Brice Maxime Hugues Ozenne

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• 2025

  Acute psilocybin and ketanserin effects on cerebral blood flow: 5-HT2AR neuromodulation in healthy humans

  Larsen, K., Lindberg, U., Ozenne, B., McCulloch, D. E., Armand, S., Madsen, M. K., Johansen, A., Stenbæk, D. S., Knudsen, G. M. & Fisher, P. M., 2025, (E-pub ahead of print) In: Journal of Cerebral Blood Flow and Metabolism.

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• Changes in hippocampal volume, 5-HT₄ receptor binding, and verbal memory over the course of antidepressant treatment in major depressive disorder

  Jensen, K. H. R., Dam, V. H., Köhler-Forsberg, K., Ozenne, B., Stenbæk, D. S., Ganz, M., Fisher, P. M. D., Frokjaer, V. G., Knudsen, G. M. & Jørgensen, M. B., 2025, In: Journal of Psychiatric Research. 181, p. 197-205 9 p.

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• DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response

  Bruzzone, S. E. P., Ozenne, B., Fisher, P. M. D., Ortega, G., Jørgensen, M. B., Knudsen, G. M., Lesch, K. P. & Frokjaer, V. G., 2025, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 136, 9 p., 111160.

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• Effect of Antidepressant Treatment on 5-HT₄ Receptor Binding and Associations With Clinical Outcomes and Verbal Memory in Major Depressive Disorder

  Dam, V. H., Köhler-Forsberg, K., Ozenne, B., Larsen, S. V., Ip, C. T., Jorgensen, A., Stenbæk, D. S., Madsen, J., Svarer, C., Jørgensen, M. B., Knudsen, G. M. & Frokjaer, V. G., 2025, In: Biological Psychiatry. 97, 3, p. 261-268 8 p.

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  2 Citations (Scopus)

• Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A [123I]-CLINDE-SPECT Study

  Jensen, P., Ozenne, B., Meden, P., Feng, L., Thomsen, G., Knudsen, L., Steglich-Arnholm, H., Møller, K., Thomsen, C., Svarer, C., Beliveau, V., Mikkelsen, J., Knudsen, G. & H Pinborg, L., 2025, In: Journal of Neuroimaging. 35, 1, 10 p., e70002.

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• Relation Between Brain Morphological Features and Psychiatric Hospitalization Risk in Major Depressive and Bipolar Disorders

  Miskowiak, K. W., Macoveanu, J., Ozenne, B., Beaman, E. E., Dam, V. H., Fisher, P. M., Knudsen, G. M., Kessing, L. V., Jørgensen, M. B., Frokjaer, V. G. & Sankar, A., 2025, (E-pub ahead of print) In: Acta Psychiatrica Scandinavica. 9 p.

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• 2024

  Amygdala response to emotional faces following acute administration of psilocybin in healthy individuals

  Armand, S., larsen, K., Madsen, M., Ozenne, B. M. H., Preller, K. H., Knudsen, G. M., Stenbæk, D. S. & Fisher, P. M. D., 24 Jan 2024, In: Neuroscience Applied. 3, 9 p., 103934.

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• Association Between Intrauterine System Hormone Dosage and Depression Risk

  Larsen, S. V., Mikkelsen, A. P., Ozenne, B., Munk-Olsen, T., Lidegaard, Ø. & Frokjaer, V. G., 2024, In: The American Journal of Psychiatry. 181, 9, p. 834-841 8 p.

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  3 Citations (Scopus)

• Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression

  Høgsted, E. S., Beliveau, V., Ozenne, B., Madsen, M. K., Svarer, C., Dam, V. H., Johansen, A., Fisher, P., Knudsen, G. M., Frokjaer, V. G. & Sankar, A., 2024, (E-pub ahead of print) In: The British journal of psychiatry : the journal of mental science. 7 p.

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• Effects of a carbohydrate-reduced high-protein diet delivered with meal kits to Danish people with type 2 diabetes: protocol for a 12-month randomised controlled trial

  Kopp, L. H. P., Søgaard-Hansen, C. M., Zachhau, K. M., Bastkjær, R. M., Andersen, B. V., Budtz-Jørgensen, E., Byrne, D. V., Chaaban, N., Holst, J. J., Klindt, T. B., Magkos, F., Ozenne, B., Samkani, A., Skytte, M. J., Madsbad, S., Krarup, T. & Thomsen, M. N., 2024, In: BMJ Open. 14, 8, 12 p., e084686.

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• Effects of escitalopram on synaptic density in the healthy human brain: a randomized controlled trial

  Johansen, A., Armand, S., Plavén-Sigray, P., Nasser, A., Ozenne, B., Petersen, I. N., Keller, S. H., Madsen, J., Beliveau, V., Møller, K., Vassilieva, A., Langley, C., Svarer, C., Stenbæk, D. S., Sahakian, B. J. & Knudsen, G. M., 2024, In: Molecular Psychiatry. p. 4272–4279 8 p.

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• Functional brain responses to emotional faces after three to five weeks of intake of escitalopram in healthy individuals: a double-blind, placebo-controlled randomised study

  Armand, S., Langley, C., Johansen, A., Ozenne, B., Overgaard-Hansen, O., Larsen, K., Jensen, P. S., Knudsen, G. M., Sahakian, B. J., Stenbæk, D. S. & Fisher, P. M., 2024, In: Scientific Reports. 14, 1, 12 p., 3149.

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• Individualised prediction of major bleeding in patients with atrial fibrillation treated with anticoagulation

  Toft-Petersen, A. P., J-Y Lee, C., Phelps, M., Ozenne, B., Gerds, T. A. & Torp-Pedersen, C., 2024, In: PLoS ONE. 19, 11, 14 p., e0312294.

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• Neocortical serotonin 2A receptor binding, neuroticism and risk of developing depression in healthy individuals

  Sankar, A., Ziersen, S. C., Ozenne, B., Dam, V. H., Beaman, E. E., Kessing, L. V., Fisher, P. M., Budtz-jørgensen, E., Knudsen, G. M., Miskowiak, K. W. & Frokjaer, V. G., 2024, In: Nature Mental Health. 2, 10, p. 1231-1238 8 p.

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  1 Citation (Scopus)

• No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state

  Bruzzone, S. E. P., Ozenne, B., Fisher, P. M., Ortega, G., Jensen, P. S., Dam, V. H., Svarer, C., Knudsen, G. M., Lesch, K. P. & Frokjaer, V. G., 2024, In: Clinical Epigenetics. 16, 1, 17 p., 71.

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• Restricted Net Treatment Benefit in oncology

  Piffoux, M., Ozenne, B., De Backer, M., Buyse, M., Chiem, J. C. & Péron, J., 2024, In: Journal of Clinical Epidemiology. 170, 8 p., 111340.

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• Rumination in patients with major depressive disorder before and after antidepressant treatment

  Segerberg, T. S. S., Ozenne, B., Dam, V. H., Köhler-Forsberg, K., Jørgensen, M. B., Frokjaer, V. G., Knudsen, G. M. & Stenbæk, D. S., 2024, In: Journal of Affective Disorders. 360, p. 322-325 4 p.

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• 2023

  (108) SEXUAL ANHEDONIA AND SEROTONIN 4 RECEPTOR BRAIN BINDING IN DEPRESSED PATIENTS – A NEUROPHARM POSITRON EMISSION TOMOGRAPHY STUDY

  Annika L, R., Søren V, L., Brice, O., Dea S, S., Prof. Martin B, J., Annamaria, G. & Vibe G, F., 2023, In: The journal of sexual medicine. 20, Supplement 4

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• Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals

  Sankar, A., Ozenne, B., Dam, V. H., Svarer, C., Jorgensen, M. B., Miskowiak, K. W., Frokjaer, V. G., Knudsen, G. M. & Fisher, P. M., 2023, In: Translational Psychiatry. 13, 1, 7 p., 165.

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• Association between the loudness dependence of auditory evoked potential, serotonergic neurotransmission and treatment outcome in patients with depression

  Ip, C-T., Ganz, M., Ozenne, B., Olbrich, S., Beliveau, V., Dam, V. H., Köhler-Forsberg, K., Jørgensen, M. B., Frøkjær, V. G. & Knudsen, G. M., 2023, In: European Neuropsychopharmacology. 70, p. 32-44 13 p.

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• Association of neurocognitive function with psychiatric hospitalization and socio-demographic conditions in individuals with bipolar and major depressive disorders

  Sankar, A., Ziersen, S. C., Ozenne, B., Beaman, E. E., Dam, V. H., Fisher, P. M., Knudsen, G. M., Kessing, L. V., Frokjaer, V. & Miskowiak, K. W., 2023, In: EClinicalMedicine. 58, 101927.

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• Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer’s disease in hypertension

  Beaman, E., Bonde, A. N., Larsen, S. M. U., Ozenne, B. M. H., Lohela, T. J., Nedergaard, M., Gislason, G. H., Knudsen, G. M. & Holst, S. C., 2023, In: Brain. 146, 3, p. 1141–1151 11 p.

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• Controlling the familywise error rate when performing multiple comparisons in a linear latent variable model

  Ozenne, B., Budtz-Jorgensen, E. & Ebert, S. E., 2023, In: Computational Statistics. 38, p. 1-23 23 p.

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• Deep phenotyping towards precision psychiatry of first-episode depression - the Brain Drugs-Depression cohort

  Jensen, K. H. R., Dam, V. H., Ganz, M., Fisher, P. M., Ip, C-T., Sankar, A., Marstrand-Joergensen, M. R., Ozenne, B., Osler, M., Penninx, B. W. J. H., Pinborg, L. H., Frokjaer, V. G., Knudsen, G. M. & Jørgensen, M. B., 2023, In: BMC Psychiatry. 23, 1, 15 p., 151.

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• Efficient Estimation in the Fine and Gray Model

  Scheike, T. H., Martinussen, T. & Ozenne, B., 2023, In: Journal of the American Statistical Association. 118, 544, p. 2482-2490 9 p.

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• Genetic contributions to brain serotonin transporter levels in healthy adults

  Bruzzone, S. E. P., Nasser, A., Aripaka, S. S., Spies, M., Ozenne, B., Jensen, P. S., Knudsen, G. M., Frokjaer, V. G. & Fisher, P. M. D., 2023, In: Scientific Reports. 13, 1, 11 p., 16426.

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• Individualized Net Benefit estimation and meta-analysis using generalized pairwise comparisons in N-of-1 trials

  Giai, J., Peron, J., Roustit, M., Cracowski, J-L., Roy, P., Ozenne, B., Buyse, M. & Maucort-Boulch, D., 2023, In: Statistics in Medicine. 42, 6, p. 878-893 16 p.

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  2 Citations (Scopus)

• Low-Dose Atropine Induces Changes in Ocular Biometrics in Myopic Children: Exploring Temporal Changes by Linear Mixed Models and Contribution to Treatment Effect by Mediation Analyses

  Hvid-Hansen, A., Jacobsen, N., Hjortdal, J., Møller, F., Ozenne, B. & Kessel, L., 2023, In: Journal of Clinical Medicine. 12, 4, 13 p., 1605.

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• Myopia Control with Low-Dose Atropine in European Children: Six-Month Results from a Randomized, Double-Masked, Placebo-Controlled, Multicenter Study

  Hvid-Hansen, A., Jacobsen, N., Møller, F., Bek, T., Ozenne, B. & Kessel, L., 2023, In: Journal of Personalized Medicine. 13, 2, 13 p., 325.

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• Reliability of three versus five saliva sampling times for assessing the cortisol awakening response

  Nasser, A., Ozenne, B., Hogsted, E. S., Jensen, P. S. & Frokjaer, V. G., 2023, In: Psychoneuroendocrinology. 147, 10 p., 105950.

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  9 Citations (Scopus)

• Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction

  Koehler-Forsberg, K., Dam, V. H., Ozenne, B., Sankar, A., Beliveau, V., Landman, E. B., Larsen, S. V., Poulsen, A. S., Ip, C-T., Jørgensen, A., Meyer, M., Stenbaek, D. S., Eiberg, H. R. L., Madsen, J., Svarer, C., Jorgensen, M. B., Frokjaer, V. G. & Knudsen, G. M., 2023, In: JAMA Psychiatry. 80, 4, p. 296-304 9 p.

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  15 Citations (Scopus)

• Sexual health and serotonin 4 receptor brain binding in unmedicated patients with depression-a NeuroPharm study

  Rasmussen, A. L., Larsen, S. V., Ozenne, B., Köhler-Forsberg, K., Stenbæk, D. S., Jørgensen, M. B., Giraldi, A. & Frokjaer, V. G., 2023, In: Translational Psychiatry. 13, 1, 8 p., 247.

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• Stress hormone dynamics are coupled to brain serotonin 4 receptor availability in unmedicated patients with Major Depressive Disorder - a NeuroPharm study

  Vulpius, G. M., Köhler-Forsberg, K., Ozenne, B., Larsen, S. V., Nasser, A., Svarer, C., Gillings, N., Keller, S. H., Jørgensen, M. B., Knudsen, G. M. & Frokjaer, V. G., 2023, In: The international journal of neuropsychopharmacology. 26, 9, p. 639–648 10 p.

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• The BrainDrugs-epilepsy study: A prospective open-label cohort precision medicine study in epilepsy

  Marstrand-Joergensen, M. R., Dam, V. H., Vinter, K., Ip, C. T., Jensen, K. R., Jørgensen, M. B., Hoei-Hansen, C. E., Ozenne, B., Fisher, P. M., Knudsen, G. M. & Pinborg, L. H., 2023, In: Neuroscience Applied. 2, 13 p., 101136.

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• 2022

  Acute Traumatic Stress Screening Can Identify Patients and Their Partners at Risk for Posttraumatic Stress Disorder Symptoms After a Cardiac Arrest: A Multicenter Prospective Cohort Study

  Armand, S., Wagner, M. K., Ozenne, B., Verbunt, J., Sep, S. J. S., Berg, S. K., Knudsen, G. M. & Stenbæk, D. S., 2022, In: The Journal of Cardiovascular Nursing. 37, 4, p. 394-401 8 p.

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  6 Citations (Scopus)

• Brain serotonin transporter is associated with cognitive-affective biases in healthy individuals

  Armand, S., Ozenne, B., Svart, N., Frokjaer, V. G., Knudsen, G. M., Fisher, P. M. & Stenbæk, D. S., 2022, In: Human Brain Mapping. 43, 13, p. 4174-4184 11 p.

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• Concurrent anxiety in patients with major depression and cerebral serotonin 4 receptor binding: A NeuroPharm-1 study

  Köhler-Forsberg, K., Ozenne, B., Larsen, S. V., Poulsen, A. S., Landman, E. B., Dam, V. H., Ip, C. T., Jørgensen, A., Svarer, C., Knudsen, G. M., Frokjaer, V. G. & Jørgensen, M. B., 2022, In: Translational Psychiatry. 12, 1, 8 p., 273.

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• Emotional faces processing in major depressive disorder and prediction of antidepressant treatment response: A NeuroPharm study

  Fisher, P. M., Ozenne, B., Ganz, M., Frokjær, V. G., Dam, V. N., Penninx, B. W., Sankar, A., Miskowiak, K., Jensen, P. S., Knudsen, G. M. & Jorgensen, M. B., 2022, In: Journal of psychopharmacology (Oxford, England). 36, 5, p. 626-636 11 p.

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  15 Citations (Scopus)

• Evaluating cognitive disturbances as treatment target and predictor of antidepressant action in major depressive disorder: A NeuroPharm study

  Dam, V. H., Stenbaek, D. S., Köhler-Forsberg, K., Ip, C., Ozenne, B., Sahakian, B. J., Knudsen, G. M., Jorgensen, M. B. & Frokjaer, V. G., 2022, In: Translational Psychiatry. 12, 1, 8 p., 468.

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• Lasting effects of a single psilocybin dose on resting-state functional connectivity in healthy individuals

  McCulloch, D. E-W., Madsen, M. K., Stenbaek, D. S., Kristiansen, S., Ozenne, B., Jensen, P. S., Knudsen, G. M. & Fisher, P. M., 2022, In: Journal of Psychopharmacology. 36, 1, p. 74-84 11 p.

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• Lasting increases in trait mindfulness after psilocybin correlate positively with the mystical-type experience in healthy individuals

  Søndergaard, A., Madsen, M. K., Ozenne, B., Armand, S., Knudsen, G. M., Fisher, P. M. & Stenbaek, D. S., 2022, In: Frontiers in Psychology. 13, 11 p., 948729.

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• Psilocybin-Induced Mystical-Type Experiences are Related to Persisting Positive Effects: A Quantitative and Qualitative Report

  McCulloch, D. E-W., Grzywacz, M. Z., Madsen, M. K., Jensen, P. S., Ozenne, B., Armand, S., Knudsen, G. M., Fisher, P. M. & Stenbaek, D. S., 2022, In: Frontiers in Pharmacology. 13, 17 p., 841648.

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• Psilocybin modulation of time-varying functional connectivity is associated with plasma psilocin and subjective effects

  Olsen, A. S., Lykkebo-Valløe, A., Ozenne, B., Madsen, M. K., Stenbæk, D. S., Armand, S., Mørup, M., Ganz, M., Knudsen, G. M. & Fisher, P. M., 2022, In: NeuroImage. 264, 12 p., 119716.

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• The Impact of Hormonal Contraceptive Use on Serotonergic Neurotransmission and Antidepressant Treatment Response: Results From the NeuroPharm 1 Study

  Larsen, S. V., Ozenne, B., Kohler-Forsberg, K., Poulsen, A. S., Dam, V. H., Svarer, C., Knudsen, G. M., Jorgensen, M. B. & Frokjaer, V. G., 2022, In: Frontiers in Endocrinology. 13, 12 p., 799675.

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• 2021

  A new measure of treatment effect in clinical trials involving competing risks based on generalized pairwise comparisons

  Cantagallo, E., De Backer, M., Kicinski, M., Ozenne, B., Collette, L., Legrand, C., Buyse, M. & Péron, J., 2021, In: Biometrical Journal. 63, 2, p. 272-288 17 p.

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  6 Citations (Scopus)

• A single dose of psilocybin increases synaptic density and decreases 5-HT_2A receptor density in the pig brain

  Raval, N. R., Johansen, A., Donovan, L. L., Ros, N. F., Ozenne, B., Hansen, H. D. & Knudsen, G. M., 2021, In: International Journal of Molecular Sciences. 22, 2, 14 p., 835.

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• Assessing absolute stroke risk in patients with atrial fibrillation using a risk factor-based approach

  Lee, C. J-Y., Toft-Petersen, A. P., Ozenne, B., Phelps, M., Olesen, J. B., Ellinor, P. T., Gislason, G., Lip, G. Y. H., Torp-Pedersen, C. & Gerds, T. A., 2021, In: European Heart Journal - Cardiovascular Pharmacotherapy. 7, F11, p. F3-F10 8 p.

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  17 Citations (Scopus)

• Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans

  Stenbæk, D. S., Madsen, M. K., Ozenne, B., Kristiansen, S., Burmester, D., Erritzoe, D., Knudsen, G. M. & Fisher, P. M. D., 2021, In: Journal of Psychopharmacology. 35, 4, p. 459-468

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  50 Citations (Scopus)

• Correcting the bias of the net benefit estimator due to right-censored observations

  Péron, J., Idlhaj, M., Maucort-Boulch, D., Giai, J., Roy, P., Collette, L., Buyse, M. & Ozenne, B., 2021, In: Biometrical Journal. 63, 4, p. 893-906 14 p.

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  5 Citations (Scopus)

• Default mode network functional connectivity negatively associated with trait openness to experience

  Marstrand-Joergensen, M. R., Madsen, M. K., Stenbæk, D. S., Ozenne, B., Jensen, P. S., Frøkjær, V. G., Knudsen, G. M. & Fisher, P. M., 2021, In: Social Cognitive and Affective Neuroscience. 16, 9, p. 950-961 12 p.

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