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Glycosaminoglycans are clinically used heterogeneous polysaccharides drugs derived from animal sources. Miller R. Group works on applying genetic engineering of the GAG biosynthetic pathway in cells to generate materials that can be used to systematically develop instrumentation, such as mass spectrometry and single-molecule methods. Characterisation of the glycosaminoglycan sulfation code with its function paves the way for the development of sustainable lab-derived homogenous glycosaminoglycan drugs.
Collaborations and top research areas from the last five years
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Discovery of a secreted <i>Bacteroides fragilis</i> mucinase that cleaves mucins with bis-T O-glycans through a carbohydrate binding module-dependent mechanism
Narimatsu, Y., Pleguezuelos-Manzano, C., Hornikx, D., Goerdeler, F., Jaroentomeechai, T., Flores, K., Narimatsu, S., Boot, C., Hansen, L., Durbesson, F., Vincentelli, R., Comstock, L., Clevers, H., Taleb, V., Corzana, F., Henrissat, B., Clausen, H., Hurtado-Guerrero, R. & Bull, C., 2026, In: Gut Microbes. 18, 1, 25 p., 2644983.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Downloads (Pure) -
Presentation Is Essential for Glycan-Lectin Recognition at the Molecular and Cellular Levels: The Interaction of Tumor-Associated O-Glycans with the Macrophage Galactose-Type Lectin
Grosso, A. S., Diniz, A., Soares, C. O., Goerdeler, F., Gimeno, A., Coelho, P., Coelho, H., Lima, C. D. L., Pinheiro, B., Lete, M. G., Garcia-Martin, F., Jaroentomeechai, T., Gomes, J., Reis, C. A., Westerlind, U., Corzana, F., Palma, A. S., Clausen, H., Jimenez-Barbero, J. & Van Vliet, S. J. & 2 others, , 2026, In: JACS Au. 6, 1, p. 82-94Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Downloads (Pure) -
Bifunctional Cysteine-Engineered CAR-T Cells Enable Thiol-Mediated Targeting to Overcome Antigen Escape in B Cell Lymphoma
Luehle, J., Krost, S., Goerdeler, F., Valenti, A., Shanin, E., Seitz, C., Seeberger, P. H. & Moscovitz, O., 2025, (E-pub ahead of print) In: ACS Central Science. 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access2 Citations (Scopus) -
Microbial binding module employs sophisticated clustered saccharide patches to selectively adhere to mucins
Jaroentomeechai, T., Veloz, B., Soares, C. O., Goerdeler, F., Grosso, A. S., Büll, C., Miller, R. L., Furukawa, S., Ginés-Alcober, I., Taleb, V., Merino, P., Ghirardello, M., Compañón, I., Coelho, H., Dias, J. S., Vincentelli, R., Henrissat, B., Joshi, H., Clausen, H. & Corzana, F. & 3 others, , 2025, In: Nature Communications. 16, 1, 14 p., 9058.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)5 Downloads (Pure) -
Siglec-7 and-15 recognize repeated clustered sulfo-sialo O-glycan motifs on select O-glycoproteins
Goerdeler, F., Narimatsu, Y., Hornikx, D. L. A. H., Chien, Y.-C., De Wit, D., Jaroentomeechai, T., Jaeger, M., Furukawa, S., Tseng, H.-C., Jung, J., Schmidt, E. N., Khoo, K.-H., Miller, R. L., Macauley, M. S., Clausen, H. & Bull, C., 2025, In: Glycobiology. 35, 11, p. 68-68 PT11-025.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Vibrio MARTX toxin binding of biantennary N-glycans at host cell surfaces
Chen, J., Goerdeler, F., Jaroentomeechai, T., Hernandez, F. X. S., Wang, X., Clausen, H., Narimatsu, Y. & Satchell, K. J. F., 2025, In: Science Advances. 11, 15, 13 p., eadt0063.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)11 Downloads (Pure) -
Mammalian cell-based production of glycans, glycopeptides and glycomodules
Jaroentomeechai, T., Karlsson, R., Goerdeler, F., Teoh, F. K. Y., Grønset, M. N., de Wit, D., Chen, Y.-H., Furukawa, S., Psomiadou, V., Hurtado-Guerrero, R., Vidal-Calvo, E. E., Salanti, A., Boltje, T. J., van den Bos, L. J., Wunder, C., Johannes, L., Schjoldager, K. T., Joshi, H. J., Miller, R. L. & Clausen, H. & 2 others, , 2024, In: Nature Communications. 15, 1, 16 p., 9668.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile9 Citations (Scopus)33 Downloads (Pure) -
Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate
Vidal-Calvo, E. E., Martin-Salazar, A., Choudhary, S., Dagil, R., Raghavan, S. S. R., Duvnjak, L., Nordmaj, M. A., Clausen, T. M., Skafte, A., Oberkofler, J., Wang, K., Agerbæk, M. Ø., Løppke, C., Jørgensen, A. M., Ropac, D., Mujollari, J., Willis, S., Garcias López, A., Miller, R. L. & Karlsson, R. T. G. & 21 others, , 2024, In: Nature Communications. 15, 1, 20 p., 7553.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile16 Citations (Scopus)71 Downloads (Pure)