Research output per year
Research output per year
Personal profile
Short presentation
From Vancouver, Canada
BRIDGE fellow (Sept 2022-present), Department of Drug Design and Pharmacology, University of Copenhagen. Mentors: Drs. Niels H. Skotte and Jørgen E. Nielsen (Rigshospitalet). Project: Delineating neuroglial communication in health and Huntington's disease
Postdoc (Sept 2020-Aug 2022), Department of Drug Design and Pharmacology, University of Copenhagen. Supervisor: Prof. Hans Bräuner-Osborne, in collaboration with LF Prof. Shohreh Issazadeh-Navikas at BRIC. Project: In vivo role of GPR15 in T-cell mediated inflammation
PhD (MoMeD, Sept 2016-Oct 2021), Biotech Research and Innovation Centre, University of Copenhagen. Supervisor: Prof. Shohreh Issazadeh-Navikas, Project: Type-I interferon signaling in CNS homeostasis and Parkinson's disease dementia
Research technician, Centre of Molecular Medicine and Therapeutics (2012-2015). Supervisors: Drs. Michael Hayden and Amber Southwell. Projects: Behavioural and neuropathological charaterization of preclinical Huntington's disease mouse models
MSc in Biology, University of British Columbia Okanagan (2011). Supervisor: Dr. Andis Klegeris. Project: Impact of a glial-secreted proinflammatory phospholipase on neuronal health
BSc in Honours Health Studies, University of Waterloo (2008)
Primary fields of research
Neuroinflammation, Neurodegeneration, Parkinson's disease, Huntington's disease
Education/Academic qualification
Biology, Master of Science, Department of Biology, University of British Columbia Okanagan
2 Jan 2009 → 30 Apr 2011
Award Date: 30 Apr 2011
External positions
Research Technician, Centre for Molecular Medicine and Therapeutics at BC Children's Hospital Research, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.
5 Feb 2012 → 15 Dec 2015
Keywords
- BRIC
- Neuroinflammation
- Neurodegeneration
- Huntington's disease
- Parkinson's disease
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Neuronal TNFα, not α-syn, underlies PDD-like disease progression in IFNβ-KO mice
Villanueva, E. B., Tresse, E., Liu, Y., Duarte, J. N., Jimenez-Duran, G., Ejlerskov, P., Kretz, O., Loreth, D., Goldmann, T., Prinz, M. & Issazadeh-Navikas, S., 2021, In: Annals of Neurology. 90, 5, p. 789-807Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)66 Downloads (Pure) -
ANTIBODIES INHIBIT CELL TO CELL TRANSMISSION OF MUTANT HTT
Bartl, S., Oueslati, A., Southwell, A. L., Parth, M., Salhat, N., Siddu, A., Burkert, M., Pankevych, H., David, L., Villanueva, E. B., Xie, Y., Dal Cengio, L., Ko, S., Hayden, M. R., Cicchetti, F. & Smrzka, O. W., Sep 2018, p. A91-A91.Research output: Contribution to conference › Poster › Research
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HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo
Ehrnhoefer, D. E., Southwell, A. L., Sivasubramanian, M., Qiu, X., Villanueva, E. B., Xie, Y., Waltl, S., Anderson, L., Fazeli, A., Casal, L., Felczak, B., Tsang, M. & Hayden, M. R., 15 Jan 2018, In: Human Molecular Genetics. 27, 2, p. 239-253 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
26 Citations (Scopus) -
Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease
Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, N. H., Parsons, M. P., Villanueva, E. B., Caron, N. S., Østergaard, M. E., Anderson, L. M., Xie, Y., Cengio, L. D., Findlay-Black, H., Doty, C. N., Fitsimmons, B., Swayze, E. E., Seth, P. P., Raymond, L. A., Frank Bennett, C. & Hayden, M. R., 2018, In: Science Translational Medicine. 10, 461, p. 1-12 eaar3959.Research output: Contribution to journal › Journal article › Research › peer-review
94 Citations (Scopus) -
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
Southwell, A. L., Skotte, N. H., Villanueva, E. B., Østergaard, M. E., Gu, X., Kordasiewicz, H. B., Kay, C., Cheung, D., Xie, Y., Waltl, S., Dal Cengio, L., Findlay-Black, H., Doty, C. N., Petoukhov, E., Iworima, D., Slama, R., Ooi, J., Pouladi, M. A., Yang, X. W., Swayze, E. E. & 2 others, , 15 Mar 2017, In: Human Molecular Genetics. 26, 6, p. 1115-1132 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
25 Citations (Scopus) -
An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes
Southwell, A. L., Smith-Dijak, A., Kay, C., Sepers, M., Villanueva, E. B., Parsons, M. P., Xie, Y., Anderson, L., Felczak, B., Waltl, S., Ko, S., Cheung, D., Dal Cengio, L., Slama, R., Petoukhov, E., Raymond, L. A. & Hayden, M. R., 1 Sep 2016, In: Human Molecular Genetics. 25, 17, p. 3654-3675 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
70 Citations (Scopus) -
Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease
Southwell, A. L., Franciosi, S., Villanueva, E. B., Xie, Y., Winter, L. A., Veeraraghavan, J., Jonason, A., Felczak, B., Zhang, W., Kovalik, V., Waltl, S., Hall, G., Pouladi, M. A., Smith, E. S., Bowers, W. J., Zauderer, M. & Hayden, M. R., Apr 2015, In: Neurobiology of Disease. 76, p. 46-56 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
86 Citations (Scopus) -
Therapeutic Potential of Cannabinoids in the Treatment of Neuroinflammation Associated with Parkinson's Disease
Villanueva, E. B., Little, J. P. & Klegeris, A., 30 Nov 2015, Recent Advances in Medicinal Chemistry. Atta-ur-Rahman, Choudhary, M. I. & Perry, G. (eds.). Bentham Science Publishers, p. 59-75Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review