Research output per year
Research output per year
Personal profile
Short presentation
The Kornum Lab studies sleep-wake neurophysiology with focus on the hypocretin (hcrt, also called orexin) system. We study how these neurons are affected by the immune system not only in narcolepsy but during sickness in general. We leverage single cell technology, animal disease models and human genetics to explore and discover how hcrt neurons and surrounding cells, networks and pathways are involved in the disease mechanisms of sickness behavior and sleep disorders.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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Downregulation of hypocretin/orexin after H1N1 Pandemrix vaccination of adolescent mice
Pagh-berendtsen, N., Pavlovskyi, A., Flores Téllez, D., Egebjerg, C., Kolmos, M. G., Justinussen, J. & Kornum, B. R., 2024, In: Sleep. 47, 4, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
3 Citations (Scopus) -
The immunopathogenesis of narcolepsy type 1
Liblau, R. S., Latorre, D., Kornum, B. R., Dauvilliers, Y. & Mignot, E. J., 2024, In: Nature Reviews Immunology. 24, p. 33-48Research output: Contribution to journal › Review › Research › peer-review
28 Citations (Scopus) -
Emerging therapeutic targets for narcolepsy
Vringer, M. & Kornum, B. R., 2023, In: Expert Opinion On Therapeutic Targets. 25, 7, p. 559-572 14 p.Research output: Contribution to journal › Review › Research › peer-review
6 Citations (Scopus) -
Experimental sickness reduces hypocretin receptor 1 expression in the lateral hypothalamus and ventral tegmental area of female mice
Kolmos, M. G., Arribas, A. P., Kornum, B. R. & Justinussen, J. L., 2023, In: European Journal of Neuroscience. 58, 9, p. 4002-4010 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Downloads (Pure) -
How hypocretin agonists may improve the quality of wake in narcolepsy
Justinussen, J. L., Egebjerg, C. & Kornum, B. R., 2023, In: Trends in Molecular Medicine. 29, 1, p. 61-69 9 p.Research output: Contribution to journal › Review › Research › peer-review
6 Citations (Scopus) -
Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings
Viste, R., Follin, L. F., Kornum, B. R., Lie, B. A., Viken, M. K., Thorsby, P. M., Rootwelt, T., Christensen, J. A. E. & Knudsen-Heier, S., 2023, In: Sleep. 46, 3, 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile15 Downloads (Pure) -
In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid
Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, , 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507Research output: Contribution to journal › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
Molecular consequences of peripheral Influenza A infection on cell populations in the murine hypothalamus
Lemcke, R., Egebjerg, C., Berendtsen, N. T., Egerod, K. L., Thomsen, A. R., Pers, T. H., Christensen, J. P. & Kornum, B. R., 2023, In: eLife. 12, 28 p., RP87515.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile22 Downloads (Pure)
Prizes
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AASM Young Investigator Award
Kornum, Birgitte Rahbek (Recipient), 2011
Prize: Prizes, scholarships, distinctions