Dan Stærk

Search results

• 2024

  3-Hydroxy-2-methylpropylglucosinolate and other glucosinolates from Reseda luteola (Resedaceae)

  De Nicola, G. R., Zhu, J., Pattison, D. I., Koch, M. A., Staerk, D. & Agerbirk, N., 2024, In: Biochemical Systematics and Ecology. 117, 10 p., 104902.

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  2 Citations (Scopus)

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• Cytotoxicity of endemic Haplophyllum megalanthum Bornm. and its newly isolated alkaloids and lignans

  Demir, S., Petersen, M. J., Kjaerulff, L., Unver-Somer, N. & Staerk, D., 2024, In: Biochemical Systematics and Ecology. 117, 12 p., 104901.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Eremane, viscidane and isozizaene diterpenoids from the leaves of Eremophila rigida and their absolute configurations

  Liang, C., Ndi, C., Semple, S., Buirchell, B., Coriani, S., Møller, B. L. & Stærk, D., 2024, In: Phytochemistry. 219, 16 p., 113972.

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• Not all cytochrome b5s are created equal: How a specific CytB5 boosts forskolin biosynthesis in Saccharomyces cerevisiae

  Forman, V., Luo, D., Kampranis, S. C., Stærk, D., Møller, B. L. & Pateraki, I., 2024, In: Metabolic Engineering. 86, p. 288-299

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  1 Citation (Scopus)

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• Oxetane ring formation in taxol biosynthesis is catalyzed by a bifunctional cytochrome P450 enzyme

  Zhao, Y., Liang, F., Xie, Y., Duan, Y. T., Andeadelli, A., Pateraki, I., Makris, A. M., Pomorski, T. G., Staerk, D. & Kampranis, S. C., 2024, In: Journal of the American Chemical Society. 146, p. 801-810

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  19 Citations (Scopus)

• Structure-Agnostic Bioactivity-Driven Combinatorial Biosynthesis Reveals New Antidiabetic and Anticancer Triterpenoids

  Zhao, Y., Duan, Y. T., Zang, J., Raadam, M. H., Pateraki, I., Miettinen, K., Staerk, D. & Kampranis, S. C., 2024, (E-pub ahead of print) In: Angewandte Chemie International Edition. e202416218.

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• 2023

  Biosynthesis and biotechnological production of the anti-obesity agent celastrol

  Zhao, Y., Hansen, N. L., Duan, Y., Prasad, M., Motawia, M. S., Møller, B. L., Pateraki, I., Staerk, D., Bak, S., Miettinen, K. & Kampranis, S. C., 2023, In: Nature Chemistry. 15, p. 1236–1246

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  22 Citations (Scopus)

• Characterization of serrulatane diterpenoids in Eremophila phyllopoda subsp. phyllopoda by triple high-resolution α-glucosidase/PTP1B/radical scavenging profiling, NMR spectroscopy, DFT-GIAO NMR, and electronic circular dichroism calculations

  Liang, C., Ndi, C., Kjaerulff, L., Semple, S., Buirchell, B., Coriani, S., Møller, B. L. & Stærk, D., 2023, In: Journal of Natural Products. 86, 4, p. 694–709

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• Identification of new PTP1B-inhibiting decipiene diterpenoid esters from Eremophila clarkei by high-resolution PTP1B inhibition profiling, enzyme kinetics analysis, and molecular docking

  Liang, C., Zang, J., Ndi, C., Semple, S., Buirchell, B., Coriani, S., Møller, B. L. & Stærk, D., 2023, In: Bioorganic Chemistry. 139, 15 p., 106744.

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  3 Citations (Scopus)

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• Orthogonal reversed-phase C₁₈ and pentafluorophenyl HPLC separation for phytochemical profiling of serrulatanes in Eremophila denticulata

  Zhao, Y., Li, T., Kjaerulff, L., Venter, H., Coriani, S., Møller, B. L., Semple, S. & Staerk, D., 2023, In: Journal of Natural Products. 86, 12, p. 2638-2650

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  2 Citations (Scopus)

• Polypharmacology-labeled molecular networking: An analytical technology workflow for accelerated identification of multiple bioactive constituents in complex extracts

  Zhao, Y., Gericke, O., Li, T., Kjaerulff, L., Kongstad, K. T., Heskes, A. M., Møller, B. L., Jørgensen, F. S., Venter, H., Coriani, S., Semple, S. J. & Staerk, D., 2023, In: Analytical Chemistry. 95, 9, p. 4381-4389 9 p.

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• Semi-synthesis of novel thebaine derivatives with low cytotoxicity and their antibacterial and antihemolytic properties

  Hasanpour, Z., Salehi, P., Aliahmadi, A., Hoseinpour, M., Behboodi, H., Staerk, D. & Bararjanian, M., 2023, In: Medicinal Chemistry Research. 32, p. 1713–1725

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• The causal mutation leading to sweetness in modern white lupin cultivars

  Mancinotti, D., Czepiel, K., Taylor, J. L., Galehshahi, H. G., Møller, L. A., Jensen, M. K., Motawia, M. S., Hufnagel, B., Soriano, A., Yeheyis, L., Kjaerulff, L., Péret, B., Staerk, D., Wendt, T., Nelson, M. N., Kroc, M. & Geu-Flores, F., 2023, In: Science Advances. 9, 31, 10 p., eadg8866.

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  5 Citations (Scopus)

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• 2022

  A gene cluster in Ginkgo biloba encodes unique multifunctional cytochrome P450s that initiate ginkgolide biosynthesis

  Forman, V., Luo, D., Geu-Flores, F., Lemcke, R., Nelson, D., Kampranis, S., Stærk, D., Møller, B. L. & Pateraki, I., 2022, In: Nature Communications. 13, 14 p., 5143.

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  40 Citations (Scopus)

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• A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

  Miettinen, K., Leelahakorn, N., Almeida Robles, A. R., Zhao, Y., Hansen, L. R., Nikolajsen, I. E., Andersen, J. B., Givskov, M., Stærk, D., Bak, S. & Kampranis, S., 2022, In: Nature Communications. 13, 16 p., 3664.

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  26 Citations (Scopus)

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• Ancient biosynthesis in an oil crop: Glucosinulate profiles in Limnanthes alba and its relatives (Limnanthaceae, Brassicales)

  Agerbirk, N., Pattison, D., Mandáková, T., Lysak, M. A., Montaut, S. & Stærk, D., 2022, In: Journal of Agricultural and Food Chemistry. 70, p. 1134-1147

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  7 Citations (Scopus)

• An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method

  Nordin, E., Steffensen, S. K., Laursen, B. B., Andersson, S-O., Johansson, J-E., Åman, P., Hallmans, G., Borre, M., Stærk, D., Hanhineva, K., Fomsgaard, I. S. & Landberg, R., 2022, In: Scientific Reports. 12, 14 p., 5260.

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  4 Citations (Scopus)

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• Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

  Semple, S., Stærk, D., Buirchell, B., Fowler, R., Gericke, O., Kjaerulff, L., Zhao, Y., Pedersen, H. A., Petersen, M. J., Rasmussen, L. F., Bredahl, E. K., Pedersen, G. B., McNair, L. M., Ndi, C., Hansen, N. L., Heskes, A., Bayly, M., Loland, C. J., Heinz, N. & Møller, B. L., 2022, In: Plant Journal. 111, 4, p. 936-953 15866.

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• Data-dependent acquisition-mass spectrometry guided isolation of new benzoxazinoids from the roots of Acanthus mollis L.

  Bhattarai, B., Steffensen, S. K., Stærk, D., Laursen, B. B. & Fomsgaard, I. S., 2022, In: International Journal of Mass Spectrometry. 474, 10 p., 116815.

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• Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks

  Ignea, C., Raadam, M. H., Koutsaviti, A., Zhao, Y., Duan, Y., Harizani, M., Miettinen, K., Georgantea, P., Rosenfeldt, M., Viejo-Ledesma, S. E., Petersen, M. A., Bredie, W., Stærk, D., Roussis, V., Ioannou, E. & Kampranis, S., 2022, In: Nature Communications. 13, 16 p., 5188.

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  31 Citations (Scopus)

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• Fremtidens bæredygtige medicin fra naturen: Nye teknologier hjælper med at finde nålen i høstakken

  Stærk, D., 2022, In: Pharma. 2022, 2, p. 20-22

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• Investigation of the mechanism and chemistry underlying Staphylococcus aureus' ability to inhibit Pseudomonas aeruginosa growth in vitro

  Kvich, L. A., Crone, S. G., Christensen, M. H., Lima, R. D. C. L., Alhede, M., Alhede, M., Stærk, D. & Bjarnsholt, T., 2022, In: Journal of Bacteriology. 204, 11, 16 p.

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  13 Citations (Scopus)

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• Isolation and structure elucidation of caryophyllane sesquiterpenoids from leaves of Eremophila spathulata

  Bredahl, E. K., Kjaerulff, L., Ndi, C., Semple, S., Buirchell, B., Møller, B. L. & Stærk, D., 2022, In: Phytochemistry Letters. 47, p. 156-163

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  6 Citations (Scopus)

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• Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads

  Petersen, M. J., Liang, C., Kjaerulff, L., Ndi, C., Semple, S., Buirchell, B., Coriani, S., Møller, B. L. & Stærk, D., 2022, In: Phytochemistry. 196, 11 p., 113072.

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  11 Citations (Scopus)

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• Serrulatane diterpenoids with unusual side chain modifications from root bark of Eremophila longifolia

  Rasmussen, L. F., Anton, J., Kjaerulff, L., Zhao, Y., Semple, S. J., Ndi, C., Buirchell, B., Møller, B. L. & Stærk, D., 2022, In: Phytochemistry. 203, 14 p., 113408.

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  2 Citations (Scopus)

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• Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide

  Hansen, N. L., Kjaerulff, L., Heck, Q. K., Forman, V., Stærk, D., Møller, B. L. & Andersen-Ranberg, J., 2022, In: Nature Communications. 13, 5011.

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  25 Citations (Scopus)

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• 2021

  An independent evolutionary origin for insect deterrent cucurbitacins in Iberis amara

  Dong, L., Almeida Robles, A. R., Pollier, J., Khakimov, B., Bassard, J-É. A., Miettinen, K., Stærk, D., Mehran, R., Olsen, C. E., Motawie, M. S., Goossens, A. & Bak, S., 2021, In: Molecular Biology and Evolution. 38, 11, p. 4659-4673 15 p., msab213.

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• A systematic review of possible interactions for herbal medicines and dietary supplements used concomitantly with disease-modifying or symptom-alleviating multiple sclerosis drugs

  Petersen, M. J., Bergien, S. O. & Stærk, D., 2021, In: Phytotherapy Research. 35, 7, p. 3610-3631

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• Characterization of antidiabetic serrulatane diterpenoids from Eremophila phyllopoda by triple high-resolution α-glucosidase / PTP1B / radical scavenging profiling

  Liang, C., Ndi, C., Semple, S., Coriani, S., Møller, B. L. & Stærk, D., 2021. 1 p.

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• Coupling microplate-based antibacterial assay with liquid chromatography for high-resolution growth inhibition profiling of crude extracts: Validation and proof-of-concept study with Staphylococcus aureus

  Ardalani, H., Anam, S., Kromphardt, K. J. K., Stærk, D. & Kongstad, K. T., 2021, In: Molecules. 26, 6, 12 p., 1550.

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  5 Citations (Scopus)

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• Dual high-resolution α-glucosidase and PTP1B profiling combined with HPLC-PDA-HRMS-SPE-NMR analysis for the identification of potentially antidiabetic chromene meroterpenoids in Rhododendron capitatum

  Liang, C., Kjaerulff, L., Hansen, P. R., Kongstad, K. T. & Stærk, D., 2021, In: Journal of Natural Products. 84, p. 2454-2467

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  27 Citations (Scopus)

• Furolabdane diterpenoids from Pseudodictamnus aucheri (Boiss.) Salmaki & Siadati (Lamiaceae) as chemophenetic markers

  Sadani, S., Sarrafi, Y. & Stærk, D., 2021, In: Biochemical Systematics and Ecology. 98, 4 p., 104304.

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  1 Citation (Scopus)

• Insects as sources for sustainable peptide drugs against type 2 diabetes

  Didriksen, A. H., Petersen, M. J. & Stærk, D., 8 Jun 2021. 1 p.

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• Isolation and structure elucidation of serrulatane diterpenoids from the roots of Eremophila longifolia

  Rasmussen, L. F., Anton, J., Kjaerulff, L. & Stærk, D., 2021, p. 1.

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• Jagten på bioaktive naturstoffer: Sammenkoblet HPLC-PDA-HRMS-SPE-NMR til hurtig identifikation af bioaktive naturstoffer i komplekse blandinger

  Stærk, D., 2021, In: Dansk Kemi. 102, 4, p. 40-44

  Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication

• Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

  Gericke, O., Fowler, R., Heskes, A., Bayly, M., Semple, S., Ndi, C. P., Stærk, D., Loland, C. J., Murphy, D. J., Buirchell, B. & Møller, B. L., 2021, In: Plant Journal. 108, 2, p. 555-578

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  12 Citations (Scopus)

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• Phytochemical investigation of Eremophila spp.

  Bredahl, E. K., Ergin, Y., Kjaerulff, L. & Stærk, D., 2021, p. 1.

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• Reversal of ABCG2/BCRP-mediated multidrug resistance by 5,3’,5’-trihydroxy-3,6,7,4’-tetramethoxyflavone isolated from the Australian desert plant Eremophila galeata Chinnock

  Petersen, M. J., Lund, X. L., Semple, S. J., Buirchell, B., Franzyk, H., Gajhede, M., Kongstad, K. T., Stenvang, J. & Stærk, D., 2021, In: Biomolecules. 11, 10, 19 p., 1534.

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  9 Citations (Scopus)

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• Semi-synthesis of novel buprenorphine derivatives and their anti-nociceptive properties and dependency potential

  Hasanpour, Z., Salehi, P., Bunch, L., Khoramjouy, M., Bararjanian, M., Stærk, D. & Faizi, M., 2021, In: Canadian Journal of Chemistry. 99, 11, p. 910-919

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  2 Citations (Scopus)

• α-Glucosidase inhibitory activity of plant extracts from the Danish Medicinal Plant Biobank

  Madsen, A. T., Soelberg, J. & Stærk, D., 8 Jun 2021. 1 p.

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• 2020

  4-Benzyloxylonchocarpin and muracatanes A-C from Ranunculus muricatus L. and their biological effects

  Hussain, H., Ali, I., Wang, D., Mamadalieva, N. Z., Hussain, W., Csuk, R., Loesche, A., Fischer, L., Stærk, D., Anam, S., AlZain, M. N., Mushtaq, M., Ul-Haq, Z., Ullah, R., Noman, O. M., Abbas, G. & Green, I. R., 2020, In: Biomolecules. 10, 11, 15 p., 1562.

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  8 Citations (Scopus)

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• Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens

  Malik, A., Ardalani, H., Anam, S., McNair, L. M., Kromphardt, K. J. K., Frandsen, R. J. N., Franzyk, H., Stærk, D. & Kongstad, K. T., 2020, In: Fitoterapia. 142, 8 p., 104522.

  Research output: Contribution to journal › Journal article › Research › peer-review
  42 Citations (Scopus)

• Evaluation of the antidiabetic potential of Psidium guajava L. (Myrtaceae) using assays for α-glucosidase, α-amylase, muscle glucose uptake, liver glucose production and triglyceride accumulation in adipocytes

  Beidokhti, M. N., Eid, H. M., Villavicencio, M. L. S., Jäger, A. K., Lobbens, E. S., Rasoanaivo, P. R., McNair, L. M., Haddad, P. S. & Stærk, D., 17 Apr 2020, In: Journal of Ethnopharmacology. 257, 8 p., 112877.

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  34 Citations (Scopus)

• Identification of Amaryllidaceae alkaloids in larvae of the ‘lily borer’ moth Brithys crini

  Nair, J. J., Andresen, A. L., Papenfus, H., Stærk, D. & van Staden, J., 2020, In: South African Journal of Botany. 131, p. 351-359

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  6 Citations (Scopus)

• Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol

  Hansen, N. L., Miettinen, K., Zhao, Y., Ignea, C., Andreadeli, A., Raadam, M. H., Makris, A. M., Møller, B. L., Stærk, D., Bak, S. & Kampranis, S., 2020, In: Microbial Cell Factories. 19, 17 p., 15.

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  37 Citations (Scopus)

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• Isolation, structure elucidation and PTP1B inhibitory activity of serrulatane diterpenoids from the roots of Myoporum insulare

  Kjaerulff, L., Jensen, A. B. J., Ndi, C., Semple, S. J., Møller, B. L. & Stærk, D., 2020, In: Phytochemistry Letters. 39, p. 49-56

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  13 Citations (Scopus)

• Nerylneryl diphosphate is the precursor of serrulatane, viscidane and cembrane-type diterpenoids in Eremophila species

  Gericke, O., Hansen, N. L., Pedersen, G. B., Kjaerulff, L., Luo, D., Stærk, D., Møller, B. L., Pateraki, I. & Heskes, A., 2020, In: B M C Plant Biology. 20, 15 p., 91.

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• Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives

  Liang, C., Stærk, D. & Kongstad, K. T., 2020, In: Journal of Functional Foods. 64, 10 p., 103623.

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  18 Citations (Scopus)

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• PTP1B-inhibiting branched-chain fatty acid dimers from Eremophila oppositifolia subsp. angustifolia identified by high-resolution PTP1B inhibition profiling and HPLC-PDA-HRMS-SPE-NMR analysis

  Pedersen, H. A., Ndi, C., Semple, S. J., Buirchell, B., Møller, B. L. & Stærk, D., 7 Apr 2020, In: Journal of Natural Products. 83, p. 1598-1610

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  21 Citations (Scopus)

• Structure elucidation and absolute configuration determination of nortriterpenoids from Picramnia glazioviana

  Gimenes, L., Luna-Dulcey, L., Batista Junior, J. M., dos Santos Junior, F. M., Popolin, C. P., Cominetti, M. R., Fernandes, J. B. & Stærk, D., 2020, In: Journal of Natural Products. 83, p. 1859-1876

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  3 Citations (Scopus)