Personal profile
Short presentation
Skilled ion channel electrophysiologist and pharmacologist with both academic and pharmaceutical training. I work on diagnosing, understanding and treating cardiac arrhythmia. To this end I take advantage of my knowledge on drug discovery, cell, tissue and animals experiments. I do basic research to understand the physiology of the heart and apply this to explore novel ways of diagnosing and treating cardiac disorders
Primary fields of research
- Ion channels
- Electrophysiology
- Cardiac arrhythmia
- pharmacology
- Novel ion channel targets for treatment of atrial fibrillation
CV
Education
2015 Harvard Business School, Pasteur Program (leading and managing innovation)
2010 Ph.D. Health Sciences, University of Copenhagen
2006 M.Sc. Human Biology, University of Copenhagen
2002 B.Sc. Dentistry
Academic work experience and leadership
2023 - Member of Department of Biomedical Sciences Leadership team
2023 - Appointed member of the UCPH Quantum HUB network representing The Faculty of Health and Medical Sciences
2023 - Steering committee member of Arla Food for Health, a public-private research partnership
2014 – Onwards
Associate professor and research group leader, Department of Biomedical Sciences, UCPH
Innovation ambassador and member of the Faculty Innovation Network, University of Copenhagen. Appointed by the head of department to boost innovation and entrepreneurship.
2014-2018 Director of “Novel safe and effective pharmacological treatment for atrial fibrillation” a joint project between University of Copenhagen and Acesion Pharma, funded by Innovation Fund Denmark
2013-2014 Non-tenured associate professor, Dep. of Biomedical Sciences, University of Copenhagen
2010-2011 Postdoc, Danish National Research Foundation Centre of Cardiac Arrhythmia, KU
2009 Visiting Research Scientist, Freiburg University, Germany
Industry
2017- Onwards
Consultant (Principal Scientist), Acesion Pharma
2016- 2018 Member of the board of The Industrial PhD & PostDoc Association
2015- 2017 Senior Scientist, Acesion Pharma
2012-2015 Research Scientist, Acesion Pharma, Denmark
2011–2012 Research Scientist, NSDiscovery, NeuroSearch A/S.
Teaching and supervision:
I teach dentistry, medical, medtech, human biology students in cell biology, kidney physiology and cardiac physiology and pharmacology. Course leader of the Novo BRIDGE programe «Translational tools I», and the PhD course in Innovation at SUND, UCPH. I supervise bachelor, master and PhD-students
Possible conflicts of interest
Employed at Acesion Pharma
Keywords
- Faculty of Health and Medical Sciences
- Ion channels
- Pharmacology
- Cardiovascular physiology
- Cardiac arrhythmia
- Electrophysiology
Collaborations and top research areas from the last five years
Research output
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NaV1.5 or KCa2 channel blockade does not increase arrhythmia risk in hypokalemic rabbit hearts, unlike KV11.1 inhibition with dofetilide
Yan, Y., Abildgaard, L., Skarsfeldt, M. A., Bomholtz, S. H., Sørensen, U., Holst, A. G., Grunnet, M., Diness, J. G. & Bentzen, B. H., 2025, In: IJC Heart and Vasculature. 59, 8 p., 101699.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Downloads (Pure) -
The SH protein of mumps virus is a druggable pentameric viroporin
Devantier, K., Toft-Bertelsen, T. L., Prestel, A., Kjaer, V. M. S., Sahin, C., Giulini, M., Louka, S., Spiess, K., Manandhar, A., Qvortrup, K., Ulven, T., Bentzen, B. H., Bonvin, A. M. J. J., MacAulay, N., Kragelund, B. B. & Rosenkilde, M. M., 2025, In: Science Advances. 11, 23, 12 p., eads3071.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)15 Downloads (Pure) -
A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation
Yfanti, C., Vestbjerg, B., van't Westende, J., Edvardsson, N., Monfort, L. M., Olesen, M. S., Bentzen, B. H., Grunnet, M., Eveleens Maarse, B. C., Diness, J. G., Kemme, M. J. B., Sørensen, U., Moerland, M., van Esdonk, M. J., Klaassen, E. S., Gal, P. & Holst, A. G., 2024, In: British Journal of Clinical Pharmacology. 90, 4, p. 1027-1035Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)37 Downloads (Pure) -
Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node
Lubberding, A. F., Veedfald, S., Achter, J. S., Nissen, S. D., Soattin, L., Sorrentino, A., Torres Vega, E., Linz, B., Eggertsen, C. H. E., Mulvey, J., Toräng, S., Larsen, S. A., Nissen, A., Petersen, L. G., Erbil Bilir, S., Bentzen, B. H., Rosenkilde, M. M., Hartmann, B., Lilleør, T. N. B. & Qazi, S. & 6 others, , 2024, In: Cardiovascular Research. 120, 12, p. 1427–1441 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile44 Citations (Scopus)39 Downloads (Pure) -
Inhibition of the KCa2 potassium channel in atrial fibrillation: a randomized phase 2 trial
Holst, A. G., Tomcsányi, J., Vestbjerg, B., Grunnet, M., Sørensen, U. S., Diness, J. G., Bentzen, B. H., Edvardsson, N., Hohnloser, S. H., Bhatt, D. L. & Dorian, P., 2024, In: Nature Medicine. 30, 1, p. 106-111Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile26 Citations (Scopus)13 Downloads (Pure) -
Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval
Hiniesto-Iñigo, I., Castro-Gonzalez, L. M., Corradi, V., Skarsfeldt, M. A., Yazdi, S., Lundholm, S., Nikesjö, J., Noskov, S. Y., Bentzen, B. H., Tieleman, D. P. & Liin, S. I., 2023, In: EBioMedicine. 89, 17 p., 104459.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Citations (Scopus)46 Downloads (Pure) -
Gating kinetics and pharmacological properties of small-conductance Ca2+-activated potassium channels
van Herck, I. G. M., Seutin, V., Bentzen, B. H., Marrion, N. V. & Edwards, A. G., 4 Apr 2023, In: Biophysical Journal. 122, 7, p. 1143-1157 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)55 Downloads (Pure) -
Increased Density of Endogenous Adenosine A2A Receptors in Atrial Fibrillation: From Cellular and Porcine Models to Human Patients
Godoy-Marín, H., Jiménez-Sábado, V., Tarifa, C., Ginel, A., Santos, J. L. D., Bentzen, B. H., Hove-Madsen, L. & Ciruela, F., 2023, In: International Journal of Molecular Sciences. 24, 4, 11 p., 3668.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)47 Downloads (Pure)