heavy resistance training
Soendenbroe, C., Karlsen, A., Svensson, R. B., Kjaer, M., Andersen, J. L. & Mackey, A. L., 2024, In: Journal of Cachexia, Sarcopenia and Muscle. 15, 1, p. 306-318 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)30 Downloads (Pure)