Research output per year
Research output per year
Ph.D.
Universitetsparken 2
2100 København Ø
Research activity per year
Personal Details:
Last name: |
Bartling |
First name: |
Christian Reinhard Otto |
Date of birth: |
11.05.1989 |
Place of birth: |
Herford, Germany |
Family status: |
unmarried |
E-mail (work): |
School Education:
1995 - 1999: | Primary School Herringhausen, Germany |
1999 - 2008: |
Ravensberger Gymnasium Herford, Germany Intensive courses: Chemistry, Biology Miscellaneous: University Trail course in Chemistry, University of Bielefeld |
Tertiary Education:
October 2008 – April 2013 |
University of Göttingen, Germany Degree: Bachelor of Science, Chemistry Thesis title: “Transition Metal catalyzed Transformation of Cyclopropane containing Molecules: Applications in Indole Synthesis” |
May 2013 – February 2015 |
University of Göttingen, Germany Degree: Master of Science, Chemistry Thesis title: “Total Synthesis of Analogues of Cyclic Depsipeptide YM-254890” |
August 2013 – December 2013 |
ERASMUS exchange semester Norwegian University of Science and Technology, Trondheim, Norway with Associated Professor Bård Helge Hoff Project title: “Synthesis and EGFR Tyrosine Kinase Activity of substituted new Furopyrimidines” |
April 2014 – November 2014 |
ERASMUS internship University of Copenhagen, Denmark, Master Thesis with Professor Kristian Strømgaard Thesis title: “Total Synthesis of Analogues of Cyclic Depsipeptide YM-254890” |
June 2015 – ongoing |
University of Copenhagen Department of Drug Design and Pharmacology, Center for Biopharmaceuticals PhD Student with Professor PhD Kristian Strømgaard Thesis title: “Design and synthesis of novel dimeric inhibitors of Mint2” |
March 2017 – April 2017 |
Boston University, USA Department of Biology External research stay with Associate Professor Angela Ho |
Publications:
January 2014 |
Poster Conference: “29. Organisk Kjemisk Vintermøte (OKV29)“ Poster Title: “Challenges in Synthesis of electron rich Furopyrimidines“ (presented by a third party) |
December 2016 |
Poster Conference: “Protein-Protein-Interactions London 2016” Poster Title: “Probing the Interaction between Mint2 and Amyloid Precursor Protein” |
Awards and Funding:
March 2017 |
Travel Award Grant – 8500 DKK Conference: ”American Peptide Symposium 2017” Poster Title: “Probing the protein-protein interactions between Mint2 and amyloid precursor protein as putative treatment for Alzheimer’s disease” |
Work Experience:
Summer 2009; 2010 |
Life guard at outdoor pools in the city of Enger, Germany |
Spring 2012 Autumn 2012/2013 |
Tutoring the “Chemical laboratory course for medical students“ – student assistant, seminar and practical course, University of Göttingen, Germany |
Spring 2013 |
Tutoring the “Basic organic laboratory course for biochemistry students” – student assistant, practical course, University of Göttingen, Germany |
March 2015 – May 2015 |
Research Assistant at the Department of Drug Design and Pharmacology, Chemical Biology Group, Kristian Strømgaard, University of Copenhagen, Denmark |
Engagement/Activities:
2002 – 2014 |
Member of DLRG Enger e.V. (German Life Saving Association) |
2004 – 2012 |
Member of Turngemeide Herford e.V. (track-and-field club) |
Summer 2008 |
Ostwestfalen-Champion over 400 m Participation at the Western-German Athletic Championship, 4 x 100m relay (4th place) |
My PhD project focuses around the question whether it is possible to modulate the development and progression of Alzheimer’s disease (AD) by inhibiting disease relevant protein-protein interactions (PPIs) using peptide ligands.
PPIs are vital for cellular and biochemical processes and hence are promising drug targets. However, targeting PPIs is often challenging as the binding sites are typically shallow and devoid of obvious binding pockets. The Munc18-interacting (Mint) protein family, Mint1-3, are multidomain scaffolding proteins comprising a phosphotyrosine binding domain (PTB) and two PSD-95/discs large/zonula occludens 1 (PDZ) domains. The two members, Mint1 and Mint2, are primarily expressed in neurons and being assigned to key functions in synaptic vesicle exocytosis, protein transport and synapse formation. Furthermore, Mint1 and Mint2 are important for amyloid precursor protein (APP) processing through a direct interaction via the endoplasmatic sorting motif of APP with the PTB domain in Mint. Proteases process APP into the plaque forming Aβ peptide, which is the main component of the toxic amyloid plaques found in excess in brains of patients suffering from AD.
By mapping the interaction between APP and Mint2, we envisioned to design novel PPI inhibitors for the Mint2/APP-interaction. After determining the minimal binding peptide sequence of APP, this peptide was subjected to extensive mutational scans, allowing us to highlight structural properties in the APP sequence crucial for the interaction with Mint2. Based on this data, peptides characterized by significantly improved affinity and metabolic stability have been developed. In collaboration, lead compounds have recently been tested in neurons. Importantly, we were able to show that these conceptually new inhibitors are able to reduce the formation of the toxic Aβ peptide.
In perspective, we expect that these novel peptide inhibitors will be evaluated in relevant AD models in vivo.
Chemistry, M.Sc., University of Göttingen
Award Date: 19 Feb 2015
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review