Clare Louise Hawkins

Search results

• 2023

  Antioxidant Strategies to Modulate NETosis and the Release of Neutrophil Extracellular Traps during Chronic Inflammation

  Hallberg, L. A. E., Hawkins, C. L. & Barlous, K. A., 2023, In: Antioxidants. 12, 2, 16 p., 478.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  10 Citations (Scopus)

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• Detrimental Actions of Chlorinated Nucleosides on the Function and Viability of Insulin-Producing Cells

  Sileikaite-Morvaközi, I., Hansen, W. H., Davies, M. J., Mandrup-Poulsen, T. & Hawkins, C. L., 2023, In: International Journal of Molecular Sciences. 24, 19, 13 p., 14585.

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• Exposure to peroxynitrite impacts the ability of anastellin to modulate the structure of extracellular matrix

  He, J., Chuang, C. Y., Hawkins, C. L., Davies, M. J. & Hägglund, P., 2023, In: Free Radical Biology and Medicine. 206, p. 83-93 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  1 Citation (Scopus)

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• Hypochlorous Acid and Chloramines Induce Specific Fragmentation and Cross-Linking of the G1-IGD-G2 Domains of Recombinant Human Aggrecan, and Inhibit ADAMTS1 Activity

  Wang, Y., Hammer, A., Hoefler, G., Malle, E., Hawkins, C. L., Chuang, C. Y. & Davies, M. J., 2023, In: Antioxidants. 12, 2, 25 p., 420.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

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• Identification and quantification of protein nitration sites in human coronary artery smooth muscle cells in the absence and presence of peroxynitrous acid/peroxynitrite

  Xu, S., Chuang, C. Y., Hawkins, C. L., Hägglund, P. & Davies, M. J., 2023, In: Redox Biology. 64, 13 p., 102799.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

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• Modification of histones by the myeloperoxidase-derived oxidant hypochlorous acid (HOCl) alters their reactivity with vascular smooth muscle cells.

  Hartsema, E. A., Hallberg, L. A. E., Barlous, K. A. & Hawkins, C. L., 2023, In: Redox Biochemistry and Biology. 5-6, 11 p., 100010.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• New insight into the composition of extracellular traps released by macrophages exposed to different types of inducers

  Jensen, M., Thorsen, N. W., Hallberg, L. A. E., Hägglund, P. & Hawkins, C. L., 2023, In: Free Radical Biology and Medicine. 202, p. 97-109 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  9 Citations (Scopus)

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• 2022

  Activation and Inhibition of Human Matrix Metalloproteinase-9 (MMP9) by HOCl, Myeloperoxidase and Chloramines

  Wang, Y., Chuang, C. Y., Hawkins, C. L. & Davies, M. J., Aug 2022, In: Antioxidants. 11, 8, 22 p., 1616.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  7 Citations (Scopus)

  31 Downloads (Pure)

• Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells

  He, J., Steffen, J. H., Thulstrup, P. W., Pedersen, J. N., Sauerland, M. B., Otzen, D. E., Hawkins, C. L., Gourdon, P., Davies, M. J. & Hägglund, P., 2022, In: Scientific Reports. 12, 1, 15 p., 22051.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

  27 Downloads (Pure)

• Influence of plasma halide, pseudohalide and nitrite ions on myeloperoxidase-mediated protein and extracellular matrix damage

  Xu, S., Chuang, C. Y., Malle, E., Gamon, L. F., Hawkins, C. L. & Davies, M. J., 2022, In: Free Radical Biology and Medicine. 188, p. 162-174

  Research output: Contribution to journal › Journal article › Research › peer-review

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  8 Citations (Scopus)

  42 Downloads (Pure)

• Mapping the modification of histones by the myeloperoxidase-derived oxidant hypochlorous acid (HOCl)

  Hallberg, L. A. E., Thorsen, N. W., Hartsema, E. A., Hägglund, P. M. & Hawkins, C. L., 2022, In: Free Radical Biology and Medicine. 192, p. 152-164 13 p.

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  4 Citations (Scopus)

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• New roles of neutrophils and granulocytic MDSC in autoimmune diseases, inflammation, and anti-microbial immunity

  Odobasic, D., Hawkins, C. L. & Radic, M., 2022, In: Frontiers in Immunology. 13, 2 p., 974062.

  Research output: Contribution to journal › Editorial › Research › peer-review

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  1 Citation (Scopus)

  14 Downloads (Pure)

• Role of macrophage extracellular traps in innate immunity and inflammatory disease

  Rasmussen, K. H. & Hawkins, C. L., 2022, In: Biochemical Society Transactions. 50, 1, p. 21-32 12 p.

  Research output: Contribution to journal › Review › Research › peer-review
  25 Citations (Scopus)
• 2021

  Chlorination and nitration of extracellular matrix by inflammatory myeloperoxidase-derived oxidants in the presence of nitrite

  Xu, S., Chuang, C. Y., Hawkins, C. L. & Davies, M. J., 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1, p. 566 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research

• Modification of histones by hypochlorous acid and its influence on vascular cell function

  Hallberg, L. A. E., Barlous, K. & Hawkins, C. L., 2021, In: Free Radical Biology and Medicine. 165, S1, p. 19

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Modulation of hypochlorous acid (HOCl) induced damage to vascular smooth muscle cells by thiocyanate and selenium analogues

  Flouda, K., Gammelgaard, B., Davies, M. J. & Hawkins, C. L., May 2021, In: Redox Biology. 41, 101873.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  21 Citations (Scopus)

  38 Downloads (Pure)

• Oral pre-treatment with thiocyanate (SCN-) protects against myocardial ischaemia-reperfusion injury in rats

  Hall, L., Guo, C., Tandy, S., Broadhouse, K., Dona, A. C., Malle, E., Bartels, E. D., Christoffersen, C., Grieve, S. M., Figtree, G., Hawkins, C. L. & Davies, M. J., 2021, In: Scientific Reports. 11, 1, 18 p., 12712.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  11 Citations (Scopus)

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• ROLE OF EXTRACELLULAR TRAP RELEASE BY MACROPHAGES DURING THE DEVELOPMENT OF CHRONIC INFLAMMATION.

  Jensen, M., Hagglund, P., Zhang, Y., Rayner, B. & Hawkins, C. L., 2021, In: Atherosclerosis. 331, p. E72-E72 PO51.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Role of histone modification by hypochlorous acid on vascular cell function

  Hallberg, L. A. E., Barlous, K. A. & Hawkins, C. L., 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1, p. 593

  Research output: Contribution to journal › Conference abstract in journal › Research

• Role of myeloperoxidase and oxidant formation in the extracellular environment in inflammation-induced tissue damage

  Hawkins, C. L. & Davies, M. J., 2021, In: Free Radical Biology and Medicine. 172, p. 633-651

  Research output: Contribution to journal › Review › Research › peer-review

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  89 Citations (Scopus)

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• Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage

  Flouda, K., Mercer, J., Davies, M. J. & Hawkins, C. L., 2021, In: Free Radical Biology & Medicine. 166, p. 165-177

  Research output: Contribution to journal › Journal article › Research › peer-review

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  6 Citations (Scopus)

  24 Downloads (Pure)

• The role of RNA oxidation in islet dysfunction in Type 2 diabetes

  Sileikaite, I., Davies, M. J., Mandrup-Poulsen, T. & Hawkins, C. L., 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1 , p. S37-S38

  Research output: Contribution to journal › Conference abstract in journal › Research
• 2020

  8-chloroadenosine alters the metabolic profile and downregulates antioxidant and DNA damage repair pathways in macrophages

  Macer-Wright, J., Sileikaite, I., Rayner, B. & Hawkins, C. L., 2020, In: Chemical Research in Toxicology. 33, 2, p. 402-413

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Absolute quantitative analysis of intact and oxidized amino acids by LC-MS without prior derivatization

  Gamon, L. F., Guo, C., He, J., Hägglund, P., Hawkins, C. L. & Davies, M. J., Sep 2020, In: Redox Biology. 36, 9 p., 101586.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  26 Citations (Scopus)

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• Binding of myeloperoxidase to the extracellular matrix of smooth muscle cells and subsequent matrix modification

  Cai, H., Chuang, C., Hawkins, C. L. & Davies, M. J., 2020, In: Scientific Reports. 13 p., 666.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  30 Citations (Scopus)

  154 Downloads (Pure)

• Dermal fibroblasts have different extracellular matrix profiles induced by TGF-beta, PDGF and IL-6 in a model for skin fibrosis

  Juhl, P., Bondesen, S., Hawkins, C. L., Karsdal, M. A., Bay-Jensen, A-C., Davies, M. J. & Siebuhr, A. S., 2020, In: Scientific Reports. 10, 1, 10 p., 17300.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  78 Citations (Scopus)

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• Hypochlorous acid-mediated modification of proteins and its consequences

  Hawkins, C. L., 2020, In: Essays in Biochemistry. 64, 1, p. 75-86

  Research output: Contribution to journal › Review › Research › peer-review
  58 Citations (Scopus)

• Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway

  Shu, N., Hagglund, P., Cai, H., Hawkins, C. L. & Davies, M. J., Jan 2020, In: Redox Biology. 29, UNSP 101400.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  14 Citations (Scopus)

  81 Downloads (Pure)

• Myeloperoxidase-derived damage to human plasma fibronectin: Modulation by protein binding and thiocyanate ions (SCN⁻)

  Vanichkitrungruang, S., Chuang, C. Y., Hawkins, C. L. & Davies, M. J., 2020, In: Redox Biology. 36, 13 p., 101641.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  13 Citations (Scopus)

  27 Downloads (Pure)

• Myeloperoxidase Modulates Hydrogen Peroxide Mediated Cellular Damage in Murine Macrophages

  Guo, C., Sileikaite, I., Davies, M. J. & Hawkins, C. L., 2020, In: Antioxidants. 9, 12, 14 p., 1255.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  8 Citations (Scopus)

  40 Downloads (Pure)

• Role of thiocyanate in the modulation of myeloperoxidase-derived oxidant induced damage to macrophages

  Guo, C., Davies, M. J. & Hawkins, C. L., Sep 2020, In: Redox Biology. 36, 14 p., 101666.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  19 Citations (Scopus)

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• Selenomethionine supplementation reduces lesion burden, improves vessel function and modulates the inflammatory response within the setting of atherosclerosis

  Zhang, Y., Cartland, S. P., Henriquez, R., Patel, S., Gammelgaard, B., Flouda, K., Hawkins, C. L. & Rayner, B. S., Jan 2020, In: Redox Biology. 29, 11 p., 101409.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  34 Citations (Scopus)

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• The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease

  Davies, M. J. & Hawkins, C. L., 2020, In: Antioxidants & Redox Signaling. 32, 13, p. 957-981

  Research output: Contribution to journal › Review › Research › peer-review
  201 Citations (Scopus)

• The role of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) in the induction of mitochondrial dysfunction in macrophages

  Love, D. T., Guo, C., Nikelshparg, E. I., Brazhe, N. A., Sosnovtseva, O. & Hawkins, C. L., 2020, In: Redox Biology. 36, 12 p., 101602.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  20 Citations (Scopus)

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• 2019

  8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response

  Tang, V., Fu, S., Rayner, B. S. & Hawkins, C. L., 2019, In: Redox Biology. 26, 11 p., UNSP 101274.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  25 Citations (Scopus)

  72 Downloads (Pure)

• A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation

  Macer-Wright, J. L., Stanley, N. R., Portman, N., Tan, J. T., Bursill, C., Rayner, B. S. & Hawkins, C. L., 2019, In: Chemical Research in Toxicology. 32, 6, p. 1223-1234

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

  Reyes, L., Bishop, D. P., Hawkins, C. L. & Rayner, B. S., 2019, In: Antioxidants. 8, 546 .

  Research output: Contribution to journal › Journal article › Research › peer-review

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  14 Citations (Scopus)

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• Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts

  Reyes, L., Hawkins, C. L. & Rayner, B. S., 2019, In: Archives of Biochemistry and Biophysics. 665, p. 132-142

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Detection, identification, and quantification of oxidative protein modifications

  Hawkins, C. L. & Davies, M. J., 2019, In: Journal of Biological Chemistry. 294, 51, p. 19683-19708

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  271 Citations (Scopus)

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• Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase

  Lim, Y. J., Foo, T. C., Yeung, A. W. S., Tu, X., Ma, Y., Hawkins, C. L., Witting, P. K., Jameson, G. N. L., Terentis, A. C. & Thomas, S. R., 2019, In: Biochemistry. 58, 7, p. 974-986

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells

  Cai, H., Chuang, C. Y., Vanichkitrungruang, S., Hawkins, C. L. & Davies, M. J., 2019, In: Free Radical Biology and Medicine. 134, p. 526-536

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)

• In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

  Zhang, Y., Rayner, B. S., Jensen, M. & Hawkins, C. L., 2019, In: Journal of Visualized Experiments. 153, e60541 .

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function

  Vanichkitrungruang, S., Chuang, C. Y., Hawkins, C. L., Hammer, A., Hoefler, G., Malle, E. & Davies, M. J., 2019, In: Free Radical Biology and Medicine. 136, p. 118-134

  Research output: Contribution to journal › Journal article › Research › peer-review
  30 Citations (Scopus)
• 2018

  A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid

  Pan, G., Rayner, B., Zhang, Y., van Reyk, D. & Hawkins, C., 2018, In: Archives of Biochemistry and Biophysics. 642, p. 23-30 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• A therapeutic role for selenoprotein T in reducing ischaemia/reperfusion injury in the heart?

  Hawkins, C. L., 2018, In: Acta Physiologica. 223, 4, 3 p., e13106 .

  Research output: Contribution to journal › Editorial › Research › peer-review
  3 Citations (Scopus)

• Cellular responses to radical propagation from ion-implanted plasma polymer surfaces

  Stewart, C. A. C., Akhavan, B., Santos, M., Hung, J., Hawkins, C. L., Bao, S., Wise, S. G. & Bilek, M. M. M., 2018, In: Applied Surface Science. 456, p. 701-710

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Protein carbamylation: a key driver of vascular calcification during chronic kidney disease

  Hawkins, C. L., 2018, In: Kidney International. 94, 1, p. 12-14

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  7 Citations (Scopus)

• Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation

  Rayner, B. S., Zhang, Y., Brown, B. E., Reyes, L., Cogger, V. C. & Hawkins, C. L., 2018, In: Free Radical Biology and Medicine. 129, p. 25-34

  Research output: Contribution to journal › Journal article › Research › peer-review
  44 Citations (Scopus)

• The dys-regulation of anti-oxidant defense via an impairment of Nrf2 response in the pathology of Friedreich's ataxia: [Meeting Abstract]

  Chiang, S., Anzovino, A., Brown, B. E., Hawkins, C. L., Richardson, D. R. & Huang, M. L. -H., 2018, In: Free Radical Biology and Medicine. 120, p. S35-S35 OP-19 .

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
• 2017

  Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes

  Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, M. J. & Hawkins, C. L., 2017, In: Redox Biology. 12, p. 872-882 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  32 Citations (Scopus)

  289 Downloads (Pure)