Personal profile
Short presentation
Cord Brakebusch studied Biochemistry at the University of Hannover, Germany, and received his diploma 1989. After carrying out his PhD work on TNF receptors in the lab of David Wallach at the Weizmann Institute of Science in Rehovot, Israel, he received his PhD 1993 from the University of Hannover and started a post doc with Axel Ullrich at the Max Planck Institute of Biochemistry in Munich, Germany, on an extracellular matrix compound with anti-cancer properties. 1996 he joined the group of Reinhard Fässler, where he learned how to generate and analyze mice with targeted mutations and investigated the function of b1 integrin in vivo. Together with Reinhard Fässler he moved 1998 to the University of Lund, Sweden, where he obtained a fellowship as an assistant professor from the Swedish Medical Research Council. 2002 he received a Heisenberg Fellowship, which allowed him to establish an independent research group focusing on the function of Rho GTPases in vivo at the Max Planck Institute of Biochemistry in Munich at the Department of Molecular Medicine, headed by Reinhard Fässler. In 2006 Cord Brakebusch moved to Copenhagen to become professor at the University of Copenhagen, Faculty of Health, and director of the Transgenic Mouse Core Facility. Since 2007 he is in addition a group leader at BRIC.
Primary fields of research
- Rho GTPase function
- Cancer
- Inflammation
- Mouse models
CV
Education
- 1993 PhD, University of Hannover, Germany
- 1989 BA Biochemistry, University of Hannover, Germany
Career
- 2006- Professor, University of Copenhagen
- 2002-2005 Heisenberg Group Leader, MPI of Biochemistry, Martinsried, Germany
- 1998-2001 Assisstant professor, University of Lund, Sweden
- 1996-1998 Postdoctoral fellow, Laboratory of Reinhard Fässler, MPI of Biochemistry, Germany
- 1993-1996 Postdoctoral fellow, Laboratory of Axel Ullrich, MPI of Biochemistry, Martinsried, Germany
Keywords
- Faculty of Health and Medical Sciences
Collaborations and top research areas from the last five years
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Cdc42 is crucial for mural cell migration, proliferation and patterning of the retinal vasculature
Álvarez-Aznar, A., Desai, M. B., Orlich, M. M., Vázquez-Liébanas, E., Adams, R. H., Brakebusch, C. & Gaengel, K., 2025, In: Vascular Pharmacology. 159, 15 p., 107472.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)32 Downloads (Pure) -
Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium
Schoofs, H., Daubel, N., Schnabellehner, S., Grönloh, M. L. B., Palacios Martínez, S., Halme, A., Marks, A. M., Jeansson, M., Barcos, S., Brakebusch, C., Benedito, R., Engelhardt, B., Vestweber, D., Gaengel, K., Linsenmeier, F., Schürmann, S., Saharinen, P., van Buul, J. D., Friedrich, O. & Smith, R. S. & 2 others, , 2025, In: Nature. 641, 8062, p. 465–475 39 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)9 Downloads (Pure) -
Lack of epithelial RhoA in the gut, a new colitis-associated cancer experimental model
Muccioli, S. E., Hidalgo-Garcia, L., Erkert, L., Becker, L. S., Martinez-Sanchez, L., Gonzalez-Acera, M., Vieth, M., Atreya, R., Becker, C., Wirtz, S., Brakebusch, C. H., Atreya, I., Neurath, M. F. & Lopez-Posadas, R., 2025, In: Journal of Crohn's & colitis. 19, Suppl. 1, p. i285-i285 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Nuclear N-WASP Induces Actin Polymerization in the Nucleus with Cortactin as an Essential Factor
Jiang, X., Mohapatra, P., Rossing, M., Zheng, W., Zbodakova, O., Thatte, J. V., Sørensen, C. S., Le Phan, T. H. & Brakebusch, C., 2025, In: Cells. 14, 1, 22 p., 59.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile12 Downloads (Pure) -
Nuclear RhoA Activation Regulates Nucleus Size and DNA Content via Nuclear Activation of ROCK and pErk
Nguyen, L. P., Svensmark, J., Jiang, X., Jordan, A. & Brakebusch, C., 2025, In: Cells. 14, 6, 16 p., 404.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)8 Downloads (Pure) -
Rac1 promotes proximal tubule kidney repair by coupling the actin cytoskeleton to mitochondrial function
Viquez, O. M., Melzer, M., Li, S., Tantengco, M., Dong, X., Sha, E., Huang, J., Krystofiak, E. S., Hart, R. C., Luo, W., Warren, C., Bayazid, A. B., Zhang, R., Bessho, R., Haase, V. H., Brakebusch, C., Inoue, T., Brooks, C., Wilson, M. H. & Terker, A. S. & 4 others, , 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 47, 11 p., e2504565122.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)2 Downloads (Pure) -
RhoA regulates oligodendrocyte differentiation and myelination by orchestrating cortical and membrane tension
Vale-Silva, R., de Paes de Faria, J., Seixas, A. I., Brakebusch, C., Franklin, R. J. M. & Relvas, J. B., 2025, In: Glia. 73, 2, p. 381–398 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)10 Downloads (Pure) -
SC2Spa: a deep learning based approach to map transcriptome to spatial origins at cellular resolution
Liao, L., Madan, E., Palma, A. M., Kim, H., Kumar, A., Bhoopathi, P., Winn, R., Trevino, J., Fisher, P., Brakebusch, C. H., Kim, G., Kim, J., Gogna, R. & Won, K. J., 2025, In: BMC Bioinformatics. 26, 1, 19 p., 148.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile10 Downloads (Pure)