Christian Janfelt

Search results

• 2025

  Design and Implementation of a Desorption Electro-flow Focusing Sprayer on an Orbitrap Mass Spectrometer for DESI Mass Spectrometry Imaging at High Spatial Resolution and at High Speed

  Hansen, C. F. M., Dobrovolskis, L. & Janfelt, C., 2025, In: Journal of the American Society for Mass Spectrometry. 36, 3, p. 473–482

  Research output: Contribution to journal › Journal article › Research › peer-review

• Evaluation of the Photocarcinogenic Potential of Perfluorooctanoic Acid in Mice after Topical and Oral Exposure

  Donslund, M. F. S., Granborg, J. R., Niklas, A. A., Janfelt, C., Sloth, J. J., Philipsen, P. A., Wulf, H. C. & Lerche, C. M., 2025, (Accepted/In press) In: Journal of Investigative Dermatology.

  Research output: Contribution to journal › Letter › Research › peer-review

  Open Access

• The aerial epidermis is a major site of quinolizidine alkaloid biosynthesis in narrow-leafed lupin

  Frick, K. M., Lorensen, M. D. B. B., Micic, N., Esteban, E., Pasha, A., Schulz, A., Provart, N. J., Nour-Eldin, H. H., Bjarnholt, N., Janfelt, C. & Geu-Flores, F., 2025, In: New Phytologist. 245, 5, p. 2052-2068

  Research output: Contribution to journal › Journal article › Research › peer-review

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• 2024

  Cutaneous squamous cell carcinoma characterized by MALDI mass spectrometry imaging in combination with machine learning

  Brorsen, L. F., McKenzie, J. S., Tullin, M. F., Bendtsen, K. M. S., Pinto, F. E., Jensen, H. E., Haedersdal, M., Takats, Z., Janfelt, C. & Lerche, C. M., 2024, In: Scientific Reports. 14, 1, 11 p., 11091.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

  13 Downloads (Pure)

• Metabolomic profiling and accurate diagnosis of basal cell carcinoma by MALDI imaging and machine learning

  Brorsen, L. F., McKenzie, J. S., Pinto, F. E., Glud, M., Hansen, H. S., Haedersdal, M., Takats, Z., Janfelt, C. & Lerche, C. M., 2024, In: Experimental Dermatology. 33, 7, 11 p., e15141.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• Oral administration of quercetin and fisetin potentiates photocarcinogenesis in UVR-exposed hairless mice

  Pihl, C., Granborg, J. R., Pinto, F. E., Bjerring, P., Andersen, F., Janfelt, C., Haedersdal, M. & Lerche, C. M., 2024, In: Phytomedicine Plus. 4, 2, 8 p., 100547.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• Oral Squamous Cell Carcinoma Lipid Evaluation in Gingiva Tissue Stored in TRIzol via Shotgun Lipidomics and MALDI Mass Spectrometry Imaging

  Bernardo, R. A., de Oliveira Júnior, C. I., Roque, J. V., Costa, N. D. L., Roriz, V. M., Sorgi, C. A., Janfelt, C., Vaz, B. G. & Chaves, A. R., 2024, In: Journal of Proteome Research. 23, 8, p. 2750–2761

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)
• 2023

  Elucidating the spatial distribution of organic contaminants and their biotransformation products in amphipod tissue by MALDI- and DESI-MS-imaging

  Raths, J., Pinto, F. E., Janfelt, C. & Hollender, J., 2023, In: Ecotoxicology and Environmental Safety. 264, 10 p., 115468.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

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• Importance of Dietary Uptake for in Situ Bioaccumulation of Systemic Fungicides Using Gammarus pulex as a Model Organism

  Raths, J., Schnurr, J., Bundschuh, M., Pinto, F. E., Janfelt, C. & Hollender, J., 2023, In: Environmental Toxicology and Chemistry. 42, 9, p. 1993-2006

  Research output: Contribution to journal › Journal article › Research › peer-review

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  5 Citations (Scopus)

  17 Downloads (Pure)

• In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid

  Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, Janfelt, C., Kornum, B. R. & Kristensen, J. L., 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

• Leaves of Cannabis sativa and their trichomes studied by DESI and MALDI mass spectrometry imaging for their contents of cannabinoids and flavonoids

  Lorensen, M. D. B. B., Hayat, S. Y., Wellner, N., Bjarnholt, N. & Janfelt, C., 2023, In: Phytochemical Analysis. 34, 3, p. 269-279

  Research output: Contribution to journal › Journal article › Research › peer-review

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  15 Citations (Scopus)

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• Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging

  Lorensen, M. D. B. B., Bjarnholt, N., St-Pierre, B., Heinicke, S., Courdavault, V., O'Connor, S. & Janfelt, C., 2023, In: Phytochemistry. 209, 15 p., 113620.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  16 Citations (Scopus)

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• The aerial epidermis is a major site of quinolizidine alkaloid biosynthesis in narrow-leafed lupin

  Frick, K. M., Lorensen, M. D. B. B., Esteban, E., Pasha, A., Schulz, A., Provart, N. J., Janfelt, C., Nour-Eldin, H. H. & Geu-Flores, F., 2023, bioRxiv, 18 p.

  Research output: Working paper › Preprint › Research

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• The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids

  Stander, E. A., Lehka, B., Carqueijeiro, I., Cuello, C., Hansson, F. G., Jansen, H. J., Dugé De Bernonville, T., Birer Williams, C., Vergès, V., Lezin, E., Lorensen, M. D. B. B., Dang, T. T., Oudin, A., Lanoue, A., Durand, M., Giglioli-Guivarc’h, N., Janfelt, C., Papon, N., Dirks, R. P., O’connor, S. E. & 3 others, Jensen, M. K., Besseau, S. & Courdavault, V., 2023, In: Communications Biology . 6, 1, 19 p., 1197.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  16 Citations (Scopus)

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• Tissue-specific stilbene accumulation is an early response to wounding/grafting as revealed by using spatial and temporal metabolomics

  Loupit, G., Fonayet, J. V., Lorensen, M. D. B. B., Franc, C., De Revel, G., Janfelt, C. & Cookson, S. J., 2023, In: Plant Cell and Environment. 46, 12, p. 3871-3886

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

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• Variation in oligosaccharide profiles observed with AP-MALDI in different regions of maize kernels after treatment with xylanases

  Granborg, J. R., Kaasgaard, S. G. & Janfelt, C., 2023, In: Journal of Cereal Science. 109, 10 p., 103586.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

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• 2022

  A one-time pneumatic jet-injection of 5-fluorouracil and triamcinolone acetonide for treatment of hypertrophic scars: A blinded randomized controlled trial

  Erlendsson, A. M., Rosenberg, L. K., Lerche, C. M., Togsverd-Bo, K., Wiegell, S. R., Karmisholt, K., Philipsen, P. A., Hansen, A. C. N., Janfelt, C., Holmes, J., Rossi, A. & Haedersdal, M., 2022, In: Lasers in Surgery and Medicine. 54, 5, p. 663-671

  Research output: Contribution to journal › Journal article › Research › peer-review

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  5 Citations (Scopus)

  18 Downloads (Pure)

• In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry

  Bik, L., van Doorn, M., Hansen, A. C. N., Janfelt, C., Olesen, U. H., Haedersdal, M., Lerche, C. M. & Hendel, K., 2022, In: Expert Opinion on Drug Delivery. 19, 2, p. 213-219

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

  23 Downloads (Pure)

• Mass spectrometry imaging in drug distribution and drug metabolism studies: Principles, applications and perspectives

  Granborg, J. R., Handler, A. M. & Janfelt, C., 2022, In: Trends in Analytical Chemistry. 146, 13 p., 116482.

  Research output: Contribution to journal › Review › Research › peer-review

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  41 Citations (Scopus)

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• Mass spectrometry imaging of oligosaccharides following in situ enzymatic treatment of maize kernels

  Granborg, J. R., Kaasgaard, S. G. & Janfelt, C., 2022, In: Carbohydrate Polymers. 275, 10 p., 118693.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  10 Citations (Scopus)

  24 Downloads (Pure)

• Quantitative Mass Spectrometry Imaging of Bleomycin in Skin Using a Mimetic Tissue Model for Calibration

  Traberg, A., Pinto, F. E., Hansen, A. C. N., Haedersdal, M., Lerche, C. M. & Janfelt, C., 2022, In: Pharmaceuticals. 15, 12, 15 p., 1583.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  8 Citations (Scopus)

  19 Downloads (Pure)

• Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models

  Christensen, S. L., Rasmussen, R. H., Cour, S. L., Ernstsen, C., Hansen, T. F., Kogelman, L. J. A., Lauritzen, S. P., Guzaite, G., Styrishave, B., Janfelt, C., Christensen, S. T., Aziz, Q., Tinker, A., Jansen-Olesen, I., Olesen, J. & Kristensen, D. M., 2022, In: Cephalalgia. 42, 2, p. 93-107

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Tissue distribution and metabolic profiling of cyclosporine (CsA) in mouse and rat investigated by DESI and MALDI mass spectrometry imaging (MSI) of whole-body and single organ cryo-sections

  Holm, N. B., Deryabina, M., Knudsen, C. B. & Janfelt, C., 2022, In: Analytical and Bioanalytical Chemistry. 414, p. 7167–7177

  Research output: Contribution to journal › Journal article › Research › peer-review

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  19 Citations (Scopus)

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• 2021

  A Comparison of Human and Porcine Skin in Laser-Assisted Drug Delivery of Chemotherapeutics

  Rosenberg, L. K., Bagger, C., Janfelt, C., Haedersdal, M., Olesen, U. H. & Lerche, C. M., 2021, In: Lasers in Surgery and Medicine. 53, 1, p. 162-170 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: in vivo investigations with mass spectrometry imaging

  Hendel, K., Hansen, A. C. N., Bik, L., Bagger, C., van Doorn, M. B. A., Janfelt, C., Olesen, U. H., Haedersdal, M. & Lerche, C. M., 1 Jan 2021, In: Drug Delivery. 28, 1, p. 1141-1149 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  10 Citations (Scopus)

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• Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging

  Handler, A. M., Eirefelt, S., Lambert, M., Johansson, F., Hollesen Schefe, L., Knudsen, N. Ø., Bodenlenz, M., Birngruber, T., Sinner, F., Eriksson, A. H., Pedersen, G. P., Janfelt, C. & Troensegaard Nielsen, K., 2021, In: Molecular Pharmaceutics. 18, 8, p. 3063-3072

  Research output: Contribution to journal › Journal article › Research › peer-review

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  9 Citations (Scopus)

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• Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT_2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography

  Jacobsen, S. C., Speth, N. R., Xiong, M., Herth, M. M., Kristensen, J. L., Palner, M. & Janfelt, C., 2021, In: Molecular Imaging and Biology. 23, p. 676–685

  Research output: Contribution to journal › Journal article › Research › peer-review

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  12 Citations (Scopus)

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• Efficacy and Safety of Laser‐Assisted Combination Chemotherapy: An Explorative Imaging‐Guided Treatment With 5‐Fluorouracil and Cisplatin for Basal Cell Carcinoma

  Wenande, E., Hendel, K., Mogensen, M., Bagger, C., Mårtensson, N. L., Persson, D. P., Lerche, C. M., Husted, S., Janfelt, C., Togsverd‐bo, K., Anderson, R. R. & Haedersdal, M., 2021, In: Lasers in Surgery and Medicine. 53, 1, p. 119-128 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Quantitative MALDI mass spectrometry imaging for exploring cutaneous drug delivery of tofacitinib in human skin

  Handler, A. M., Pedersen, G. P., Nielsen, K. T., Janfelt, C., Pedersen, A. J. & Clench, M. R., 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 159, p. 1-10 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  15 Citations (Scopus)

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• Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

  Ozgür, B., Saaby, L., Janfelt, C., Langthaler, K., Eneberg, E., Jacobsen, A-M., Badolo, L., Montanari, D. & Larsen, B. B., 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219

  Research output: Contribution to journal › Journal article › peer-review

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• Visualization of penetration of topical antifungal drug substances through mycosis-infected nails by matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI)

  Joly-Tonetti, N., Pinto, F. E., Bagger, C., Osman-Ponchet, H. & Janfelt, C., 2021, In: Journal of the American Academy of Dermatology. 85, 3, p. AB191-AB191 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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• Visualizing the Journey of Fenofibrate through the Rat Gastrointestinal Tract by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging

  Strindberg, S., Plum, J., Bagger, C., Janfelt, C. & Müllertz, A., 2021, In: Molecular Pharmaceutics. 18, 6, p. 2189–2197

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)
• 2020

  Electrospun α-lactalbumin nanofibers for site-specific and fast-onset delivery of nicotine in the oral cavity: an in vitro, ex vivo and tissue spatial distribution study

  Kalouta, K., Stie, M. B., Janfelt, C., Chronakis, I. S., Jacobsen, J., Mørck Nielsen, H. & Foderà, V., 2020, In: Molecular Pharmaceutics. 17, 11, p. 4189-4200

  Research output: Contribution to journal › Journal article › Research › peer-review

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  13 Citations (Scopus)

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• Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone

  Thakur, A., Pinto, F. E., Hansen, H. S., Andersen, P., Christensen, D., Janfelt, C. & Foged, C., 2020, In: Frontiers in Immunology. 11, p. 803

  Research output: Contribution to journal › Journal article › Research › peer-review

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  19 Citations (Scopus)

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• MALDI mass spectrometry imaging as a complementary analytical method for improved skin distribution analysis of drug molecule and excipients

  Handler, A. M., Fallah, M., Just Pedersen, A., Pommergaard Pedersen, G., Troensegaard Nielsen, K. & Janfelt, C., 2020, In: International Journal of Pharmaceutics. 590, 119949.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Metabolites during Sorghum Germination

  Montini, L., Crocoll, C., Gleadow, R. M., Motawia, M. S., Janfelt, C. & Bjarnholt, N., 2020, In: Plant Physiology. 183, 3, p. 925-942 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  35 Citations (Scopus)

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• Visualisation of penetration of topical antifungal drug substances through mycosis-infected nails by matrix-assisted laser desorption ionisation mass spectrometry imaging

  Endringer Pinto, F., Bagger, C., Kunze, G., Joly-Tonetti, N., Thenot, J-P., Osman-Ponchet, H. & Janfelt, C., 2020, In: Mycoses. 63, 8, p. 869-875 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)
• 2019

  Characterisation and localisation of the endocannabinoid system components in the adult human testis

  Nielsen, J. E., Rolland, A. D., Rajpert-De Meyts, E., Janfelt, C., Jørgensen, A., Winge, S. B., Kristensen, D. M., Juul, A., Chalmel, F., Jégou, B. & Skakkebæk, N. E., 2019, In: Scientific Reports. 9, 1, 14 p., 12866.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  56 Citations (Scopus)

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• Developing a predictive in vitro dissolution model based on gastrointestinal fluid characterisation in rats

  Christfort, J. F., Strindberg, S., Plum, J., Hall-Andersen, J., Janfelt, C., Nielsen, L. H. & Müllertz, A., 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 307-314 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  25 Citations (Scopus)

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• Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

  Hendel, K. K., Bagger, C., Olesen, U. H., Janfelt, C., Hansen, S. H., Haedersdal, M. & Lerche, C. M., Dec 2019, In: Drug Delivery. 26, 1, p. 244-251 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  26 Citations (Scopus)

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• Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

  Clitherow, K. H., Murdoch, C., Spain, S. G., Handler, A. M., Colley, H. E., Stie, M. B., Nielsen, H. M., Janfelt, C., Hatton, P. V. & Jacobsen, J., Sep 2019, In: Molecular Pharmaceutics. 16, 9, p. 3948-3956

  Research output: Contribution to journal › Journal article › Research › peer-review

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  32 Citations (Scopus)

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• Quinolizidine alkaloids are transported to seeds of bitter narrow-leafed lupin

  Otterbach, S. L., Yang, T., Kato, L., Janfelt, C. & Geu-Flores, F., 15 Oct 2019, In: Journal of Experimental Botany. 70, 20, p. 5799-5808

  Research output: Contribution to journal › Journal article › Research › peer-review

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  36 Citations (Scopus)

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• Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery

  Handler, A. M., Marxen, E., Jacobsen, J. & Janfelt, C., 15 Jan 2019, In: European Journal of Pharmaceutical Sciences. 127, p. 276-281 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)
• 2018

  Buccal delivery of small molecules - Impact of levulinic acid, oleic acid, sodium dodecyl sulfate and hypotonicity on ex vivo permeability and spatial distribution in mucosa

  Hansen, S. E., Marxen, E., Janfelt, C. & Jacobsen, J., Dec 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 133, p. 250-257

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Delivery of amitriptyline by intravenous and intraperitoneal administration compared in the same animal by whole-body mass spectrometry imaging of a stable isotope labelled drug substance in mice

  Morineau, L., Jacobsen, S. C., Kleberg, K., Hansen, H. S. & Janfelt, C., 2 Dec 2018, In: Expert Opinion on Drug Delivery. 15, 12, p. 1157-1163

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging

  Marxen, E., Jin, L., Jacobsen, J., Janfelt, C., Hyrup, B. & Nicolazzo, J. A., 21 Feb 2018, In: Pharmaceutical Research. 35, 3, 12 p., 70.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• MALDI imaging of enzymatic degradation of glycerides by lipase on textile surface

  Hall-Andersen, J., Kaasgaard, S. G. & Janfelt, C., Mar 2018, In: Chemistry and Physics of Lipids. 211, p. 100-106

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging

  Marxen, E., Jacobsen, J., Hyrup, B. & Janfelt, C., 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• The intracellular localization of the vanillin biosynthetic machinery in pods of Vanilla planifolia

  Gallage, N. J., Jørgensen, K., Janfelt, C., Nielsen, A. J. Z., Naake, T., Dunski, E., Dalsten, L., Grisoni, M. & Møller, B. L., 2018, In: Plant and Cell Physiology. 59, 2, p. 304-318 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  48 Citations (Scopus)

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• The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

  Ozgür, B., Saaby, L., Eneberg, E., Langthaler, K., Jacobsen, A-M., Janfelt, C., Badolo, L., Montanari, D. & Brodin, B., 22 Jun 2018.

  Research output: Contribution to conference › Poster › Research › peer-review