Freja Herborg

Search results

• 2024

  Parkinson’s disease gene, Synaptojanin1, dysregulates the surface maintenance of the dopamine transporter

  Saenz, J., Khezerlou, E., Aggarwal, M., Shaikh, A., Ganti, N., Herborg, F. & Pan, P. Y., 2024, In: npj Parkinson's Disease. 10, 1, 14 p., 148.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Downloads (Pure)

• Substance- and Cell-Specific Roles of Mesolimbic Dopamine D₃ Receptors

  Herborg, F., 2024, In: Biological Psychiatry. 96, 9, p. 691-693 3 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
• 2023

  Amphetamine-induced reverse transport of dopamine does not require cytosolic Ca²⁺

  Støier, J. F., Konomi-Pilkati, A., Christiansen, M., Herborg, F. & Gether, U., 2023, In: Journal of Biological Chemistry. 299, 8, 14 p., 105063.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  8 Citations (Scopus)

  18 Downloads (Pure)

• Behavioral encoding across timescales by region-specific dopamine dynamics

  Jørgensen, S. H., Ejdrup, A. L., Lycas, M. D., Posselt, L. P., Madsen, K. L., Tian, L., Dreyer, J. K., Herborg, F., Sørensen, A. T. & Gether, U., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 7, 10 p., e2215230120.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  13 Citations (Scopus)

  64 Downloads (Pure)
• 2022

  A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data

  Ejdrup, A. L., Lycas, M. D., Lorenzen, N., Konomi, A., Herborg, F., Madsen, K. L. & Gether, U., 2022, In: Nature Communications. 13, 1, 4388.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  2 Citations (Scopus)

  42 Downloads (Pure)

• Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

  Klein Herenbrink, C., Støier, J. F., Reith, W. D., Dagra, A., Gregorek, M. A. C., Cola, R. B., Patriarchi, T., Li, Y., Tian, L., Gether, U. & Herborg, F., 2022, In: Communications Biology . 5, 1, 578.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  15 Citations (Scopus)

  33 Downloads (Pure)

• Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity

  Lycas, M. D., Ejdrup, A. L., Sørensen, A. T., Haahr, N. O., Jørgensen, S. H., Guthrie, D. A., Støier, J. F., Werner, C., Newman, A. H., Sauer, M., Herborg, F. & Gether, U., 2022, In: Cell Reports. 40, 13, 27 p., 111431.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)

  15 Downloads (Pure)

• Structural basis of organic cation transporter-3 inhibition

  Khanppnavar, B., Maier, J., Herborg, F., Gradisch, R., Lazzarin, E., Luethi, D., Yang, J. W., Qi, C., Holy, M., Jäntsch, K., Kudlacek, O., Schicker, K., Werge, T., Gether, U., Stockner, T., Korkhov, V. M. & Sitte, H. H., 2022, In: Nature Communications. 13, 1, 13 p., 6714.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  37 Citations (Scopus)

  13 Downloads (Pure)
• 2021

  Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

  Sørensen, G., Rickhag, M., Leo, D., Lycas, M. D., Ridderstrøm, P. H., Weikop, P., Lilja, J. H., Rifes, P., Herborg, F., Woldbye, D., Wörtwein, G., Gainetdinov, R. R., Fink-Jensen, A. & Gether, U., 2021, In: Journal of Biological Chemistry. 297, 6, 101361.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  4 Citations (Scopus)

  46 Downloads (Pure)

• Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals

  Ducrot, C., Bourque, M-J., Delmas, C. V. L., Racine, A-S., Guadarrama Bello, D., Delignat-Lavaud, B., Domenic Lycas, M., Fallon, A., Michaud-Tardif, C., Burke Nanni, S., Herborg, F., Gether, U., Nanci, A., Takahashi, H., Parent, M. & Trudeau, L-E., 2021, In: FASEB Journal. 35, 8, 24 p., 21791.

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  12 Citations (Scopus)

  15 Downloads (Pure)

• Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

  Herborg, F., Jensen, K. L., Tolstoy, S., Arends, N., Posselt, L. P., Shekar, A., Aguilar, J., Lund, V. K., Erreger, K., Rickhag, M., Lycas, M. D., Lonsdale, M. N., Rahbek-Clemmensen, T., Sorensen, A. T., Newman, A. H., Lokkegaard, A., Kjaerulff, O., Werge, T., Moller, L. B., Matthies, H. J. G. & 4 others, Galli, A., Hjermind, L. E., Gether, U. & IPSYCH Researchers, 2021, In: JCI insight. 6, 18, 21 p., 151496.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  11 Citations (Scopus)

  57 Downloads (Pure)
• 2020

  Constitutive internalization across therapeutically targeted GPCRs correlates with constitutive activity

  Hendrik Schmidt, J., Perslev, M., Bukowski, L., Stoklund, M., Herborg, F., Herlo, R. & Lindegaard Madsen, K., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, S6, p. 116-121 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)
• 2019

  Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors

  DiCarlo, G. E., Aguilar, J. I., Matthies, H. J. G., Harrison, F. E., Bundschuh, K. E., West, A., Hashemi, P., Herborg, F., Rickhag, M., Chen, H., Gether, U., Wallace, M. T. & Galli, A., 2019, In: Journal of Clinical Investigation. 129, 8, p. 3407-3419 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  98 Citations (Scopus)

  54 Downloads (Pure)

• Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

  Giguère, N., Delignat-Lavaud, B., Herborg, F., Voisin, A., Li, Y., Jacquemet, V., Anand-Srivastava, M., Gether, U., Giros, B. & Trudeau, L-E., 2019, In: PLOS Genetics. 15, 8, 26 p., e1008352.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  48 Citations (Scopus)

  155 Downloads (Pure)
• 2018

  Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

  Herborg, F., Andreassen, T. F., Berlin, F., Loland, C. J. & Gether, U., 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  34 Citations (Scopus)
• 2017

  Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

  Rahbek-Clemmensen, T., Lycas, M. D., Erlendsson, S., Eriksen, J., Christiansen, M., Vilhardt, F., Jorgensen, T. N., Hansen, F. H. & Gether, U., 2017, In: Nature Communications. 8, 14 p., 740.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  58 Citations (Scopus)

  604 Downloads (Pure)
• 2015

  A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity

  Christiansen, M., Stilling, S., Rahbek-Clemmensen, T., Sørensen, G., Fortin, G., Herborg Hansen, F., Eriksen, J., Trudeau, L-E., Egerod, K., Gether, U. & Rickhag, K. M., 2015, In: European Journal of Neuroscience. 42, 7, p. 2438-2454 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)
• 2014

  Missense dopamine transporter mutations associate with adult parkinsonism and ADHD

  Hansen, F. H., Skjørringe, T., Yasmeen, S., Arends, N. V., Sahai, M. A., Erreger, K., Andreassen, T. F., Holy, M., Hamilton, P. J., Neergheen, V., Karlsborg, M., Newman, A. H., Pope, S., Heales, S. J. R., Friberg, L., Law, I., Pinborg, L. H., Sitte, H. H., Loland, C., Shi, L. & 5 others, Weinstein, H., Galli, A., Hjermind, L. E., Møller, L. B. & Gether, U., 1 Jul 2014, In: The Journal of Clinical Investigation. 124, 7, p. 3107-20 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  115 Citations (Scopus)
• 2013

  A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter

  Rickhag, K. M., Hansen, F. H., Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, K., Madsen, K. L., Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E-M., Gomeza, J., Woldbye, D. P. D., Wörtwein, G. & Gether, U., 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.

  Research output: Contribution to journal › Journal article › Research › peer-review
  34 Citations (Scopus)

• De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder

  Hamilton, P. J., Campbell, N. G., Sharma, S., Erreger, K., Hansen, F. H., Saunders, C., Belovich, A. N., NIH ARRA Autism Sequencing Consortium, Sahai, M. A., Cook, E. H., Gether, U., McHaourab, H. S., Matthies, H. J. G., Sutcliffe, J. S. & Galli, A., Dec 2013, In: Molecular Psychiatry. 18, 12, p. 1315-23 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  164 Citations (Scopus)

• Drosophila melanogaster: a novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter gene

  Hamilton, P. J., Campbell, N. G., Sharma, S., Erreger, K., Hansen, F. H., Saunders, C., Belovich, A. N., Sahai, M. A., Cook, E. H., Gether, U., McHaourab, H. S., Matthies, H. J. G., Sutcliffe, J. S. & Galli, A., Dec 2013, In: Molecular Psychiatry. 18, 12, p. 1235

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)
• 2009

  Possible functional consequences of structural adaptation along single arterioles

  Jacobsen, J. C. B., Hornbech, M., Henriksen, F. H., Jensen, L. J. & Holstein-Rathlou, N-H., 2009, In: The FASEB Journal. 949.11, p. 295 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research

• Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A₂/¿-hydroxylase/20-HETE pathways

  Inoue, R., Jensen, L. J., Jian, Z., Shi, J., Hai, L., Lurie, A. I., Henriksen, F. H., Salomonsson, M., Morita, H., Kawarabayashi, Y., Mori, M., Mori, Y. & Ito, Y., 2009, In: Circulation Research. 104, 12, p. 1399-1409 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  145 Citations (Scopus)