Annette Eva Langkilde

Search results

• 2025

  Structure and dynamics of the active site of hen egg-white lysozyme from atomic resolution neutron crystallography

  Ramos, J., Laux, V., Mason, S. A., Lemée, M-H., Bowler, M. W., Diederichs, K., Haertlein, M., Forsyth, V. T., Mossou, E., Larsen, S. & Langkilde, A. E., 2025, In: Structure (London, England : 1993). 33, 1, p. 136-148

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)
• 2024

  Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity

  Narayanan, D., Larsen, A. S. G., Gauger, S. J., Adafia, R., Hammershøi, R. B., Hamborg, L., Bruus-Jensen, J., Griem-Krey, N., Gee, C. L., Frølund, B., Stratton, M. M., Kuriyan, J., Kastrup, J. S., Langkilde, A. E., Wellendorph, P. & Solbak, S. M. Ø., 2024, In: Protein science : a publication of the Protein Society. 33, 10, 17 p., e5152.

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• Sex-dependent effects of monomeric α-syn on calcium and cell death of lateral hypothalamic mouse neurons are altered by orexin

  Bohid, S., Ali, L. K., Leguizamon, C. R. R., Langkilde, A. E., Brito dos Santos, A. & Kohlmeier, K. A., 2024, In: Molecular and Cellular Neurosciences. 129, 14 p., 103934.

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  1 Citation (Scopus)

  12 Downloads (Pure)
• 2023

  Identifying Biological and Biophysical Features of Different Maturation States of α-Synuclein Amyloid Fibrils

  Skamris, T., Vestergaard, B., Madsen, K. L., Langkilde, A. E. & Foderà, V., 2023, In: Methods in molecular biology (Clifton, N.J.). 2551, p. 321-344 24 p.

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  1 Citation (Scopus)

  21 Downloads (Pure)

• Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching

  Skriver, K., Sjørup, S. A., Langkilde, A. E., Balouka, E., Christensen, C. S., Carbel, K., Decker, J. N. V., Essenbæk, D. N., Gräf, J. F., Jessen, C. H., Kristensen, P., Merrild, C., Mortensen, T. S., Nalepa, I. F., Nordsteen, B. W., Svoren, S. K., van Hall, M., Weicher, J., Wind, M. L., Zhang, D. & 8 others, Saar, D., Blæsild, H., Stahlhut, M., Andersen, K. V., Dagil, R., Vestergaard, B., Ryberg, M. L. & Kragelund, B. B., 2023, In: The Biophysicist. 4 , 2, p. 1-7 7 p.

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• Monomeric α-synuclein activates the plasma membrane calcium pump

  Kowalski, A., Betzer, C., Larsen, S. T., Gregersen, E., Newcombe, E. A., Bermejo, M. C., Bendtsen, V. W., Diemer, J., Ernstsen, C. V., Jain, S., Bou, A. E., Langkilde, A. E., Nejsum, L. N., Klipp, E., Edwards, R., Kragelund, B. B., Jensen, P. H. & Nissen, P., 2023, In: EMBO Journal. 42, 23, 21 p., e111122.

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  4 Citations (Scopus)

  18 Downloads (Pure)

• Protein fibrillation from another small angle—SAXS data analysis of developing systems

  Langkilde, A. E. & Vestergaard, B., 2023, Methods in Enzymology. Elsevier, Vol. 678. p. 377-409

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  1 Citation (Scopus)

• Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons

  Santos, A. B. D., Thaneshwaran, S., Ali, L. K., Leguizamón, C. R. R., Wang, Y., Kristensen, M. P., Langkilde, A. E. & Kohlmeier, K. A., 2023, Research Square-Preprint, 29 p.

  Research output: Working paper › Preprint › Research

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• Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons

  Santos, A. B. D., Thaneshwaran, S., Ali, L. K., Leguizamón, C. R. R., Wang, Y., Kristensen, M. P., Langkilde, A. E. & Kohlmeier, K. A., 2023, In: Cell & Bioscience. 13, 1, 16 p., 172.

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  2 Citations (Scopus)

  22 Downloads (Pure)

• Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors

  Zang, J., Peters, F., Cambet, Y., Cifuentes-Pagano, E., Hissabu, M. M. S., Dustin, C. M., Svensson, L. H., Olesen, M. M., Poulsen, M. F. L., Jacobsen, S., Tuelung, P. S., Narayanan, D., Langkilde, A. E., Gajhede, M., Pagano, P. J., Jaquet, V., Vilhardt, F. & Bach, A., 2023, In: Journal of Medicinal Chemistry. 66, 21, p. 14963–15005

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)
• 2022

  Protein fibrillation from another small angle: Sample preparation and SAXS data collection

  Vestergaard, B. & Langkilde, A. E., 2022, Methods in Enzymology. Academic Press, Vol. 677. p. 291-321 (Methods in Enzymology).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  1 Citation (Scopus)

• Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases

  Solomon, M., Foderà, V., Langkilde, A. E., Elliott, P., Tagliavini, F., Forsyth, V. T., Klementieva, O. & Bellotti, V., 2022, In: Journal of Translational Medicine. 20, 1, 7 p., 213.

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• Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies

  Dos Santos, A. B., Skaanning, L. K., Thaneshwaran, S., Mikkelsen, E., Romero-Leguizamón, C. R., Skamris, T., Kristensen, M. P., Langkilde, A. E. & Kohlmeier, K. A., 2022, In: Cellular and Molecular Life Sciences. 79, 8, 450.

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  5 Citations (Scopus)

  18 Downloads (Pure)

• Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies

  Santos, A. B. D., Skaanning, L. K., Thaneskwaran, S., Mikkelsen, E., Romero-Leguizamon, C. R., Skamris, T., Kristensen, M. P., Langkilde, A. E. & Kohlmeier, K. A., 9 May 2022, Research Square-Preprint, 46 p.

  Research output: Working paper › Preprint › Research

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• 2021

  Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins

  Newcombe, E. A., Fernandes, C. B., Lundsgaard, J. E., Brakti, I., Lindorff-Larsen, K., Langkilde, A. E., Skriver, K. & Kragelund, B. B., 2021, In: Biomolecules. 11, 8, 17 p., 1173.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  13 Citations (Scopus)

  41 Downloads (Pure)

• Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods

  Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, E. A., Kragelund, B. B., Camilloni, C., Langkilde, A. E. & Lindorff-Larsen, K., 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.

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  42 Citations (Scopus)

  57 Downloads (Pure)

• Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme

  Ramos, J. C. M., Laux, V., Haertlein, M., Boeri Erba, E., McAuley, K., Forsyth, V. T., Mossou, E., Larsen, S. & Langkilde, A. E., 2021, In: IUCrJ. 8, 3, 15 p.

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  4 Citations (Scopus)

  30 Downloads (Pure)

• Structure and thermodynamics of transient protein-protein complexes by chemometric decomposition of SAXS datasets

  Sagar, A., Herranz-Trillo, F., Langkilde, A. E., Vestergaard, B. & Bernadó, P., 2021, In: Structure. 29, 9, p. 1074-1090

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme

  Ramos, J., Laux, V., Haertlein, M., Forsyth, V. T., Mossou, E., Larsen, S. & Langkilde, A. E., 1 Dec 2021, In: Acta crystallographica Section D: Structural biology . 77, 12, p. 1579-1590 12 p.

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  5 Citations (Scopus)

  25 Downloads (Pure)

• α-Synuclein Responses in the Laterodorsal Tegmentum, the Pedunculopontine Tegmentum and the Substantia Nigra: Implications for Early Appearance of Sleep Disorders in Parkinson’s Disease

  Brito dos Santos, A., Skaanning, L. K., Mikkelsen, E., Leguizamon, C. R. R., Kristensen, M. P., Klein, A. B., Thaneshwaran, S. S., Langkilde, A. E. & Kohlmeier, K. A., 2021, In: Journal of Parkinson's Disease. 11, 4, p. 1773-1790

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  6 Citations (Scopus)

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• 2020

  Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion

  Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, B., Pedersen, S. F., Rheinstädter, M. C., Langkilde, A. E. & Kragelund, B. B., 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.

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  29 Citations (Scopus)

  103 Downloads (Pure)

• Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery

  Solbak, S. M. Ø., Zang, J., Narayanan, D., Høj, L. J., Bucciarelli, S., Softley, C., Meier, S., Langkilde, A. E., Gotfredsen, C. H., Sattler, M. & Bach, A., 2020, In: Journal of Medicinal Chemistry. 63, 3, p. 1156-1177

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  28 Citations (Scopus)

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• Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4

  Juul-madsen, K., Qvist, P., Bendtsen, K. L., Langkilde, A. E., Vestergaard, B., Howard, K. A., Dehesa-etxebeste, M., Paludan, S. R., Andersen, G. R., Jensen, P. H., Otzen, D. E., Romero-ramos, M. & Vorup-jensen, T., 22 Jan 2020, In: The Journal of Immunology. 204, 5, p. 1345-1361

  Research output: Contribution to journal › Journal article › peer-review
  25 Citations (Scopus)

• The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

  Skaanning, L. K., Santoro, A., Skamris, T., Martinsen, J. H., D’Ursi, A. M., Bucciarelli, S., Vestergaard, B., Bugge, K., Langkilde, A. E. & Kragelund, B. B., 2020, In: Biomolecules. 10, 8, 23 p., 1192.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  6 Citations (Scopus)

  41 Downloads (Pure)

• The structural basis of fungal glucuronoyl esterase activity on natural substrates

  Ernst, H. A., Mosbech, C., Langkilde, A. E., Westh, P., Meyer, A. S., Wittrup Agger, J. & Larsen, S., 2020, In: Nature Communications. 11, 1026, p. 1-12

  Research output: Contribution to journal › Journal article › Research › peer-review

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  23 Citations (Scopus)

  87 Downloads (Pure)
• 2019

  Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior

  Cholak, E., Bucciarelli, S., Bugge, K., Johansen, N. T., Vestergaard, B., Arleth, L., Kragelund, B. B. & Langkilde, A. E., Nov 2019, In: Biochemistry. 58, 50, p. 5052-5065

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)
• 2018

  Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene

  Seuring, C., Ayyer, K., Filippaki, E., Barthelmess, M., Longchamp, J-N., Ringler, P., Pardini, T., Wojtas, D. H., Coleman, M. A., Dörner, K., Fuglerud, S., Hammarin, G., Habenstein, B., Langkilde, A. E., Loquet, A., Meents, A., Riek, R., Stahlberg, H., Boutet, S., Hunter, M. S. & 7 others, Koglin, J., Liang, M., Ginn, H. M., Millane, R. P., Frank, M., Barty, A. & Chapman, H. N., 9 May 2018, In: Nature Communications. 9, 1, 10 p., 1836.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  38 Citations (Scopus)

  171 Downloads (Pure)

• Noninvasive Structural Analysis of Intermediate Species During Fibrillation: An Application of Small-Angle X-Ray Scattering

  Langkilde, A. E., Herranz-Trillo, F., Bernadó, P. & Vestergaard, B., 8 Jun 2018, Amyloid Proteins: methods and protocols. Sigurdsson, E., Calero, M. & Gasset, M. (eds.). Humana Press, Vol. 1779. p. 209-239 31 p. (Methods in Molecular Biology).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
  5 Citations (Scopus)
• 2016

  Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization

  Pedersen, T. S., Tian, X., Thorolfsson, M., Karkov, H. S., Rasmussen, H. B., Langkilde, A. E. & Vestergaard, B., Mar 2016, In: Pharmaceutical Research. 33, 3, p. 716-28 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  49 Citations (Scopus)
• 2015

  Formation of covalent di-tyrosine dimers in recombinant α-synuclein

  van Maarschalkerweerd, A., Pedersen, MN., Peterson, H., Nilsson, M., Nguyen, TTT., Skamris, T., Rand, K., Vetri, V., Langkilde, AE. & Vestergaard, B., 19 Oct 2015, In: Intrinsically Disordered Proteins. 3, 1, p. 1-12 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• In-depth analysis of subclass-specific conformational preferences of IgG antibodies

  Tian, X., Vestergaard, B., Thorolfsson, M., Yang, Z., Rasmussen, H. B. & Langkilde, A. E., 1 Jan 2015, In: IUCrJ. 2, 1, p. 9-18 10 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access
  58 Citations (Scopus)

• The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy

  Langkilde, A. E., Morris, K. L., Serpell, L. C., Svergun, D. I. & Vestergaard, B., Apr 2015, In: Acta crystallographica. Section D, Biological crystallography. 71, Pt 4, p. 882-95 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  50 Citations (Scopus)

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• 2014

  Protein/lipid coaggregates are formed during α-synuclein-induced disruption of lipid bilayers

  van Maarschalkerweerd, A., Vetri, V., Langkilde, A. E., Foderà, V. & Vestergaard, B., 13 Oct 2014, In: Biomacromolecules. 15, 10, p. 3643-54 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  50 Citations (Scopus)

• Small-Angle X-ray Scattering Screening Complements Conventional Biophysical Analysis: Comparative Structural and Biophysical Analysis of Monoclonal Antibodies IgG1, IgG2, and IgG4

  Tian, X., Langkilde, A. E., Thorolfsson, M., Rasmussen, H. B. & Vestergaard, B., Jun 2014, In: Journal of Pharmaceutical Sciences. 103, 6, p. 1701-10 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  53 Citations (Scopus)
• 2013

  Wildtype and A30P mutant alpha-synuclein form different fibril structures

  Nielsen, S. B., Macchi, F., Raccosta, S., Langkilde, A. E., Giehm, L., Kyrsting, A. H., Svane, A. S. P., Manno, M., Christiansen, G., Nielsen, N. C., Oddershede, L. B., Vestergaard, B. & Otzen, D., 2013, In: PLOS ONE. 8, 7, e67713.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  51 Citations (Scopus)

  1585 Downloads (Pure)
• 2012

  Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

  Clausen, T. M., Christoffersen, S., Dahlbäck, M., Langkilde, A. E., Jensen, K. E., Resende, M., Agerbæk, M. Ø., Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, M. A., Theander, T. G., Larsen, S. & Salanti, A., 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  147 Citations (Scopus)

• Structural characterization of prefibrillar intermediates and amyloid fibrils by small-angle X-ray scattering

  Langkilde, A. E. & Vestergaard, B., 2012, Amyloid proteins: methods and protocols. Sigurdsson, E. M., Calero, M. & Gasset, M. (eds.). 2 ed. New York: Springer Science+Business Media, Vol. 849. p. 137-155 18 p. (Methods in Molecular Biology, Vol. 849).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
  12 Citations (Scopus)
• 2011

  The first lesson in the classroom - getting students engaged in active learning process

  Langkilde, A. E., 2011, Improving University Science Teaching and Learning: Pedagogical Projects 2010. Ulriksen, L., Rump, C. & Hansen, H. W. (eds.). Department of Science Education, University of Copenhagen, Vol. 3. p. 3-17

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
• 2009

  Methods for structural characterization of prefibrillar intermediates and amyloid fibrils

  Langkilde, A. E. & Vestergaard, B., 2009, In: FEBS Letters. 583, 16, p. 2600-2609

  Research output: Contribution to journal › Journal article › Research › peer-review
  66 Citations (Scopus)

• Sparing the ortho-position in nucleophilic aromatic substitution-specific displacement of the 4-SePh group in 2,4-bis(phenylseleno)nitrobenzene

  Stuhr-Hansen, N., Götze, T. F., Henriksen, L., Sølling, T. I., Langkilde, A. E. & Sørensen, H. O., 2009, In: Heteroatom Chemistry. 20, 2, p. 101-108

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)
• 2008

  High resolution X-ray diffraction of macromolecular crystals: The challenge of obtaining accurate data and extracting valid information

  Langkilde, A. E., 2008, Kemisk Institut, Københavns Universitet.

  Research output: Book/Report › Ph.D. thesis › Research

• Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

  Langkilde, A. E., Kristensen, S. M., Lo Leggio, L., Mølgaard, A., Jensen, J. H., Houk, A. R., Poulsen, J-C. N., Larsen, S. Y. & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863

  Research output: Contribution to journal › Journal article › Research › peer-review
  45 Citations (Scopus)
• 2005

  Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates

  Barfod, R., Eriksen, J., Golding, B. T., Hammershøi, A., Jacobsen, T. A., Langkilde, A. E., Larsen, S., Mønsted, O., Sargeson, A. M. & Sørensen, H. O., 2005, In: Dalton Transactions (Print Edition). 3, p. 491-500 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  8 Citations (Scopus)
• 2004

  Structures of three salts of phthalic acid; variation in crystal packing and geometry of the hydrogen phthalate ion

  Langkilde, A. E., Madsen, D. & Larsen, S., 2004, In: Acta Crystallographica. B60, p. 502-511

  Research output: Contribution to journal › Journal article › Research › peer-review

  15 Citations (Scopus)
• 2002

  Diastereomeric salts of lactic acid and 1-phenylethylamine, their structures and relative stabilities

  Langkilde, A. E., Oddershede, J. & Larsen, S., 2002, In: Acta Crystallographica B. 58, p. 1044-1050

  Research output: Contribution to journal › Journal article › Research › peer-review

  9 Citations (Scopus)