Anne-Marie Heegaard

Search results

• 2025

  Levels of plasma 25-hydroxy vitamin D and risk of developing type 2 diabetes in a large Danish primary health care population

  Rohold, C. K., Jørgensen, H. L., Vojdeman, F. J., Madsen, C. M., Olsen, A., Heegaard, A. M., Lind, B. S., Tjønneland, A., Schwarz, P. & Gæde, P. H., 2025, In: Acta Diabetologica. 62, p. 397–404 8 p.

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  2 Citations (Scopus)

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• Pain, Quality of Life and Mental Health in Adults With X-Linked Hypophosphatemia: A Cross-Sectional Study

  Diaz-delCastillo, M., Espersen, R. B., Beck-Nielsen, S. S., Rejnmark, L. & Heegaard, A.-M., 2025, (Accepted/In press) In: The Journal of clinical endocrinology and metabolism.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Pain in fibrous dysplasia: identifying nociceptive mechanisms in a preclinical model

  Hopkins, C., de Castro, L. F., Benthin, J., Diaz-delCastillo, M., Manjappa, P., Boyce, A., Mendoza, R. E. M., Mora, J. A. V., Lopez-Delgado, G. E., Gomez, L. Y. P., Mohamed, K. E., Linley, J. E., Collins, M. T., Jimenez-Andrade, J. M. & Heegaard, A.-M., 2025, (Accepted/In press) In: Journal of Bone and Mineral Research. 13 p.

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• 2024

  Association of routine hematological parameters with the development of monoclonal gammopathies: a case-control study of 134,740 patients: Resubmitted to annals of Hematology 26 March 2024

  Røllum-Larsen, J., Engell, A. E., Diaz-delCastillo, M., Heegaard, A. M. & Jørgensen, H. L., 2024, In: Annals of Hematology. 103, p. 3005–3013

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• Peripherally restricted PICK1 inhibitor mPD5 ameliorates pain behaviors in murine inflammatory and neuropathic pain models

  Jensen, K. L., Riis Christensen, N., Goddard, C. M., Jager, S. E., Noes-Holt, G., Kanneworff, I. B., Jakobsen, A., Jiménez-Fernández, L., Peck, E. G., Sivertsen, L., Baro, R. C., Houser, G. A., Mayer, F. P., Diaz-DelCastillo, M., Topp, M. L., Hopkins, C., Thomsen, C. D., Soltan, A. B. I., Tidemand, F. G. & Arleth, L. & 3 others, Heegaard, A. M., Sørensen, A. T. & Madsen, K. L., 2024, In: JCI insight. 9, 20, 19 p., e170976.

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• Topical Neuropeptide Y for Ischemic Skin Wounds

  Stangerup, T., Gjerdrum, L. M. R., Bzorek, M., Andersen, L., Heegaard, A. M., Jorgensen, L. N. & Ågren, M. S., 2024, In: International Journal of Molecular Sciences. 25, 6, 14 p., 3346.

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  2 Citations (Scopus)

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• 2023

  Metastatic Infiltration of Nervous Tissue and Periosteal Nerve Sprouting in Multiple Myeloma-Induced Bone Pain in Mice and Human

  Diaz-delCastillo, M., Palasca, O., Nemler, T. T., Thygesen, D. M., Chávez-Saldaña, N. A., Vázquez-Mora, J. A., Ponce Gomez, L. Y., Jensen, L. J., Evans, H., Andrews, R. E., Mandal, A., Neves, D., Mehlen, P., Caruso, J. P., Dougherty, P. M., Price, T. J., Chantry, A., Lawson, M. A., Andersen, T. L. & Jimenez-Andrade, J. M. & 1 others, Heegaard, A.-M., 2023, In: The Journal of Neuroscience. 43, 29, p. 5414-5430

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  5 Citations (Scopus)

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• 2022

  Neuronal Sprouting and Reorganization in Bone Tissue Infiltrated by Human Breast Cancer Cells

  Hansen, R. B., Sayilekshmy, M., Sørensen, M. S., Jørgensen, A. H., Kanneworff, I. B., Bengtsson, E. K. E., Grum-schwensen, T. A., Petersen, M. M., Ejersted, C., Andersen, T. L., Andreasen, C. M. & Heegaard, A.-M., 2022, In: Frontiers in Pain Research. 3, p. 1-8 887747.

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  4 Citations (Scopus)

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• Neuropathic-like Pain in Fibrous Dysplasia/McCune-Albright Syndrome

  Spencer, T. L., Watts, L., Soni, A., Pinedo-Villanueva, R., Heegaard, A. M., Boyce, A. M. & Javaid, M. K., 2022, In: The Journal of clinical endocrinology and metabolism. 107, 6, p. e2258-e2266

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  10 Citations (Scopus)

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• 2021

  Bone Pain in Multiple Myeloma (BPMM)—A Protocol for a Prospective, Longitudinal, Observational Study

  Diaz-delcastillo, M., Andrews, R. E., Mandal, A., Andersen, T. L., Chantry, A. D. & Heegaard, A.-M., 2021, In: Cancers. 13, 7, 13 p., 1596.

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  4 Citations (Scopus)

  23 Downloads (Pure)

• Multiple myeloma—A painful disease of the bone marrow

  Diaz-delcastillo, M., Chantry, A. D., Lawson, M. A. & Heegaard, A.-M., 2021, In: Seminars in Cell and Developmental Biology. 112, p. 49-58

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  19 Citations (Scopus)

• The nociceptin/orphanin FQ receptor system as a target to alleviate cancer-induced bone pain in rats: Model validation and pharmacological evaluation

  Sliepen, S. H. J., Korioth, J., Christoph, T., Tzschentke, T. M., Diaz-delCastillo, M., Heegaard, A.-M. & Rutten, K., 2021, In: British Journal of Pharmacology. 178, 9, p. 1995-2007 13 p., 14899.

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  7 Citations (Scopus)

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• Vitamin D levels and the risk of prostate cancer and prostate cancer mortality

  Stroomberg, H. V., Vojdeman, F. J., Madsen, C. M., Helgstrand, J. T., Schwarz, P., Heegaard, A.-M., Olsen, A., Tjønneland, A., Struer Lind, B., Brasso, K., Jorgensen, H. L. & Roder, M. A., 2021, In: Acta Oncologica. 60, 3, p. 316-322 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  27 Citations (Scopus)
• 2020

  Differential Pain-Related Behaviors and Bone Disease in Immunocompetent Mouse Models of Myeloma

  Diaz-delCastillo, M., Kamstrup, D., Olsen, R. B., Hansen, R. B., Pembridge, T., Simanskaite, B., Jimenez-Andrade, J. M., Lawson, M. A. & Heegaard, A.-M., 2020, In: JBMR Plus. 4, 2, 14 p., e10252.

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  6 Citations (Scopus)

  106 Downloads (Pure)

• Hypophosphatemic Hypovitaminosis D Induces Osteomalacia in the Adult Female Rat

  Durup, D., Diaz-delCastillo, M., Morgenlykke, J., Jensen, L. T., Frandsen, E., Abelson, K. S. P., Pedersen, L., Lykkesfeldt, J., Ding, M., Jørgensen, N. R., Syberg, S., Petersen, S. & Heegaard, A.-M., 2020, In: Endocrinology. 161, 8, bqaa100.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Modulation of Rat Cancer-Induced Bone Pain is Independent of Spinal Microglia Activity

  Diaz-delCastillo, M., Hansen, R. B., Appel, C. K., Nielsen, L., Nielsen, S. N., Karyniotakis, K., Dahl, L. M., Andreasen, R. B. & Heegaard, A.-M., 2020, In: Cancers. 12, 10, 19 p., 2740.

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  13 Citations (Scopus)

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• 2019

  Best practice management guidelines for fibrous dysplasia/McCune-Albright syndrome: a consensus statement from the FD/MAS international consortium

  Javaid, M. K., Boyce, A., Appelman-Dijkstra, N., Ong, J., Defabianis, P., Offiah, A., Arunde, P., Shaw, N., Dal Pos, V., Underhil, A., Portero, D., Heral, L., Heegaard, A.-M., Masi, L., Monsell, F., Stanton, R., Dijkstra, P. D. S., Brandi, M. L., Chapurlat, R. & Hamdy, N. A. T. & 1 others, Collins, M. T., 13 Jun 2019, In: Orphanet Journal of Rare Diseases. 14, 19 p., 139.

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  189 Citations (Scopus)

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• Cancer-induced Bone Pain Impairs Burrowing Behaviour in Mouse and Rat

  Sliepen, S. H. J., Diaz-Delcastillo, M., Korioth, J., Olsen, R. B., Appel, C. K., Christoph, T., Heegaard, A.-M. & Rutten, K., 2019, In: In Vivo. 33, 4, p. 1125-1132 8 p.

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  15 Citations (Scopus)

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• Chronic high dose P2X7 receptor inhibition exacerbates cancer-induced bone pain

  Falk, S., Appel, C. K., Bennedbæk, H. B., Al-Dihaissy, T., Unger, A., Dinkel, K. & Heegaard, A.-M., 15 Feb 2019, In: European Journal of Pharmacology. 845, p. 48-55 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Decitabine attenuates nociceptive behavior in a murine model of bone cancer pain

  Appel, C. K., Scheff, N. N., Viet, C. T., Schmidt, B. L. & Heegaard, A. M., 1 Mar 2019, In: Pain. 160, 3, p. 619-631

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  12 Citations (Scopus)

• Innervation is higher above Bone Remodeling Surfaces and in Cortical Pores in Human Bone: Lessons from patients with primary hyperparathyroidism

  Sayilekshmy, M., Hansen, R. B., Delaissé, J. M., Rolighed, L., Andersen, T. L. & Heegaard, A. M., 1 Dec 2019, In: Scientific Reports. 9, 1, 14 p., 5361.

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  60 Citations (Scopus)

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• Vitamin D levels and cancer incidence in 217,244 individuals from primary health care in Denmark

  Vojdeman, F. J., Madsen, C. M., Frederiksen, K., Durup, D., Olsen, A., Hansen, L., Heegaard, A. M., Lind, B., Tjønneland, A., Jørgensen, H. L. & Schwarz, P., 2019, In: International Journal of Cancer. 145, 2, p. 338-346 9 p.

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  30 Citations (Scopus)

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• 2018

  Neuropeptide Y is Up-regulated and Induces Antinociception in Cancer-induced Bone Pain.

  Diaz del Castillo, M., Christiansen, S. H., Appel, C., Falk, S., Woldbye, D. P. D. & Heegaard, A.-M., 1 Aug 2018, In: Neuroscience. 384, p. 111-119

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• The effect of gender on early colonic anastomotic wound healing

  Kjaer, M., Kristjánsdóttir, H., Andersen, L., Heegaard, A. M., Ågren, M. S. & Jorgensen, L. N., 2018, In: International Journal of Colorectal Disease. 33, 9, p. 1269-1276 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• The β-lactam clavulanic acid mediates glutamate transport-sensitive pain relief in a rat model of neuropathic pain

  Kristensen, P. J., Gegelashvili, G., Munro, G., Heegaard, A. M. & Bjerrum, O. J., 1 Feb 2018, In: European Journal of Pain. 22, 2, p. 282-294

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)
• 2017

  Quantification of the Pharmacodynamic Interaction of Morphine and Gabapentin Using a Response Surface Approach

  Papathanasiou, T., Juul, R. V., Gabel-Jensen, C., Kreilgaard, M., Heegaard, A. M. & Lund, T. M., 1 Nov 2017, In: AAPS Journal. 19, 6, p. 1804–1813 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain

  Appel, C. K., Gallego-Pedersen, S., Andersen, L., Kristensen, S. B., Ding, M., Falk, S., Sayilekshmy, M., Gabel-Jensen, C. & Heegaard, A.-M., 6 Jul 2017, In: Scientific Reports. 7, 1, 14 p., 4792.

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  27 Citations (Scopus)

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• Vendor-derived differences in injury-induced pain phenotype and pharmacology of Sprague-Dawley rats: Does it matter?

  Kristensen, P. J., Heegaard, A. M., Kristensen, S. H., Jeggo, R. D., Bjerrum, O. J. & Munro, G., Apr 2017, In: European Journal of Pain. 21, 4, p. 692-704 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)
• 2016

  Bone pain: current and future treatments

  Frost, C. Ø., Hansen, R. R. & Heegaard, A.-M., Jun 2016, In: Current Opinion in Pharmacology. 28, p. 31-7 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  23 Citations (Scopus)

• Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain

  Papathanasiou, T., Juul, R. V., Heegaard, A.-M., Kreilgaard, M. & Lund, T. M., 2016, In: European Journal of Pharmaceutical Sciences. 82, p. 97–105 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)
• 2015

  A reverse J-shaped association between serum 25-hydroxyvitamin D and cardiovascular disease mortality - the CopD-study

  Durup, D., Jørgensen, H. L., Christensen, J., Tjønneland, A., Olsen, A., Halkjær, J., Lind, B., Heegaard, A.-M. & Schwarz, P., 24 Feb 2015, In: The Journal of clinical endocrinology and metabolism. 100, 6, p. 2339-46 8 p., jc20144551.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  142 Citations (Scopus)

• Effect of sex in the MRMT-1 model of cancer-induced bone pain

  Falk, S., Al-Dihaissy, T., Mezzanotte, L. & Heegaard, A.-M., 2015, In: F1000Research. 4, 445, p. 1-18 18 p., 445.

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  8 Citations (Scopus)

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• P2X7 receptor-mediated analgesia in cancer-induced bone pain

  Falk, S., D. Schwab, S., Frøsig-Jørgensen, M., Clausen, R. P., Dickenson, A. & Heegaard, A.-M., 13 Feb 2015, In: Neuroscience. 291, p. 93–105 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)

• Randall Selitto pressure algometry for assessment of bone-related pain in rats

  Falk, S., Ipsen, D. H., Appel, C. K., Ugarak, A., Durup, D., Dickenson, A. H. & Heegaard, A. M., 2015, In: European Journal of Pain. 19, 3, p. 305-312 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Spinal neuronal correlates of tapentadol analgesia in cancer pain: A back-translational approach

  Falk, S., Patel, R., Heegaard, A.-M., Mercadante, S. & Dickenson, A. H., 2015, In: European Journal of Pain. 19, 2, p. 152-158 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)
• 2014

  Pain without nociceptors? Nav1.7-independent pain mechanisms

  Minett, M. S., Falk, S., Santana-Varela, S., Bogdanov, Y. D., Nassar, M. A., Heegaard, A.-M. & Wood, J. N., 30 Jan 2014, In: Cell Reports. 6, 2, p. 245-246

  Research output: Contribution to journal › Journal article › Research › peer-review
  141 Citations (Scopus)
• 2013

  Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain

  Nasser, A., Bjerrum, O. J., Heegaard, A.-M., Møller, A. T., Larsen, M., Dalbøge, L. S., Dupont, E., Jensen, T. S. & Møller, L. B., 19 Feb 2013, In: Molecular Pain. 9, p. 5

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Influence of sex differences on the progression of cancer-induced bone pain

  Falk, S., Uldall, M., Appel, C., Ding, M. & Heegaard, A.-M., 2013, In: Anticancer Research. 33, 5, p. 1963-1969

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)
• 2012

  A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: The CopD study

  Durup, D. T., Jørgensen, H. L., Christensen, J., Schwarz, P., Heegaard, A.-M. & Lind, B., 1 Aug 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 8, p. 2644-52 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  232 Citations (Scopus)

• A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice, the CopD study

  Durup, D., Jørgensen, H. L., Christensen, J., Schwarz, P., Heegaard, A.-M. & Lind, B., 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 8, p. 2644 –2652

  Research output: Contribution to journal › Journal article › Research › peer-review
  232 Citations (Scopus)

• Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice

  Hansen, R. R., Nasser, A., Falk, S., Baldvinsson, S. B., Ohlsson, P. H., Bahl, J. M. C., Jarvis, M. F., Ding, M. & Heegaard, A.-M., 2012, In: European Journal of Pharmacology. 688, 1-3, p. 27-34 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  64 Citations (Scopus)
• 2011

  Nonselective matrix metalloproteinase but not tumor necrosis factor-a inhibition effectively preserves the early critical colon anastomotic integrity

  Ågren, M. S., Andersen, T. L., Andersen, L., Schiødt, C. B., Surve, V., Andreassen, T. T., Risteli, J., Franzén, L. E., Delaissé, J.-M., Heegaard, A.-M. & Jørgensen, L. N., 2011, In: International Journal of Colorectal Disease. 26, 3, p. 329-337 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)

• P2X7 receptor-deficient mice are susceptible to bone cancer pain

  Hansen, R. R., Nielsen, C. K., Nasser, A., Thomsen, S. I. M., Eghorn, L. F., Pham, Y., Schulenburg, C., Syberg, S., Ding, M., Stojilkovic, S. S., Jorgensen, N. R. & Heegaard, A.-M., 2011, In: Pain. 152, 8, p. 1766-76 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  72 Citations (Scopus)
• 2010

  Genetik kan forudsige følsomhed for smerte

  Nasser, A., Bjerrum, O. J., Heegaard, A.-M. & Møller, L. B., 2010, In: Lægemiddelforskning. 2010, p. 34-36

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• 2009

  Cancer-induced bone loss and associated pain-related behavior is reduced by risedronate but not its phosphonocarboxylate analog NE-10790

  Hald, A., Hansen, R. R., Thomsen, M. W., Ding, M., Croucher, P. I., Gallagher, O., Ebetino, F. H., Kassem, M. & Heegaard, A.-M., 2009, In: International Journal of Cancer. 125, 5, p. 1177-85 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Potential roles for the small leucine-rich proteoglycans biglycan and fibromodulin in ectopic ossification of tendon induced by exercise and in modulating rotarod performance

  Kilts, T., Ameye, L., Syed-Picard, F., Ono, M., Berendsen, A. D., Oldberg, A., Heegaard, A.-M., Bi, Y. & Young, M. F., 2009, In: Scandinavian Journal of Medicine & Science in Sports Online. 19, 4, p. 536-46 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  32 Citations (Scopus)
• 2008

  Differential activation of spinal cord glial cells in murine models of neuropathic and cancer pain

  Hald, A., Nedergaard, S., Hansen, R. R., Ding, M. & Heegaard, A.-M., 2008, In: European Journal of Pain.

  Research output: Contribution to journal › Journal article › Research › peer-review
  127 Citations (Scopus)

• Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain

  Hald, A., Ding, M., Egerod, K. L., Hansen, R. R., Konradsen, D., Jørgensen, S. G., Atalay, B., Nasser, A., Bjerrum, O. J. & Heegaard, A.-M., 2008, In: Pharmacology, Biochemistry and Behavior. 91, 1, p. 38-46 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  32 Citations (Scopus)

• Doxycycline-coated sutures improve mechanical strength of intestinal anastomoses

  Pasternak, B., Rehn, M., Andersen, L., Ågren, M. S., Heegaard, A.-M., Tengvall, P. & Aspenberg, P., 2008, In: International Journal of Colorectal Disease. 23, 3, p. 271-276

  Research output: Contribution to journal › Journal article › Research › peer-review
  43 Citations (Scopus)

• Effect of parenteral zinc sulfate on colon anastomosis repair in the rat

  Ågren, M. S., Andersen, L., Heegaard, A.-M. & Jorgensen, L. N., 2008, In: International Journal of Colorectal Disease. 23, 9, p. 857-861

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)