Carolyn F. Deacon

Search results

• 2024

  Signs of a Glucose- and Insulin-Independent Gut-Bone Axis and Aberrant Bone Homeostasis in Type 1 Diabetes

  Hartmann, B., Longo, M., Mathiesen, D. S., Hare, K. J., Jørgensen, N. R., Esposito, K., Deacon, C. F., Vilsbøll, T., Holst, J. J. & Knop, F. K., 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 1, p. e259-e265 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)
• 2023

  Impact of dipeptidyl peptidase-4 inhibitors on glucose-dependent insulinotropic polypeptide in type 2 diabetes mellitus: a systematic review and meta-analysis

  Chai, S., Zhang, R., Carr, R. D., Deacon, C. F., Zheng, Y., Rajpathak, S., Chen, J. & Yu, M., 2023, In: Frontiers in Endocrinology. 14, 12 p., 1203187.

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  2 Citations (Scopus)

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• 2022

  Acute effects of linagliptin on intact and total glucagon-like peptide-1 and gastric inhibitory polypeptide levels in insulin-dependent type 2 diabetes patients with and without moderate renal impairment

  Meier, J. J., Quast, D. R., Nauck, M. A., Schenker, N., Deacon, C. F., Holst, J. J., Plum-Mörschel, L. & Kapitza, C., 2022, In: Diabetes, Obesity and Metabolism. 24, 5, p. 806-815

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  1 Citation (Scopus)

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• Acute effects on glucose tolerance by neprilysin inhibition in patients with type 2 diabetes

  Wewer Albrechtsen, N. J., Møller, A., Martinussen, C., Gluud, L. L., Rashu, E. B., Richter, M. M., Plomgaard, P., Goetze, J. P., Kjeldsen, S., Hansen, L. H., Gustafsson, F., Deacon, C. F., Holst, J. J., Madsbad, S. & Bojsen-Møller, K. N., 2022, In: Diabetes, Obesity and Metabolism. 24, 10, p. 2017-2026 10 p.

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  13 Citations (Scopus)

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• Four weeks treatment with the GLP-1 receptor analogue liraglutide lowers liver fat and concomitantly circulating glucagon in individuals with overweight

  Svane, M. S., Johannesen, H. H., Hansen, A. E., Martinussen, C., Bojsen-Møller, K. N., Hansen, M. L., Deacon, C. F., Keller, S. H., Klausen, T. L., Loft, A., Kjaer, A., Löfgren, J., Madsbad, S., Holst, J. J. & Wewer Albrechtsen, N. J., 2022, In: International Journal of Obesity. 46, 11, p. 2058–2062 8 p.

  Research output: Contribution to journal › Letter › Research › peer-review

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  5 Citations (Scopus)

• Measurement of plasma glucagon in humans: A shift in the performance of a current commercially available radioimmunoassay kit

  Wu, T., Rayner, C. K., Jones, K. L., Horowitz, M., Feinle-Bisset, C., Standfield, S. D., Xie, C., Deacon, C. F., Holst, J. J. & Wewer Albrechtsen, N. J., 2022, In: Diabetes, Obesity and Metabolism. 24, 6, p. 1182-1184

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  13 Citations (Scopus)

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• Neurotensin secretion after Roux-en-Y gastric bypass, sleeve gastrectomy, and truncal vagotomy with pyloroplasty

  Svane, M. S., Øhrstrøm, C. C., Plamboeck, A., Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Martinussen, C., Vilsbøll, T., Hartmann, B., Deacon, C. F., Kristiansen, V. B., Knop, F. K., Svendsen, L. B., Madsbad, S., Holst, J. J. & Veedfald, S., 2022, In: Neurogastroenterology and Motility. 34, 1, e14210.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Role of endogenous incretins in the regulation of postprandial lipoprotein metabolism

  Taskinen, M-R., Matikainen, N., Björnson, E., Söderlund, S., Ainola, M., Hakkarainen, A., Lundbom, N., Sihlbom, C., Thorsell, A., Andersson, L., Adiels, M., Hartmann, B., Deacon, C. F., Holst, J. J., Packard, C. J. & Borén, J., 2022, In: European Journal of Endocrinology. 187, 1, p. 75-84 10 p.

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  3 Citations (Scopus)

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• 2021

  Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner

  Jepsen, S. L., Albrechtsen, N. J. W., Windeløv, J. A., Galsgaard, K. D., Hunt, J. E., Farb, T. B., Kissow, H., Pedersen, J., Deacon, C. F., Martin, R. E. & Holst, J. J., 2021, In: JCI insight. 6, 4, 15 p., e143228.

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  23 Citations (Scopus)

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• Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women: A proof-of-concept resting-state functional MRI study

  van Duinkerken, E., Bernardes, G., van Bloemendaal, L., Veltman, D. J., Barkhof, F., Mograbi, D. C., Gerdes, V. E. A., Deacon, C. F., Holst, J. J., Drent, M. L., Diamant, M., ten Kulve, J. & Ijzerman, R. G., 2021, In: Diabetes, Obesity and Metabolism. 23, 2, p. 415-424 10 p.

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  7 Citations (Scopus)

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• Do sodium-glucose transporter-2 inhibitors increase plasma glucagon by direct actions on the alpha-cell? - and does the increase matter for the associated increase in endogenous glucose production?

  Kuhre, R. E., Deacon, C. F., Wewer Albrechtsen, N. J. & Holst, J. J., 2021, In: Diabetes, Obesity and Metabolism. 23, 9, p. 2009-2019

  Research output: Contribution to journal › Review › Research › peer-review
  3 Citations (Scopus)

• Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism

  Kjeldsen, S. A. S., Hansen, L. H., Esser, N., Mongovin, S., Winther-Sørensen, M., Galsgaard, K. D., Hunt, J. E., Kissow, H., Ceutz, F. R., Terzic, D., Mark, P. D., Plomgaard, P., Goetze, J. P., Goossens, G. H., Blaak, E. E., Deacon, C. F., Rosenkilde, M. M., Zraika, S., Holst, J. J. & Wewer Albrechtsen, N. J., 2021, In: Endocrine Research. 5, 9, 15 p., bvab084.

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  19 Citations (Scopus)

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• What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?

  Kuhre, R. E., Deacon, C. F., Holst, J. J. & Petersen, N., 2021, In: Frontiers in Endocrinology. 12, 19 p., 694284.

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  33 Citations (Scopus)

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• 2020

  Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus

  Deacon, C. F., 2020, In: Nature Reviews Endocrinology. 16, 11, p. 642-653

  Research output: Contribution to journal › Review › Research › peer-review
  219 Citations (Scopus)

• Effects of a six-week intervention with glucagon-like peptide-1 receptor analogue on pancreatic volume, oedema and DNA synthesis in obese men

  Svane, M. S., Johannesen, H. H., Martinussen, C., Bojsen-Moller, K. N., Hansen, M. L., Hansen, A. E., Deacon, C., Hartmann, B., Keller, S. H., Loft, A., Kjaer, A., Madsbad, S., Lofgren, J., Holst, J. J. & Albrechtsen, N. J. W., 2020, In: Diabetologia. 63, SUPPL 1, p. S216-S217 442.

  Research output: Contribution to journal › Conference abstract in journal › Research

• Effects of Pioglitazone on Glucose-Dependent Insulinotropic Polypeptide-Mediated Insulin Secretion and Adipocyte Receptor Expression in Patients With Type 2 Diabetes

  Tharp, W. G., Gupta, D., Sideleva, O., Deacon, C. F., Holst, J. J., Elahi, D. & Pratley, R. E., 2020, In: Diabetes. 69, 2, p. 146-157

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  9 Citations (Scopus)

• Glucose-Dependent Insulinotropic Polypeptide Is a Pancreatic Polypeptide Secretagogue in Humans

  Veedfald, S., Vedtofte, L., Skov-Jeppesen, K., Deacon, C. F., Hartmann, B., Vilsbøll, T., Knop, F. K., Christensen, M. B. & Holst, J. J., 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 3, p. e502-e510

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• Metabolism of GIP and the contribution of GIP to the glucose-lowering properties of DPP-4 inhibitors

  Deacon, C. F., 2020, In: Peptides. 125, 7 p., 170196.

  Research output: Contribution to journal › Review › Research › peer-review
  20 Citations (Scopus)

• No effects of a 6-week intervention with a glucagon-like peptide-1 receptor agonist on pancreatic volume and oedema in obese men without diabetes

  Svane, M. S., Johannesen, H. H., Martinussen, C., Bojsen-Moller, K. N., Hansen, M. L., Hansen, A. E., Deacon, C. F., Hartmann, B., Keller, S. H., Klausen, T. L., Loft, A., Kjaer, A., Madsbad, S., Lofgren, J., Holst, J. J. & Wewer Albrechtsen, N. J., 2020, In: Diabetes, Obesity and Metabolism. 22, 10, p. 1837-1846

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• No evidence of tachyphylaxis for insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) in subjects with type 2 diabetes, their first-degree relatives, or in healthy subjects

  Nauck, M. A., Holle, H., Kahle, M., Tytko, A., Deacon, C. F., Holst, J. J. & Meier, J. J., 2020, In: Peptides. 125, 170176.

  Research output: Contribution to journal › Review › Research › peer-review
  3 Citations (Scopus)

• The clinical effects of a carbohydrate-reduced high-protein diet on glycaemic variability in metformin-treated patients with type 2 diabetes mellitus: A randomised controlled study

  Thomsen, M. N., Skytte, M. J., Astrup, A., Deacon, C. F., Holst, J. J., Madsbad, S., Krarup, T., Haugaard, S. B. & Samkani, A., 2020, In: Clinical Nutrition ESPEN. 39, p. 46-52 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)
• 2019

  Effects of Acute GLP-1 Infusion on Pulmonary and Systemic Hemodynamics in Patients With Heart Failure: A Pilot Study

  Clarke, S. J., Pettit, S., Giblett, J. P., Zhao, T., Kydd, A. C., Albrechtsen, N. J. W., Deacon, C. F., Parameshwar, J. & Hoole, S. P., 2019, In: Clinical Therapeutics. 41, 1, p. 118-127 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice

  Jepsen, S. L., Grunddal, K. V., Wewer Albrechtsen, N. J., Engelstoft, M. S., Gabe, M. B. N., Jensen, E. P., Ørskov, C., Poulsen, S. S., Rosenkilde, M. M., Pedersen, J., Gribble, F. M., Reimann, F., Deacon, C. F., Schwartz, T. W., Christ, A. D., Martin, R. E. & Holst, J. J., 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 317, 6, p. E1081-E1093

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)

• Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes

  Deacon, C. F., 2019, In: Frontiers in Endocrinology. 10, 14 p., 80.

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  7 Citations (Scopus)

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• Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications

  Holst, J. J., Albrechtsen, N. J. W., Rosenkilde, M. M. & Deacon, C. F., 2019, In: Comprehensive Physiology. 9, 4, p. 1339-1381

  Research output: Contribution to journal › Journal article › Research › peer-review
  44 Citations (Scopus)

• Sacubitril/Valsartan Augments Postprandial Plasma Concentrations of Active GLP-1 When Combined With Sitagliptin in Men

  Wewer Albrechtsen, N. J., Mark, P. D., Terzic, D., Hansen, L. H., Andersen, U. Ø., Hartmann, B., Carr, R. D., Gustafsson, F., Deacon, C. F., Holst, J. J., Goetze, J. P. & Plomgaard, P., 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 9, p. 3868-3876

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  20 Citations (Scopus)
• 2018

  A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients

  Samkani, A., Skytte, M. G. J., Kandel, D., Kjaer, S., Astrup, A., Deacon, C. F., Holst, J. J., Madsbad, S., Rehfeld, J. F., Haugaard, S. B. & Krarup, T., 2018, In: British Journal of Nutrition. 119, 8, p. 910-917 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  44 Citations (Scopus)

• Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice

  Christiansen, C. B., Lind, S. J., Svendsen, B., Balk-Møller, E., Dahlby, T., Kuhre, R. E., Hartmann, B., Mandrup-Poulsen, T., Deacon, C. F., Albrechtsen, N. J. W. & Holst, J. J., 2018, In: Physiological Reports. 6, 13, p. 1-8 e13788.

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  9 Citations (Scopus)

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• Acute effects of dietary carbohydrate restriction on glycemia, lipemia and appetite regulating hormones in normal-weight to obese subjects

  Samkani, A. A., Skytte, M. J., Thomsen, M. N., Astrup, A., Deacon, C. F., Holst, J. J., Madsbad, S., Rehfeld, J. F., Krarup, T. & Haugaard, S. B., 2018, In: Nutrients. 10, 9, 14 p., 1285.

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  17 Citations (Scopus)

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• A review of dipeptidyl peptidase-4 inhibitors: Hot topics from randomized controlled trials

  Deacon, C. F., Feb 2018, In: Diabetes, Obesity and Metabolism. 20, p. 34-46 13 p.

  Research output: Contribution to journal › Review › Research › peer-review
  62 Citations (Scopus)

• A review of dipeptidyl peptidase-4 inhibitors. Hot topics from randomised controlled trials

  Deacon, C. F., 2018, In: Diabetes, Obesity and Metabolism. 20, Suppl. 1, p. 34-46

  Research output: Contribution to journal › Review › Research › peer-review

• Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

  Kuhre, R. E., Albrechtsen, N. J. W., Larsen, O., Jepsen, S. L., Balk-Møller, E., Andersen, D. B., Deacon, C. F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, R., Hartmann, B., Rosenkilde, M. & Holst, J. J., 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.

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  157 Citations (Scopus)

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• Do we know the true mechanism of action of the DPP-4 inhibitors?

  Andersen, E. S., Deacon, C. F. & Holst, J. J., 2018, In: Diabetes, Obesity and Metabolism. 20, 1, p. 34-41 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  74 Citations (Scopus)

• Ghrelin secretion in humans - a role for the vagus nerve?

  Veedfald, S., Plamboeck, A., Hartmann, B., Vilsbøll, T., Knop, F. K., Deacon, C. F., Svendsen, L. B. & Holst, J. J., Jun 2018, In: Neurogastroenterology and Motility. 30, 6, e13295.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• GLP-1 Is a Coronary Artery Vasodilator in Humans

  Clarke, S. J., Giblett, J. P., Yang, L. L., Hubsch, A., Zhao, T., Aetesam-ur-Rahman, M., West, N. E. J., O'Sullivan, M., Figg, N., Bennett, M., Albrechtsen, N. J. W., Deacon, C. F., Cheriyan, J. & Hoole, S. P., 20 Nov 2018, In: Journal of the American Heart Association. 7, 22, 14 p., e010321.

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  19 Citations (Scopus)

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• Hyperosmolar Duodenal Saline Infusion Lowers Circulating Ghrelin and Stimulates Intestinal Hormone Release in Young Men

  Veedfald, S., Wu, T., Bound, M., Grivell, J., Hartmann, B., Rehfeld, J. F., Deacon, C. F., Horowitz, M., Holst, J. J. & Rayner, C. K., 2018, In: Journal of Clinical Endocrinology & Metabolism. 103, 12, p. 4409-4418

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Is glucagon‐like peptide‐1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes?

  Andersen, E. S., Lund, A., Bagger, J. I., Andreasen, C., Grøndahl, MF., Deacon, C. F., Hartmann, B., Holst, J. J., Knop, F. K. & Lauritsen, T. V., Aug 2018, In: Diabetes, Obesity and Metabolism. 20, 8, p. 1937-1943

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes

  Deacon, C. F., Feb 2018, In: Peptides. 100, p. 150-157 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  57 Citations (Scopus)

• The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial

  Samkani, A., Skytte, M. G. J., Anholm, C., Astrup, A., Deacon, C. F., Holst, J. J., Madsbad, S., Boston, R., Krarup, T. & Haugaard, S. B., 2018, In: Lipids in Health and Disease. 17, 9 p., 295.

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• 2017

  Addition of a dipeptidyl peptidase-4 inhibitor, sitagliptin, to ongoing therapy with the glucagon-like peptide-1 receptor agonist liraglutide: A randomized controlled trial in patients with type 2 diabetes

  Nauck, M. A., Kahle, M., Baranov, O., Deacon, C. F. & Holst, J. J., 6 Feb 2017, In: Diabetes, Obesity and Metabolism. 19, 2, p. 200-207 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)

• A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite

  Wewer Albrechtsen, N. J., Asmar, A., Jensen, F., Törang, S., Simonsen, L., Kuhre, R. E., Asmar, M., Veedfald, S., Plamboeck, A., Knop, F. K., Vilsbøll, T., Madsbad, S., Nauck, M. A., Deacon, C. F., Bülow, J., Holst, J. J. & Hartmann, B., 1 Sep 2017, In: American Journal of Physiology: Endocrinology and Metabolism. 313, 3, p. E284-E291

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  13 Citations (Scopus)

• Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

  Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, Idorn, T., Deacon, C. F., Knop, F. K., Rosenkilde, M. M., Hartmann, B., Feldt-Rasmussen, B., Mann, M., Madsbad, S. & Holst, J. J., Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460

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• Critical role for GLP-1 in symptomatic post-bariatric hypoglycaemia

  Craig, C. M., Liu, L-F., Deacon, C. F., Holst, J. J. & McLaughlin, T. L., Mar 2017, In: Diabetologia. 60, 3, p. 531-540

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  97 Citations (Scopus)

• Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men

  Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, J. J., Deacon, C. F., Rehfeld, J. F., Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., 2017, In: European Journal of Nutrition. 56, 3, p. 1063-1076 14 p.

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  29 Citations (Scopus)

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• Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues

  Ten Kulve, J. S., Veltman, D. J., Gerdes, V. E. A., van Bloemendaal, L., Barkhof, F., Deacon, C. F., Holst, J. J., Drent, M. L., Diamant, M. & IJzerman, R. G., Nov 2017, In: Diabetes Care. 40, 11, p. 1522-1529 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  51 Citations (Scopus)

• Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men

  Matikainen, N., Söderlund, S., Björnson, E., Bogl, L. H., Pietiläinen, K. H., Hakkarainen, A., Lundbom, N., Eliasson, B., Räsänen, S. M., Rivellese, A., Patti, L., Prinster, A., Riccardi, G., Després, J-P., Alméras, N., Holst, J. J., Deacon, C. F., Borén, J. & Taskinen, M-R., Jun 2017, In: Nutrition, Metabolism & Cardiovascular Diseases. 27, 6, p. 534-542 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Why is it so difficult to measure glucagon-like peptide-1 in a mouse?

  Windeløv, J. A., Wewer Albrechtsen, N. J., Kuhre, R. E., Jepsen, S. L., Hornburg, D., Pedersen, J., Jensen, E. P., Galsgaard, K. D., Winther-Sørensen, M., Ørgaard, A., Deacon, C. F., Mann, M., Kissow, H., Hartmann, B. & Holst, J. J., Oct 2017, In: Diabetologia. 60, 10, p. 2066-2075 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  48 Citations (Scopus)
• 2016

  A comparative review of DPP-4 inhibitors and sulphonylureas

  Deacon, C. F. & Lebovitz, HE., 2016, In: Diabetes, Obesity and Metabolism. 18, p. 333-347

  Research output: Contribution to journal › Journal article › Research › peer-review

• A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes

  Wu, T., Little, TL., Bound, MJ., Borg, M., Zhang, X., Deacon, C. F., Horowitz, M., Jones, KL. & Rayner, CK., 2016, In: Diabetes Care. 39, 4, p. 511-517 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  79 Citations (Scopus)

• Cephalic phase secretion of insulin and other enteropancreatic hormones in humans

  Veedfald, S., Plamboeck, A., Deacon, C. F., Hartmann, B., Knop, F. K., Lauritsen, T. V. & Holst, J. J., 1 Jan 2016, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 310, 1, p. G43-51

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  39 Citations (Scopus)