Research output per year
Research output per year
Personal profile
Primary fields of research
The research focus of my group concerns human brown fat, its potential to counteract obesity and type 2 diabetes and its role in human metabolism. We characterized human supraclavicular brown fat and demonstrated, for the first time, that brown fat precursor cells can be isolated from adult humans and differentiated in vitro while maintaining features of brown fat. We further concluded that human brown fat is a heterogeneous tissue and since then we have been developing single cell methods with the aim of isolating pure brown fat cells, to investigate the full potential of these cells in terms of energy consumption and additional metabolic features. Another major interest of my group is to identify adipokines specifically secreted from brown fat. We hypothesize that there are yet unknown brown adipokines, i.e. batokines, with an important role in regulating human metabolism.
Education/Academic qualification
Biology, Master of Science
Award Date: 15 Oct 2010
Functional Genomics, PhD, Karolinska Institutet
Award Date: 15 Nov 2007
External positions
Copenhagen University Hospital - Rigshospitalet
1 Apr 2007 → …
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Integrating a Multi-label Deep Learning Approach with Protein Information to Compare Bioactive Peptides in Brain and Plasma
Grønning, A. G. B. & Schéele, C., 2024, Peptidomics: Methods and Protocols. Schrader, M. & Fricker, L. D. (eds.). Humana Press, p. 179-195 17 p. (Methods in Molecular Biology, Vol. 2758).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
2 Citations (Scopus) -
Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes
Wang, T., Sharma, A. K., Wu, C., Maushart, C. I., Ghosh, A., Yang, W., Stefanicka, P., Kovanicova, Z., Ukropec, J., Zhang, J., Arnold, M., Klug, M., De Bock, K., Schneider, U., Popescu, C., Zheng, B., Ding, L., Long, F., Dewal, R. S., Moser, C. & 23 others, , 2024, In: Cell Metabolism. 36, 9, p. 2130-2145.e7 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)1 Downloads (Pure) -
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis
Talamonti, E., Davegardh, J., Kalinovich, A., van Beek, S. M. M., Dehvari, N., Halleskog, C., Bokhari, H. M., Hutchinson, D. S., Ham, S., Humphrys, L. J., Dijon, N. C., Motso, A., Sandstrom, A., Zacharewicz, E., Mutule, I., Suna, E., Spura, J., Ditrychova, K., Stoddart, L. A., Holliday, N. D. & 11 others, , 2024, In: Molecular Metabolism. 85, 16 p., 101931.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Downloads (Pure) -
Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots
Palani, N. P., Horvath, C., Timshel, P. N., Folkertsma, P., Grønning, A. G. B., Henriksen, T. I., Peijs, L., Jensen, V. H., Sun, W., Jespersen, N. Z., Wolfrum, C., Pers, T. H., Nielsen, S. & Scheele, C., 2023, In: Nature Metabolism. 5, 6, p. 996-1013 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)56 Downloads (Pure) -
Can we target obesity using a single-cell atlas of adipose tissue?
Scheele, C. & Nielsen, S., 2022, In: Med. 3, 5, p. 276-278 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
3 Citations (Scopus) -
Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity
Hayashi, Y., Shimizu, I., Yoshida, Y., Ikegami, R., Suda, M., Katsuumi, G., Fujiki, S., Ozaki, K., Abe, M., Sakimura, K., Okuda, S., Hayano, T., Nakamura, K., Walsh, K., Jespersen, N. Z., Nielsen, S., Scheele, C. & Minamino, T., 2022, In: iScience. 25, 7, 23 p., 104547.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)39 Downloads (Pure) -
Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity
Mathur, N., Severinsen, M. C. K., Jensen, M. E., Naver, L., Schrölkamp, M., Laye, M. J., Watt, M. J., Nielsen, S., Krogh-Madsen, R., Pedersen, B. K. & Scheele, C., 2022, In: Frontiers in Cell and Developmental Biology. 10, 12 p., 983899.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)33 Downloads (Pure) -
Isolation and Characterization of Human Brown Adipocytes
Scheele, C., Henriksen, T. I. & Nielsen, S., 2022, In: Methods in Molecular Biology. 2448, p. 217-234 18 p.Research output: Contribution to journal › Journal article › Research › peer-review