Research output per year
Research output per year
Universitetsparken 5
2100 København Ø
Research activity per year
Updated 01/01/2019.
PERSONAL INFORMATION
Name: Dimitrios Stamou (DS)
Born: 24/03/1974 in Athens, Greece
Contact: stamoulab.com, [email protected], +45 2498 1658
ACADEMIC DEGREES & TRAINING
1992 – 1995 B.Sc. Hon. Physics, Awarded grade: A-, Leeds University (UK)
1996 – 2000 Ph.D. Physical Chemistry, Ecole Polytechnique Fédéral de Lausanne with Prof. H. Vogel (CH)
2000 – 2002 Postdoctoral Fellow, Ecole Polytechnique Fédéral de Lausanne (CH)
APPOINTMENTS
2010 - Professor of Bionanotechnology and Nanomedicine, Department of Chemistry, University of Copenhagen
2006 – 2010 Associate Professor, Department of Neuroscience and Pharmacology, University of Copenhagen
2004 – 2006 Assistant Professor, Department of Neuroscience and Pharmacology, University of Copenhagen
2004 – Member of the Nano-Science Center, University of Copenhagen
2002 – 2004 First Assistant (Subgroup Leader), Ecole Polytechnique Fédéral de Lausanne
LEADERSHIP & MANAGEMENT OF RESEARCH
2018 – 2024 Director of Center of Excellence for Geometrically Engineered Cellular Systems (60M DKK, Novo Nordisk Foundation)
2014 – 2018 PI of NABIIT council Frame grant (23 M DKK). Strategic research activity in collaboration with Novo Nordisk A/S.
2010 – 2015 Director of Center of Excellence for Biomembranes in Nanomedicine (35M DKK, Lundbeck Foundation).
2004 – DS established and directs the Bio-Nanotechnology and Nanomedicine Laboratory, University of Copenhagen (~210M DKK in external funding).
SELECTED POSITIONS OF TRUST & EDITORIAL WORK
2019 – 2021 European Science Foundation, College of Expert Reviewers
2019 – 2021 Editorial Advisory Board Member for the Journal of General Physiology (IF 3.8)
2017 – 2019 Editorial Board Member for the Biophysical Journal (IF 3.5).
2013 – 2018 Member of steering committee, Large Project, 90M DKK, Advanced Technology Foundation.
2009 – 2014 Member of steering committee, Center for Pharmaceutical Nanotechnology, 28M DKK, Danish Council for Strategic Research
2004 – Ad hoc reviewer of manuscripts for journals: Nat. Rev. Mol. Cell Biol.; Nat. Meth., Nat. Nanotech.; Nat. Struct. Mol. Biol.; Nat. Comm.; PNAS, Angew. Chem. Int. Ed.; Biophys. J.; J. Am. Chem. Soc.; Anal. Chem.; Soft Matter; Langmuir; Nanolett..
2004 – Ad hoc reviewer for grant agencies: National Science Foundation (USA), European Research Council, European Science Foundation, Netherlands Organisation for Scientific Research, Israel Science Foundations, CNRS.
SUPERVISION
Since 2005 DS has supervised 13 postdocs, and has graduated 12 PhD, 12 MSc and 16 BSc students.
RECENT INVITED PRESENTATIONS (selected out of >80 since 2006):
SELECTED AWARDS & HONORS
2019 Thomas E. Thompson Award, Biophysical Society
2017 Best research at Dept. of Chemistry, University of Copenhagen
2016 Torkil Holm, National Prize (50,000 DKK biannual award in all areas of chemical science)
2010 Annual Award of the Danish Biotechnology Society
COLLABORATORS (selected)
J. T. Groves, UC Berkley; B. Kobilka, Stanford University; D. Owen, Cambridge University; R. Jahn, Director Max Planck Gottingen; T. Ha, HHMI Investigator, Johns Hopkins; J. Mindell, NIH; M. Grabe, UC San Fransisco.
OUTREACH
Writing of popular texts, frequent press releases, interviews with national newspapers (e.g. Jyllands Posten, Politiken).
PUBLICATIONS
Since 1997, 69 publications have been accepted in peer reviewed journals including: Science (x3); Nat. Chem. Biol. (x4, two front covers); Nat. Nanotech.; Nat. Meth.; PNAS; EMBO J.; and Angew. Chem. Int. Ed. (x3, two front covers). Web of Science citation index indicates an average of 42 citations per paper and an H-index=31.
RESEARCHER ID
RESEARCH KEYWORDS
Membrane biophysics; membrane protein biophysics; membrane curvature; quantitative fluorescence microscopy; single molecule biology.
SELECTED PEER REVIEWED ARTICLES (* corresponding author)
Webpage: stamoulab.com
Dimitrios Stamou is a Professor in the Department of Chemistry and the Nanoscience Center at the University of Copenhagen. He received his primary education in Greece, and his Bachelor’s in Physics from Leeds University in England. During his PhD and postdoc at the Swiss Federal Polytechnique School in Lausanne, he worked on surface-patterning of self-assembled monolayers, bilayers and vesicles under the guidance of Claus Duschl and Horst Vogel. He established his own group at the University of Copenhagen in 2004 with a focus on the biophysics of membranes and membrane proteins.
Dimitrios has developed disruptive technologies that made significant contributions in two major fields:
Single molecule biology. In a breakthrough paper in Science (2016) he developed a method that resolved ionic currents with sensitivity 106-fold higher than the Nobel prize awarded method of patch clamp. These transformative studies enabled him to observe for the first time the function of single transporter molecules, and revealed that transporter function and regulation is controlled by long-lived on/off states (similarly to ion channels). In collaboration with the Groves lab, he reached a related conclusion, using a novel assay able to observe for the first time at the single molecule level the activation of the oncogene small GTPase Ras (Science 2014).
Membrane biophysics. To understand the origins and biological function of Membrane Polymorphism (the distinct shapes assumed by cells and cellular organelles), Dimitrios developed a series of methods investigate quantitatively membrane curvature/shape. One of the most important insights emerging from this work was identifying and characterizing two novel classes of membrane curvature sensors which are of ubiquitous biological and pharmacological importance: lipidated proteins (Nat. Chem. Biol. 2009, 2015a, 2015b) and G-protein coupled receptors (Nat. Chem. Biol. 2017).
Dimitrios also pioneered the development of methods to investigate individual proteoliposomes revealing that ensemble populations of proteoliposomes can be dramatically heterogeneous. He demonstrated that such heterogeneities can severely skew ensemble-average measurements of biophysical and biochemical proteoliposome properties, but also enable a new generation of high-throughput ultraminiaturised assays with 109-fold lower sample consumption (Nat. Nanotech. 2012; Nat. Meth. 2014).
Membrane biophysics; membrane protein biophysics; membrane curvature; quantitative fluorescence microscopy; single molecule biology.
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Review › Research › peer-review
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review