Research output per year
Research output per year
Personal profile
Short presentation
My lab studies the consequences of sequence variants on proteins, focusing on their cellular stability and function. We perform high-throughput assays on protein variants and build on this data to develop and improve methods for prediction of variant consequences. We then apply these methods to determine whether genomic variants are likely to be pathogenic. Further we aim to integrate effects of multiple mutations for applications in protein engineering.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A mutational atlas for Parkin proteostasis
Clausen, L., Voutsinos, V., Cagiada, M., Johansson, K. E., Grønbæk-Thygesen, M., Nariya, S., Powell, R. L., Have, M. K. N., Oestergaard, V. H., Stein, A., Fowler, D. M., Lindorff-Larsen, K. & Hartmann-Petersen, R., 2024, In: Nature Communications. 15, 1, 17 p., 1541.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)17 Downloads (Pure) -
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay
Gersing, S., Schulze, T. K., Cagiada, M., Stein, A., Roth, F. P., Lindorff-Larsen, K. & Hartmann-Petersen, R., 2024, In: Genome Biology. 25, 1, 22 p., 98.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)16 Downloads (Pure) -
Computational methods for protein design
Ferruz, N. & Stein, A., 2024, In: Protein Engineering, Design and Selection. 37, 2 p., gzae011.Research output: Contribution to journal › Editorial › Research › peer-review
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Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants
Grønbæk-Thygesen, M., Voutsinos, V., Johansson, K. E., Schulze, T. K., Cagiada, M., Pedersen, L., Clausen, L., Nariya, S., Powell, R. L., Stein, A., Fowler, D. M., Lindorff-Larsen, K. & Hartmann-Petersen, R., 2024, In: Nature Communications. 15, 1, 18 p., 4026.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)7 Downloads (Pure) -
MutationExplorer: a webserver for mutation of proteins and 3D visualization of energetic impacts
Philipp, M., Moth, C. W., Ristic, N., Tiemann, J. K. S., Seufert, F., Panfilova, A., Meiler, J., Hildebrand, P. W., Stein, A., Wiegreffe, D. & Staritzbichler, R., 2024, In: Nucleic Acids Research. 52, W1, p. W132–W139 8 p., gkae301.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Downloads (Pure) -
SSEmb: A joint embedding of protein sequence and structure enables robust variant effect predictions
Blaabjerg, L. M., Jonsson, N., Boomsma, W., Stein, A. & Lindorff-Larsen, K., 2024, In: Nature Communications. 15, 1, 9 p., 9646.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile -
Accurate protein stability predictions from homology models
Valanciute, A., Nygaard, L., Zschach, H., Maglegaard Jepsen, M., Lindorff-Larsen, K. & Stein, A., 2023, In: Computational and Structural Biotechnology Journal. 21, p. 66-73 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile10 Citations (Scopus)94 Downloads (Pure) -
A comprehensive map of human glucokinase variant activity
Gersing, S., Cagiada, M., Gebbia, M., Gjesing, A. P., Coté, A. G., Seesankar, G., Li, R., Tabet, D., Weile, J., Stein, A., Gloyn, A. L., Hansen, T., Roth, F. P., Lindorff-Larsen, K. & Hartmann-Petersen, R., 2023, In: Genome Biology. 24, 1, 23 p., 97.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile10 Citations (Scopus)58 Downloads (Pure)