Research output per year
Research output per year
Personal profile
Short presentation
Fena Ochs received her Ph.D. in 2018 from the Novo Nordisk Foundation Centre for Protein Research at the University of Copenhagen. Her doctoral dissertation under supervision of Prof Jiri Lukas described a novel role for the tumour suppressor 53BP1 in control of homology-directed repair and identified a tight interconnection between 3D chromatin organization and the DNA damage response. Dr. Ochs joined the laboratory of Prof Kim Nasmyth at the University of Oxford in 2019, where her research illuminated the role of cohesin complexes in 3D chromatin organization. Fena’s background is in cutting-edge microscopy technologies, including high-content and live-3D-Structured Illumination super-resolution microscopy. In 2023, Fena was appointed Associate Professor and group leader at BRIC.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Sister chromatid cohesion is mediated by individual cohesin complexes
Ochs, F., Green, C., Szczurek, A. T., Pytowski, L., Kolesnikova, S., Brown, J., Gerlich, D. W., Buckle, V., Schermelleh, L. & Nasmyth, K. A., 2024, In: Science. 383, 6687, p. 1122-1130 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
11 Citations (Scopus) -
Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells
Groelly, F. J., Dagg, R. A., Petropoulos, M., Rossetti, G. G., Prasad, B., Panagopoulos, A., Paulsen, T., Karamichali, A., Jones, S. E., Ochs, F., Dionellis, V. S., Puig Lombardi, E., Miossec, M. J., Lockstone, H., Legube, G., Blackford, A. N., Altmeyer, M., Halazonetis, T. D. & Tarsounas, M., 2022, In: Molecular Cell. 82, 18, p. 3382-3397.e7Research output: Contribution to journal › Journal article › Research › peer-review
Open Access33 Citations (Scopus) -
Replication Labeling Methods for Super-Resolution Imaging of Chromosome Territories and Chromatin Domains
Miron, E., Windo, J., Ochs, F. & Schermelleh, L., 2022, Chromosome Architecture. Leake, M. C. (ed.). 2 ed. Springer, p. 111-128 18 p. (Methods in Molecular Biology, Vol. 2476).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
Ercilla, A., Benada, J., Amitash, S., Zonderland, G., Baldi, G., Somyajit, K., Ochs, F., Costanzo, V., Lukas, J. & Toledo, L., 2020, In: Cell Reports. 30, 7, p. 2416-2429.e7 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile48 Citations (Scopus)184 Downloads (Pure) -
Stabilization of chromatin topology safeguards genome integrity
Ochs, F., Karemore, G., Miron, E., Brown, J., Sedlackova, H., Rask, M.-B., Lampe, M., Buckle, V., Schermelleh, L., Lukas, J. & Lukas, C., 2019, In: Nature. 574, 7779, p. 571-574 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile132 Citations (Scopus)135 Downloads (Pure) -
Redox-sensitive alteration of replisome architecture safeguards genome integrity
Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, F., Rask, M.-B., Choudhary, C. & Lukas, J., 10 Nov 2017, In: Science. 358, 6364, p. 797-802 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile135 Citations (Scopus)59 Downloads (Pure) -
53BP1 fosters fidelity of homology-directed DNA repair
Ochs, F., Somyajit, K., Altmeyer, M., Rask, M.-B. D., Lukas, J. & Lukas, C., Aug 2016, In: Nature Structural and Molecular Biology. 23, 8, p. 714-21 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
177 Citations (Scopus) -
Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks
Sotiriou, S. K., Kamileri, I., Lugli, N., Evangelou, K., Da-Ré, C., Huber, F., Padayachy, L., Tardy, S., Nicati, N. L., Barriot, S., Ochs, F., Lukas, C., Lukas, J., Gorgoulis, V. G., Scapozza, L. & Halazonetis, T. D., 15 Dec 2016, In: Molecular Cell. 64, 6, p. 1127-1134 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access208 Citations (Scopus)