Andrea Heinz

Research output

Research output per year 2007 2024 2024

• 2108 Citations
• 51 Journal article
• 6 Review
• 1 Book chapter
• 1 Conference abstract in journal

Research output per year

Research output per year

Search results

• 2024

  Advancing inflammatory skin disease therapy: Sustained tofacitinib release via electrospun fiber dressings

  Gürtler, A., Maltschik, A. M., Meryem Güler Yildiz, S., Vangelofski, K., Gade, L., Grohganz, H., Rades, T. & Heinz, A., 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 202, 8 p., 114423.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  7 Downloads (Pure)

• Characterization of extracellular vesicles by capillary zone electrophoresis: A novel concept for characterization of a next-generation drug delivery platform

  Steć, A., Heinz, A. & Dziomba, S., 2024, (Accepted/In press) In: Journal of Pharmaceutical Analysis. 101004.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  1 Downloads (Pure)

• Coaxial electrospinning of polycaprolactone: A design of experiments approach

  Gürtler, A., Linseisen, I., Grohganz, H. & Heinz, A., 2024, In: European Polymer Journal. 208, 11 p., 112886.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  12 Downloads (Pure)

• Comparing effects of terpene-based deep eutectic solvent and solid microneedles on skin permeation of drugs with varying lipophilicity

  Czyrski, G. S., Frese Hjort, M. K., Rades, T. & Heinz, A., 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 205, 13 p., 114576.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Elastin

  Rønnow, S. R., Kristensen, J. H., Thorlacius-Ussing, J., Karsdal, M. A. & Heinz, A., 2024, Biochemistry of Collagens, Laminins and Elastin. 3 ed. Academic Press, p. 279-289

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Electrospun dressings with a dual release functionality of two anti-inflammatory active ingredients

  Gürtler, A., Sirois, J. P., Lang, J. C., Melican, K., Rades, T. & Heinz, A., 2024, In: RSC Pharmaceutics. 1, p. 570-580

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Downloads (Pure)

• Electrospun fiber patches for inflammatory skin diseases: Correlating in vitro drug release with ex vivo permeation

  Gürtler, A., Lang, J. C., Czyrski, G. S., Sirois, J. P., Melican, K., Rades, T. & Heinz, A., 2024, In: Biomaterials Advances. 166, 11 p., 214068.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Identity confirmation of extracellular vesicles by capillary electrophoresis using non-specific dyes

  Steć, A., Klocek, K., Czyrski, G. S., Heinz, A. & Dziomba, S., 1 Dec 2024, In: Microchemical Journal. 207, p. 112288

  Research output: Contribution to journal › Journal article › Research › peer-review

• Influence of co-solvents on properties of terpene-based eutectic mixtures: Implications for skin delivery

  Czyrski, G. S., Rades, T. & Heinz, A., 2024, In: International Journal of Pharmaceutics. 664, 15 p., 124615.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Downloads (Pure)

• In Situ Imaging of Subcutaneous Drug Delivery Systems Using Microspatially Offset Low-Frequency Raman Spectroscopy

  Berziņš, K., Czyrski, G. S., Aljabbari, A., Heinz, A. & Boyd, B. J., 2024, In: Analytical Chemistry. 96, 16, p. 6408–6416

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Matrikines in the skin: Origin, effects, and therapeutic potential

  Sirois, J. P. & Heinz, A., 2024, In: Pharmacology & Therapeutics. 260, 20 p., 108682.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  4 Downloads (Pure)

• Matrix metalloproteinase landscape in the imiquimod-induced skin inflammation mouse model

  Noddeland, H. K., Canbay, V., Lind, M., Savickas, S., Jensen, L. B., Petersson, K., Malmsten, M., Koch, J., Auf Dem Keller, U. & Heinz, A., 2024, In: Biochimie. 226, p. 99-106

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  6 Downloads (Pure)

• Stimuli-Responsive Drug Delivery Systems for Inflammatory Skin Conditions

  Gade, L., Boyd, B. J., Malmsten, M. & Heinz, A., 2024, In: Acta Biomaterialia. 187, p. 1-19

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File

• Terpene-based eutectic mixtures for cutaneous delivery: Eutectic point vs. molar ratio - which matters more?

  Czyrski, G. S., Kirkensgaard, J. J. K., Rønholt, S., Rades, T. & Heinz, A., 2024, In: Journal of Molecular Liquids. 411, 13 p., 125726.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  3 Citations (Scopus)

  7 Downloads (Pure)

• Transdermal delivery of Acheta domesticus protein hydrolysate using nanostructured lipid carriers and Derma Stamp ― Does the combination of lipid-based formulation and a physical technique add value for permeation and retention?

  Yeerong, K., Czyrski, G. S., Heinz, A., Müllertz, A., Rades, T. & Chaiyana, W., 1 Dec 2024, In: Journal of Drug Delivery Science and Technology. p. 106470

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
• 2023

  Design and characterization of matrix metalloproteinase-responsive hydrogels for the treatment of inflammatory skin diseases

  Noddeland, H. K., Lind, M., Jensen, L. B., Petersson, K., Skak-Nielsen, T., Larsen, F. H., Malmsten, M. & Heinz, A., 2023, In: Acta Biomaterialia. 157, p. 149-161

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  17 Citations (Scopus)

  36 Downloads (Pure)

• Electrospun fibers for the treatment of skin diseases

  Gürtler, A-L., Rades, T. & Heinz, A., 2023, In: Journal of controlled release : official journal of the Controlled Release Society. 363, p. 621-640

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  27 Downloads (Pure)

• Protease-Responsive Hydrogel Microparticles for Intradermal Drug Delivery

  Noddeland, H. K., Lind, M., Petersson, K., Caruso, F., Malmsten, M. & Heinz, A., 2023, In: Biomacromolecules. 24, 7, p. 3203–3214

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  7 Citations (Scopus)

  7 Downloads (Pure)
• 2022

  In Situ Transformation of Electrospun Nanofibers into Nanofiber-Reinforced Hydrogels

  Martin, A., Nyman, J. N., Reinholdt, R., Cai, J., Schaedel, A-L., Plas, M. J. A. V. D., Malmsten, M., Rades, T. & Heinz, A., 2022, In: Nanomaterials. 12, 14, 2437.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Citations (Scopus)

  72 Downloads (Pure)

• Zein-polycaprolactone core-shell nanofibers for wound healing

  Martin, A., Cai, J., Schaedel, A-L., van der Plas, M., Malmsten, M., Rades, T. & Heinz, A., 2022, In: International Journal of Pharmaceutics. 621, 10 p., 121809.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  30 Citations (Scopus)

  46 Downloads (Pure)
• 2021

  Characterization of novel interactions with plasma membrane NEU1 reveals new biological functions for the elastin receptor complex in vascular diseases

  Tembely, D., Bocquet, O., Kawecki, C., Terryn, C., Schmelzer, C., Heinz, A., Romier-Crouzet, B., Bennasroune, A., Blaise, S., Sartelet, H., Martiny, L., Duca, L. & Maurice, P., 2021, In: Atherosclerosis. 331, 1 p., E24.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  File

• Elastic fibers during aging and disease

  Heinz, A., 2021, In: Ageing Research Reviews. 66, 19 p., 101255.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  81 Citations (Scopus)

  15 Downloads (Pure)
• 2020

  Elastases and elastokines: elastin degradation and its significance in health and disease

  Heinz, A., 2020, In: Critical Reviews in Biochemistry and Molecular Biology. 55, 3, p. 252-273 22 p.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  107 Citations (Scopus)

  44 Downloads (Pure)

• Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

  Akhmetova, A. & Heinz, A., 2020, In: Pharmaceutics. 13, 1, 22 p., 4.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  85 Citations (Scopus)

  72 Downloads (Pure)

• Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation

  Panwar, P., Hedtke, T., Heinz, A., Andrault, P-M., Hoehenwarter, W., Granville, D. J., Schmelzer, C. E. H. & Brömme, D., 2020, In: B B A - General Subjects. 1864, 5, 18 p., 129544.

  Research output: Contribution to journal › Journal article › Research › peer-review
  27 Citations (Scopus)

• Extracellular Matrix Stiffness and Composition Regulate the Myofibroblast Differentiation of Vaginal Fibroblasts

  Ruiz-Zapata, A. M., Heinz, A., Kerkhof, M. H., van de Westerlo-van Rijt, C., Schmelzer, C. E. H., Stoop, R., Kluivers, K. B. & Oosterwijk, E., 2020, In: International Journal of Molecular Sciences . 21, 13, 15 p., 4762.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  32 Citations (Scopus)

  48 Downloads (Pure)

• Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing

  Akhmetova, A., Lanno, G-M., Kogermann, K., Malmsten, M., Rades, T. & Heinz, A., 2020, In: Pharmaceutics. 12, 5, 19 p., 458.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  23 Citations (Scopus)

  35 Downloads (Pure)

• Unique molecular networks: Formation and role of elastin cross-links

  Schmelzer, C. E. H., Hedtke, T. & Heinz, A., 2020, In: IUBMB Life. 55, 3, p. 842-854 13 p.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

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  42 Citations (Scopus)

  143 Downloads (Pure)
• 2019

  A comprehensive map of human elastin cross-linking during elastogenesis

  Hedtke, T., Schräder, C. U., Heinz, A., Hoehenwarter, W., Brinckmann, J., Groth, T. & Schmelzer, C. E. H., 2019, In: The F E B S Journal (Online). p. 3594-3610

  Research output: Contribution to journal › Journal article › Research › peer-review
  33 Citations (Scopus)

• Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex

  Kawecki, C., Bocquet, O., Schmelzer, C. E. H., Heinz, A., Ihling, C., Wahart, A., Romier, B., Bennasroune, A., Blaise, S., Terryn, C., Linton, K. J., Martiny, L., Duca, L. & Maurice, P., 2019, In: Cellular and molecular life sciences : CMLS. 76, 4, p. 791–807

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  40 Citations (Scopus)

  154 Downloads (Pure)

• Lysyl oxidase-like 2 (LOXL2)-mediated cross-linking of tropoelastin

  Schmelzer, C. E. H., Heinz, A., Troilo, H., Lockhart-Cairns, M. P., Jowitt, T. A., Marchand, M. F., Bidault, L., Bignon, M., Hedtke, T., Barret, A., McConnell, J. C., Sherratt, M. J., Germain, S., Hulmes, D. J. S., Baldock, C. & Muller, L., 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 4, p. 5468-5481

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  54 Citations (Scopus)

  230 Downloads (Pure)

• MMP-14 degrades tropoelastin and elastin

  Miekus, N., Luise, C., Sippl, W., Baczek, T., Schmelzer, C. E. H. & Heinz, A., 2019, In: Biochimie. p. 32-39

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)
• 2018

  Degradation of tropoelastin and skin elastin by neprilysin

  Mora Huertas, A. C., Schmelzer, C. E. H., Luise, C., Sippl, W., Pietzsch, M., Hoehenwarter, W. & Heinz, A., 2018, In: Biochimie. 146, p. 73-78 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Elastin is heterogeneously cross-linked

  Schräder, C. U., Heinz, A., Majovsky, P., Karaman, B., Brinckmann, J., Sippl, W. & Schmelzer, C. E. H., 2018, In: The Journal of Biological Chemistry. 293, 39, p. 15107-15119

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  51 Citations (Scopus)

  128 Downloads (Pure)

• Production of Elastin-Derived Peptides Contribute to the Development of Non-Alcoholic Steatohepatitis

  Romier, B., Ivaldi, C., Sartelet, H., Heinz, A., Schmelzer, C. E. H., Garnotel, R., Guillot, A., Jonquet, J., Bertin, E., Guéant, J-L., Alberto, J-M., Bronowicki, J-P., Amoyel, J., Hocine, T., Duca, L., Maurice, P., Bennasroune, A., Martiny, L., Debelle, L., Durlach, V. & 1 others, Blaise, S., 2018, In: Diabetes. 67, p. 1604-1615

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)

• Role for Cela1 in Postnatal Lung Remodeling and AAT-deficient Emphysema

  Joshi, R., Heinz, A., Fan, Q., Guo, S., Monia, B., Schmelzer, C. E. H., Weiss, A. S., Batie, M., Parameshwaran, H. & Varisco, B. M., 8 Feb 2018, In: American Journal of Respiratory Cell and Molecular Biology. 59, 2, p. 167-178 0361OC .

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  20 Citations (Scopus)
• 2016

  Cadmium toxicity investigated at the physiological and biophysical levels under environmentally relevant conditions using the aquatic model plant Ceratophyllum demersum

  Andresen, E., Kappel, S., Stärk, H-J., Riegger, U., Borovec, J., Mattusch, J., Heinz, A., Schmelzer, C. E. H., Matoušková, Š., Dickinson, B. & Küpper, H., Jun 2016, In: New Phytologist. 210, 4, p. 1244-58 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  67 Citations (Scopus)

• Elastins from patients with Williams-Beuren syndrome and healthy individuals differ on the molecular level

  Heinz, A., Huertas, A. C. M., Schräder, C. U., Pankau, R., Gosch, A. & Schmelzer, C. E. H., Jul 2016, In: American Journal of Medical Genetics. Part A. 170, 7, p. 1832-42 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Molecular-level insights into aging processes of skin elastin

  Mora Huertas, A. C., Schmelzer, C. E. H., Hoehenwarter, W., Heyroth, F. & Heinz, A., 30 Aug 2016, In: Biochimie. 128-129, p. 163-73 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  83 Citations (Scopus)

• Prolyl hydroxylation in elastin is not random

  Schmelzer, C. E. H., Nagel, M. B. M., Dziomba, S., Merkher, Y., Sivan, S. S. & Heinz, A., Oct 2016, In: B B A - Reviews on Cancer. 1860, 10, p. 2169-77 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  23 Citations (Scopus)
• 2015

  Fingerprinting desmosine-containing elastin peptides

  Schräder, C. U., Heinz, A., Majovsky, P. & Schmelzer, C. E. H., May 2015, In: Journal of the American Society for Mass Spectrometry. 26, 5, p. 762-73 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms

  Bultmann-Mellin, I., Conradi, A., Maul, A. C., Dinger, K., Wempe, F., Wohl, A. P., Imhof, T., Wunderlich, F. T., Bunck, A. C., Nakamura, T., Koli, K., Bloch, W., Ghanem, A., Heinz, A., von Melchner, H., Sengle, G. & Sterner-Kock, A., Apr 2015, In: Disease models & mechanisms. 8, 4, p. 403-15 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  38 Citations (Scopus)
• 2014

  Molecular-level characterization of elastin-like constructs and human aortic elastin

  Heinz, A., Schräder, C. U., Baud, S., Keeley, F. W., Mithieux, S. M., Weiss, A. S., Neubert, R. H. H. & Schmelzer, C. E. H., Sep 2014, In: Matrix Biology. 38, p. 12-21 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  29 Citations (Scopus)
• 2013

  Elastin-derived peptides are new regulators of insulin resistance development in mice

  Blaise, S., Romier, B., Kawecki, C., Ghirardi, M., Rabenoelina, F., Baud, S., Duca, L., Maurice, P., Heinz, A., Schmelzer, C. E. H., Tarpin, M., Martiny, L., Garbar, C., Dauchez, M., Debelle, L. & Durlach, V., Nov 2013, In: Diabetes. 62, 11, p. 3807-16 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  91 Citations (Scopus)

• Investigating the role of (2S,4R)-4-hydroxyproline in elastin model peptides

  Bochicchio, B., Laurita, A., Heinz, A., Schmelzer, C. E. H. & Pepe, A., 9 Dec 2013, In: Biomacromolecules. 14, 12, p. 4278-88 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)

• In vitro cross-linking of elastin peptides and molecular characterization of the resultant biomaterials

  Heinz, A., Ruttkies, C. K. H., Jahreis, G., Schräder, C. U., Wichapong, K., Sippl, W., Keeley, F. W., Neubert, R. H. H. & Schmelzer, C. E. H., Apr 2013, In: B B A - Reviews on Cancer. 1830, 4, p. 2994-3004 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)
• 2012

  Does human leukocyte elastase degrade intact skin elastin?

  Schmelzer, C. E. H., Jung, M. C., Wohlrab, J., Neubert, R. H. H. & Heinz, A., Nov 2012, In: F E B S Journal. 279, 22, p. 4191-200 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  49 Citations (Scopus)

• Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid

  Sivan, S-S., Van El, B., Merkher, Y., Schmelzer, C. E. H., Zuurmond, A-M., Heinz, A., Wachtel, E., Varga, P-P., Lazary, A., Brayda-Bruno, M. & Maroudas, A., Oct 2012, In: B B A - Reviews on Cancer. 1820, 10, p. 1671-7 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  23 Citations (Scopus)

• The action of neutrophil serine proteases on elastin and its precursor

  Heinz, A., Jung, M. C., Jahreis, G., Rusciani, A., Duca, L., Debelle, L., Weiss, A. S., Neubert, R. H. H. & Schmelzer, C. E. H., Jan 2012, In: Biochimie. 94, 1, p. 192-202 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  50 Citations (Scopus)
• 2011

  Insights into the degradation of human elastin by matrilysin-1

  Heinz, A., Taddese, S., Sippl, W., Neubert, R. H. H. & Schmelzer, C. E. H., Feb 2011, In: Biochimie. 93, 2, p. 187-94 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  34 Citations (Scopus)