Research output per year
Research output per year
Personal profile
Short presentation
Staphylococcus aureus is the leading cause of bacterial infections in developed countries and Methicillin-Resistant S. aureus (MRSA) is one of the most significant antibiotic resistant bacteria world-wide. For this reason, my research is dedicated to unravel the molecular mechanisms underlying the ability of Staphylococcus aureus to cause disease and to develop antibiotic resistance. Focus has been on the highly conserved ClpP proteases and Clp chaperones that we have shown to be absolutely essential for the virulence of Staphylococcus aureus. We are currently investigating how the Clp proteases and chaperones central activities such as:
- Virulence gene regulation
- Antibiotic resistance
- Cell division
The long-term objective of my research is to provide the scientific basis for the development of drugs interfering with these mechanisms.
CV
Academic Degrees
cand. scient (1994) University of Copenhangen; Ph. D. (2000) KVL, Department of Food Science
Employments
2000-2003 Assistant professor at the Department of Veterinary Microbiology (KVL).
2003-present Associate professor at the Department of Veterinary Pathobiology KVL (from January the 1 st 2007 KU)
Keywords
- Faculty of Health and Medical Sciences
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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Lack of correlation between growth, stress, and virulence phenotypes in strains of Salmonella enterica serovar Enteritidis, S. Typhimurium DT104, S. 4,12, b:- and S. Liverpool
Olsen, J. E., Frees, D., Kyvsgaard, N. C. & Barco, L., 2024, In: Letters in Applied Microbiology. 77, 2, 9 p., ovae015.Research output: Contribution to journal › Journal article › Research › peer-review
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The ClpX chaperone and a hypermorphic FtsA variant with impaired self-interaction are mutually compensatory for coordinating Staphylococcus aureus cell division
Henriksen, C., Bæk, K. T., Wacnik, K., Gallay, C., Veening, J. W., Foster, S. J. & Frees, D., 2024, In: Molecular Microbiology. 121, 1, p. 98-115Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile19 Downloads (Pure) -
The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin-resistant Staphylococcus aureus
Nielsen, T. K., Petersen, I. B., Xu, L., Barbuti, M. D., Mebus, V., Justh, A., Alqarzaee, A. A., Jacques, N., Oury, C., Thomas, V., Kjos, M., Henriksen, C. & Frees, D., 2024, In: Antimicrobial Agents and Chemotherapy. 68, 6, 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Ticagrelor alters the membrane of Staphylococcus aureus and enhances the activity of vancomycin and daptomycin without eliciting cross-resistance
Leeten, K., Jacques, N., Esquembre, L. A., Schneider, D. C., Straetener, J., Henriksen, C., Musumeci, L., Putters, F., Melo, S., Sánchez-López, E., Giera, M., Penoy, N., Piel, G., Verlaine, O., Amoroso, A., Joris, B., Slavetinsky, C. J., Goffin, E., Pirotte, B. & Frees, D. & 3 others, , 2024, In: mBio. 15, 10, 20 p., e01322-24.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Downloads (Pure) -
A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology
Xu, L., Henriksen, C., Mebus, V., Guérillot, R., Petersen, A., Jacques, N., Jiang, J. H., Derks, R. J. E., Sánchez-López, E., Giera, M., Leeten, K., Stinear, T. P., Oury, C., Howden, B. P., Peleg, A. Y. & Frees, D., 2023, In: Antimicrobial Agents and Chemotherapy. 67, 6, 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)33 Downloads (Pure) -
Clinical Staphylococcus aureus inhibits human T-cell activity through interaction with the PD-1 receptor
Mellergaard, M., Skovbakke, S. L., Jepsen, S. D., Panagiotopoulou, N., Hansen, A. B. R., Tian, W., Lund, A., Høgh, R. I., Møller, S. H., Guérillot, R., Hayes, A. S., Erikstrup, L. T., Andresen, L., Peleg, A. Y., Larsen, A. R., Stinear, T. P., Handberg, A., Erikstrup, C., Howden, B. P. & Goletz, S. & 2 others, , 2023, In: mBio. 14, 5, 21 p., e01349-23.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)22 Downloads (Pure) -
A porcine model of subcutaneous Staphylococcus aureus infection: a pilot study
Nielsen, O. L., Mellergaard, M., Frees, D., Larsen, M. N., Skov, S., Olsen, L. H. & Reimann, M. J., 2022, In: APMIS - Journal of Pathology, Microbiology and Immunology. 130, 7, p. 359-370Research output: Contribution to journal › Journal article › Research › peer-review
3 Citations (Scopus) -
Finding New Fundamental Pieces for the Bacterial Cell Division Puzzle
Frees, D. & Ingmer, H., 2022, In: mBio. 13, 4, e0073722.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile35 Downloads (Pure)
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The ClpP proteases control processes of vital importance for the pathogenesis of Staphylococcus aureus
Frees, D. (Lecturer)
3 Oct 2007Activity: Talk or presentation types › Lecture and oral contribution
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Regulated proteolysis controls vital processes in Staphylococcus aureus
Frees, D. (Lecturer)
5 Sept 2007Activity: Talk or presentation types › Lecture and oral contribution
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Synthesis and activity of the alternative sigma factor, SigB is serely reduced in Staphylococcus aureus cells lacking the ClpP protease
Frees, D. (Lecturer)
23 May 2007Activity: Talk or presentation types › Lecture and oral contribution
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A possible role of ClpP proteases and chaperones in regulating activity of SigmaB
Frees, D. (Lecturer)
23 Jan 2007Activity: Talk or presentation types › Lecture and oral contribution
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Microbiology (Journal)
Frees, D. (Editor)
1 Jan 2007Activity: Peer-review and editorial work types › Peer review of manuscripts › Research
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FEMS Microbiology Letters (Journal)
Frees, D. (Editor)
1 Jan 2007Activity: Peer-review and editorial work types › Peer review of manuscripts › Research
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FEMS Immunology & Medical Microbiology (Journal)
Frees, D. (Editor)
1 Jan 2007Activity: Peer-review and editorial work types › Peer review of manuscripts › Research
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Journal of Applied Microbiology (Journal)
Frees, D. (Editor)
1 Jan 2007Activity: Peer-review and editorial work types › Peer review of manuscripts › Research