Alexander Sebastian Hauser

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• 2025

  PGxDB: an interactive web-platform for pharmacogenomics research

  Duong Nguyen, T. T., Tanoli, Z., Hassan, S., Özcan, U. O., Caroli, J., Kooistra, A. J., Gloriam, D. E. & Hauser, A. S., 2025, In: Nucleic Acids Research. 53, D1, p. D1486–D1497

  Research output: Contribution to journal › Journal article › Research › peer-review

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• 2024

  AI chatbots as Co-Pilots in Learning During Practical Teaching Activities

  Hauser, A. S., Hansen, U. K. & Skov, S., 2024, Improving University Science Teaching and Learning : Pedagogical Projects 2024. Department of Science Education, University of Copenhagen, 19 p. (Improving University Science Teaching and Learning - Pedagogical Projects; No. 2, Vol. 20).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

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• Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

  Kizilkaya, H. S., Sørensen, K. V., Madsen, J. S., Lindquist, P., Douros, J. D., Bork-Jensen, J., Berghella, A., Gerlach, P. A., Gasbjerg, L. S., Mokrosiński, J., Mowery, S. A., Knerr, P. J., Finan, B., Campbell, J. E., D’Alessio, D. A., Perez-Tilve, D., Faas, F., Mathiasen, S., Rungby, J., Sørensen, H. T. & 15 others, Vaag, A., Nielsen, J. S., Holm, J. C., Lauenborg, J., Damm, P., Pedersen, O., Linneberg, A., Hartmann, B., Holst, J. J., Hansen, T., Wright, S. C., Lauschke, V. M., Grarup, N., Hauser, A. S. & Rosenkilde, M. M., 2024, In: Nature Metabolism. 6, p. 1268–1281

  Research output: Contribution to journal › Journal article › Research › peer-review

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  9 Citations (Scopus)

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• Differential G protein activation by the long and short isoforms of the dopamine D₂ receptor

  Reiner-Link, D., Madsen, J. S., Gloriam, D. E., Bräuner-Osborne, H. & Hauser, A. S., 2024, (Accepted/In press) In: British Journal of Pharmacology.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

• G protein-coupled receptor (GPCR) gene variants and human genetic disease

  Thompson, M. D., Percy, M. E., Cole, D. E. C., Bichet, D. G., Hauser, A. S. & Gorvin, C. M., 2024, In: Critical Reviews in Clinical Laboratory Sciences. 61, 5, p. 317-346

  Research output: Contribution to journal › Review › Research › peer-review

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  2 Citations (Scopus)

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• G protein-coupled receptor (GPCR) pharmacogenomics

  Thompson, M. D., Reiner-Link, D., Berghella, A., Rana, B. K., Rovati, G. E., Capra, V., Gorvin, C. M. & Hauser, A. S., 2024, In: Critical Reviews in Clinical Laboratory Sciences. 61, 8, p. 641-684

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• 2023

  A community Biased Signaling Atlas

  Caroli, J., Mamyrbekov, A., Harpsøe, K., Gardizi, S., Dörries, L., Ghosh, E., Hauser, A. S., Kooistra, A. J. & Gloriam, D. E., 2023, In: Nature Chemical Biology. 19, p. 531–535

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics

  Wright, S. C., Motso, A., Koutsilieri, S., Beusch, C. M., Sabatier, P., Berghella, A., Blondel-Tepaz, É., Mangenot, K., Pittarokoilis, I., Sismanoglou, D. C., Le Gouill, C., Olsen, J. V., Zubarev, R. A., Lambert, N. A., Hauser, A. S., Bouvier, M. & Lauschke, V. M., 2023, In: Nature Communications. 14, 1, 13 p., 6243.

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  14 Citations (Scopus)

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• Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes

  Melchiorsen, J. U., Sørensen, K. V., Bork-Jensen, J., Kizilkaya, H. S., Gasbjerg, L. S., Hauser, A. S., Rungby, J., Sørensen, H. T., Vaag, A., Nielsen, J. S., Pedersen, O., Linneberg, A., Hartmann, B., Gjesing, A. P., Holst, J. J., Hansen, T., Rosenkilde, M. M. & Grarup, N., 2023, In: Journal of Clinical Endocrinology and Metabolism. 108, 11, p. 2821–2833 38 p.

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  4 Citations (Scopus)

  25 Downloads (Pure)
• 2022

  Common coupling map advances GPCR-G protein selectivity

  Hauser, A. S., Avet, C., Normand, C., Mancini, A., Inoue, A., Bouvier, M. & Gloriam, D. E., 2022, In: eLife. 11, 22 p., e74107.

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  71 Citations (Scopus)

  37 Downloads (Pure)

• Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

  Avet, C., Mancini, A., Breton, B., Le Gouill, C., Hauser, A. S., Normand, C., Kobayashi, H., Gross, F., Hogue, M., Lukasheva, V., St-Onge, S., Carrier, M., Héroux, M., Morissette, S., Fauman, E. B., Fortin, J. P., Schann, S., Leroy, X., Gloriam, D. E. & Bouvier, M., 2022, In: eLife. 11, 34 p., e74101.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  125 Citations (Scopus)

  19 Downloads (Pure)

• Ligand-directed bias of G protein signaling at the dopamine D₂ receptor

  Von Moo, E., Harpsøe, K., Hauser, A. S., Masuho, I., Bräuner-Osborne, H., Gloriam, D. E. & Martemyanov, K. A., 2022, In: Cell Chemical Biology. 29, 2, p. 226-238

  Research output: Contribution to journal › Journal article › Research › peer-review

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  20 Citations (Scopus)

• Molecular and in vivo phenotyping of missense variants of the human glucagon receptor

  van der Velden, W. J. C., Lindquist, P., Madsen, J. S., Stassen, R. H. M. J., Wewer Albrechtsen, N. J., Holst, J. J., Hauser, A. S. & Rosenkilde, M. M., 2022, In: Journal of Biological Chemistry. 298, 2, 101413.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  13 Citations (Scopus)

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• P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity

  Gasparri, F., Sarkar, D., Bielickaite, S., Poulsen, M. H., Hauser, A. S. & Pless, S. A., 2022, In: British Journal of Pharmacology. 179, 14, p. 3859-3874

  Research output: Contribution to journal › Journal article › Research › peer-review

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• Psychopharmacological treatment patterns prior to a schizophrenia diagnosis: A Danish nationwide study

  Rohde, C., Højlund, M., Gasse, C., Hauser, A. S., Petersen, L. V., Christensen, R. H., Benros, M. E., Hallas, J., Mors, O. & Köhler-Forsberg, O., 2022, In: Schizophrenia Research. 246, p. 268-276

  Research output: Contribution to journal › Journal article › Research › peer-review

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  1 Citation (Scopus)

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• The G protein database, GproteinDb

  Pandy-Szekeres, G., Esguerra, M., Hauser, A. S., Caroli, J., Munk, C., Pilger, S., Keseru, G. M., Kooistra, A. J. & Gloriam, D. E., 2022, In: Nucleic Acids Research. 50, D1, p. D518-D525

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  48 Citations (Scopus)

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• The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection

  Lindquist, P., Gasbjerg, L. S., Mokrosinski, J., Holst, J. J., Hauser, A. S. & Rosenkilde, M. M., 2022, In: Frontiers in Endocrinology. 13, 14 p., 891586.

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  6 Citations (Scopus)

  30 Downloads (Pure)

• Wie Rezeptormutationen Arzneimittelwirkungen beeinflussen können

  Reiner-Link, D. & Hauser, A. S., 2022, In: BioSpektrum. 28, 2, p. 140-143

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  1 Citation (Scopus)
• 2021

  An online GPCR structure analysis platform

  Kooistra, A. J., Munk, C., Hauser, A. S. & Gloriam, D. E., 2021, In: Nature Structural and Molecular Biology. 28, 11, p. 875-878

  Research output: Contribution to journal › Journal article › Research › peer-review

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  18 Citations (Scopus)

  58 Downloads (Pure)

• Glaucoma Clinical Research: Trends in Treatment Strategies and Drug Development

  Storgaard, L., Tran, T. L., Freiberg, J. C., Hauser, A. S. & Kolko, M., 2021, In: Frontiers in Medicine. 8, 14 p., 733080.

  Research output: Contribution to journal › Review › Research › peer-review

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  52 Citations (Scopus)

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• GPCR activation mechanisms across classes and macro/microscales

  Hauser, A. S., Kooistra, A. J., Munk, C., Heydenreich, F. M., Veprintsev, D. B., Bouvier, M., Babu, M. M. & Gloriam, D. E., 2021, In: Nature Structural and Molecular Biology. 28, 11, p. 879-888

  Research output: Contribution to journal › Journal article › Research › peer-review

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  125 Citations (Scopus)

  61 Downloads (Pure)

• Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes

  Kizilkaya, H. S., Sørensen, K. V., Kibsgaard, C. J., Gasbjerg, L. S., Hauser, A. S., Sparre-Ulrich, A. H., Grarup, N. & Rosenkilde, M. M., 2021, In: Frontiers in Cell and Developmental Biology. 9, 12 p., 749607.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  24 Citations (Scopus)

  48 Downloads (Pure)

• Mutational Landscape of the Proglucagon-Derived Peptides

  Lindquist, P., Madsen, J. S., Brauner-Osborne, H., Rosenkilde, M. M. & Hauser, A. S., 2021, In: Frontiers in Endocrinology. 12, 14 p., 698511.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  9 Citations (Scopus)

  32 Downloads (Pure)

• Personalized Medicine Through GPCR Pharmacogenomics

  Hauser, A. S., 2021, Personalized Medicine Through GPCR Pharmacogenomics. Kenakin, T. (ed.). Elsevier, 29 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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  3 Citations (Scopus)
• 2020

  Novel approaches leading towards peptide GPCR de-orphanisation

  Hauser, A. S., Gloriam, D. E., Bräuner-Osborne, H. & Foster, S. R., 1 Mar 2020, In: British Journal of Pharmacology. 177, 5, p. 961-968 8 p.

  Research output: Contribution to journal › Review › Research › peer-review

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  27 Citations (Scopus)

  147 Downloads (Pure)

• Primary Care Prescription Drug Use and Related Actionable Drug-Gene Interactions in the Danish Population

  Lunenburg, C. A. T. C., Hauser, A. S., Ishtiak-Ahmed, K. & Gasse, C., 2020, In: Clinical and Translational Science. 13, 4, p. 798-806

  Research output: Contribution to journal › Journal article › Research › peer-review

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  9 Citations (Scopus)

  61 Downloads (Pure)

• Utilizing drug-target-event relationships to unveil safety patterns in pharmacovigilance

  Hauser, A. S., Kooistra, A. J., Sverrisdóttir, E. & Sessa, M., 2020, In: Expert Opinion on Drug Safety. 19, p. 961-968

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)
• 2019

  Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

  Foster, S. R., Hauser, A. S., Vedel, L., Strachan, R. T., Huang, X-P., Gavin, A. C., Shah, S. D., Nayak, A. P., Haugaard-Kedström, L. M., Penn, R. B., Roth, B. L., Bräuner-Osborne, H. & Gloriam, D. E., 31 Oct 2019, In: Cell. 179, 4, p. 895-908

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  160 Citations (Scopus)

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• Receptor selectivity between the G proteins Gα ₁₂ and Gα ₁₃ is defined by a single leucine-to-isoleucine variation

  Mackenzie, A. E., Quon, T., Lin, L. C., Hauser, A. S., Jenkins, L., Inoue, A., Tobin, A. B., Gloriam, D. E., Hudson, B. D. & Milligan, G., 1 Apr 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 4, p. 5005-5017 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  29 Citations (Scopus)

  169 Downloads (Pure)
• 2018

  GPCRdb in 2018: adding GPCR structure models and ligands

  Pándy-Szekeres, G., Munk, C., Tsonkov, T. M., Mordalski, S., Harpsøe, K., Hauser, A. S., Bojarski, A. J. & Gloriam, D. E., 2018, In: Nucleic Acids Research. 46, D1, 7 p., gkx1109.

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  386 Citations (Scopus)

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• Pharmacogenomics of GPCR Drug Targets

  Hauser, A. S., Chavali, S., Masuho, I., Jahn, L., Martemyanov, K., Gloriam, D. E. & Babu, M., Jan 2018, In: Cell. 172, p. 41–54

  Research output: Contribution to journal › Journal article › Research › peer-review

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  436 Citations (Scopus)

  659 Downloads (Pure)
• 2017

  Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method

  Frandsen, I. O., Boesgaard, M. W., Fidom, K., Hauser, A. S., Isberg, V., Bräuner-Osborne, H., Wellendorph, P. & Gloriam, D. E., 6 Jul 2017, In: Scientific Reports. 7, 1, 10 p., 4829.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  10 Citations (Scopus)

  305 Downloads (Pure)

• Selectivity determinants of GPCR-G-protein binding

  Flock, T., Hauser, A. S., Lund, N., Gloriam, D. E., Balaji, S. & Babu, M. M., 18 May 2017, In: Nature. 545, 7654, p. 317-322 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  280 Citations (Scopus)

• The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW

  Jensen, A. C. N., Shehata, M. A., Hauser, A. S., Isberg, V., Mokrosinski, J., Farooqi, I. S., Pedersen, D. S., Gloriam, D. E. & Bräuner-Osborne, H., 1 Jan 2017, In: Neurochemistry International. 102, p. 105-113

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  34 Citations (Scopus)

  512 Downloads (Pure)

• Trade-off between GPCR folding and functional versatility

  Prado, D. E., Flock, T., Hauser, A. S., Hegde, R. S. & Babu, M. M., Dec 2017, In: Protein Science. 26, p. 135-136

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Trends in GPCR drug discovery: new agents, targets and indications

  Hauser, A. S., Gloriam, D. E., Attwood, M. M., Rask-Andersen, M. & Schiöth, H. B., 27 Oct 2017, In: Nature Reviews. Drug Discovery. 16, p. 829-842 14 p., 178.

  Research output: Contribution to journal › Journal article › Research › peer-review
  1798 Citations (Scopus)
• 2016

  GPCRdb: an information system for G protein-coupled receptors

  Isberg, V., Mordalski, S., Munk, C., Rataj, K., Harpsøe, K., Hauser, A. S., Vroling, B., Bojarski, A. J., Vriend, G. & Gloriam, D. E., 4 Jan 2016, In: Nucleic Acids Research. 44, D1, p. D356-64

  Research output: Contribution to journal › Journal article › Research › peer-review

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  232 Citations (Scopus)

  434 Downloads (Pure)

• GPCRdb: The G protein-coupled receptor database - an introduction

  Munk, C., Isberg, V., Mordalski, S., Harpsøe, K., Rataj, K., Hauser, A. S., Kolb, P., Bojarski, A. J., Vriend, G. & Gloriam, D. E., Jul 2016, In: British Journal of Pharmacology. 173, 14, p. 2195-207 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  155 Citations (Scopus)

• Integrating structural and mutagenesis data to elucidate GPCR ligand binding

  Munk, C., Harpsøe, K., Hauser, A. S., Isberg, V. & Gloriam, D. E., Oct 2016, In: Current Opinion in Pharmacology. 30, p. 51-58 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  46 Citations (Scopus)

• LEADS-PEP: A Benchmark Data Set for Assessment of Peptide Docking Performance

  Hauser, A. S. & Windshügel, B., 11 Jan 2016, In: Journal of Chemical Information and Modeling. 56, 1, p. 188-200 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  74 Citations (Scopus)
• 2015

  A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors

  Fidom, K., Isberg, V., Hauser, A. S., Mordalski, S., Lehto, T., Bojarski, A. J. & Gloriam, D. E., Jan 2015, In: Methods. 71, p. 104-112 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)
• 2014

  Investigations and design of pyridine-2-carboxylic acid thiazol-2-ylamide analogs as methionine aminopeptidase inhibitors using 3D-QSAR and molecular docking

  Hauser, A. S., 1 Aug 2014, In: Medicinal Chemistry Research. 23, 8, p. 3861 3875 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)