Birgitte Nielsen

Research output

Research output per year 1987 1989 2003 2004 2005 2006 2007 2008 2009 2010 2012 2013 2014 2016 2017 2019 2024

• 2434 Citations
• 123 Journal article
• 8 Book chapter
• 3 Comment/debate
• 1 Poster
• 2 More
  • 1 Conference abstract in journal
  • 1 Letter

Research output per year

Research output per year

Search results

• 2024

  Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5)

  Buschbom-Helmke, S., Wang, P., Alcaide, A., Miguez-Cabello, F., Carta, M., Viotti, J. S., Nielsen, B., Mulle, C., Bowie, D., Jørgensen, F. S., Pickering, D. S. & Bunch, L., 2024, In: Journal of Medicinal Chemistry. 67, 16, p. 14524–14542

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2023

  Structure-Activity Relationship and Solubility Studies of Novel N1-substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists

  Chałupnik, P., Vialko, A., Pickering, D. S., Nielsen, B., Bay, Y., Kristensen, A. S., Hinkkanen, M., Szczepańska, K., Karcz, T., Latacz, G., Johansen, T. N. & Szymanska, E. M., 2023, In: ChemMedChem. 18, 18, 15 p., e202300278.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Citations (Scopus)

  4 Downloads (Pure)
• 2022

  (S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist

  Poulie, C. B. M., Larsen, Y., Leteneur, C., Barthet, G., Bjorn-Yoshimoto, W. E., Malhaire, F., Nielsen, B., Pin, J. P., Mulle, C., Pickering, D. S. & Bunch, L., 2022, In: ACS Chemical Neuroscience. 13, 10, p. 1580–1587

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype

  Chałupnik, P., Vialko, A., Pickering, D. S., Hinkkanen, M., Donbosco, S., Møller, T. C., Jensen, A. A., Nielsen, B., Bay, Y., Kristensen, A. S., Johansen, T. N., Łątka, K., Bajda, M. & Szymańska, E., 2022, In: International Journal of Molecular Sciences. 23, 15, 16 p., 8797.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  7 Citations (Scopus)

  53 Downloads (Pure)
• 2021

  Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based ?-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect

  Bavo, F., De-Jong, H., Petersen, J., Falk-Petersen, C. B., Löffler, R., Sparrow, E., Rostrup, F., Eliasen, J. N., Wilhelmsen, K. S., Barslund, K., Bundgaard, C., Nielsen, B., Kristiansen, U., Wellendorph, P., Bogdanov, Y. & Frølund, B., 2021, In: Journal of Medicinal Chemistry. 64, 24, p. 17795-17812

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)
• 2020

  A Diversity Oriented Synthesis Approach to New 2,3-trans-Substituted l-Proline Analogs as Potential Ligands for the Ionotropic Glutamate Receptors

  Kayser, S., Temperini, P., Poulie, C. B. M., Staudt, M., Nielsen, B., Pickering, D. S. & Bunch, L., 4 Mar 2020, In: ACS Chemical Neuroscience. 11, p. 702-714 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Stereoselective Synthesis of New (2S,3R)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp3)-H Activation Strategy and Structure-Activity Relationship Studies at the Ionotropic Glutamate Receptors

  Kayser, S., Hansen, J. C., Staudt, M., Moroz, A., Larsen, Y., Temperini, P., Yi, F., Syrenne, J. T., Krogsgaard-Larsen, N., Iliadis, S., Nielsen, B., Hansen, K. B., Pickering, D. S. & Bunch, L., 2020, In: ACS Chemical Neuroscience. 11, p. 674-701 28 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  8 Citations (Scopus)
• 2019

  Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters

  Poulie, C. B. M., Alcaide Lopez, A., Krell-Jørgensen, M. P., Larsen, Y., Astier, E., Bjørn-Yoshimoto, W. E., Yi, F., Syrenne, J. T., Storgaard, M., Nielsen, B., Frydenvang, K. A., Jensen, A. A., Hansen, K. B., Pickering, D. S. & Bunch, L., 19 Jun 2019, In: A C S Chemical Neuroscience. 10, 6, p. 2989-3007 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  4 Citations (Scopus)

• Developing New 4-PIOL and 4-PHP Analogues for Photoinactivation of γ-Aminobutyric Acid Type A Receptors

  Mortensen, M., Krall, J., Kongstad, K. T., Brygger, B. M., Lenzi, O., Francotte, P., Sørensen, T. E., Nielsen, B., Jensen, A. A., Smart, T. G. & Frølund, B., 2019, In: ACS Chemical Neuroscience. 10, 11, p. 4669-4684

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  5 Citations (Scopus)

  32 Downloads (Pure)

• Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

  Krall, J., Bavo, F., Falk-Petersen, C. B., Jensen, C. H., Nielsen, J. O., Tian, Y., Anglani, V., Kongstad, K. T., Piilgaard, L., Nielsen, B., Gloriam, D. E., Kehler, J., Jensen, A. A., Harpsøe, K., Wellendorph, P. & Frølund, B., 14 Mar 2019, In: Journal of Medicinal Chemistry. 62, 5, p. 2798-2813

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

  Giraudo, A., Krall, J., Bavo, F., Nielsen, B., Kongstad, K. T., Rolando, B., De Blasio, R., Gloriam, D. E., Löffler, R., Thiesen, L., Harpsøe, K., Frydenvang, K., Boschi, D., Wellendorph, P., Lolli, M. L., Jensen, A. A. & Frølund, B., 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide - a new kainate receptor selective antagonist and analgesic: Synthesis, X-ray crystallography, structure-affinity relationships, in vitro and in vivo pharmacology

  Møllerud, S., Hansen, R. B., Pallesen, J. S., Temperini, P., Pasini, D., Bornholdt, J., Nielsen, B., Mamedova, E., Chalupnik, P., Paternain, A. V., Lerma, J., Del Castillo, M. D., Andreasen, J. T., Frydenvang, K., Kastrup, J. S., Johansen, T. N. & Pickering, D. S., 2019, In: ACS Chemical Neuroscience. 10, p. 4685-4695 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology

  Pallesen, J. S., Møllerud, S., Frydenvang, K. A., Pickering, D. S., Bornholt, J., Nielsen, B., Pasini, D., Han, L., Marconi, L., Kastrup, J. S. J. & Johansen, T. N., 20 Mar 2019, In: A C S Chemical Neuroscience. 10, p. 1841-1853 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool for the Development of Ionotropic Glutamate Receptor Ligands

  Sainas, S., Temperini, P., Farnsworth, J. C., Yi, F., Møllerud, S., Jensen, A. A., Nielsen, B., Kastrup, J. S. J., Hansen, K. B., Boschi, D., Pickering, D. S., Clausen, R. P. & Lolli, M., 2019, In: Journal of Medicinal Chemistry. 62, p. 4467-4482

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  20 Citations (Scopus)
• 2018

  4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric gamma-aminobutyric acid receptor binding site

  Alessandro, G., Krall, J., Nielsen, B., Sørensen, T. E., Kongstad, K. T., Barbara, R., Donatella, B., Frølund, B. & Lolli, M. L., 5 Oct 2018, In: European Journal of Medicinal Chemistry. 158, p. 311-321 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)
• 2017

  Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands

  Szymańska, E., Chałupnik, P., Johansen, T. N., Nielsen, B., Cuñado Moral, A. M., Pickering, D. S. & Kieć-Kononowicz, K., 1 Dec 2017, In: Chemical Biology & Drug Design. 90, p. 1271-1281 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist

  Gynther, M., Proietti Silvestri, I., Hansen, J. C., Hansen, K. B., Malm, T., Ishchenko, Y., Larsen, Y., Han, L., Kayser, S., Auriola, S., Petsalo, A., Nielsen, B., Pickering, D. S. & Bunch, L., 14 Dec 2017, In: Journal of Medicinal Chemistry. 60, 23, p. 9885-9904 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)

• Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid

  Krogsgaard-Larsen, N., Delgar, C., Koch, K., Brown, P. M. G. E., Møller, C., Han, L., Huynh, T. H. V., Hansen, S. W., Nielsen, B., Bowie, D., Pickering, D. S., Kastrup, J. S. J., Frydenvang, K. A. & Bunch, L., 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 441-457 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Exploring pharmacological mechanisms of lavender (Lavandula angustifolia) essential oil on central nervous system targets

  López, V., Nielsen, B., Solas, M., Ramirez, M. J. & Jäger, A. K., 2017, In: Frontiers in Pharmacology. 8 p., 269652 .

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  187 Citations (Scopus)

  343 Downloads (Pure)

• Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors

  Szymańska, E., Nielsen, B., Johansen, T. N., Cuñado Moral, A. M., Pickering, D. S., Szczepańska, K., Mickowska, A. & Kieć-Kononowicz, K., 2017, In: European Journal of Medicinal Chemistry. 138, p. 874-883 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Revisiting the Quinoxalinedione scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors.

  Demmer, C. S., Rombach, D., Liu, N., Nielsen, B., Pickering, D. S. & Bunch, L., 1 Dec 2017, In: A C S Chemical Neuroscience. 8, 11, p. 2477-2495 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Synthesis of L-Tricholomic acid analogues and pharmacological characterization at ionotropic glutamate receptors

  Tamborini, L., Mastronardi, F., Lo Presti, L., Nielsen, B., De Micheli, C., Conti, P. & Pinto, A., 2017, In: ChemistrySelect. 2, 31, p. 10295-99 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)
• 2016

  Beta-Sulfonamido Functionalized Aspartate Analogs as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype-Selectivity Profiles Arising from Subtle Structural Differences

  Hansen, J. C., Bjørn-Yoshimoto, W. E., Bisballe, N., Nielsen, B., Jensen, A. A. & Bunch, L., 2016, In: Journal of Medicinal Chemistry. 59, p. 8771-8786 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands

  Szymańska, E., Chałupnik, P., Szczepańska, K., Moral, A. M. C., Pickering, D. S., Nielsen, B., Johansen, T. N. & Kieć-Kononowicz, K-K., 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 22, p. 5568-5572 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1 γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone

  Krall, J., Brygger, B. M., Sigurðardóttir, S. B., Ng, C. K. L., Bundgaard, C., Kehler, J., Nielsen, B., Bek, T., Jensen, A. A. & Frølund, B., 13 Sep 2016, In: ChemMedChem. 11, 20, p. 2299-2310 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III

  Huynh, T. H. V., Erichsen, M. N., Tora, A. S., Goudet, C., Sagot, E., Assaf, Z., Thomsen, C., Brodbeck, R., Stensbol, T. B., Bjorn-Yoshimoto, W. E., Nielsen, B., Pin, J-P., Gefflaut, T. & Bunch, L., 2016, In: Journal of Medicinal Chemistry. 59, 3, p. 914-924 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

  Szymanska, E., Frydenvang, K. A., Pickering, D. S., Krintel, C., Nielsen, B., Kooshki, A., Zachariassen, L. G., Olsen, L., Kastrup, J. S. J. & Johansen, T. N., 2016, In: Journal of Medicinal Chemistry. 59, 1, p. 448-461 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Synthesis and Pharmacological Characterization of the Selective GluK1 Radioligand (S)-2-Amino-3-(6-[3H]-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)propanoic acid ([3H]-NF608)

  Alcaide, A., Marconi, L., Marek, A., Haym, I., Nielsen, B., Møllerud, S., Jensen, M., Conti, P., Pickering, D. S. & Bunch, L., 2016, In: MedChemComm. 7, p. 2136-2144 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Synthesis and pharmacological evaluation of conformationally constrained glutamic acid higher homologues

  Tamborini, L., Cullia, G., Nielsen, B., De Micheli, C., Conti, P. & Pinto, A., 15 Nov 2016, In: Bioorganic & Medicinal Chemistry. 24, 22, p. 5741-5747 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues

  Wang, S-Y., Larsen, Y., Navarrete, C. V., Jensen, A. A., Nielsen, B., Al-Musaed, A., Frydenvang, K., Kastrup, J. S., Pickering, D. S. & Clausen, R. P., 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2244-2254 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of ionotropic glutamate receptor binding pocket

  Tamborini, L., Nicosia, V., Conti, P., Dall'Oglio, F., De Micheli, C., Nielsen, B., Jensen, A. A., Pickering, D. S. & Pinto, A., 1 Dec 2016, In: Tetrahedron. 72, 51, p. 8586-8492 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)
• 2015

  Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1

  Demmer, C. S., Møller, C., Brown, P. M. G. E., Han, L., Pickering, D. S., Nielsen, B., Bowie, D., Frydenvang, K., Kastrup, J. S. & Bunch, L., 9 Apr 2015, In: A C S Chemical Neuroscience. 6, p. 845-854 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Structure activity relationship of selective GABA uptake inhibitors

  Vogensen, S. B., Jørgensen, L., Madsen, K. K., Jurik, A., Borkar, N., Rosatelli, E., Nielsen, B., Ecker, G. F., Schousboe, A. & Clausen, R. P., 15 May 2015, In: Bioorganic & Medicinal Chemistry. 23, 10, p. 2480-2488 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  30 Citations (Scopus)

• Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

  Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, B., Tapken, D., Pickering, D. S., Kastrup, J. S., Frydenvang, K. & Bunch, L., 2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6131-50 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• Synthesis of unusual isoxazoline containing β and γ-dipeptides as potential glutamate receptor ligands

  Tamborini, L., Mastronardi, F., Dall'Oglio, F., De Micheli, C., Nielsen, B., Lo Presti, L., Conti, P. & Pinto, A., 2015, In: MedChemComm. 6, 7, p. 1260-1266 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  7 Citations (Scopus)
• 2014

  5-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric γ-Aminobutyric Acid Type A Receptor Binding Site

  Krall, J., Kongstad, K. T., Nielsen, B., Sørensen, T. E., Balle, T., Jensen, A. A. & Frølund, B., 2014, In: ChemMedChem. 9, 11, p. 2475-2485 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Analogues of 3-Hydroxyisoxazole-Containing Glutamate Receptor Ligands Based on the 3-Hydroxypyrazole-Moiety: Design, Synthesis and Pharmacological Characterization

  Jørgensen, L., Nielsen, B., Pickering, D. S., Kristensen, A. S., Frydenvang, K. A., Madsen, U. & Clausen, R. P., 2014, In: Neurochemical Research. 39, 10, p. 1895-1905 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites

  Sköld, N., Nielsen, B., Olsen, J., Han, L., Olsen, L., Madsen, U., Kristensen, J. L., Pickering, D. S. & Johansen, T. N., 2 Aug 2014, In: Bioorganic & Medicinal Chemistry. 22, 19, p. 5368-5377 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Efficient synthesis of novel glutamate homologues and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

  Pinto, A., Tamborini, L., Mastronardi, F., Ettari, R., Romano, D., Nielsen, B., De Micheli, C. & Conti, P., 2014, In: Bioorganic and Medicinal Chemistry Letters. 24, 8, p. 1980-1982 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel γ-aminobutyric acidA receptor agonists

  Petersen, J. G., Sørensen, T. E., Damgaard, M., Nielsen, B., Jensen, A. A., Balle, T., Bergmann, R. & Frølund, B., 2014, In: European Journal of Medicinal Chemistry. 84, p. 404-416 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors

  Pinto, A., Tamborini, L., Mastronardi, F., Ettari, R., Safoz, Y., Bunch, L., Nielsen, B., Jensen, A. A., De Micheli, C. & Conti, P., 2014, In: European Journal of Medicinal Chemistry. 75, p. 151-158 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)
• 2013

  3-Carboxy-pyrazolinalanine as a new scaffold for developing potent and selective NMDA receptor antagonists.

  Tamborini, L., Pinto, A., Mastronardi, F., Iannuzzi, M. C., Cullia, G., Nielsen, B., De Micheli, C. & Conti, P., Oct 2013, In: European Journal of Medicinal Chemistry. 68, p. 33-37 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

  Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, B., Gajhede, M., Kastrup, J. S., Jensen, A. A., Pickering, D. S., Frydenvang, K., Gefflaut, T. & Bunch, L., 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

  Research output: Contribution to journal › Journal article › Research › peer-review
  38 Citations (Scopus)

• Development of 2 '-substituted (2S,1 ' R,2 ' S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-D-aspartic acid receptor agonists

  Risgaard, R., Nielsen, S. D., Hansen, K. B., Jensen, C. M., Nielsen, B., Traynelis, S. F. & Clausen, R. P., 23 May 2013, In: Journal of Medicinal Chemistry. 56, 10, p. 4071-4081

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Erratum: Chemoenzymatic synthesis of new 2,4- syn -functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters (Journal of Medicinal Chemistry (2013) 56 (1614-1628))

  Assaf, Z., Larsen, A. P., Venskutonyteì, R., Han, L., Abrahamsen, B., Nielsen, B., Gajhede, M., Kastrup, J. S., Jensen, A. A., Pickering, D. S., Frydenvang, K., Gefflaut, T. & Bunch, L., 25 Jul 2013, In: Journal of Medicinal Chemistry. 56, 14, p. 5985 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

• Exploring the orthosteric binding site of the γ-aminobutyric acid type A receptor using 4-(piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-imidazolyl substituted: design, synthesis, and pharmacological evaluation

  Krall, J., Jensen, C. H., Sørensen, T. E., Nielsen, B., Jensen, A. A., Sander, T., Balle, T. & Frølund, B., 15 Jul 2013, In: Journal of Medicinal Chemistry. 56, 16, p. 6536−6540 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acid_A receptor agonists

  Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, C. G., Nielsen, B., Kehler, J., Frydenvang, K., Kristensen, J., Balle, T., Jensen, A. A., Kristiansen, U. & Frølund, B., 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 993-1006

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)
• 2012

  5-(Piperidine-4-yl)-3-hydroxypyrazole: a novel scaffold forprobing the orthosteric GABA_A receptor binding site

  Krall, J., Johansen, K., Balle, T., Nielsen, B., Jensen, A. A. & Frølund, B., 2 Sep 2012.

  Research output: Contribution to conference › Poster › Research

  File
  1824 Downloads (Pure)

• Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

  Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, B., Gajhede, M., Kastrup, J. S. J., Bunch, L., Frydenvang, K. & Pickering, D. S., 2012, In: Journal of Structural Biology. 180, 1, p. 39-46

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor

  Jäger, A., Knap, D. M., Nielsen, B., Stafford, G. I. & van Staden, J., Jan 2012, In: South African Journal of Botany. 78, p. 312–314 3 p.

  Research output: Contribution to journal › Letter › Research › peer-review
  2 Citations (Scopus)