Gitta Wörtwein

Search results

• 2024

  Effect of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on alcohol consumption in alcohol-preferring male vervet monkeys

  Fink-Jensen, A., Wörtwein, G., Klausen, M. K., Holst, J. J., Hartmann, B., Thomsen, M., Ptito, M., Beierschmitt, A. & Palmour, R. M., 2024, (Accepted/In press) In: Psychopharmacology.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

• Expression of erythropoietin receptor protein in the mouse hippocampus in response to normobaric hypoxia

  Fussing, F., Christensson, J. & Wörtwein, G., 2024, In: Heliyon. 10, 3, 8 p., e25051.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• 2023

  Did Stress Prevalence Among Adolescents in Scandinavia Change from 2000 to 2019? A literature review

  Flægstad, T. K., Åström, M., Baudocco, S. & Wörtwein, G., 2023, In: Scandinavian Journal of Child and Adolescent Psychiatry and Psychology. 11, 1, p. 150-162 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• 2022

  Inactivation of the cholinergic M₄ receptor results in a disinhibited endophenotype predicting alcohol use

  Molander, A., Thorbek, D. D., Lysne, C., Weikop, P., Fink-Jensen, A. & Wörtwein, G., 2022, In: Behavioural Brain Research. 430, 10 p., 113921.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  1 Citation (Scopus)

  25 Downloads (Pure)

• Proinflammatory biomarkers are associated with prediabetes in patients with schizophrenia

  Mller, M., Fredholm, S., Jensen, M. E., Wörtwein, G., Larsen, J. R., Vilsbøll, T., Ødum, N. & Fink-Jensen, A., 2022, In: CNS Spectrums. 27, 3, 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• The role of glucagon-like peptide 1 (GLP-1) in addictive disorders

  Kruse Klausen, M., Thomsen, M., Wortwein, G. & Fink-Jensen, A., 2022, In: British Journal of Pharmacology. 179, 4, p. 625-641 17 p.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access
  74 Citations (Scopus)
• 2021

  Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

  Sørensen, G., Rickhag, M., Leo, D., Lycas, M. D., Ridderstrøm, P. H., Weikop, P., Lilja, J. H., Rifes, P., Herborg, F., Woldbye, D., Wörtwein, G., Gainetdinov, R. R., Fink-Jensen, A. & Gether, U., 2021, In: Journal of Biological Chemistry. 297, 6, 101361.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  4 Citations (Scopus)

  46 Downloads (Pure)
• 2020

  The effect of erythropoietin on electroconvulsive stimulation induced cognitive impairment in rats

  Kjær, K., Jorgensen, M. B., Hageman, I., Miskowiak, K. W. & Wörtwein, G., 2020, In: Behavioural Brain Research. 382, 112484.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)
• 2019

  G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization

  Runegaard, A. H., Dencker, D., Wörtwein, G. & Gether, U., 2019, In: Neuropharmacology. 161, 107663.

  Research output: Contribution to journal › Review › Research › peer-review
  1 Citation (Scopus)

• Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol

  Runegaard, A. H., Jensen, K. L., Wörtwein, G. & Gether, U., 2019, In: European Journal of Neuroscience. 50, 3, p. 2156-2163 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats

  Jørgensen, A., Breitenstein, K., Kalliokoski, O., Weimann, A., Henriksen, T., Poulsen, H. E., Jørgensen, M. B. & Wörtwein, G., 2019, In: Acta Neuropsychiatrica. 31, 6, p. 287-293 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

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• 2018

  Erythropoietin prevents the effect of chronic restraint stress on the number of hippocampal CA3c dendritic terminals-relation to expression of genes involved in synaptic plasticity, angiogenesis, inflammation, and oxidative stress in male rats

  Aalling, N., Hageman, I., Miskowiak, K., Orlowski, D., Wegener, G. & Wortwein, G., Jan 2018, In: Journal of Neuroscience Research. 96, 1, p. 103–116

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• Ketogenic Diet suppresses Alcohol Withdrawal Syndrome in Rats

  Dencker, D., Molander, A., Thomsen, M., Schlumberger, C., Wortwein, G., Weikop, P., Benveniste, H., Volkow, N. D. & Fink-Jensen, A., Feb 2018, In: Alcoholism: Clinical and Experimental Research. 42, 2, p. 270-277

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)

• Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons

  Runegaard, A. H., Sørensen, A. T., Fitzpatrick, C. M., Jørgensen, S. H., Petersen, A. V., Hansen, N. W., Weikop, P., Andreasen, J. T., Mikkelsen, J. D., Perrier, J-F., Woldbye, D., Rickhag, M., Wortwein, G. & Gether, U., 2018, In: eNeuro. 5, 3, 26 p., e0345.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  37 Citations (Scopus)

  294 Downloads (Pure)

• PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

  Jensen, K. L., Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, P., Wörtwein, G., Fink-Jensen, A., Madsen, K. L., Daws, L., Gether, U. & Rickhag, M., 2018, In: eNeuro. 5, 3

  Research output: Contribution to journal › Journal article › Research › peer-review

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  12 Citations (Scopus)

  189 Downloads (Pure)

• The circadian oscillator of the cerebral cortex: molecular, biochemical and behavioral effects of deleting the Arntl clock gene in cortical neurons

  Bering, T., Carstensen, M. B., Wörtwein, G., Weikop, P. & Rath, M. F., Feb 2018, In: Cerebral Cortex. 28, 2, p. 644–657

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)
• 2017

  A chronic increase of corticosterone age-dependently reduces systemic DNA damage from oxidation in rats

  Jorgensen, A., Kalliokoski, O., Forsberg, K., Breitenstein, K., Weimann, A., Henriksen, T., Hau, J., Wörtwein, G., Poulsen, H. E. & Jorgensen, M. B., Mar 2017, In: Free Radical Biology & Medicine. 104, p. 64-74 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Electroconvulsive stimulation results in long-term survival of newly generated hippocampal neurons in rats

  Olesen, M. V., Wörtwein, G., Folke, J. & Pakkenberg, B., Jan 2017, In: Hippocampus. 27, 1, p. 52-60 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  43 Citations (Scopus)

• Erytropoietin behandling kan forbedre kognition ved neuropsykiatriske lidelser

  Translated title of the contribution: Erythropoietin treatment may improve cognition in neuropsychiatric disordersKjær, K. S., Hageman, I., Wörtwein, G., Jørgensen, M. B. & Miskowiak, K. W., 14 Aug 2017, In: Ugeskrift for Laeger. 179, 22, p. 2-6 5 p., V01170037.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

  Runegaard, A. H., Jensen, K. L., Dencker, D., Wörtwein, G. & Gether, U., 2017, In: Journal of Neuroscience Methods. 289, p. 85-92 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)
• 2016

  5-HT2A Receptor Binding in the Frontal Cortex of Parkinson's Disease Patients and Alpha-Synuclein Overexpressing Mice: A Postmortem Study

  Rasmussen, N. B., Olesen, M. V., Brudek, T., Plenge, P., Klein, A. B., Westin, J. E., Fog, K., Wörtwein, G. & Aznar, S., 2016, In: Parkinson’s Disease. 2016, 8 p., 3682936.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  8 Citations (Scopus)

  177 Downloads (Pure)

• Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels

  Reddy, I. A., Pino, J. A., Weikop, P., Osses, N., Sørensen, G., Bering, T., Valle, C., Bluett, R. J., Erreger, K., Wörtwein, G., Reyes, J. G., Graham, D., Stanwood, G. D., Hackett, T. A., Patel, S., Fink-Jensen, A., Torres, G. E. & Galli, A., 2016, In: Translational Psychiatry. 6, 11 p., e809.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  63 Citations (Scopus)

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• 2015

  Corrigendum to: "Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage" [Prog Neuropsychopharmacol Biol Psychiatry 40 (2013) 30-37]http://dx.doi.org/10.1016/j.pnpbp.2012.08.016.

  Jorgensen, A., Maigaard, K., Wörtwein, G., Hageman, I., Henriksen, T., Weimann, A., Møller, P., Loft, S., Hau, J., Poulsen, H. E. & Jorgensen, M. B., 3 Apr 2015, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 58, p. 105 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

• Delayed restraint procedure enhances cognitive recovery of spatial function after fimbria-fornix transection

  Gram, M. G., Wogensen, E., Wörtwein, G., Mogensen, J. & Rytter, H. M., 2015, In: Restorative Neurology and Neuroscience. 34, 1, p. 1-17

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Dynamic regulation of cerebral DNA repair genes by psychological stress

  Forsberg, K., Aalling, N., Wörtwein, G., Loft, S., Møller, P., Hau, J., Hageman, I., Jørgensen, M. B. & Jørgensen, A., 15 Jan 2015, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 778, p. 37-43 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Electroconvulsive Stimulation, but not Chronic Restraint Stress, Causes Structural Alterations in Adult Rat Hippocampus: A Stereological Study

  Olesen, M. V., Wörtwein, G. & Pakkenberg, B., Jan 2015, In: Hippocampus. 25, 1, p. 72-80 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Enhanced self-administration of alcohol in muscarinic acetylcholine M₄ receptor knockout mice

  de la Cour, C., Sørensen, G., Wörtwein, G., Weikop, P., Nielsen, D. D., Fink-Jensen, A. & Molander, A., 5 Jan 2015, In: European Journal of Pharmacology. 746, p. 1-5 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• INACTIVATION OF THE CHOLINERGIC M4 RECEPTOR RESULTS IN THE DEVELOPMENT OF A LOW ANXIETY ENDOPHENOTYPE PREDICTING FUTURE ALCOHOL CONSUMPTION

  Dencker, D., Woertwein, G., Lysne, C., Weikop, P., Fink-Jensen, A. & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i57-i58 2 p., P-49.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• SUBCHRONIC LOW DOSE EXENDIN-4 PRETREATMENT INHIBITS RELAPSE TO ALCOHOL DRINKING IN HIGH ALCOHOL PREFERING C57BL6 MICE

  Dencker, D., Egecioglu, E., Jerlhag, E., Wörtwein, G., Weikop, P., Fink-Jensen, A. & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i17-i18 2 p., SY15-2.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice

  Sorensen, G., Reddy, I. A., Weikop, P., Graham, D. L., Stanwood, G. D., Wörtwein, G., Galli, A. & Fink-Jensen, A., 1 Oct 2015, In: Physiology & Behavior. 149, p. 262-268 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  93 Citations (Scopus)
• 2014

  Addiction-Related Effects of DOV 216,303 and Cocaine: A Comparative Study in the Mouse

  Sørensen, G., Husum, H., Brennum, L. T., Bundgaard, C., Montezinho, L. C. P., Mørk, A., Wörtwein, G. & Woldbye, D. P. D., Jun 2014, In: Basic & Clinical Pharmacology & Toxicology. 114, 6, p. 451-9 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice

  Elbrønd-Bek, H., Olling, J. D., Gøtzsche, C. R., Waterfield, A., Wörtwein, G. & Woldbye, D. P. D., 9 Jul 2014, In: Synapse. 68, 10, p. 427-36 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)
• 2013

  A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter

  Rickhag, K. M., Hansen, F. H., Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, K., Madsen, K. L., Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E-M., Gomeza, J., Woldbye, D. P. D., Wörtwein, G. & Gether, U., 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.

  Research output: Contribution to journal › Journal article › Research › peer-review
  34 Citations (Scopus)

• Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage

  Jorgensen, A., Maigaard, K., Wörtwein, G., Hageman, I., Henriksen, T., Weimann, A., Moller, P., Loft, S., Hau, J., Poulsen, H. E. & Jorgensen, M. B., 10 Jan 2013, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 40, p. 30-37

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.

  Rickhag, K. M., Owens, WA., Winkler, M-T., Strandfelt, K. N., Rathje, M., Sørensen, G., Andresen, B., Madsen, K. L., Nygaard Jørgensen, T., Wörtwein, G., Woldbye, D. P. D., Sitte, H. H., Daws, L. C. & Gether, U., 2013, In: Journal of Biological Chemistry. 288, p. 27534-44 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  25 Citations (Scopus)

• Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference

  Sørensen, G., Wörtwein, G., Fink-Jensen, A. & Woldbye, D. P. D., Apr 2013, In: Pharmacology, Biochemistry and Behavior. 105, p. 151-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)
• 2012

  An allosteric enhancer of M₄ muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

  Nielsen, D. D., Weikop, P., Sørensen, G., Woldbye, D. P. D., Wörtwein, G., Wess, J. & Fink-Jensen, A., 2012, In: Psychopharmacology. 224, 2, p. 277-87 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  43 Citations (Scopus)

• Electroconvulsive stimulations prevent chronic stress-induced increases in L-type calcium channel mRNAs in the hippocampus and basolateral amygdala

  Maigaard, K., Pedersen, I. H., Jørgensen, A., Jørgensen, M. B. & Wörtwein, G., 2012, In: Neuroscience Letters. 516, 1, p. 24-8 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

  Sørensen, G., Jensen, M., Weikop, P., Nielsen, D. D., Christiansen, S. H. O., Løland, C. J., Bengtsen, C. H., Petersen, J. H., Fink-Jensen, A., Wörtwein, G. & Woldbye, D. P. D., Feb 2012, In: Psychopharmacology. 222, p. 565-577 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  31 Citations (Scopus)

• The effect of subchronic fluoxetine treatment on learning and memory in adolescent rats

  Sass, A. & Wörtwein, G., 2012, In: Behavioural Brain Research. 228, 1, p. 169-75 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  30 Citations (Scopus)

• Time course and duration of changes in Kv7.2 and Kv11.1 mRNA expression in the hippocampus and piriform cortex following electroconvulsive stimulations

  Hjaeresen, M-L., Hageman, I., Wörtwein, G. & Jørgensen, M. B., 2012, In: Brain Stimulation. 5, 1, p. 55-60 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)
• 2011

  Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor.

  Fink-Jensen, A., Schmidt, L. S., Dencker, D., Schülein, C., Wess, J., Wörtwein, G. & Woldbye, D. P. D., 10 Apr 2011, In: European Journal of Pharmacology. 656, 1-3, p. 39-44 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  47 Citations (Scopus)

• Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice

  Christiansen, S. H. O., Olesen, M. V., Wörtwein, G. & Woldbye, D. P. D., 20 Jan 2011, In: Behavioural Brain Research. 216, 2, p. 585-91 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  82 Citations (Scopus)

• Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice.

  Schmidt, L. S., Thomsen, M., Weikop, P., Nielsen, D. D., Wess, J., Woldbye, D. P. D., Wörtwein, G. & Fink-Jensen, A., 2011, In: Psychopharmacology. 216, 3, p. 367-378 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  61 Citations (Scopus)

• Increased numbers of orexin/hypocretin neurons in a genetic rat depression model

  Mikrouli, E., Wörtwein, G., Soylu, R., Mathé, A. A. & Petersén, Å., 2011, In: Neuropeptides (Sheffield). 45, 6, p. 401-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  54 Citations (Scopus)

• Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline

  Dencker, D., Wörtwein, G., Weikop, P., Jeon, J., Thomsen, M., Sager, T. N., Mørk, A., Woldbye, D. P. D., Wess, J. & Fink-Jensen, A., 2011, In: Journal of Neuroscience. 31, 16, p. 5905-8 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  48 Citations (Scopus)

• Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease

  Dencker, D., Thomsen, M., Wörtwein, G., Weikop, P., Cui, Y., Jeon, J., Wess, J. & Fink-Jensen, A., 22 Nov 2011, In: ACS Chemical Neuroscience. 3, 2, p. 80-89 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  56 Citations (Scopus)

• Pharmacological characterization of social isolation-induced hyperactivity

  Fabricius, K., Helboe, L., Fink-Jensen, A., Wörtwein, G. & Steiniger-Brach, B., 2011, In: Psychopharmacology. 215, 2, p. 257-66 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  31 Citations (Scopus)

• Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia

  Fabricius, K., Steiniger-Brach, B., Helboe, L., Fink-Jensen, A. & Wörtwein, G., 2011, In: International Journal of Developmental Neuroscience. 29, 3, p. 347-50 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  23 Citations (Scopus)
• 2010

  A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors

  Jeon, J., Dencker, D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C-X., Fink-Jensen, A., Wess, J., Jeon, J., Nielsen, D. D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A. & 8 others, Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C-X., Fink-Jensen, A. & Wess, J., 10 Feb 2010, In: Journal of Neuroscience. 30, 6, p. 2396-405 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  134 Citations (Scopus)