Research output per year
Research output per year
Research output
- 1 - 50 out of 203 results
Search results
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2024
Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of Alzheimer's disease
Salcedo, C., Pozo Garcia, V., Garcia-Adan, B., Ameen, A. O., Gegelashvili, G., Waagepetersen, H. S., Freude, K. K. & Aldana, B. I., 2024, In: Journal of Neurochemistry. 168, 5, p. 822-840Research output: Contribution to journal › Journal article › Research › peer-review
7 Citations (Scopus) -
2023
Stable isotope tracing reveals disturbed cellular energy and glutamate metabolism in hippocampal slices of aged male mice
McNair, L. M., Andersen, J. V. & Waagepetersen, H. S., 2023, In: Neurochemistry International. 171, 10 p., 105626.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)14 Downloads (Pure) -
2022
Progressive Mitochondrial Dysfunction of Striatal Synapses in R6/2 Mouse Model of Huntington's Disease
Petersen, M. H., Willert, C. W., Andersen, J. V., Madsen, M., Waagepetersen, H. S., Skotte, N. H. & Nørremølle, A., 2022, In: Journal of Huntington's disease. 11, 2, p. 121-140Research output: Contribution to journal › Journal article › Research › peer-review
7 Citations (Scopus) -
Proteomic phenotype of cerebral organoids derived from autism spectrum disorder patients reveal disrupted energy metabolism, cellular components, and biological processes
Ilieva, M., Aldana, B. I., Vinten, K. T., Hohmann, S., Woofenden, T. W., Lukjanska, R., Waagepetersen, H. S. & Michel, T. M., 2022, In: Molecular Psychiatry. 27, p. 3749–3759Research output: Contribution to journal › Journal article › Research › peer-review
14 Citations (Scopus) -
Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2-13C]/[1-13C]glucose infusion and 1H-[13C]NMR ex vivo
McNair, L. M., Mason, G. F., Chowdhury, G. M. I., Jiang, L., Ma, X., Rothman, D. L., Waagepetersen, H. S. & Behar, K. L., 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 8, p. 1507–1523Research output: Contribution to journal › Journal article › Research › peer-review
Open Access11 Citations (Scopus) -
2021
Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease
Aldana, B. I., Salcedo, C., Freude, K. K. & Waagepetersen, H. S., 2021, Current Progress in iPSC-derived Cell Types. Birbrair, A. (ed.). Elsevier, p. 205-221 17 p. (Advances in Stem Cell Biology, Vol. 10).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease
Andersen, J. V., Christensen, S. K., Westi, E. W., Diaz-delcastillo, M., Tanila, H., Schousboe, A., Aldana, B. I. & Waagepetersen, H. S., 2021, In: Neurobiology of Disease. 148, 13 p., 105198.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile66 Citations (Scopus)131 Downloads (Pure) -
Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease
Salcedo, C., Wagner, A., Andersen, J. V., Vinten, K. T., Waagepetersen, H. S., Schousboe, A., Freude, K. K. & Aldana, B. I., 2021, In: Neurochemical Research. 46, p. 2676–2686Research output: Contribution to journal › Journal article › Research › peer-review
15 Citations (Scopus) -
Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease
Salcedo, C., Andersen, J. V., Vinten, K. T., Pinborg, L. H., Waagepetersen, H. S., Freude, K. K. & Aldana, B. I., 2021, In: Frontiers in Aging Neuroscience. 13, 736580.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile34 Citations (Scopus)45 Downloads (Pure) -
Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia
Voss, C. M., Arildsen, L., Nissen, J. D., Waagepetersen, H. S., Schousboe, A., Maechler, P., Ott, P., Vilstrup, H. & Walls, A. B., 2021, In: Frontiers in Neuroscience. 15, 18 p., 646291.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile16 Citations (Scopus)23 Downloads (Pure) -
Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration
Andersen, J. V., Markussen, K. H., Jakobsen, E., Schousboe, A., Waagepetersen, H. S., Rosenberg, P. A. & Aldana, B. I., 2021, In: Neuropharmacology. 196, 14 p., 108719.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile184 Citations (Scopus)23 Downloads (Pure) -
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease
Andersen, J. V., Skotte, N. H., Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, E. W., Diaz-delCastillo, M., Sun, R. C., Kohlmeier, K. A., Schousboe, A., Gentry, M. S., Tanila, H., Freude, K. K., Aldana, B. I., Mann, M. & Waagepetersen, H. S., 2021, In: Cell Death & Disease. 12, 11, 13 p., 954 .Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile53 Citations (Scopus)71 Downloads (Pure) -
Pharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen
Jakobsen, E., Andersen, J. V., Christensen, S. K., Siamka, O., Larsen, M. R., Waagepetersen, H. S., Aldana, B. I. & Bak, L. K., 2021, In: Glia. 69, 12, p. 2828-2844 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
9 Citations (Scopus) -
Two Metabolic Fuels, Glucose and Lactate, Differentially Modulate Exocytotic Glutamate Release from Cultured Astrocytes
Montana, V., Flint, D., Waagepetersen, H. S., Schousboe, A. & Parpura, V., 2021, In: Neurochemical Research. 46, p. 2551–2579Research output: Contribution to journal › Journal article › Research › peer-review
Open Access5 Citations (Scopus) -
2020
AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics
Voss, C. M., Andersen, J. V., Jakobsen, E., Siamka, O., Karaca, M., Maechler, P. & Waagepetersen, H. S., 2020, In: Glia. 68, 9, p. 1824-1839 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
31 Citations (Scopus) -
Clearance of activity-evoked K+ transients and associated glia cell swelling occur independently of AQP4: A study with an isoform-selective AQP4 inhibitor
Toft-Bertelsen, T. L., Larsen, B. R., Christensen, S. K., Khandelia, H., Waagepetersen, H. S. & MacAulay, N., 2020, In: Glia. 69, 1, p. 28-41 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile29 Citations (Scopus)12 Downloads (Pure) -
Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus
McNair, L. F., Andersen, J. V., Nissen, J. D., Sun, Y., Fischer, K. D., Hodgson, N. W., Du, M., Aoki, C. J., Waagepetersen, H. S., Rosenberg, P. A. & Aldana, B. I., 2020, In: Neurochemical Research. 45, p. 1420–1437 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
19 Citations (Scopus) -
Diphenylalanine Peptide Nanowires as a Substrate for Neural Cultures
Walls, A. B., Dimaki, M., Korsgaard, T., Swiniarska, M. M., Castillo-León, J., Waagepetersen, H. S. & Svendsen, W. E., 1 Mar 2020, In: BioNanoScience. 10, 1, p. 224-234 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)75 Downloads (Pure) -
Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex
Andersen, J. V., Jakobsen, E., Westi, E. W., Lie, M. E. K., Voss, C. M., Aldana, B. I., Schousboe, A., Wellendorph, P., Bak, L. K., Pinborg, L. H. & Waagepetersen, H. S., 2020, In: Glia. 68, 12, p. 2601-2612Research output: Contribution to journal › Journal article › Research › peer-review
35 Citations (Scopus) -
Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia
Aldana, B. I., Zhang, Y., Jensen, P., Chandrasekaran, A., Christensen, S. K., Nielsen, T. T., Nielsen, J. E., Hyttel, P., Larsen, M. R., Waagepetersen, H. S. & Freude, K. K., 2020, In: Molecular Brain. 13, 1, 7 p., 125.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile40 Citations (Scopus)88 Downloads (Pure) -
Patient iPSC-Derived Neorons for Disease Modeling of Familiar Alzheimer's Disease with Mutations in Presenilin 1
Haukedal, H., Poon, A. F-Y., Jensen, P., Aldana Garcia, B. I., Pires, C., Chandrasekaran, A., Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, J., Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, H. S., Larsen, M. R. & Freude, K., Oct 2020.Research output: Contribution to conference › Conference abstract for conference › Research
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Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes
Mellergaard, M., Høgh, R. I., Lund, A., Aldana, B. I., Guérillot, R., Møller, S. H., Hayes, A. S., Panagiotopoulou, N., Frimand, Z., Jepsen, S. D., Hansen, C. H. F., Andresen, L., Larsen, A. R., Peleg, A. Y., Stinear, T. P., Howden, B. P., Waagepetersen, H. S., Frees, D. & Skov, S., 2020, In: The Journal of Biological Chemistry. 295, p. 11803-11821Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile7 Citations (Scopus)55 Downloads (Pure) -
2019
Astrocytic pyruvate carboxylation: Status after 35 years
Schousboe, A., Waagepetersen, H. S. & Sonnewald, U., 1 Jan 2019, In: Journal of Neuroscience Research. 97, p. 890-896Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile35 Citations (Scopus)272 Downloads (Pure) -
Deletion of neuronal GLT-1 in mice reveals its role in synaptic glutamate homeostasis and mitochondrial function
McNair, L. F., Andersen, J. V., Aldana, B. I., Hohnholt, M. C., Nissen, J. D., Sun, Y., Fischer, K. D., Sonnewald, U., Nyberg, N., Webster, S. C., Kapur, K., Rimmele, T. S., Barone, I., Hawks-Mayer, H., Lipton, J. O., Hodgson, N. W., Aoki, C. J., Rosenberg, P. A. & Waagepetersen, H. S., 2019, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 25, p. 4847-4863Research output: Contribution to journal › Journal article › Research › peer-review
Open Access45 Citations (Scopus) -
Distinct differences in rates of oxygen consumption and ATP synthesis of regionally isolated non-synaptic mouse brain mitochondria
Andersen, J. V., Jakobsen, E., Waagepetersen, H. S. & Aldana, B. I., 2019, In: Journal of Neuroscience Research. 97, p. 961–974Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile24 Citations (Scopus)411 Downloads (Pure) -
Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation
Vohra, R., Aldana, B. I., Waagepetersen, H., Bergersen, L. H. & Kolko, M., 1 Mar 2019, In: Investigative Ophthalmology & Visual Science. 60, 4, p. 999-1008 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile21 Citations (Scopus)152 Downloads (Pure) -
Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington's disease
Andersen, J. V., Skotte, N. H., Aldana, B. I., Nørremølle, A. & Waagepetersen, H. S., 2019, In: Cellular and Molecular Life Sciences. 76, 12, p. 2449-2461Research output: Contribution to journal › Journal article › Research › peer-review
11 Citations (Scopus) -
Functional Differences between Synaptic Mitochondria from the Striatum and the Cerebral Cortex
Petersen, M. H., Willert, C. W., Andersen, J. V., Waagepetersen, H. S., Skotte, N. H. & Nørremølle, A., May 2019, In: Neuroscience. 406, p. 432-443 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
7 Citations (Scopus) -
Glutamate homeostasis revisited - neuronal transport and metabolism
Waagepetersen, H., McNair, L., Christensen, S. K., Andersen, J. V. & Aldana, B. I., 2019, p. 19-19.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Open AccessFile180 Downloads (Pure) -
Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto-Kakizaki rats
Soares, A. F., Nissen, J. D., Garcia-Serrano, A. M., Nussbaum, S. S., Waagepetersen, H. S. & Duarte, J. M. N., 1 Jan 2019, In: Journal of Neuroscience Research. 97, p. 1004-1017Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile15 Citations (Scopus)228 Downloads (Pure) -
Hypermetabolism and impaired endothelium-dependent vasodilation in mesenteric arteries of type 2 diabetes mellitus db/db mice
Arildsen, L., Andersen, J. V., Waagepetersen, H. S., Nissen, J. B. D. & Sheykhzade, M., 2019, In: Diabetes and Vascular Disease Research. 16, 6, p. 539 548 p.Research output: Contribution to journal › Journal article › Research › peer-review
12 Citations (Scopus) -
Lactate-Mediated Protection of Retinal Ganglion Cells
Vohra, R., Aldana, B. I., Bulli, G., Skytt, D. M., Waagepetersen, H., Bergersen, L. H. & Kolko, M., 19 Apr 2019, In: Journal of Molecular Biology. 431, 9, p. 1878-1888 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile27 Citations (Scopus)493 Downloads (Pure) -
Metabolic impairments in neurons and astrocytes derived from human induced pluripotent stem cells of Alzheimer's disease patients
Garcia, B. A., Salcedo, C., Hyttel, P., Waagepetersen, H. & Freude, K., 2019, p. 111-111.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Open AccessFile166 Downloads (Pure) -
PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons
Bogetofte, H., Jensen, P., Ryding, M., Schmidt, S. I., Okarmus, J., Ritter, L., Worm, C. S., Hohnholt, M. C., Azevedo, C., Roybon, L., Bak, L. K., Waagepetersen, H., Ryan, B. J., Wade-Martins, R., Larsen, M. R. & Meyer, M., 2019, In: Frontiers in Cellular Neuroscience. 13, 14 p., 297.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile45 Citations (Scopus)62 Downloads (Pure) -
Patient iPSC-Derived Neurons for Disease Modeling of Familiar Alzheier's Disease with Mutations in Presenilin 1
Haukedal, H., Poon, A. F-Y., Jensen, P., Aldana Garcia, B. I., Pires, C., Chandrasekaran, A., Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, J., Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, H. S., Larsen, M. R. & Freude, K., 26 Mar 2019.Research output: Contribution to conference › Poster › Communication
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Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy
Huyghe, D., Denninger, A. R., Voss, C. M., Frank, P., Gao, N., Brandon, N., Waagepetersen, H. S., Ferguson, A. D., Pangalos, M., Doig, P. & Moss, S. J., 21 May 2019, In: Frontiers in Molecular Neuroscience. 12, 14 p., 120.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile9 Citations (Scopus)102 Downloads (Pure) -
State-Dependent Changes in Brain Glycogen Metabolism
DiNuzzo, M., Walls, A. B., Öz, G., Seaquist, E. R., Waagepetersen, H. S., Bak, L. K., Nedergaard, M. & Schousboe, A., 2019, Brain Glycogen Metabolism. DiNuzzo, M. & Schousboe, A. (eds.). Springer, p. 269-309 41 p. (Advances in Neurobiology, Vol. 23).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
6 Citations (Scopus) -
The role of astrocytes in seizure generation: Insights from a novel in vitro seizure model based on mitochondrial dysfunction
Chan, F., Lax, N. Z., Voss, C. M., Aldana, B. I., Whyte, S., Jenkins, A., Nicholson, C., Nichols, S., Tilley, E., Powell, Z., Waagepetersen, H. S., Davies, C. H., Turnbull, D. M. & Cunningham, M. O., 1 Feb 2019, In: Brain. 142, 2, p. 391-411 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access52 Citations (Scopus) -
2018
Astrocytic glycogen metabolism in the healthy and diseased brain
Bak, L. K., Walls, A. B., Schousboe, A. & Waagepetersen, H. S., 11 May 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7108-7116 9 p.Research output: Contribution to journal › Review › Research › peer-review
Open Access104 Citations (Scopus) -
Essential Roles of Lactate in Müller Cell Survival and Function
Vohra, R., Aldana Garcia, B. I., Skytt, D. M., Freude, K., Waagepetersen, H. S., Bergersen, L. H. & Kolko, M., 1 Dec 2018, In: Molecular Neurobiology. 55, 12, p. 9108-9121 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
23 Citations (Scopus) -
Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation
Hohnholt, M. C., Andersen, V. H., Andersen, J. V., Christensen, S. K., Karaca, M., Maechler, P. & Waagepetersen, H. S., Oct 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 10, p. 1754–1768Research output: Contribution to journal › Journal article › Research › peer-review
Open Access41 Citations (Scopus) -
Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism
Skotte, N. H., Andersen, J. V., Santos, A., Aldana, B. I., Willert, C. W., Nørremølle, A., Waagepetersen, H. S. & Nielsen, M. L., 2018, In: Cell Reports. 23, 7, p. 2211-2224 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile75 Citations (Scopus)318 Downloads (Pure) -
Lactate: More than merely a metabolic waste product
Vohra, R., Aldana, B. I., Skytt, D. M., Waagepetersen, H., Bergersen, L. H. & Kolko, M., 2018, In: Acta Ophthalmologica. 96, Supplement 261, p. 137 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Muller cell survival and function is maintained by the presence of lactate
Vohra, R., Skytt, D. M., Aldana, B. I., Freude, K., Waagepetersen, H., Bergersen, L. H. & Kolko, M., Jul 2018, p. 1480. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Open Access -
The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms
Jakobsen, E., Lange, S. C., Andersen, J. V., Madsen, C. D., Kihl, H. F., Hohnholt, M., Stridh, M. H., Rasmussen, L. J., Waagepetersen, H. S. & Bak, L. K., 2018, In: Biochemical Pharmacology. 155, p. 92-101 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
20 Citations (Scopus) -
2017
Alterations in Cerebral Cortical Glucose and Glutamine Metabolism Precedes Amyloid Plaques in the APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease
Andersen, J. V., Christensen, S. K., Aldana, B. I., Nissen, J. D., Tanila, H. & Waagepetersen, H. S., Jun 2017, In: Neurochemical Research. 42, 6, p. 1589–1598Research output: Contribution to journal › Journal article › Research › peer-review
61 Citations (Scopus) -
Augmented cerebral mitochondrial function and hippocampal ketone body metabolism in Db/db mice
Andersen, J., Nissen, J., Christensen, S. & Waagepetersen, H., Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 145-145Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Open AccessFile250 Downloads (Pure) -
Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons
Aldana, B. I., Zhang, Y., Lihme, M. F., Bak, L. K., Nielsen, J. E., Holst, B., Hyttel, P., Freude, K. K. & Waagepetersen, H. S., 2017, In: Neurochemistry International. 106, p. 48-61Research output: Contribution to journal › Journal article › Research › peer-review
13 Citations (Scopus)45 Downloads (Pure) -
Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model
Helms, H. C., Aldana, B. I., Groth, S., Jensen, M. M., Waagepetersen, H. S., Nielsen, C. U. & Brodin, B., 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 12, p. 3744–3758Research output: Contribution to journal › Journal article › Research › peer-review
8 Citations (Scopus) -
Citrate, a Ubiquitous Key Metabolite with Regulatory Function in the CNS
Westergaard, N., Waagepetersen, H. S., Belhage, B. & Schousboe, A., Jun 2017, In: Neurochemical Research. 42, 6, p. 1583-1588 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
44 Citations (Scopus)