Research output per year
Research output per year
Personal profile
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538
Bay, Y., Cabello, F. J. M., Koens, C. C., Frantsen, S. M., Pickering, D. S., Frydenvang, K., Francotte, P., Pirotte, B., Kristensen, A. S., Bowie, D. & Kastrup, J. S., 2024, In: Journal of Structural Biology. 216, 3, 9 p., 108113.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Downloads (Pure) -
Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5)
Buschbom-Helmke, S., Wang, P., Alcaide, A., Miguez-Cabello, F., Carta, M., Viotti, J. S., Nielsen, B., Mulle, C., Bowie, D., Jørgensen, F. S., Pickering, D. S. & Bunch, L., 2024, (Accepted/In press) In: Journal of Medicinal Chemistry.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators
Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., de Tullio, P., Beaufour, C., Botez, I., Pickering, D. S., Frydenvang, K., Danober, L., Kristensen, A. S., Kastrup, J. S. & Pirotte, B., 2024, In: European Journal of Medicinal Chemistry. 264, 15 p., 116036.Research output: Contribution to journal › Journal article › Research › peer-review
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Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure
Bay, Y., Venskutonytė, R., Frantsen, S. M., Thorsen, T. S., Musgaard, M., Frydenvang, K., Francotte, P., Pirotte, B., Biggin, P. C., Kristensen, A. S., Boesen, T., Pickering, D. S., Gajhede, M. & Kastrup, J. S., 2024, In: FEBS Journal. 291, 7, p. 1506-1529Research output: Contribution to journal › Journal article › Research › peer-review
2 Citations (Scopus) -
The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2
Bay, Y., Egeberg Jeppesen, M., Frydenvang, K., Francotte, P., Pirotte, B., Pickering, D. S., Kristensen, A. S. & Kastrup, J. S., 2024, In: FEBS Letters. 598, 7, p. 743-757Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)5 Downloads (Pure) -
Tritium and deuterium labelling of a kainate receptor antagonist and evaluation as a radioligand
Chałupnik, P., Marek, A., Hovah, M. E. L., Pickering, D. S., Temperini, P., Donbosco, S., Szymańska, E. & Johansen, T. N., 2024, In: Journal of Labelled Compounds and Radiopharmaceuticals. 67, 4, p. 120-130Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Downloads (Pure) -
Structure-Activity Relationship and Solubility Studies of Novel N1-substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists
Chałupnik, P., Vialko, A., Pickering, D. S., Nielsen, B., Bay, Y., Kristensen, A. S., Hinkkanen, M., Szczepańska, K., Karcz, T., Latacz, G., Johansen, T. N. & Szymanska, E. M., 2023, In: ChemMedChem. 18, 18, 15 p., e202300278.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)4 Downloads (Pure) -
(S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist
Poulie, C. B. M., Larsen, Y., Leteneur, C., Barthet, G., Bjorn-Yoshimoto, W. E., Malhaire, F., Nielsen, B., Pin, J. P., Mulle, C., Pickering, D. S. & Bunch, L., 2022, In: ACS Chemical Neuroscience. 13, 10, p. 1580–1587Research output: Contribution to journal › Journal article › Research › peer-review