Research output per year
Research output per year
- 37 results
Search results
-
2025
Structure and dynamics of the active site of hen egg-white lysozyme from atomic resolution neutron crystallography
Ramos, J., Laux, V., Mason, S. A., Lemée, M.-H., Bowler, M. W., Diederichs, K., Haertlein, M., Forsyth, V. T., Mossou, E., Larsen, S. & Langkilde, A. E., 2025, In: Structure (London, England : 1993). 33, 1, p. 136-148Research output: Contribution to journal › Journal article › Research › peer-review
2 Citations (Scopus) -
2024
Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity
Narayanan, D., Larsen, A. S. G., Gauger, S. J., Adafia, R., Hammershøi, R. B., Hamborg, L., Bruus-Jensen, J., Griem-Krey, N., Gee, C. L., Frølund, B., Stratton, M. M., Kuriyan, J., Kastrup, J. S., Langkilde, A. E., Wellendorph, P. & Solbak, S. M. Ø., 2024, In: Protein science : a publication of the Protein Society. 33, 10, 17 p., e5152.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)11 Downloads (Pure) -
Sex-dependent effects of monomeric α-syn on calcium and cell death of lateral hypothalamic mouse neurons are altered by orexin
Bohid, S., Ali, L. K., Leguizamon, C. R. R., Langkilde, A. E., Brito dos Santos, A. & Kohlmeier, K. A., 2024, In: Molecular and Cellular Neurosciences. 129, 14 p., 103934.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)14 Downloads (Pure) -
2023
Identifying Biological and Biophysical Features of Different Maturation States of α-Synuclein Amyloid Fibrils
Skamris, T., Vestergaard, B., Madsen, K. L., Langkilde, A. E. & Foderà, V., 2023, In: Methods in molecular biology (Clifton, N.J.). 2551, p. 321-344 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)24 Downloads (Pure) -
Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching
Skriver, K., Sjørup, S. A., Langkilde, A. E., Balouka, E., Christensen, C. S., Carbel, K., Decker, J. N. V., Essenbæk, D. N., Gräf, J. F., Jessen, C. H., Kristensen, P., Merrild, C., Mortensen, T. S., Nalepa, I. F., Nordsteen, B. W., Svoren, S. K., van Hall, M., Weicher, J., Wind, M. L. & Zhang, D. & 8 others, , 2023, In: The Biophysicist. 4 , 2, p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile81 Downloads (Pure) -
Monomeric α-synuclein activates the plasma membrane calcium pump
Kowalski, A., Betzer, C., Larsen, S. T., Gregersen, E., Newcombe, E. A., Bermejo, M. C., Bendtsen, V. W., Diemer, J., Ernstsen, C. V., Jain, S., Bou, A. E., Langkilde, A. E., Nejsum, L. N., Klipp, E., Edwards, R., Kragelund, B. B., Jensen, P. H. & Nissen, P., 2023, In: EMBO Journal. 42, 23, 21 p., e111122.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)19 Downloads (Pure) -
Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons
Santos, A. B. D., Thaneshwaran, S., Ali, L. K., Leguizamón, C. R. R., Wang, Y., Kristensen, M. P., Langkilde, A. E. & Kohlmeier, K. A., 2023, In: Cell & Bioscience. 13, 1, 16 p., 172.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)24 Downloads (Pure) -
Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors
Zang, J., Peters, F., Cambet, Y., Cifuentes-Pagano, E., Hissabu, M. M. S., Dustin, C. M., Svensson, L. H., Olesen, M. M., Poulsen, M. F. L., Jacobsen, S., Tuelung, P. S., Narayanan, D., Langkilde, A. E., Gajhede, M., Pagano, P. J., Jaquet, V., Vilhardt, F. & Bach, A., 2023, In: Journal of Medicinal Chemistry. 66, 21, p. 14963–15005Research output: Contribution to journal › Journal article › Research › peer-review
4 Citations (Scopus) -
2022
Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases
Solomon, M., Foderà, V., Langkilde, A. E., Elliott, P., Tagliavini, F., Forsyth, V. T., Klementieva, O. & Bellotti, V., 2022, In: Journal of Translational Medicine. 20, 1, 7 p., 213.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile16 Downloads (Pure) -
Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies
Dos Santos, A. B., Skaanning, L. K., Thaneshwaran, S., Mikkelsen, E., Romero-Leguizamón, C. R., Skamris, T., Kristensen, M. P., Langkilde, A. E. & Kohlmeier, K. A., 2022, In: Cellular and Molecular Life Sciences. 79, 8, 450.Research output: Contribution to journal › Journal article › Research › peer-review
File5 Citations (Scopus)18 Downloads (Pure) -
2021
Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins
Newcombe, E. A., Fernandes, C. B., Lundsgaard, J. E., Brakti, I., Lindorff-Larsen, K., Langkilde, A. E., Skriver, K. & Kragelund, B. B., 2021, In: Biomolecules. 11, 8, 17 p., 1173.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)43 Downloads (Pure) -
Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods
Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, E. A., Kragelund, B. B., Camilloni, C., Langkilde, A. E. & Lindorff-Larsen, K., 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile43 Citations (Scopus)60 Downloads (Pure) -
Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme
Ramos, J. C. M., Laux, V., Haertlein, M., Boeri Erba, E., McAuley , K., Forsyth, V. T., Mossou, E., Larsen, S. & Langkilde, A. E., 2021, In: IUCrJ. 8, 3, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)30 Downloads (Pure) -
Structure and thermodynamics of transient protein-protein complexes by chemometric decomposition of SAXS datasets
Sagar, A., Herranz-Trillo, F., Langkilde, A. E., Vestergaard, B. & Bernadó, P., 2021, In: Structure. 29, 9, p. 1074-1090Research output: Contribution to journal › Journal article › Research › peer-review
10 Citations (Scopus) -
The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme
Ramos, J., Laux, V., Haertlein, M., Forsyth, V. T., Mossou, E., Larsen, S. & Langkilde, A. E., 1 Dec 2021, In: Acta crystallographica Section D: Structural biology . 77, 12, p. 1579-1590 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)26 Downloads (Pure) -
α-Synuclein Responses in the Laterodorsal Tegmentum, the Pedunculopontine Tegmentum and the Substantia Nigra: Implications for Early Appearance of Sleep Disorders in Parkinson’s Disease
Brito dos Santos, A., Skaanning, L. K., Mikkelsen, E., Leguizamon, C. R. R., Kristensen, M. P., Klein, A. B., Thaneshwaran, S. S., Langkilde, A. E. & Kohlmeier, K. A., 2021, In: Journal of Parkinson's Disease. 11, 4, p. 1773-1790Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile7 Citations (Scopus)24 Downloads (Pure) -
2020
Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion
Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, B., Pedersen, S. F., Rheinstädter, M. C., Langkilde, A. E. & Kragelund, B. B., 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile29 Citations (Scopus)114 Downloads (Pure) -
Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery
Solbak, S. M. Ø., Zang, J., Narayanan, D., Høj, L. J., Bucciarelli, S., Softley, C., Meier, S., Langkilde, A. E., Gotfredsen, C. H., Sattler, M. & Bach, A., 2020, In: Journal of Medicinal Chemistry. 63, 3, p. 1156-1177Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile28 Citations (Scopus)29 Downloads (Pure) -
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4
Juul-madsen, K., Qvist, P., Bendtsen, K. L., Langkilde, A. E., Vestergaard, B., Howard, K. A., Dehesa-etxebeste, M., Paludan, S. R., Andersen, G. R., Jensen, P. H., Otzen, D. E., Romero-ramos, M. & Vorup-jensen, T., 22 Jan 2020, In: The Journal of Immunology. 204, 5, p. 1345-1361Research output: Contribution to journal › Journal article › Research › peer-review
25 Citations (Scopus) -
The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin
Skaanning, L. K., Santoro, A., Skamris, T., Martinsen, J. H., D’Ursi, A. M., Bucciarelli, S., Vestergaard, B., Bugge, K., Langkilde, A. E. & Kragelund, B. B., 2020, In: Biomolecules. 10, 8, 23 p., 1192.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile7 Citations (Scopus)42 Downloads (Pure) -
The structural basis of fungal glucuronoyl esterase activity on natural substrates
Ernst, H. A., Mosbech, C., Langkilde, A. E., Westh, P., Meyer, A. S., Wittrup Agger, J. & Larsen, S., 2020, In: Nature Communications. 11, 1026, p. 1-12Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile24 Citations (Scopus)89 Downloads (Pure) -
2019
Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior
Cholak, E., Bucciarelli, S., Bugge, K., Johansen, N. T., Vestergaard, B., Arleth, L., Kragelund, B. B. & Langkilde, A. E., Nov 2019, In: Biochemistry. 58, 50, p. 5052-5065Research output: Contribution to journal › Journal article › Research › peer-review
13 Citations (Scopus) -
2018
Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene
Seuring, C., Ayyer, K., Filippaki, E., Barthelmess, M., Longchamp, J.-N., Ringler, P., Pardini, T., Wojtas, D. H., Coleman, M. A., Dörner, K., Fuglerud, S., Hammarin, G., Habenstein, B., Langkilde, A. E., Loquet, A., Meents, A., Riek, R., Stahlberg, H., Boutet, S. & Hunter, M. S. & 7 others, , 1 Dec 2018, In: Nature Communications. 9, 1, 10 p., 1836.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile38 Citations (Scopus)172 Downloads (Pure) -
2016
Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization
Pedersen, T. S., Tian, X., Thorolfsson, M., Karkov, H. S., Rasmussen, H. B., Langkilde, A. E. & Vestergaard, B., Mar 2016, In: Pharmaceutical Research. 33, 3, p. 716-28 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
49 Citations (Scopus) -
2015
Formation of covalent di-tyrosine dimers in recombinant α-synuclein
van Maarschalkerweerd, A., Pedersen, M., Peterson, H., Nilsson, M., Nguyen, T., Skamris, T., Rand, K., Vetri, V., Langkilde, A. & Vestergaard, B., 19 Oct 2015, In: Intrinsically Disordered Proteins. 3, 1, p. 1-12 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
16 Citations (Scopus) -
In-depth analysis of subclass-specific conformational preferences of IgG antibodies
Tian, X., Vestergaard, B., Thorolfsson, M., Yang, Z., Rasmussen, H. B. & Langkilde, A. E., 1 Jan 2015, In: IUCrJ. 2, 1, p. 9-18 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access59 Citations (Scopus) -
The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy
Langkilde, A. E., Morris, K. L., Serpell, L. C., Svergun, D. I. & Vestergaard, B., Apr 2015, In: Acta crystallographica. Section D, Biological crystallography. 71, Pt 4, p. 882-95 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile50 Citations (Scopus)227 Downloads (Pure) -
2014
Protein/lipid coaggregates are formed during α-synuclein-induced disruption of lipid bilayers
van Maarschalkerweerd, A., Vetri, V., Langkilde, A. E., Foderà, V. & Vestergaard, B., 13 Oct 2014, In: Biomacromolecules. 15, 10, p. 3643-54 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
50 Citations (Scopus) -
Small-Angle X-ray Scattering Screening Complements Conventional Biophysical Analysis: Comparative Structural and Biophysical Analysis of Monoclonal Antibodies IgG1, IgG2, and IgG4
Tian, X., Langkilde, A. E., Thorolfsson, M., Rasmussen, H. B. & Vestergaard, B., Jun 2014, In: Journal of Pharmaceutical Sciences. 103, 6, p. 1701-10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
53 Citations (Scopus) -
2013
Wildtype and A30P mutant alpha-synuclein form different fibril structures
Nielsen, S. B., Macchi, F., Raccosta , S., Langkilde, A. E., Giehm, L., Kyrsting, A. H., Svane, A. S. P., Manno, M., Christiansen, G., Nielsen, N. C., Oddershede, L. B., Vestergaard, B. & Otzen, D., 2013, In: PLOS ONE. 8, 7, e67713.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile51 Citations (Scopus)1588 Downloads (Pure) -
2012
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria
Clausen, T. M., Christoffersen, S., Dahlbäck, M., Langkilde, A. E., Jensen, K. E., Resende, M., Agerbæk, M. Ø., Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, M. A., Theander, T. G., Larsen, S. & Salanti, A., 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
147 Citations (Scopus) -
2009
Methods for structural characterization of prefibrillar intermediates and amyloid fibrils
Langkilde, A. E. & Vestergaard, B., 2009, In: FEBS Letters. 583, 16, p. 2600-2609Research output: Contribution to journal › Journal article › Research › peer-review
67 Citations (Scopus) -
Sparing the ortho-position in nucleophilic aromatic substitution-specific displacement of the 4-SePh group in 2,4-bis(phenylseleno)nitrobenzene
Stuhr-Hansen, N., Götze, T. F., Henriksen, L., Sølling, T. I., Langkilde, A. E. & Sørensen, H. O., 2009, In: Heteroatom Chemistry. 20, 2, p. 101-108Research output: Contribution to journal › Journal article › Research › peer-review
7 Citations (Scopus) -
2008
Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase
Langkilde, A. E., Kristensen, S. M., Lo Leggio, L., Mølgaard, A., Jensen, J. H., Houk, A. R., Poulsen, J.-C. N., Larsen, S. Y. & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863Research output: Contribution to journal › Journal article › Research › peer-review
45 Citations (Scopus) -
2005
Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates
Barfod, R., Eriksen, J., Golding, B. T., Hammershøi, A., Jacobsen, T. A., Langkilde, A. E., Larsen, S., Mønsted, O., Sargeson, A. M. & Sørensen, H. O., 2005, In: Dalton Transactions (Print Edition). 3, p. 491-500 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
8 Citations (Scopus) -
2004
Structures of three salts of phthalic acid; variation in crystal packing and geometry of the hydrogen phthalate ion
Langkilde, A. E., Madsen, D. & Larsen, S., 2004, In: Acta Crystallographica. B60, p. 502-511Research output: Contribution to journal › Journal article › Research › peer-review
15 Citations (Scopus) -
2002
Diastereomeric salts of lactic acid and 1-phenylethylamine, their structures and relative stabilities
Langkilde, A. E., Oddershede, J. & Larsen, S., 2002, In: Acta Crystallographica B. 58, p. 1044-1050Research output: Contribution to journal › Journal article › Research › peer-review
9 Citations (Scopus)