Cardiac proteomics is the merging of two scientific disciplines: molecular cardiac physiology and high resolution proteomics technology. In the interface between these two disciplines novel mechanistic insight on molecular regulatory mechanisms of the heart can be achieved. Cardiac proteomics allows for unbiased investigations of protein and signaling changes taking place in cardiac tissue, and it is a scientific field spearheaded by the Lundby group.

In the Lundby group cardiac proteomics is applied to gain molecular insights into regulatory processes in the heart. The efforts undertaken aim at uncovering a deep molecular understanding of the changes in hearts exposed to various perturbations ultimately allowing us to identify novel pharmaceutical targets for cardiac disease intervention.

The application of high resolution proteomics to investigate protein- and signaling regulation directly in cardiac tissue has opened a new avenue of molecular cardiac research. In recent years proteomics method developments have been achieved that allows for in-depth investigations of the cardiac protein landscape. In the Lundby group we exploit state-of-the-art proteomics technologies to pinpoint specific proteins and peptides crucial for proper cardiac function. Our proteomics based strategies allow us to address fundamental questions on protein- and signaling regulation for all cardiac proteins in single experiments. 

Please visit www.lundbylab.com

The Lundby group works on a multitude of diverse projects, but the overarching aim of all projects is to identify specific proteins crucial for a given cardiac phenotype. Our projects are based on our combined expertise in high-resolution proteomics technology, cardiac ion channel research and human population genetics. We have previously shown that integration of quantitative interaction proteomics with human population genetics is a strong tool to uncover novel proteins associated with a cardiac phenotype. We are currently exploiting our expertise within this interdisciplinary approach to specifically untangle molecular players involved in the cardiac disorders atrial fibrillation and heart failure.

As many cardiac diseases are primarily associated with dysfunction of one of the four cardiac chambers we are also performing detailed investigations of the protein-specific differences among the four chambers. We believe this will be key information to identify novel pharmaceutical targets with chamber-specific impact. 

Professor wsr, Department of Biomedical Sciences, UCPH.

Education

• June 2009: PhD in Health Sciences. Faculty of Medical and Health Sciences, University of Copenhagen. Advisor: Prof. Søren-Peter Olesen. Including research stay at RIKEN Brain Science Institute, Saitama, Japan.
• Sep 2005: M.Sc. in Physics and Biophysics. The Niels Bohr Institute, Department of Physics, University of Copenhagen. Advisor: Prof. Stig Steenstrup. Research conducted at University of California at San Diego, USA.
• July 2003: B.Sc. in Physics and Biophysics. The Niels Bohr Institute, Department of Physics, University of Copenhagen. Advisor: Ass. prof. Claus Helix Nielsen

Current position

• 2020-present: Professor wsr. Department of Biomedical Sciences, University of Copenhagen.

Previous positions

• 2015-2020: Associate professor. Department of Biomedical Sciences, University of Copenhagen. Affiliated associate professor of Novo Nordisk Foundation Center for Protein Research.
• 2009-2011+: Post Doctoral Research Fellow in Quantitative Proteomics. Department of Proteomics, NNF
• 2012-2015: Center for Protein Research, U. Copenhagen. Advisor: Prof. Jesper V. Olsen
• 2011-2012: Post Doctoral Research Fellow in Human Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, USA. Advisor: Prof. Mark Daly
• 2007-2008: Visiting scientist in voltage sensitive fluorescent proteins, RIKEN Brain Science Institute, Saitama, Japan. Advisor: Prof. Thomas Knöpfel
• 2004-2005: Visting research student, ion channel research. Department of Biology, University of California at San Diego, USA. Advisor: Prof. Mauricio Montal

Academic awards and honors 

• 2020: Hallas-Møller Ascending Investigator Award
• 2018: The Carlsberg Foundation Distinguished Associate Professorship
• 2016: Sapere Aude Elite Research Leader by The Independent Research Fund Denmark
• 2014: The Danish Council for Independent Research talent program YDUN
• 2013: For Women in Science price by L’Oréal, UNESCO and The Royal Danish Academy of Sciences and Letters.
• 2011: Member of The Young Academy, The Royal Danish Academy of Sciences and Letters.
• 2011: Sapere Aude Young Elite Researcher by The Independent Research Fund Denmark
• 2007: Talent award, The Lundbeck Foundation.
• 2006: Selected participant at MBL Neurobiology Summer course, Woods Hole, USA.
• 2006: Young Investigator Award, Health Sciences, UCPH
• 2000: Finalist in “Worldwide Young Researchers for the Environment”.