Research output per year
Research output per year
- 32 results
Search results
-
2025
Loss of PGC-1α causes depot-specific alterations in mitochondrial capacity, ROS handling and adaptive responses to metabolic stress in white adipose tissue
Gudiksen, A., Zhou, E., Pedersen, L., Zaia, C. A., Wille, C. E., Eliesen, E. V. & Pilegaard, H., 2025, In: Mitochondrion. 83, 14 p., 102034.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile7 Downloads (Pure) -
Pantothenate kinase 4 controls skeletal muscle substrate metabolism
Miranda-Cervantes, A., Fritzen, A. M., Raun, S. H., Hodek, O., Møller, L. L. V., Johann, K., Deisen, L., Gregorevic, P., Gudiksen, A., Artati, A., Adamski, J., Andersen, N. R., Sigvardsen, C. M., Carl, C. S., Voldstedlund, C. T., Kjøbsted, R., Hauck, S. M., Schjerling, P., Jensen, T. E. & Cebrian-Serrano, A. & 13 others, , 2025, In: Nature Communications. 16, 15 p., 345.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)9 Downloads (Pure) -
2024
Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise
Kristensen, J. M., Kjøbsted, R., Larsen, T. J., Carl, C. S., Hingst, J. R., Onslev, J., Birk, J. B., Thorup, A., Steenberg, D. E., Knudsen, J. R., Henriksen, N. S., Needham, E. J., Halling, J. F., Gudiksen, A., Rundsten, C. F., Hanghøj, K. E., Stinson, S. E., Hoier, B., Hansen, C. C. & Jensen, T. E. & 11 others, , 2024, In: Nature Metabolism. 6, p. 2254–2266 13 p.Research output: Contribution to journal › Letter › peer-review
Open AccessFile2 Citations (Scopus)12 Downloads (Pure) -
2023
Impact of Aging and Lifelong Exercise Training on Mitochondrial Function and Network Connectivity in Human Skeletal Muscle
Ringholm, S., Gudiksen, A., Halling, J. F., Qoqaj, A., Rasmussen, P. M., Prats, C., Plomgaard, P. & Pilegaard, H., 2023, In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 78, 3, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
File20 Citations (Scopus) -
Muscle PGC-1α modulates hepatic mitophagy regulation during aging
Christensen, N. M., Ringholm, S., Buch, B. T., Gudiksen, A., Halling, J. F. & Pilegaard, H., 2023, In: Experimental Gerontology. 172, 9 p., 112046.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)28 Downloads (Pure) -
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes
Maurer, J., Zhao, X., Irmler, M., Gudiksen, A., Pilmark, N. S., Li, Q., Goj, T., Beckers, J., Hrabě De Angelis, M., Birkenfeld, A. L., Peter, A., Lehmann, R., Pilegaard, H., Karstoft, K., Xu, G. & Weigert, C., 2023, In: American Journal of Physiology: Cell Physiology. 325, 4, p. C1131-C1143 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)13 Downloads (Pure) -
TBC1D4-S711 controls skeletal muscle insulin sensitization after exercise and contraction
Kjøbsted, R., Kristensen, J. M., Eskesen, N. O., Kido, K., Fjorder, K., Damgaard, D. F., Larsen, J. K., Andersen, N. R., Birk, J. B., Gudiksen, A., Treebak, J. T., Schjerling, P., Pilegaard, H. & Wojtaszewski, J., 2023, In: Diabetes. 72, 7, p. 857-871 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
File11 Citations (Scopus)85 Downloads (Pure) -
2022
Ameliorating effects of lifelong physical activity on healthy aging and mitochondrial function in human white adipose tissue
Gudiksen, A., Qoqaj, A., Ringholm, S., Wojtaszewski, J., Plomgaard, P. & Pilegaard, H., 2022, In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 77, 6, p. 1101-1111 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile15 Citations (Scopus)62 Downloads (Pure) -
GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans
Plomgaard, P., Hansen, J. S., Townsend, L. K., Gudiksen, A., Secher, N. H., Clemmesen, J. O., Støving, R. K., Goetze, J. P., Wright, D. C. & Pilegaard, H., 2022, In: Frontiers in Endocrinology. 13, 1037948.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile21 Citations (Scopus)33 Downloads (Pure) -
2020
Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner
Buch, B. T., Halling, J. F., Ringholm, S., Gudiksen, A., Kjøbsted, R., Olsen, M. A., Wojtaszewski, J. & Pilegaard, H., 2020, In: F A S E B Journal. 34, 6, p. 8653-8670Research output: Contribution to journal › Journal article › Research › peer-review
18 Citations (Scopus) -
Impact of skeletal muscle IL-6 on subcutaneous and visceral adipose tissue metabolism immediately after high- and moderate-intensity exercises
Bertholdt, L., Gudiksen, A., Ringholm, S. & Pilegaard, H., 2020, In: Pflügers Archiv - European Journal of Physiology. 472, 2, p. 217-233 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
9 Citations (Scopus) -
Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle: a 2x2 factorial, randomised, crossover study in human individuals
Hjelholt, A. J., Charidemou, E., Griffin, J. L., Pedersen, S. B., Gudiksen, A., Pilegaard, H., Jessen, N., Møller, N. & Jørgensen, J. O. L., 2020, In: Diabetologia. 63, 12, p. 2641-2653 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
15 Citations (Scopus) -
2019
PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training
Halling, J. F., Jessen, H., Nøhr-Meldgaard, J., Buch, B. T., Christensen, N. M., Gudiksen, A., Ringholm, S., Neufer, P. D., Prats, C. & Pilegaard, H., 2019, In: American journal of physiology. Endocrinology and metabolism. 317, 3, p. E513-E525Research output: Contribution to journal › Journal article › Research › peer-review
56 Citations (Scopus) -
Redundancy in regulation of lipid accumulation in skeletal muscle during prolonged fasting in obese men
Høgild, M. L., Gudiksen, A., Pilegaard, H., Stødkilde-Jørgensen, H., Pedersen, S. B., Møller, N., Jørgensen, J. O. L. & Jessen, N., 2019, In: Physiological Reports. 7, 21, 15 p., e14285.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Citations (Scopus)82 Downloads (Pure) -
2018
Impact of fasting followed by short-term exposure to interleukin-6 on cytochrome P450 mRNA in mice
Rasmussen, M. K., Bertholdt, L., Gudiksen, A., Pilegaard, H. & Knudsen, J. G., 5 Jan 2018, In: Toxicology Letters. 282, p. 93-99 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
23 Citations (Scopus) -
Impact of skeletal muscle IL-6 on regulation of liver and adipose tissue metabolism during fasting
Bertholdt, L., Gudiksen, A., Jessen, H. & Pilegaard, H., 2018, In: Pflügers Archiv - European Journal of Physiology. 470, 11, p. 1597-1613Research output: Contribution to journal › Journal article › Research › peer-review
16 Citations (Scopus) -
Impact of training state on fasting-induced regulation of adipose tissue metabolism in humans
Bertholdt, L., Gudiksen, A., Stankiewicz, T., Villesen, I., Tybirk, J., van Hall, G., Bangsbo, J., Plomgaard, P. & Pilegaard, H., 2018, In: Journal of Applied Physiology. 124, 3, p. 729-740 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
19 Citations (Scopus) -
Impact of β-adrenergic signaling in PGC-1α-mediated adaptations in mouse skeletal muscle
Brandt, N., Nielsen, L., Buch, B. T., Gudiksen, A., Ringholm Jørgensen, S., Hellsten, Y., Bangsbo, J. & Pilegaard, H., 1 Jan 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 314, 1, p. E1-E20 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
18 Citations (Scopus) -
Oxygen conserving mitochondrial adaptations in the skeletal muscles of breath hold divers
Kjeld, T., Stride, N., Gudiksen, A., Hansen, E. G., Arendrup, H. C., Horstmann, P. F., Zerahn, B., Jensen, L. T., Nordsborg, N. B., Bejder, J. & Halling, J. F., 19 Sept 2018, In: P L o S One. 13, 9, p. 1-13 13 p., e0201401.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile22 Citations (Scopus)236 Downloads (Pure) -
Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis
Knuth, C. M., Peppler, W. T., Townsend, L. K., Miotto, P. M., Gudiksen, A. & Wright, D. C., 15 Sept 2018, In: The Journal of Physiology. 596, 18, p. 4375-4391Research output: Contribution to journal › Journal article › Research › peer-review
Open Access25 Citations (Scopus) -
Skeletal Muscle Interleukin-6 Regulates Hepatic Cytochrome P450 Expression: Effects of 16-Week High-Fat Diet and Exercise
Knudsen, J. G., Bertholdt, L., Gudiksen, A., Gerbal-Chaloin, S. & Rasmussen, M. K., 2018, In: Toxicological Sciences. 162, 1, p. 309-317 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
18 Citations (Scopus) -
Training state and fasting-induced PDH regulation in human skeletal muscle
Gudiksen, A., Bertholdt, L., Stankiewicz, T., Villesen, I., Bangsbo, J., Plomgaard, P. & Pilegaard, H., 1 Nov 2018, In: Pflügers Archiv - European Journal of Physiology. 470, 11, p. 1633-1645 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
6 Citations (Scopus) -
Training state and skeletal muscle autophagy in response to 36 h of fasting
Dethlefsen, M. M., Bertholdt, L., Gudiksen, A., Stankiewicz, T., Bangsbo, J., van Hall, G., Plomgaard, P. & Pilegaard, H., Nov 2018, In: Journal of Applied Physiology. 125, 5, p. 1609-1619 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
15 Citations (Scopus) -
2017
Effects of training status on PDH regulation in human skeletal muscle during exercise
Gudiksen, A., Bertholdt, L., Stankiewicz, T., Tybirk, J., Plomgaard, P. S., Bangsbo, J. & Pilegaard, H., 2017, In: Pflügers Archiv - European Journal of Physiology. 469, 12, p. 1615-1630 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
14 Citations (Scopus) -
Lack of skeletal muscle IL-6 influences hepatic glucose metabolism in mice during prolonged exercise
Bertholdt, L., Gudiksen, A., Schwartz, C. L., Knudsen, J. G. & Pilegaard, H., 7 Apr 2017, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 312, 4, p. R626-R636 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
16 Citations (Scopus) -
Muscle interleukin-6 and fasting-induced PDH regulation in mouse skeletal muscle
Gudiksen, A., Bertholdt, L., Vingborg, M. B., Hansen, H. W., Jørgensen, S. R. & Pilegaard, H., 2 Mar 2017, In: American Journal of Physiology: Endocrinology and Metabolism. 312, 3, p. E204-E214 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
10 Citations (Scopus) -
PGC-1α and fasting-induced PDH regulation in mouse skeletal muscle
Gudiksen, A. & Pilegaard, H., 10 Apr 2017, In: Physiological Reports. 5, 7, 15 p., e13222.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile22 Citations (Scopus)181 Downloads (Pure) -
Skeletal muscle IL-6 regulates muscle substrate utilization and adipose tissue metabolism during recovery from an acute bout of exercise
Knudsen, J. G., Gudiksen, A., Bertholdt, L., Overby, P., Villesen, I., Schwartz, C. L. & Pilegaard, H., 18 Dec 2017, In: PLoS ONE. 12, 12, 19 p., e0189301.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile33 Citations (Scopus)229 Downloads (Pure) -
2016
Fasting- and Exercise-Induced PDH Regulation in Skeletal Muscle
Gudiksen, A., 2016, Department of Biology, Faculty of Science, University of Copenhagen.Research output: Book/Report › Ph.D. thesis
File -
Lack of skeletal muscle IL-6 affects pyruvate dehydrogenase activity at rest and during prolonged exercise
Gudiksen, A., Schwartz, C. L., Bertholdt, L., Joensen, E., Knudsen, J. G. & Pilegaard, H., 2016, In: P L o S One. 11, 6, 17 p., e0156460.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile30 Citations (Scopus)127 Downloads (Pure) -
2015
AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle
Fentz, J., Kjøbsted, R., Maag Kristensen, C., Hingst, J. R., Birk, J. B., Gudiksen, A., Foretz, M., Schjerling, P., Viollet, B., Pilegaard, H. & Wojtaszewski, J., 2015, In: American Journal of Physiology: Endocrinology and Metabolism. 309, 11, p. E900-E914 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
32 Citations (Scopus) -
2014
Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock
Dyar, K. A., Ciciliot, S., Wright, L. E., Biensø, R. S., Tagliazucchi, G. M., Patel, V. R., Forcato, M., Paz, M. I. P., Gudiksen, A., Solagna, F., Albiero, M., Moretti, I., Eckel-Mahan, K. L., Baldi, P., Sassone-Corsi, P., Rizzuto, R., Bicciato, S., Pilegaard, H., Blaauw, B. & Schiaffino, S., 2014, In: Molecular Metabolism. 3, 1, p. 29-41 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile366 Citations (Scopus)1222 Downloads (Pure)