Research output per year
Research output per year
Personal profile
Short presentation
As an Assistant Professor in the Protein Analysis Group, I will continue to develop structural mass spectrometry methods, especially hydrogen-deuterium exchange mass spectrometry (HDX-MS) and cross-linking mass spectrometry (XL-MS), to investigate the in-solution conformational dynamics and structures of challenging protein systems.
The main biological focus of my research will be the interaction between peptide-antigen loaded major histocompatibility complex (pMCH) and the T-cell receptor (TCR). An interaction that is essential for the human immune system.
Group webpage:
https://pharmacy.ku.dk/research/protein-analysis-group/
Primary fields of research
- Analysis of the primary and higher-order structure of proteins by LC-MS/MS
- Identification of protein-protein interaction sites
- Higher-order structure elucidation of proteins by hydrogen/deuterium exchange followed by mass spectrometry (HDX-MS)
- Epitope mapping of antibodies by HDX-MS
- Higher-order structure elucidation of proteins by cross linking mass spectrometry (CX-MS)
- Development of the HDX-MS and XL-MS methods
- Upstream and downstream processing of therapeutic proteins.
Keywords
- Former Faculty of Pharmaceutical Sciences
- HDX-MS
- Biopharmaceuticals
- Protein-Protein Interactions
- LC-MS
- LC-MS/MS
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Translation of a practical laboratory exercise into a theoretical laboratory exercise
Trabjerg, E., 2022, In: Improving University Science Teaching and Learning - Pedagogical Projects. 17, p. 119-130Research output: Contribution to journal › Journal article › Research › peer-review
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pH Dependence of Succinimide-Ester-Based Protein Cross-Linking for Structural Mass Spectrometry Applications
Trabjerg, E., Keller, A. & Leitner, A., 2021, (E-pub ahead of print) In: ACS Measurement Science Au. 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Probing the Conformational Dynamics of Affinity-Enhanced T Cell Receptor Variants upon Binding the Peptide-Bound Major Histocompatibility Complex by Hydrogen/Deuterium Exchange Mass Spectrometry
Merkle, P. S., Trabjerg, E., Hongjian, S., Ferber, M., Cuendet, M. A., Jorgensen, T. J. D., Luescher, I., Irving, M., Zoete, V., Michielin, O. & Rand, K. D., 2021, In: Biochemistry. 60, 11, p. 859-872Research output: Contribution to journal › Journal article › Research › peer-review
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An intact C-terminal end of albumin is required for its long half-life in humans
Nilsen, J., Trabjerg, E., Grevys, A., Azevedo, C., Brennan, S. O., Stensland, M., Wilson, J., Sand, K. M. K., Bern, M., Dalhus, B., Roopenian, D. C., Sandlie, I., Rand, K. D. & Andersen, J. T., 20 Apr 2020, In: Communications Biology. 3, 1, 11 p., 181.Research output: Contribution to journal › Journal article › Research › peer-review
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A post-translational modification of human Norovirus capsid protein attenuates glycan binding
Mallagaray, A., Creutznacher, R., Dülfer, J., Mayer, P. H. O., Grimm, L. L., Orduña, J. M., Trabjerg, E., Stehle, T., Rand, K. D., Blaum, B. S., Uetrecht, C. & Peters, T., 21 Mar 2019, In: Nature Communications. 10, 1, 14 p., 1320.Research output: Contribution to journal › Journal article › peer-review
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Assessment of chemical-crosslink-assisted protein structure modeling in CASP13
Fajardo, J. E., Shrestha, R., Gil, N., Belsom, A., Crivelli, S. N., Czaplewski, C., Fidelis, K., Grudinin, S., Karasikov, M., Karczyńska, A. S., Kryshtafovych, A., Leitner, A., Liwo, A., Lubecka, E. A., Monastyrskyy, B., Pagès, G., Rappsilber, J., Sieradzan, A. K., Sikorska, C., Trabjerg, E. & 1 others, , 1 Dec 2019, In: Proteins: Structure, Function and Bioinformatics. 87, 12, p. 1283-1297 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Investigating the Conformational Response of the Sortilin Receptor upon Binding Endogenous Peptide- and Protein Ligands by HDX-MS
Trabjerg, E., Abu-Asad, N., Wan, Z., Kartberg, F., Christensen, S. & Rand, K. D., 2 Jul 2019, In: Structure. 27, 7, p. 1103-1113.e3Research output: Contribution to journal › Journal article › Research › peer-review
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The First Community-Wide, Comparative Cross-linking Mass Spectrometry Study
Iacobucci, C., Piotrowski, C., Aebersold, R., Amaral, B. C., Andrews, P. C., Bernfur, K., Borchers, C. H., Brodie, N. I., Bruce, J. E., Cao, Y., Chaignepain, S., Chavez, J. D., Claverol, S., Cox, J., Davis, T. N., Degliesposti, G., Dong, M-Q., Edinger, N., Emanuelsson, C., Gay, M. & 53 others, , 2 May 2019, In: Analytical Chemistry. 91, 11, p. 6953-6961Research output: Contribution to journal › Journal article › Research › peer-review
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