Research output per year
Research output per year
PhD in Medical Biology major in Genetics, Istanbul University, 1995
Blegdamsvej 3
2200 København N.
Blegdamsvej 3, 2200 København N.
Research activity per year
I have a mechanistic interest into genome-wide and locus specific regulation and fine-tuning of tissue-specific gene expression. We are interested in the 3D-organization of genome within the nuclear space, non-coding RNAs and epigenetic modifications especially methylation and hydroxymethylation. The interaction of these linear and 3-dimentional mechanisms in gene regulation within the healthy brain and the neurodegenerative diseases is the primary interest.
For a very long time we have been working on a specific familial balanced translocation t(8;20) segregating with early onset cerebellar ataxi and use this translocation in learning about the organization and the function of the genome around the breakpoints. The synapse associated DLGAP4 gene which spans one of the breakpoints became my favorite gene over the years.
I do not like being limited by the technical short-comings when I need to find answers to biological questions. Therefore, I have a great interest in developing novel methods based on in situ hybridization both at RNA and DNA level, and I try novel probe technologies and develop new nuclear preparation methods in order to study the genome organization by pushing the resolution limits from different sides . We think multidiciplinary projects are always exciting. Over the years, we have been collaborating with DTU Nanotech in developing lab-on-a-chip devices for genetic analyses.
English
Danish
Turkish
German
Associate Professor, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen (2009- )
Various posts as senior scientist, postdoc, assistant Professor or research associate Professor at the;
University of Copenhagen, Healthsciences Faculty, Wilhelm Johannsen Centre for Functional Genome Research (1999-2009)
Istanbul University, Cerrahpasa Medical Faculty, Division of Biomedical Sciences (1990-1999)
Ph.D in Medical Biology (major in genetics), Istanbul University, “Assessment and application of fluorescence in situ hybridization on meiotic and mitotic chromosomes” Research performed at the J.F. Kennedy Institute, Denmark (1995)
MSc (Med.Sci.) in Medical Genetics, Glasgow University,“Assessment of non-isotopic method of in situ hybridization in detection of trisomy 21 in interphase nuclei” (1989)
BSc in Biomedical Sciences, Istanbul University, Cerrahpasa Medical Faculty, Division of Biomedical Sciences,(1988)
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Editorial › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Asli Silahtaroglu (Member)
Activity: Membership types › Membership in board of company or public organisation