Erika Villanueva

Research output

Research output per year 2010 2010 2011 2013 2014 2015 2018 2021

• 975 Citations
• 17 Journal article
• 1 Book chapter
• 1 Poster
• 1 Review

Research output per year

Research output per year

Search results

• 2021

  Neuronal TNFα, not α-syn, underlies PDD-like disease progression in IFNβ-KO mice

  Villanueva, E. B., Tresse, E., Liu, Y., Duarte, J. N., Jimenez-Duran, G., Ejlerskov, P., Kretz, O., Loreth, D., Goldmann, T., Prinz, M. & Issazadeh-Navikas, S., 2021, In: Annals of Neurology. 90, 5, p. 789-807

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Citations (Scopus)

  66 Downloads (Pure)
• 2018

  ANTIBODIES INHIBIT CELL TO CELL TRANSMISSION OF MUTANT HTT

  Bartl, S., Oueslati, A., Southwell, A. L., Parth, M., Salhat, N., Siddu, A., Burkert, M., Pankevych, H., David, L., Villanueva, E. B., Xie, Y., Dal Cengio, L., Ko, S., Hayden, M. R., Cicchetti, F. & Smrzka, O. W., Sep 2018, p. A91-A91.

  Research output: Contribution to conference › Poster › Research

• HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

  Ehrnhoefer, D. E., Southwell, A. L., Sivasubramanian, M., Qiu, X., Villanueva, E. B., Xie, Y., Waltl, S., Anderson, L., Fazeli, A., Casal, L., Felczak, B., Tsang, M. & Hayden, M. R., 15 Jan 2018, In: Human Molecular Genetics. 27, 2, p. 239-253 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease

  Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, N. H., Parsons, M. P., Villanueva, E. B., Caron, N. S., Østergaard, M. E., Anderson, L. M., Xie, Y., Cengio, L. D., Findlay-Black, H., Doty, C. N., Fitsimmons, B., Swayze, E. E., Seth, P. P., Raymond, L. A., Frank Bennett, C. & Hayden, M. R., 2018, In: Science Translational Medicine. 10, 461, p. 1-12 eaar3959.

  Research output: Contribution to journal › Journal article › Research › peer-review
  94 Citations (Scopus)
• 2017

  A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

  Southwell, A. L., Skotte, N. H., Villanueva, E. B., Østergaard, M. E., Gu, X., Kordasiewicz, H. B., Kay, C., Cheung, D., Xie, Y., Waltl, S., Dal Cengio, L., Findlay-Black, H., Doty, C. N., Petoukhov, E., Iworima, D., Slama, R., Ooi, J., Pouladi, M. A., Yang, X. W., Swayze, E. E. & 2 others, Seth, P. P. & Hayden, M. R., 15 Mar 2017, In: Human Molecular Genetics. 26, 6, p. 1115-1132 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)
• 2016

  An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

  Southwell, A. L., Smith-Dijak, A., Kay, C., Sepers, M., Villanueva, E. B., Parsons, M. P., Xie, Y., Anderson, L., Felczak, B., Waltl, S., Ko, S., Cheung, D., Dal Cengio, L., Slama, R., Petoukhov, E., Raymond, L. A. & Hayden, M. R., 1 Sep 2016, In: Human Molecular Genetics. 25, 17, p. 3654-3675 22 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  70 Citations (Scopus)
• 2015

  Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease

  Southwell, A. L., Franciosi, S., Villanueva, E. B., Xie, Y., Winter, L. A., Veeraraghavan, J., Jonason, A., Felczak, B., Zhang, W., Kovalik, V., Waltl, S., Hall, G., Pouladi, M. A., Smith, E. S., Bowers, W. J., Zauderer, M. & Hayden, M. R., Apr 2015, In: Neurobiology of Disease. 76, p. 46-56 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  86 Citations (Scopus)

• Therapeutic Potential of Cannabinoids in the Treatment of Neuroinflammation Associated with Parkinson's Disease

  Villanueva, E. B., Little, J. P. & Klegeris, A., 30 Nov 2015, Recent Advances in Medicinal Chemistry. Atta-ur-Rahman, Choudhary, M. I. & Perry, G. (eds.). Bentham Science Publishers, p. 59-75

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression

  Southwell, A. L., Smith, S. E. P., Davis, T. R., Caron, N. S., Villanueva, E. B., Xie, Y., Collins, J. A., Ye, M. L., Sturrock, A., Leavitt, B. R., Schrum, A. G. & Hayden, M. R., 15 Jul 2015, In: Scientific Reports. 5, p. 12166

  Research output: Contribution to journal › Journal article › Research › peer-review
  79 Citations (Scopus)
• 2014

  In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides

  Southwell, A. L., Skotte, N. H., Kordasiewicz, H. B., Østergaard, M. E., Watt, A. T., Carroll, J. B., Doty, C. N., Villanueva, E. B., Petoukhov, E., Vaid, K., Xie, Y., Freier, S. M., Swayze, E. E., Seth, P. P., Bennett, C. F. & Hayden, M. R., Dec 2014, In: Molecular Therapy. 22, 12, p. 2093-106 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  114 Citations (Scopus)

• Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia

  Little, J. P., Simtchouk, S., Schindler, S. M., Villanueva, E. B., Gill, N. E., Walker, D. G., Wolthers, K. R. & Klegeris, A., May 2014, In: Molecular and Cellular Neuroscience. 60, p. 88-96 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  59 Citations (Scopus)
• 2013

  A fully humanized transgenic mouse model of Huntington disease

  Southwell, A. L., Warby, S. C., Carroll, J. B., Doty, C. N., Skotte, N. H., Zhang, W., Villanueva, E. B., Kovalik, V., Xie, Y., Pouladi, M. A., Collins, J. A., Yang, X. W., Franciosi, S. & Hayden, M. R., 1 Jan 2013, In: Human Molecular Genetics. 22, 1, p. 18-34 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  82 Citations (Scopus)

• Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS

  Østergaard, M. E., Southwell, A. L., Kordasiewicz, H., Watt, A. T., Skotte, N. H., Doty, C. N., Vaid, K., Villanueva, E. B., Swayze, E. E., Bennett, C. F., Hayden, M. R. & Seth, P. P., Nov 2013, In: Nucleic Acids Research. 41, 21, p. 9634-50 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  129 Citations (Scopus)
• 2012

  Secreted phospholipase A2 group IIA is a neurotoxin released by stimulated human glial cells

  Villanueva, E. B., Little, J. P., Lambeau, G. & Klegeris, A., 2012, In: Molecular and Cellular Neuroscience.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)
• 2011

  Cultured adult porcine astrocytes and microglia express functional interferon-γ receptors and exhibit toxicity towards SH-SY5Y cells

  Ionescu, V. A., Villanueva, E. B., Hashioka, S., Bahniwal, M. & Klegeris, A., 28 Feb 2011, In: Brain Research Bulletin. 84, 3, p. 244-51 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: human cell culture studies

  Bahniwal, M., Villanueva, E. B. & Klegeris, A., Apr 2011, In: Journal of Neuroimmunology. 233, 1-2, p. 65-72 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Therapeutic potential of cannabinoids in the treatment of neuroinflammation associated with Parkinson's disease

  Little, J. P., Villanueva, E. B. & Klegeris, A., Jun 2011, In: Mini reviews in medicinal chemistry. 11, 7, p. 582-90 9 p.

  Research output: Contribution to journal › Review › Research › peer-review
  24 Citations (Scopus)

• Therapeutic Potential of Cannabinoids in the Treatment of Neuroinflammation Associated with Parkinsons Disease

  Little, J. P., Villanueva, E. B. & Klegeris, A., 1 Jun 2011, In: Mini-Reviews in Medicinal Chemistry.

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2010

  Synthesis and biological evaluation of novel pyrazole compounds

  Youssef, A. M., Neeland, E. G., Villanueva, E. B., White, M. S., El-Ashmawy, I. M., Patrick, B., Klegeris, A. & Abd-El-Aziz, A. S., 1 Aug 2010, In: Bioorganic & Medicinal Chemistry. 18, 15, p. 5685-96 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  41 Citations (Scopus)

• Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents

  Youssef, A. M., White, M. S., Villanueva, E. B., El-Ashmawy, I. M. & Klegeris, A., 1 Mar 2010, In: Bioorganic & Medicinal Chemistry. 18, 5, p. 2019-28 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  106 Citations (Scopus)