Research output per year
Research output per year
- 35 results
Search results
-
2023
Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors
Zang, J., Peters, F., Cambet, Y., Cifuentes-Pagano, E., Hissabu, M. M. S., Dustin, C. M., Svensson, L. H., Olesen, M. M., Poulsen, M. F. L., Jacobsen, S., Tuelung, P. S., Narayanan, D., Langkilde, A. E., Gajhede, M., Pagano, P. J., Jaquet, V., Vilhardt, F. & Bach, A., 2023, In: Journal of Medicinal Chemistry. 66, 21, p. 14963–15005Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Translocator protein (TSPO) expression in neoplastic cells and tumor-associated macrophages in meningiomas
Blum, N., Mirian, C., Maier, A. D., Mathiesen, T. I., Vilhardt, F. & Haslund-Vinding, J. L., 2023, In: Journal of Neuropathology and Experimental Neurology. 82, 12, p. 1020-1032 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2022
Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure
Oernbo, E. K., Steffensen, A. B., Khamesi, P. R., Toft-Bertelsen, T. L., Barbuskaite, D., Vilhardt, F., Gerkau, N. J., Tritsaris, K., Simonsen, A. H., Lolansen, S. D., Andreassen, S. N., Hasselbalch, S. G., Zeuthen, T., Rose, C. R., Kurtcuoglu, V. & MacAulay, N., 2022, In: Fluids and Barriers of the CNS. 19, 1, 25 p., 65.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile22 Citations (Scopus)29 Downloads (Pure) -
Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters
Lolansen, S. D., Rostgaard, N., Barbuskaite, D., Capion, T., Olsen, M. H., Norager, N. H., Vilhardt, F., Andreassen, S. N., Toft-Bertelsen, T. L., Ye, F., Juhler, M., Keep, R. F. & MacAulay, N., 2022, In: Fluids and Barriers of the CNS. 19, 1, 19 p., 62.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile23 Citations (Scopus)18 Downloads (Pure) -
The role of systemic inflammatory cells in meningiomas
Haslund-Vinding, J., Møller, J. R., Ziebell, M., Vilhardt, F. & Mathiesen, T., 2022, In: Neurosurgical Review. 45, p. 1205–1215Research output: Contribution to journal › Review › Research › peer-review
12 Citations (Scopus) -
α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α
Borland, H., Rasmussen, I., Bjerregaard-Andersen, K., Rasmussen, M., Olsen, A. & Vilhardt, F., 2022, In: The Journal of Biological Chemistry. 298, 11, 20 p., 102531.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile14 Downloads (Pure) -
2021
Meningioma–brain crosstalk: A scoping review
de Stricker Borch, J., Haslund-Vinding, J., Vilhardt, F., Maier, A. D. & Mathiesen, T., 2021, In: Cancers. 13, 17, 4267.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile13 Citations (Scopus)30 Downloads (Pure) -
Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington’s Disease?
Villegas, L., Nørremølle, A., Freude, K. & Vilhardt, F., 2021, In: Frontiers in Aging Neuroscience. 13, 20 p., 736734.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile31 Downloads (Pure) -
Novel and converging ways of NOX2 and SOD3 in trafficking and redox signaling in macrophages
Petersen, S. V., Poulsen, N. B., Matthiesen, C. L. & Vilhardt, F., 2021, In: Antioxidants. 10, 2, p. 1-16 16 p., 172.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile25 Downloads (Pure) -
The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus
Jorgensen, A. S., Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, K. L., Moussouras, N. A., Vilhardt, F., Kalinski, P., Basse, P., Chen, Y-H., Yang, Z., Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, P. J., Lahl, K., Goth, C. K., Rosenkilde, M. M. & Hjorto, G. M., 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Citations (Scopus)22 Downloads (Pure) -
2019
Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration
Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, T. L., Tritsaris, K., Vilhardt, F., Brodin, B. & MacAulay, N., 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512Research output: Contribution to journal › Journal article › Research › peer-review
Open Access10 Citations (Scopus) -
The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response
Hu, L., Zachariae, E. D., Larsen, U. G., Vilhardt, F. & Petersen, S. V., 2019, In: Redox Biology. 26, 9 p., 101268.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile18 Citations (Scopus)142 Downloads (Pure) -
2018
The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development
Rasmussen, K. K., Skat-Rørdam, J., Andersen, P., Warzecha, C. B., Pye, M., Andersen, T. A., Ajbro, K. D., Bendsen, E., Narimatsu, M., Vilhardt, F., Pedersen, L. B., Wrana, J. L., Anderson, R. H., Møllgård, K., Christensen, S. T. & Larsen, L. A., 2018, In: Scientific Reports. 8, 1, 14 p., 9542.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile22 Citations (Scopus)193 Downloads (Pure) -
2017
Microglia antioxidant systems and redox signaling
Vilhardt, F., Haslund-Vinding, J., Jaquet, V. & McBean, G., Jun 2017, In: British Journal of Pharmacology. 174, 12, p. 1719-1732 14 p.Research output: Contribution to journal › Review › Research › peer-review
96 Citations (Scopus) -
NADPH oxidases in Microglia oxidant production: Activating Receptors, Pharmacology, and Association with Disease
Haslund-Vinding, J., McBean, G., Jaquet, V. & Vilhardt, F., Jun 2017, In: British Journal of Pharmacology. 174, 12, p. 1733-1749 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
113 Citations (Scopus) -
Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds
Borland, H. & Vilhardt, F., 2017, In: International Journal of Molecular Sciences (Online). 18, 1, 227.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile21 Citations (Scopus)184 Downloads (Pure) -
Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
Rahbek-Clemmensen, T., Lycas, M. D., Erlendsson, S., Eriksen, J., Apuschkin, M., Vilhardt, F., Jorgensen, T. N., Hansen, F. H. & Gether, U., 2017, In: Nature Communications. 8, 14 p., 740.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile59 Citations (Scopus)599 Downloads (Pure) -
The α2β2 isoform combination dominates the astrocytic Na+/K+-ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation
Stoica, A., Larsen, B. R., Assentoft, M., Holm, R., Holt, L. M., Vilhardt, F., Vilsen, B., Lykke-Hartmann, K., Olsen, M. L. & Macaulay, N., 2017, In: Glia. 65, 11, p. 1777-1793 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
42 Citations (Scopus) -
2016
Reciprocal signals between microglia and neurons regulate alpha-synuclein secretion by exophagy through a neuronal cJU-N-Nterminal kinase-signaling axis
Christensen, D. P., Ejlerskov, P., Rasmussen, I. & Vilhardt, F., 8 Mar 2016, In: Journal of Neuroinflammation. 13, 21 p., 59.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile20 Citations (Scopus)344 Downloads (Pure) -
2015
Macropinocytosis is the Entry Mechanism of Amphotropic Murine Leukemia Virus
Rasmussen, I. & Vilhardt, F., Feb 2015, In: Journal of Virology. 89, 3, p. 1851-1866 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access20 Citations (Scopus) -
2013
Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion
Ejlerskov, P., Rasmussen, I., Nielsen, T. T., Bergström, A-L., Tohyama, Y., Jensen, P. H. & Vilhardt, F., 14 Jun 2013, In: The Journal of Biological Chemistry. 288, 24, p. 17313-35 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
177 Citations (Scopus) -
2012
NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages
Ejlerskov, P., Christensen, D. P., Beyaie, D., Burritt, J. B., Paclet, M-H., Gorlach, A., van Deurs, B. & Vilhardt, F., Feb 2012, In: Journal of Biological Chemistry. 287, 7, p. 4835-52 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
30 Citations (Scopus) -
2011
Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats
Hultqvist, M., Sareila, O., Vilhardt, F., Norin, U., Olsson, L. M., Olofsson, P., Hellman, U. & Holmdahl, R., 15 Jun 2011, In: Antioxidants & Redox Signaling. 14, 12, p. 2373-83 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
27 Citations (Scopus) -
2010
Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia
Rasmussen, I., Pedersen, L. H., Byg, L., Suzuki, K., Sumimoto, H. & Vilhardt, F., 1 Sep 2010, In: B M C Immunology. 11, p. 44Research output: Contribution to journal › Journal article › Research › peer-review
46 Citations (Scopus) -
Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells
Parhamifar, L., Sime, W., Yudina, Y., Vilhardt, F., Mörgelin, M. & Sjölander, A., 1 Dec 2010, In: PLoS ONE. 5, 12, p. e14439Research output: Contribution to journal › Journal article › Research › peer-review
26 Citations (Scopus) -
2008
Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis.
Roepstorff, K., Rasmussen, I. Z., Sawada, M., Cudre-Maroux, C., Salmon, P., Bokoch, G., van Deurs, B. & Vilhardt, F., 2008, In: Journal of Biological Chemistry. 283, 12, p. 7983-93 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
48 Citations (Scopus) -
2006
The role of caveolae and noncaveolar rafts in endocytosis
van Deurs, B., Vilhardt, F., Torgersen, M., Roepstorff, K., Hommelgaard, A. M. & Sandvig, K., 2006, Lipid Rafts and caveolae. Wiley-VCH, p. 69-89Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
1 Citation (Scopus) -
2005
Caveolae: Stable Membrane Domains with a Potential for Internalization
Hommelgaard, A. M., Roepstorff, K., Vilhardt, F., Torgersen, M. L., Sandvig, K. & van Deurs, B., 2005, In: Traffic. 6, 9, p. 720-724Research output: Contribution to journal › Journal article › Research › peer-review
94 Citations (Scopus) -
Microglia: phagocyte and glia cell
Vilhardt, F., 2005, In: International Journal of Biochemistry & Cell Biology. 37, p. 17-21Research output: Contribution to journal › Journal article › Research › peer-review
207 Citations (Scopus) -
Retroviral display of urokinase-binding domain fused to amphotropic envelope protein
Boucquey, A., Vilhardt, F., Franco, D., Weber, A. & Horellou, P., 2005, In: Biochemical and Biophysical Research Communications. 331, p. 1485-1493Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
2004
The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly
Vilhardt, F. & van Deurs, B., 2004, In: EMBO Journal. 23, p. 739-748Research output: Contribution to journal › Journal article › Research › peer-review
154 Citations (Scopus) -
2002
The HIV-1 Nef protein and phagocyte NADPH oxidase activation
Vilhardt, F., Plastre, O., Sawada, M., Suzuki, K., Wiznerowicz, M., Kiyokawa, E., Trono, D. & Krause, K-H., 1 Nov 2002, In: Journal of Biological Chemistry. 277, 44, p. 42136-43 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
80 Citations (Scopus) -
2000
Role for dynamin in late endosome dynamics and trafficking of the cation-independent mannose 6-phosphate receptor
Nicoziani, P., Vilhardt, F., Llorente, A., Hilout, L., Courtoy, P. J., Sandvig, K. & van Deurs, B., 2000, In: Molecular Biology of the Cell. 11, p. 481-495Research output: Contribution to journal › Journal article › Research › peer-review
81 Citations (Scopus) -
1999
Extraction of cholesterol with methyl-β-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles
Rodal, S. K., Skretting, G., Garred, Ø., Vilhardt, F., van Deurs, B. & Sandvig, K., 1999, In: Mol Biol Cell. Vol 10, p. 961-974Research output: Contribution to journal › Journal article › Research › peer-review
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Urokinase-type plasminogen activator receptor is internalized by different mechanisms in polarized and nonpolarized Madin-Darby canine kidney epithelial cells
Vilhardt, F., Nielsen, M., Sandvig, K. & van Deurs, B., 1999, In: Molecular Biology of the Cell. Vol 10, p. 179-195Research output: Contribution to journal › Journal article › Research › peer-review
35 Citations (Scopus)