Camilla Foged

Search results

• 2024

  Advances in the design and delivery of RNA vaccines for infectious diseases

  Lokras, A. G., Bobak, T. R., Baghel, S. S., Sebastiani, F. & Foged, C., 2024, In: Advanced Drug Delivery Reviews. 213, 33 p., 115419.

  Research output: Contribution to journal › Review › peer-review

  Open Access

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  12 Citations (Scopus)

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• Effect of lipid-polymer hybrid nanoparticles on the biophysical function and lateral structure of pulmonary surfactant: Mechanistic in vitro studies

  Xu, Y., Cañadas, O., Alonso, A., Franzyk, H., Thakur, A., Pérez-gil, J. & Foged, C., 2024, In: Journal of Colloid and Interface Science. 654, Part B, p. 1111-1123

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Engineering aspects of lipid-based delivery systems: In vivo gene delivery, safety criteria, and translation strategies

  Eş, I., Thakur, A., Mousavi Khaneghah, A., Foged, C. & de la Torre, L. G., 2024, In: Biotechnology Advances. 72, 45 p., 108342.

  Research output: Contribution to journal › Review › peer-review
  4 Citations (Scopus)

• Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development

  Li, J. & Foged, C., 2024, In: Expert Opinion on Drug Delivery. 21, 10, p. 1441-1461

  Research output: Contribution to journal › Review › peer-review

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• Lipid nanoparticles for local delivery of mRNA to the respiratory tract: Effect of PEG-lipid content and administration route

  Ongun, M., Lokras, A. G., Baghel, S., Shi, Z., Schmidt, S. T., Franzyk, H., Rades, T., Sebastiani, F., Thakur, A. & Foged, C., 2024, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 198, 10 p., 114266.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  18 Citations (Scopus)

  44 Downloads (Pure)
• 2023

  Comparative study of lipid nanoparticle-based mRNA vaccine bioprocess with machine learning and combinatorial artificial neural network-design of experiment approach

  Maharjan, R., Hada, S., Eun Lee, J., Han, H.-K., Hyun Kim, K., Jin Seo, H., Foged, C. & Hoon Jeong, S., 2023, In: International Journal of Pharmaceutics. 640, 13 p., 123012.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Elucidating the nanostructure of small interfering RNA-loaded lipidoid-polymer hybrid nanoparticles

  Aljabbari, A., Lokras, A. G., Kirkensgaard, J. J. K., Rades, T., Franzyk, H., Thakur, A., Zhang, Y. & Foged, C., 2023, In: Journal of Colloid and Interface Science. 633, p. 907-922

  Research output: Contribution to journal › Journal article › Research › peer-review

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  13 Citations (Scopus)

  66 Downloads (Pure)

• Insights into the mechanisms of interaction between inhalable lipid-polymer hybrid nanoparticles and pulmonary surfactant

  Xu, Y., Parra-Ortiz, E., Wan, F., Cañadas, O., Garcia-Alvarez, B., Thakur, A., Franzyk, H., Pérez-Gil, J., Malmsten, M. & Foged, C., 2023, In: Journal of Colloid and Interface Science. 633, p. 511-525

  Research output: Contribution to journal › Journal article › Research › peer-review

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  15 Citations (Scopus)

  51 Downloads (Pure)

• Lipid Nanoparticle-Enabled Intracellular Delivery of Prime Editors

  Herrera-Barrera, M., Gautam, M., Lokras, A., Vlasova, K., Foged, C. & Sahay, G., 2023, In: The AAPS Journal. 25, 4, 10 p., 65.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Malaria biomimetic for tumor targeted drug delivery

  Pihl, J., Clausen, T. M., Zhou, J., Krishnan, N., Ørum-Madsen, M. S., Gustavsson, T., Dagil, R., Daugaard, M., Choudhary, S., Foged, C., Esko, J. D., Zhang, L., Fang, R. H. & Salanti, A., 2023, In: ACS Nano. 17, 14, p. 13500–13509

  Research output: Contribution to journal › Journal article › Research › peer-review

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  11 Citations (Scopus)

  8 Downloads (Pure)

• Method of manufacturing CAF®09 liposomes affects immune responses induced by adjuvanted subunit proteins

  Thakur, A., Wadhwa, A., Lokras, A., Amanda Oest Müllertz, O., Christensen, D., Franzyk, H. & Foged, C., 2023, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 189, p. 84-97

  Research output: Contribution to journal › Journal article › Research › peer-review
  1 Citation (Scopus)

• Pulmonary Administration of the Liposome-Based Adjuvant CAF01: Effect of Surface Charge on Mucosal Adjuvant Function

  Müllertz, O. A. O., Andersen, P., Christensen, D., Foged, C. & Thakur, A., 2023, In: Molecular Pharmaceutics. 20, 2, p. 953–970

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Pulmonary delivery of siRNA-loaded lipid-polymer hybrid nanoparticles: Effect of nanoparticle size

  Wadhwa, A., Bobak, T. R., Bohrmann, L., Geczy, R., Sekar, S., Sathyanarayanan, G., Kutter, J. P., Franzyk, H., Foged, C., Saatchi, K. & Häfeli, U. O., 2023, In: OpenNano. 13, 12 p., 100180.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  6 Citations (Scopus)

  35 Downloads (Pure)

• Reconstituted dry powder formulations of ZnO-adjuvanted ovalbumin induce equivalent antigen specific antibodies but lower T cell responses than ovalbumin adjuvanted with Alhydrogel® or cationic adjuvant formulation 01 (CAF®01)

  Hellfritzsch, M., Christensen, D., Foged, C., Scherließ, R. & Thakur, A., 2023, In: International Journal of Pharmaceutics. 648, 15 p., 123581.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Reconstituted Dry Powder Formulations of ZnO-Adjuvanted Ovalbumin Induce Equivalent Serum Antibody Responses to Ovalbumin Adjuvanted with Alhydrogel® or Cationic Adjuvant Formulation 01 (Caf®01)

  Hellfritzsch, M., Christensen, D., Foged, C., Scherließ, R. & Thakur, A., 2023, 41 p. (SSRN Electronic Journal).

  Research output: Working paper › Preprint

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• 2022

  COVID-19: Hvem skal nu vaccineres og hvorfor? Professor giver overblikket: Hvor godt virker vaccinerne? Hvem har især gavn af dem? Og hvad ved vi om bivirkningerne? Professor i vaccinedesign guider dig.

  Foged, C., 16 Sept 2022, In: ForskerZonen. 16.09.2022

  Research output: Contribution to journal › Journal article › Research

  Open Access

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  17 Downloads (Pure)

• COVID-19: Hvordan sikrer vi, at vores vacciner virker mod de nyeste varianter? Når virus muterer, må vi tilpasse vores vacciner. Hvordan sker det i praksis? Og behøver en vaccine overhovedet være tilpasset den seneste variant for at virke?

  Foged, C., 19 Sept 2022, In: ForskerZonen. 19.09.2022

  Research output: Contribution to journal › Journal article › Communication

  Open Access

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  24 Downloads (Pure)

• Grand Challenges in Vaccine Delivery: Lessons Learned From the COVID-19 Vaccine Rollout

  Foged, C., 2022, In: Frontiers in Drug Delivery. 2, 4 p., 964298.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• Inhalable Composite Microparticles Containing siRNA-Loaded Lipid-Polymer Hybrid Nanoparticles: Saccharides and Leucine Preserve Aerosol Performance and Long-Term Physical Stability

  Xu, Y., Turan, E. T., Shi, Z., Franzyk, H., Thakur, A. & Foged, C., 2022, In: Frontiers in Drug Delivery. 2, 15 p., 945459.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  36 Downloads (Pure)

• Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles

  Xu, Y., Harinck, L., Lokras, A. G., Gerde, P., Selg, E., Sjöberg, C.-O., Franzyk, H., Thakur, A. & Foged, C., 2022, In: International Journal of Pharmaceutics. 621, 14 p., 121758.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  33 Citations (Scopus)

  37 Downloads (Pure)

• Lipid Nanoparticle-Mediated Delivery of Therapeutic and Prophylactic mRNA: Immune Activation by Ionizable Cationic Lipids

  Ongun, M., Lokras, A. G., Foged, C. & Thakur, A., 2022, Messenger RNA Therapeutics. Springer, p. 237-255 (RNA Technologies, Vol. 13).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  1 Citation (Scopus)

• Optimizing the design and dosing of dry powder inhaler formulations of the cationic liposome adjuvant CAF®01 for pulmonary immunization

  Thakur, A., Xu, Y., Cano-Garcia, G., Feng, S., Rose, F., Gerde, P., Andersen, P., Christensen, D. & Foged, C., 2022, In: Frontiers in Drug Delivery. 2, 973599.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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• Simultaneous quantification of multiple RNA cargoes co-loaded into nanoparticle-based delivery systems

  Lokras, A. G., Chakravarty, A., Rades, T., Christensen, D., Franzyk, H., Thakur, A. & Foged, C., 2022, In: International Journal of Pharmaceutics. 626, 13 p., 122171.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  12 Citations (Scopus)

  24 Downloads (Pure)
• 2021

  Adsorption of protein antigen to the cationic liposome adjuvant CAF®01 is required for induction of Th1 and Th17 responses but not for antibody induction

  Wørzner, K., Hvannastein, J., Tandrup Schmidt, S., Foged, C., Rosenkrands, I., Kristian Pedersen, G. & Christensen, D., 2021, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 165, p. 293-305

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  10 Citations (Scopus)

  21 Downloads (Pure)

• Delivery of oligonucleotide-based therapeutics: challenges and opportunities

  Hammond, S. M., Aartsma-Rus, A., Alves, S., Borgos, S. E., Buijsen, R. A. M., Collin, R. W. J., Covello, G., Denti, M. A., Desviat, L. R., Echevarría, L., Foged, C., Gaina, G., Garanto, A., Goyenvalle, A. T., Guzowska, M., Holodnuka, I., Jones, D. R., Krause, S., Lehto, T. & Montolio, M. & 2 others, Van Roon-Mom, W. & Arechavala-Gomeza, V., 2021, In: EMBO Molecular Medicine. 13, 4, 23 p., e13243.

  Research output: Contribution to journal › Review › peer-review

  Open Access

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  230 Citations (Scopus)

  63 Downloads (Pure)

• Engineering of Solid Dosage Forms of siRNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles Using a Quality-by-Design Approach

  Lokras, A., Foged, C. & Thakur, A., 2021, Design and Delivery of SiRNA Therapeutics. Ditzel, H. J., Tuttolomondo, M. & Kauppinen, S. (eds.). Humana Press, p. 137-157 (Methods in Molecular Biology, Vol. 2282).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  1 Citation (Scopus)

• Inhaled RNA Therapeutics for Obstructive Airway Diseases: Recent Advances and Future Prospects

  Xu, Y., Thakur, A., Zhang, Y. & Foged, C., 2021, In: Pharmaceutics. 13, 2, 35 p., 77.

  Research output: Contribution to journal › Review › peer-review

  Open Access

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  24 Citations (Scopus)

  98 Downloads (Pure)

• Omikron: Sådan justerer forskerne en mRNA-vaccine

  Foged, C., 3 Dec 2021, In: ForskerZonen. 2021, december

  Research output: Contribution to journal › Journal article › Communication

  Open Access

• Vaccination af børn og unge mod COVID-19: Her er, hvad forskningen viser

  Foged, C., 31 Aug 2021, In: ForskerZonen. 2021, August

  Research output: Contribution to journal › Journal article › Communication

  Open Access

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  30 Downloads (Pure)
• 2020

  Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone

  Thakur, A., Pinto, F. E., Hansen, H. S., Andersen, P., Christensen, D., Janfelt, C. & Foged, C., 2020, In: Frontiers in Immunology. 11, p. 803

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  19 Citations (Scopus)

  89 Downloads (Pure)

• Nanoparticles for mucosal vaccine delivery

  Thakur, A. & Foged, C., 2020, Nanoengineered Biomaterials for Advanced Drug Delivery. Mozafari, M. (ed.). 1 ed. Elsevier

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Nanoparticles for mucosal vaccine delivery

  Thakur, A. & Foged, C., 2020, Nanoengineered Biomaterials for Advanced Drug Delivery. Woodhead Publishing, p. 603-646 44 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  41 Citations (Scopus)

• Opportunities and Challenges in the Delivery of mRNA-based Vaccines

  Wadhwa, A., Aljabbari, A., Lokras, A., Foged, C. & Thakur, A., 28 Jan 2020, In: Pharmaceutics. 12, 2, 27 p., 102.

  Research output: Contribution to journal › Review › peer-review

  Open Access

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  412 Citations (Scopus)

  298 Downloads (Pure)

• Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles

  Lokras, A., Thakur, A., Wadhwa, A., Thanki, K., Franzyk, H. & Foged, C., 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 14 p., 601155.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  16 Citations (Scopus)

  49 Downloads (Pure)

• The Long Road Toward COVID-19 Herd Immunity: Vaccine Platform Technologies and Mass Immunization Strategies

  Frederiksen, L. S. F., Zhang, Y., Foged, C. & Thakur, A., 2020, In: Frontiers in Immunology. 11, p. 1817

  Research output: Contribution to journal › Review › peer-review

  Open Access

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  182 Citations (Scopus)

  19 Downloads (Pure)

• Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model

  Bohr, A., Tsapis, N., Foged, C., Andreana, I., Yang, M. & Fattal, E., 2020, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 156, p. 114-120

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  60 Citations (Scopus)
• 2019

  Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery

  Thanki, K., Papai, S., Lokras, A., Rose, F., Falkenberg, E., Franzyk, H. & Foged, C., 9 Jan 2019, In: Pharmaceutical Research. 36, 3, 37.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Comparison of two different PEGylation strategies for the liposomal adjuvant CAF09: Towards induction of CTL responses upon subcutaneous vaccine administration

  Tandrup Schmidt, S., Line Olsen, C., Franzyk, H., Wørzner, K., Smith Korsholm, K., Rades, T., Andersen, P., Foged, C. & Christensen, D., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 140, p. 29-39 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  19 Citations (Scopus)

  319 Downloads (Pure)

• Design of gadoteridol-loaded cationic liposomal adjuvant CAF01 for MRI of lung deposition of intrapulmonary administered particles

  Thakur, A., Rose, F., Ansari, S. R., Koch, P., Martini, V., Ovesen, S. L., Quistorff, B., Maritim, S., Hyder, F., Andersen, P., Christensen, D., Mori, Y. & Foged, C., 2019, In: Molecular Pharmaceutics. 16, 11, p. 4725-4737 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Design of Inhalable Solid Dosage Forms of Budesonide and Theophylline for Pulmonary Combination Therapy

  Leng, D., Kissi, E. O., Löbmann, K., Thanki, K., Fattal, E., Rades, T., Foged, C. & Yang, M., 7 Mar 2019, In: AAPS PharmSciTech. 20, 3, 137.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation

  Dormenval, C., Lokras, A., Cano-Garcia, G., Wadhwa, A., Thanki, K., Rose, F., Thakur, A., Franzyk, H. & Foged, C., 2019, In: Pharmaceutical Research. 36, 10, 142.

  Research output: Contribution to journal › Journal article › Research › peer-review
  42 Citations (Scopus)

• Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model

  Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, H., Nielsen, H. M., van Eden, W., Dong, M., Broere, F., Foged, C. & Zeng, X., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142, p. 38-48

  Research output: Contribution to journal › Journal article › Research › peer-review
  55 Citations (Scopus)

• Macrophage phosphoproteome analysis reveals MINCLE-dependent and -independent mycobacterial cord factor signaling

  Hansen, M., Peltier, J., Killy, B., Amin, B., Bodendorfer, B., Härtlova, A., Uebel, S., Bosmann, M., Hofmann, J., Büttner, C., Ekici, A. B., Kuttke, M., Franzyk, H., Foged, C., Beer-Hammer, S., Schabbauer, G., Trost, M. & Lang, R., Apr 2019, In: Molecular and Cellular Proteomics. 18, 4, p. 669-685

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  20 Citations (Scopus)

• Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

  Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, H., Nielsen, H. M., Braeckmans, K., Lehr, C.-M., Ogris, M. & Foged, C., 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93

  Research output: Contribution to journal › Journal article › Research › peer-review
  42 Citations (Scopus)

• Microfluidics-based self-assembly of peptide-loaded microgels: Effect of three dimensional (3D) printed micromixer design

  Borro, B. C., Bohr, A., Bucciarelli, S., Boetker, J. P., Foged, C., Rantanen, J. & Malmsten, M., 7 Mar 2019, In: Journal of Colloid and Interface Science. 538, p. 559-568 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  23 Citations (Scopus)

• Nebulised lipid-polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells

  Vencken, S., Foged, C., Ramsey, J. M., Sweeney, L., Cryan, S.-A., MacLoughlin, R. J. & Greene, C. M., Apr 2019, In: ERJ Open Research. 5, 2, 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  39 Citations (Scopus)

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• Preparation, Characterization, and In Vitro Evaluation of Lipidoid-Polymer Hybrid Nanoparticles for siRNA Delivery to the Cytosol

  Thanki, K., Zeng, X. & Foged, C., 2019, In: Methods in molecular biology (Clifton, N.J.). 1943, p. 141-152 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring

  Wan, F., Nylander, T., Foged, C., Yang, M., Baldursdottir, S. G. & Nielsen, H. M., 1 Mar 2019, In: Journal of Colloid and Interface Science. 545, p. 162-171 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)
• 2018

  Anchoring of hydrophilic coating polymers onto charged liposomes via attractive electrostatic interactions using charged tags to control the surface charge drainage properties and cellular targeting

  Andersen, P. L. (Inventor), Christensen, D. (Inventor), Franzyk, H. (Inventor), Foged, C. (Inventor) & Schmidt, S. T. (Inventor), 2018, (Submitted)

  Research output: Patent

• A strong adjuvant based on glycol-chitosan-coated lipid-polymer hybrid nanoparticles potentiates mucosal immune responses against the recombinant Chlamydia trachomatis fusion antigen CTH522

  Rose, F., Erbo Wern, J., Gavins, F., Andersen, P., Follmann, F. & Foged, C., 10 Feb 2018, In: Journal of Controlled Release. 271, p. 88-97 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  52 Citations (Scopus)