David E. Gloriam

Research output

Research output per year 2003 2010 2011 2013 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 8876 Citations
• 99 Journal article
• 7 Review
• 3 Book chapter
• 3 Letter
• 8 More
  • 2 Conference abstract in journal
  • 2 Editorial
  • 1 Report
  • 1 Comment/debate
  • 1 Conference article
  • 1 Interactive production

Research output per year

Research output per year

Search results

• 2024

  Differential G protein activation by the long and short isoforms of the dopamine D₂ receptor

  Reiner-Link, D., Madsen, J. S., Gloriam, D. E., Bräuner-Osborne, H. & Hauser, A. S., 2024, (Accepted/In press) In: British Journal of Pharmacology.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  3 Citations (Scopus)

• GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions

  Pándy-Szeker es, G., Herrera, L. P. T., Caroli, J., Kermani, A. A., Kulkarni, Y., Keseru, G. M. & Gloriam, D. E., 2024, In: Nucleic Acids Research. 52, D1, p. D466-D475

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  4 Citations (Scopus)

  9 Downloads (Pure)
• 2023

  A community Biased Signaling Atlas

  Caroli, J., Mamyrbekov, A., Harpsøe, K., Gardizi, S., Dörries, L., Ghosh, E., Hauser, A. S., Kooistra, A. J. & Gloriam, D. E., 2023, In: Nature Chemical Biology. 19, p. 531–535

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Comprehensive Peptide Cyclization Examination Yields Optimized APP Scaffolds with Improved Affinity toward Mint2

  Bartling, C. R. O., Alexopoulou, F., Kuschert, S., Chin, Y. K. Y., Jia, X., Sereikaite, V., Özcelik, D., Jensen, T. M., Jain, P., Nygaard, M. M., Harpsøe, K., Gloriam, D. E., Mobli, M. & Strømgaard, K., 2023, In: Journal of Medicinal Chemistry. 66, 4, p. 3045-3057

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources

  Pándy-Szekeres, G., Caroli, J., Mamyrbekov, A., Kermani, A. A., Keserű, G. M., Kooistra, A. J. & Gloriam, D. E., 2023, In: Nucleic Acids Research. 51, D1, p. D395–D402

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  68 Downloads (Pure)

• Ligand selectivity hotspots in serotonin GPCRs

  Simon, I. A., Bjørn-Yoshimoto, W. E., Harpsøe, K., Iliadis, S., Svensson, B., Jensen, A. A. & Gloriam, D. E., 2023, In: Trends in Pharmacological Sciences. 44, 12, p. 978-990

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  5 Citations (Scopus)

  21 Downloads (Pure)

• Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations

  Grätz, L., Kowalski-Jahn, M., Scharf, M. M., Kozielewicz, P., Jahn, M., Bous, J., Lambert, N. A., Gloriam, D. E. & Schulte, G., 2023, In: Nature Communications. 14, 1, 17 p., 4573.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Citations (Scopus)

  11 Downloads (Pure)

• Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139

  Pallareti, L., Rath, T. F., Trapkov, B., Tsonkov, T., Nielsen, A. T., Harpsøe, K., Gentry, P. R., Bräuner-Osborne, H., Gloriam, D. E. & Foster, S. R., 2023, In: European Journal of Pharmacology. 943, 175553.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  3 Citations (Scopus)

  29 Downloads (Pure)

• Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists

  Pottie, E., Poulie, C. B. M., Simon, I. A., Harpsøe, K., D’Andrea, L., Komarov, I. V., Gloriam, D. E., Jensen, A. A., Kristensen, J. L. & Stove, C. P., 2023, In: ACS Chemical Neuroscience. 14, 15, p. 2727–2742

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  5 Citations (Scopus)

  20 Downloads (Pure)

• Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor

  Deng, Y., Perez Almeria, C. V., van Gijzel, L., Schaller, K., Vedel, L., Gloriam, D. E., Ulven, T. & Bräuner-Osborne, H., 2023, In: Basic and Clinical Pharmacology and Toxicology. 132, 6, p. 459-471

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  4 Citations (Scopus)

  21 Downloads (Pure)
• 2022

  Common coupling map advances GPCR-G protein selectivity

  Hauser, A. S., Avet, C., Normand, C., Mancini, A., Inoue, A., Bouvier, M. & Gloriam, D. E., 2022, In: eLife. 11, 22 p., e74107.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  64 Citations (Scopus)

  37 Downloads (Pure)

• Community guidelines for GPCR ligand bias: IUPHAR review 32

  Kolb, P., Kenakin, T., Alexander, S. P. H., Bermudez, M., Bohn, L. M., Breinholt, C. S., Bouvier, M., Hill, S. J., Kostenis, E., Martemyanov, K. A., Neubig, R. R., Onaran, H. O., Rajagopal, S., Roth, B. L., Selent, J., Shukla, A. K., Sommer, M. E. & Gloriam, D. E., 2022, In: British Journal of Pharmacology. 179, 14, p. 3651-3674

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  89 Citations (Scopus)

  24 Downloads (Pure)

• Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT_2A Receptor Agonists

  Poulie, C. B. M., Pottie, E., Simon, I. A., Harpsøe, K., D'Andrea, L., Komarov, I. V., Gloriam, D. E., Jensen, A. A., Stove, C. P. & Kristensen, J. L., 2022, In: Journal of Medicinal Chemistry. 65, 18, p. 12031–12043

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  9 Citations (Scopus)

  48 Downloads (Pure)

• Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity

  Sandhu, M., Cho, A., Ma, N., Mukhaleva, E., Namkung, Y., Lee, S., Ghosh, S., Lee, J. H., Gloriam, D. E., Laporte, S. A., Babu, M. M. & Vaidehi, N., 2022, In: Nature Communications. 13, 1, 14 p., 7428.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  25 Citations (Scopus)

  8 Downloads (Pure)

• Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

  Avet, C., Mancini, A., Breton, B., Le Gouill, C., Hauser, A. S., Normand, C., Kobayashi, H., Gross, F., Hogue, M., Lukasheva, V., St-Onge, S., Carrier, M., Héroux, M., Morissette, S., Fauman, E. B., Fortin, J. P., Schann, S., Leroy, X., Gloriam, D. E. & Bouvier, M., 2022, In: eLife. 11, 34 p., e74101.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  108 Citations (Scopus)

  19 Downloads (Pure)

• GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors

  Huang, S., Xu, P., Shen, D-D., Simon, I. A., Mao, C., Tan, Y., Zhang, H., Harpsøe, K., Li, H., Zhang, Y., You, C., Yu, X., Jiang, Y., Zhang, Y., Gloriam, D. E. & Xu, H. E., 2022, In: Molecular Cell. 82, 14, p. 2681-2695.e6 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  59 Citations (Scopus)

  12 Downloads (Pure)

• Ligand-directed bias of G protein signaling at the dopamine D₂ receptor

  Von Moo, E., Harpsøe, K., Hauser, A. S., Masuho, I., Bräuner-Osborne, H., Gloriam, D. E. & Martemyanov, K. A., 2022, In: Cell Chemical Biology. 29, 2, p. 226-238

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  20 Citations (Scopus)

• Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139

  Zhou, Y., Daver, H., Trapkov, B., Wu, L., Wu, M., Harpsøe, K., Gentry, P. R., Liu, K., Larionova, M., Liu, J., Chen, N., Bräuner-Osborne, H., Gloriam, D. E., Hua, T. & Liu, Z. J., 2022, In: Cell Research. 32, 2, p. 210-213

  Research output: Contribution to journal › Letter › Research › peer-review

  Open Access

  File
  15 Citations (Scopus)

  41 Downloads (Pure)

• The G protein database, GproteinDb

  Pandy-Szekeres, G., Esguerra, M., Hauser, A. S., Caroli, J., Munk, C., Pilger, S., Keseru, G. M., Kooistra, A. J. & Gloriam, D. E., 2022, In: Nucleic Acids Research. 50, D1, p. D518-D525

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  45 Citations (Scopus)

  36 Downloads (Pure)
• 2021

  An online GPCR structure analysis platform

  Kooistra, A. J., Munk, C., Hauser, A. S. & Gloriam, D. E., 2021, In: Nature Structural and Molecular Biology. 28, 11, p. 875-878

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  15 Citations (Scopus)

  57 Downloads (Pure)

• A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro

  Nakamoto, C., Goto, Y., Tomizawa, Y., Fukata, Y., Fukata, M., Harpsøe, K., Gloriam, D. E., Aoki, K. & Takeuchi, T., 2021, In: Molecular Brain. 14, 1, 14 p., 173.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  17 Citations (Scopus)

  13 Downloads (Pure)

• GPCR activation mechanisms across classes and macro/microscales

  Hauser, A. S., Kooistra, A. J., Munk, C., Heydenreich, F. M., Veprintsev, D. B., Bouvier, M., Babu, M. M. & Gloriam, D. E., 2021, In: Nature Structural and Molecular Biology. 28, 11, p. 879-888

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  114 Citations (Scopus)

  53 Downloads (Pure)

• GPCRdb in 2021: integrating GPCR sequence, structure and function

  Kooistra, A. J., Mordalski, S., Pándy-Szekeres, G., Esguerra, M., Mamyrbekov, A., Munk, C., Keserű, G. M. & Gloriam, D. E., 2021, In: Nucleic Acids Research. 49, D1, p. D335-D343

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  239 Citations (Scopus)

  128 Downloads (Pure)

• Molecular Determinants underlying Delta Selective Compound 2 (DS2) Activity at δ-Containing GABAA Receptors

  Falk-Petersen, C. B., Rostrup, F., Löffler, R., Buchleihtner, S., Harpsøe, K., Gloriam, D. E., Frølund, B. & Wellendorph, P., 2021, In: Molecular Pharmacology. 100, 1, p. 46-56

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  3 Citations (Scopus)

  34 Downloads (Pure)

• Peptide inhibitors as tool compounds targeting GPCR signaling

  Daver, H., Harpsoe, K. & Gloriam, D. E., 2021, In: European Biophysics Journal. 50, SUPPL 1, p. 161-161 238.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  File

• Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors

  Rostrup, F., Falk-petersen, C. B., Harpsøe, K., Buchleithner, S., Conforti, I., Jung, S., Gloriam, D. E., Schirmeister, T., Wellendorph, P. & Frølund, B., 22 Apr 2021, In: Journal of Medicinal Chemistry. 64, 8, p. 4730-4743 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Structural dynamics bridge the gap between the genetic and functional levels of GPCRs

  Torrens-Fontanals, M., Stepniewski, T. M., Gloriam, D. E. & Selent, J., 2021, In: Current Opinion in Structural Biology. 69, p. 150-159 10 p.

  Research output: Contribution to journal › Review › Research › peer-review
  7 Citations (Scopus)

• Structural insights into the lipid and ligand regulation of serotonin receptors

  Xu, P., Huang, S., Zhang, H., Mao, C., Zhou, X. E., Cheng, X., Simon, I. A., Shen, D-D., Yen, H-Y., Robinson, C. V., Harpsøe, K., Svensson, B., Guo, J., Jiang, H., Gloriam, D. E., Melcher, K., Jiang, Y., Zhang, Y. & Xu, H. E., 2021, In: Nature. 592, p. 469-473

  Research output: Contribution to journal › Journal article › Research › peer-review
  155 Citations (Scopus)

• Structure of the class D GPCR Ste2 dimer coupled to two G proteins

  Velazhahan, V., Ma, N., Pandy-Szekeres, G., Kooistra, A. J., Lee, Y., Gloriam, D. E., Vaidehi, N. & Tate, C. G., 2021, In: Nature. 589, p. 148-153 +app 24 pp

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  46 Citations (Scopus)

• Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation

  Bartling, C. R. O., Jensen, T. M. T., Henry, S. M., Colliander, A. L., Sereikaite, V., Wenzler, M., Jain, P., Maric, H. M., Harpsøe, K., Pedersen, S. W., Clemmensen, L. S., Haugaard-Kedström, L. M., Gloriam, D. E., Ho, A. & Strømgaard, K., 2021, In: Journal of the American Chemical Society. 143, 2, p. 891-901

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  16 Citations (Scopus)

  37 Downloads (Pure)
• 2020

  24 Messages on a Sustainable Career in Research at UCPH

  Larsen, K. R. (ed.), Wegener, H. C., Stein, A., Bach, A., Williams, A. R., Gall, C., Gravert, C., Gloriam, D. E., Lorenzen, E., Yvanez, E., Cappellini, E., Poulsen, F., Mortensen, J., Bentzen, J. S., Shik, J. Z., Miskowiak, K. W., Elgaard, K. K. E., Jønsson, K. A., Won, K. J., Nørgaard, L. C. & 9 others, Cantarero Arevalo, L., Kristiansen, M., Lund, M. N., Borregaard, M. K., Høyland-Kroghsbo, N. M., Iversen, R., Viskum, U., Nosch, M. L. B. & Hjorth, J., 2020, University of Copenhagen. 31 p.

  Research output: Book/Report › Report › Communication

  File
  168 Downloads (Pure)

• Combinatorial expression of GPCR isoforms affects signalling and drug responses

  Marti-Solano, M., Crilly, S. E., Malinverni, D., Munk, C., Harris, M., Pearce, A., Quon, T., Mackenzie, A. E., Wang, X., Peng, J., Tobin, A. B., Ladds, G., Milligan, G., Gloriam, D. E., Puthenveedu, M. A. & Babu, M. M., 2020, In: Nature. 587, p. 650-656 28 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  80 Citations (Scopus)

• Delineation of molecular determinants for FR900359 inhibition of G_q/11 unlocks inhibition of Gα_s

  Boesgaard, M. W., Harpsøe, K., Malmberg, M., Underwood, C. R., Inoue, A., Mathiesen, J. M., König, G. M., Kostenis, E., Gloriam, D. E. & Bräuner-Osborne, H., 2020, In: Journal of Biological Chemistry. 295, 40, p. 13850-13861

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  13 Citations (Scopus)

  27 Downloads (Pure)

• Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

  Zhang, X., Belousoff, M. J., Zhao, P., Kooistra, A. J., Truong, T. T., Ang, S. Y., Underwood, C. R., Egebjerg, T., Šenel, P., Stewart, G. D., Liang, Y-L., Glukhova, A., Venugopal, H., Christopoulos, A., Furness, S. G. B., Miller, L. J., Reedtz-Runge, S., Langmead, C. J., Gloriam, D. E., Danev, R. & 2 others, Sexton, P. M. & Wootten, D., 2020, In: Molecular Cell. 80, 3, p. 485-500

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  110 Citations (Scopus)

  14 Downloads (Pure)

• Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA_A receptors

  Falk-Petersen, C. B., Tsonkov, T. M., Nielsen, M. S., Harpsøe, K., Bundgaard, C., Frølund, B., Kristiansen, U., Gloriam, D. E. & Wellendorph, P., 22 Jun 2020, In: Scientific Reports. 10, 1, 12 p., 10078.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

  195 Downloads (Pure)

• GPCRmd uncovers the dynamics of the 3D-GPCRome

  Rodríguez-Espigares, I., Torrens-Fontanals, M., Tiemann, J. K. S., Aranda-García, D., Ramírez-Anguita, J. M., Stepniewski, T. M., Worp, N., Varela-Rial, A., Morales-Pastor, A., Medel-Lacruz, B., Pándy-Szekeres, G., Mayol, E., Giorgino, T., Carlsson, J., Deupi, X., Filipek, S., Filizola, M., Gómez-Tamayo, J. C., Gonzalez, A., Gutiérrez-de-Terán, H. & 27 others, Jiménez-Rosés, M., Jespers, W., Kapla, J., Khelashvili, G., Kolb, P., Latek, D., Marti-Solano, M., Matricon, P., Matsoukas, M-T., Miszta, P., Olivella, M., Perez-Benito, L., Provasi, D., Ríos, S., Torrecillas, I. R., Sallander, J., Sztyler, A., Vasile, S., Weinstein, H., Zachariae, U., Hildebrand, P. W., De Fabritiis, G., Sanz, F., Gloriam, D. E., Cordomi, A., Guixà-González, R. & Selent, J., 2020, In: Nature Methods. 17, 8, p. 777-787

  Research output: Contribution to journal › Journal article › Research › peer-review
  89 Citations (Scopus)

• G protein-coupled receptor pharmacology-The next generation

  Bräuner-Osborne, H., Rosenkilde, M. M., Gether, U. & Gloriam, D. E., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, Supplement 6, p. 3-4 2 p.

  Research output: Contribution to journal › Editorial › Research
  2 Citations (Scopus)

• Novel approaches leading towards peptide GPCR de-orphanisation

  Hauser, A. S., Gloriam, D. E., Bräuner-Osborne, H. & Foster, S. R., 1 Mar 2020, In: British Journal of Pharmacology. 177, 5, p. 961-968 8 p.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  26 Citations (Scopus)

  140 Downloads (Pure)

• The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

  Sommer, M. E., Selent, J., Carlsson, J., De Graaf, C., Gloriam, D. E., Keseru, G. M., Kosloff, M., Mordalski, S., Rizk, A., Rosenkilde, M. M., Sotelo, E., Tiemann, J. K. S., Tobin, A., Vardjan, N., Waldhoer, M. & Kolb, P., 2020, In: ACS Pharmacology & Translational Science. 3, 2, p. 361-370 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  17 Citations (Scopus)

  40 Downloads (Pure)
• 2019

  An online resource for GPCR structure determination and analysis

  Munk, C., Mutt, E., Isberg, V., Nikolajsen, L. F., Bibbe, J. M., Flock, T., Hanson, M. A., Stevens, R. C., Deupi, X. & Gloriam, D. E., 2019, In: Nature Methods. 16, 2, p. 151-162

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access
  104 Citations (Scopus)

• Bigger is better in virtual drug screens

  Gloriam, D. E., Feb 2019, In: Nature. 566, p. 193-194 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  32 Citations (Scopus)

• Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites

  Krall, J., Bavo, F., Falk-Petersen, C. B., Jensen, C. H., Nielsen, J. O., Tian, Y., Anglani, V., Kongstad, K. T., Piilgaard, L., Nielsen, B., Gloriam, D. E., Kehler, J., Jensen, A. A., Harpsøe, K., Wellendorph, P. & Frølund, B., 14 Mar 2019, In: Journal of Medicinal Chemistry. 62, 5, p. 2798-2813

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

  Foster, S. R., Hauser, A. S., Vedel, L., Strachan, R. T., Huang, X-P., Gavin, A. C., Shah, S. D., Nayak, A. P., Haugaard-Kedström, L. M., Penn, R. B., Roth, B. L., Bräuner-Osborne, H. & Gloriam, D. E., 31 Oct 2019, In: Cell. 179, 4, p. 895-908

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  147 Citations (Scopus)

  256 Downloads (Pure)

• Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

  Giraudo, A., Krall, J., Bavo, F., Nielsen, B., Kongstad, K. T., Rolando, B., De Blasio, R., Gloriam, D. E., Löffler, R., Thiesen, L., Harpsøe, K., Frydenvang, K., Boschi, D., Wellendorph, P., Lolli, M. L., Jensen, A. A. & Frølund, B., 27 Jun 2019, In: Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Identification of a novel scaffold for a small molecule GPR139 receptor agonist

  Nøhr, A. C., Shehata, M. A., Palmer, D., Pokhrel, R., Vallianou, M., Foster, S. R., Gentry, P. R., Gloriam, D. E. & Bräuner-Osborne, H., 7 Mar 2019, In: Scientific Reports. 9, 1, 10 p., 3802.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

  81 Downloads (Pure)

• Pharmacology and function of the orphan GPR139 G protein-coupled receptor

  Vedel, L., Nøhr, A. C., Gloriam, D. E. & Bräuner-Osborne, H., 27 May 2019, In: Basic & Clinical Pharmacology & Toxicology. 126, p. 35-46

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  15 Citations (Scopus)

  120 Downloads (Pure)

• Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands

  Gaiser, B. I., Danielsen, M., Marcher-Rørsted, E., Røpke Jørgensen, K., Wróbel, T. M., Frykman, M., Johansson, H., Bräuner-Osborne, H., Gloriam, D. E., Mathiesen, J. M. & Sejer Pedersen, D., 12 Sep 2019, In: Journal of Medicinal Chemistry. 62, 17, p. 7806-7839 34 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

  Malfacini, D., Patt, J., Annala, S., Harpsøe, K., Eryilmaz, F., Reher, R., Crüsemann, M., Hanke, W., Zhang, H., Tietze, D., Gloriam, D. E., Bräuner-Osborne, H., Strømgaard, K., König, G. M., Inoue, A., Gomeza, J. & Kostenis, E., 12 Apr 2019, In: The Journal of Biological Chemistry. 294, 15, p. 5747-5758

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  30 Citations (Scopus)

  127 Downloads (Pure)

• Receptor selectivity between the G proteins Gα ₁₂ and Gα ₁₃ is defined by a single leucine-to-isoleucine variation

  Mackenzie, A. E., Quon, T., Lin, L. C., Hauser, A. S., Jenkins, L., Inoue, A., Tobin, A. B., Gloriam, D. E., Hudson, B. D. & Milligan, G., 1 Apr 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 4, p. 5005-5017 13 p.

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• 2018

  5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

  Peng, Y., McCorvy, J. D., Harpsøe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajsen, L. F., Huang, X., Wu, Y., Shen, L., Bjørn-Yoshimoto, W. E., Ding, K., Wacker, D., Han, G. W., Cheng, J., Katritch, V., Jensen, A. A. & 6 others, Hanson, M. A., Zhao, S., Gloriam, D. E., Roth, B. L., Stevens, R. C. & Liu, Z., 2018, In: Cell. 172, 4, p. 719-730 P719-730.E14.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  175 Citations (Scopus)