Helle S. Waagepetersen

Search results

• 2013

  Amino acid neurotransmitter synthesis and removal

  Schousboe, A., Bak, L. K., Madsen, K. K. & Waagepetersen, H. S., 2013, Neuroglia. Kettenman, H. & Ransom, B. R. (eds.). 3. ed. Oxford: Oxford University Press, p. 443-456 14 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamate and GABA

  Schousboe, A., Bak, L. K. & Waagepetersen, H. S., 15 Aug 2013, In: Frontiers in Endocrinology. 4, 102.

  Research output: Contribution to journal › Journal article › Research › peer-review
  231 Citations (Scopus)

• Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures

  Dadsetan, S., Kukolj, E., Bak, L. K., Sørensen, M., Ott, P., Vilstrup, H., Schousboe, A., Keiding, S. & Waagepetersen, H. S., Aug 2013, In: Journal of Cerebral Blood Flow and Metabolism. 33, 8, p. 1235-41 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)

• Cellemodel af blodhjernebarrieren kan mindske brugen af forsøgsdyr

  Brodin, B., Helms, H. C. C., Hersom, M. N. S., Nielsen, C. U. & Waagepetersen, H. S., 2013, In: Lægemiddelforskning. 2013, p. 47-49 3 p.

  Research output: Contribution to journal › Journal article › Communication

• Complex actions of ionomycin in cultured cerebellar astrocytes affecting both calcium-induced calcium release and store-operated calcium entry

  Müller, M. S., Obel, L. L. F., Waagepetersen, H. S., Schousboe, A. & Bak, L. K., Jun 2013, In: Neurochemical Research. 38, 6, p. 1260-5 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Excitatory amino acid transporter-1 (EAAT1) is the main transporter responsible for abluminal uptake of L-glutamate in bovine brain endothelial cells

  Helms, H. C. C., Groth, S., Mikél, M., Waagepetersen, H. S., Nielsen, C. U. & Brodin, B., 27 May 2013.

  Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

• Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

  Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, L. K., Waagepetersen, H. S., Schousboe, A. & Sørensen, M., Jan 2013, In: Hepatology. 57, 1, p. 258-65 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  57 Citations (Scopus)

• Interorgan metabolism of ornithine phenylacetate (OP)-A novel strategy for treatment of hyperammonemia

  Dadsetan, S., Sørensen, M., Bak, L. K., Vilstrup, H., Ott, P., Schousboe, A., Jalan, R., Keiding, S. & Waagepetersen, H. S., 2013, In: Biochemical Pharmacology. 85, 1, p. 115-23 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Reply to letter to the editor by Zheng G et al. Venous blood ammonia can be associated with cerebral blood flow in hepatic encephalopathy

  Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, L. K., Waagepetersen, H. S., Schousboe, A. & Sørensen, M., 2013, In: Hepatology. 58, 2, p. 833-834

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  1 Citation (Scopus)

• The effect of pH and ADP on ammonia affinity for human glutamate dehydrogenases

  Zaganas, I., Pajecka, K., Nielsen, C. W., Schousboe, A., Waagepetersen, H. S. & Plaitakis, A., Jun 2013, In: Metabolic Brain Disease. 28, 2, p. 127-131 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)
• 2012

  Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation

  Kreft, M., Bak, L. K., Waagepetersen, H. S. & Schousboe, A., 2012, In: A S N Neuro. 4, 3, p. 187 199 p.

  Research output: Contribution to journal › Review › Research › peer-review
  76 Citations (Scopus)

• Brain energy and ammonia metabolism

  Bak, L. K., Schousboe, A. & Waagepetersen, H. S., 2012, Functional molecular imaging in hepatology. Bentham Science Publishers, Vol. 1. p. 129-144 16 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Brain glycogen: new perspectives on its metabolic function and regulation at the subcellular level

  Obel, L. L. F., Müller, M. S., Walls, A. B., Sickmann, H. M., Bak, L. K., Waagepetersen, H. S. & Schousboe, A., 2 Mar 2012, In: Frontiers in Neuroenergetics. 4, 15 p.

  Research output: Contribution to journal › Review › Research › peer-review
  163 Citations (Scopus)

• Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model

  Sickmann, H. M., Waagepetersen, H. S., Schousboe, A., Benie, A. J. & Bouman, S. D., 2012, In: Neurochemistry International. 60, 3, p. 267-75 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  51 Citations (Scopus)

• Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission

  Frigerio, F., Karaca, M., De Roo, M., Mlynarik, V., Skytt, D. M., Carobbio, S., Pajecka, K., Waagepetersen, H. S., Gruetter, R., Muller, D. & Maechler, P., 2012, In: Journal of Neurochemistry. 123, 3, p. 342-348

  Research output: Contribution to journal › Journal article › Research › peer-review
  45 Citations (Scopus)

• Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission

  Frigerio, F., Karaca, M., De Roo, M., Mlynárik, V., Skytt, D. M., Carobbio, S., Pajęcka, K., Waagepetersen, H. S., Gruetter, R., Muller, D. & Maechler, P., Nov 2012, In: Journal of Neurochemistry. 123, 3, p. 342-8 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  45 Citations (Scopus)

• Delineation of glutamate pathways and secretory responses in pancreatic islets with ß-cell-specific abrogation of the glutamate dehydrogenase.

  Vetterli, L., Carobbio, S., Pournourmohammadi, S., Martin-del-Rio, R., Skytt, D. M., Waagepetersen, H. S., Tamarit-Rodriguez, J. & Maechler, P., 2012, In: Molecular Biology of the Cell. 23, 19, p. 3851-62

  Research output: Contribution to journal › Journal article › Research › peer-review
  39 Citations (Scopus)

• Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase

  Vetterli, L., Carobbio, S., Pournourmohammadi, S., Martin-Del-Rio, R., Skytt, D. M., Waagepetersen, H. S., Tamarit-Rodriguez, J. & Maechler, P., Oct 2012, In: Molecular Biology of the Cell. 23, 19, p. 3851-62 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  39 Citations (Scopus)

• Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation

  Brekke, E., Walls, A. B., Nørfeldt, L., Schousboe, A., Waagepetersen, H. S. & Sonnewald, U., 2012, In: Glia. 60, 1, p. 147-58 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Effects of adrenergic agents on intracellular ca(2+) homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: implications for glutamate neurotransmission and excitotoxicity

  Obel, L. L. F., Andersen, K. M. H., Bak, L. K., Schousboe, A. & Waagepetersen, H. S., 2012, In: Neurotoxicity Research. 21, 4, p. 405-17 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Energy Metabolism of the Brain

  McKenna, M. C., Dienel, G. A., Sonnewald, U., Waagepetersen, H. S. & Schousboe, A., 1 Dec 2012, Basic Neurochemistry. Elsevier, p. 200-231 32 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  113 Citations (Scopus)

• Glutamate efflux from brain to blood - Studies in an in vitro blood-brain barrier model

  Helms, H. C. C., Madelung, R., Waagepetersen, H. S., Nielsen, C. U. & Brodin, B., 2012.

  Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

• Impairment of the organization of locomotor and exploratory behaviors in bile duct-ligated rats

  Leke, R., de Oliveira, D. L., Mussulini, B. H. M., Pereira, M. S., Kazlauckas, V., Mazzini, G., Hartmann, C. R., Silveira, T. R., Simonsen, M., Bak, L. K., Waagepetersen, H. S., Keiding, S., Schousboe, A. & Portela, L. V., 2012, In: P L o S One. 7, 5, p. e36322

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)

• Importance of glutamate dehydrogenase, GDH, in astrocyte metabolism for maintenance of glutamate and energy homeostasis

  Skytt, D. M., 29 Jun 2012, København. 66 p.

  Research output: Book/Report › Ph.D. thesis › Research

• In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

  Helms, H. C., Madelung, R., Waagepetersen, H. S., Nielsen, C. U. & Brodin, B., 2012, In: Glia. 60, 6, p. 882-893

  Research output: Contribution to journal › Journal article › Research › peer-review
  67 Citations (Scopus)

• In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells co-cultured with astrocytes display a polarized brain-to-blood transport of glutamate

  Helms, H. C. C., Madelung, R., Groth, S., Waagepetersen, H. S., Nielsen, C. U. & Brodin, B., 13 Sep 2012. 1 p.

  Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

• In-vitro models of the blood brain barrier

  Brodin, B., Helms, H. C. C., Groth, S., Waagepetersen, H. S. & Nielsen, C. U., 2012. 1 p.

  Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

• Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca²⁺ signalling in cultured mouse glutamatergic neurons

  Bak, L. K., Obel, L. L. F., Walls, A. B., Schousboe, A., Faek, S. A. A., Jajo, F. S. & Waagepetersen, H. S., 2012, In: A S N Neuro. 4, 3, p. 151-160

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)

• Primary cultures of astrocytes: their value in understanding astrocytes in health and disease

  Lange, S. C., Bak, L. K., Waagepetersen, H. S., Schousboe, A. & Norenberg, M. D., Nov 2012, In: Neurochemical Research. 37, 11, p. 2569-88 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  137 Citations (Scopus)

• Quantitative importance of the pentose phosphate pathway determined by incorporation of 13C from [2-13C]- and [3-13C]glucose into TCA cycle intermediates and neurotransmitter amino acids in functionally intact neurons

  Brekke, E. M., Walls, A. B., Schousboe, A., Waagepetersen, H. S. & Sonnewald, U., 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, 9, p. 1788-1799 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  55 Citations (Scopus)

• siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate

  Skytt, D. M., Klawonn, A. M., Strid, M. H., Pajecka, K., Patruss, Y., Quintana-Cabrera, R., Bolanos, J. P., Schousboe, A. & Waagepetersen, H. S., 2012, In: Neurochemistry International. 61, 4, p. 490-497

  Research output: Contribution to journal › Journal article › Research › peer-review
  39 Citations (Scopus)

• Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons

  Bak, L. K., Johansen, M. L., Schousboe, A. & Waagepetersen, H. S., 2012, In: Journal of Neuroscience Research. 90, 9, p. 1768-75 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)
• 2011

  13C NMR spectroscopy and mass spectrometry analysis of intermediary metabolism in cultured neural cells

  Sonnewald, U., Schousboe, A. & Waagepetersen, H. S., 18 Mar 2011, Cell Culture Techniques. Aschner, M., Sunol, C. & Bal-Price, A. (eds.). p. 403-415 13 p. (Neuromethods, Vol. 56).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
  1 Citation (Scopus)

• Brain energy and ammonia metabolism

  Bak, L. K., Waagepetersen, H. S. & Schousboe, A., 2011, Functional molecular imaging in hepatology. Bussum, The Netherlands: Bentham Science Publishers, p. 129-144

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

• Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects

  Dam, G., Keiding, S., Munk, O. L., Ott, P., Buhl, M., Vilstrup, H., Bak, L. K., Waagepetersen, H. S., Schousboe, A., Møller, N. & Sørensen, M., 1 Aug 2011, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 301, 2, p. G269-77

  Research output: Contribution to journal › Journal article › Research › peer-review
  56 Citations (Scopus)

• Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine

  Leke, R., Bak, L. K., Anker, M., Melø, T. M., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Sonnewald, U., Schousboe, A. & Waagepetersen, H. S., 1 Apr 2011, In: Neurotoxicity Research. 19, 3, p. 496-510 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  41 Citations (Scopus)

• Glutamate and glutamine in brain disorders

  Bak, L. K., Schousboe, A. & Waagepetersen, H. S., 2011, Neurochemical mechanisms in diseases. Blass, J. P. (ed.). New York: Springer Publishing Company, Vol. 1. p. 195-212 (Advances in Neurobiology).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

  Dadsetan, S., Bak, L. K., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Leke, R., Schousboe, A. & Waagepetersen, H. S., 1 Sep 2011, In: Neurochemistry International. 59, 4, p. 482-8 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  35 Citations (Scopus)

• Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine

  Walls, A. B., Eyjolfsson, E. M., Smeland, O. B., Nilsen, L. H., Schousboe, I., Schousboe, A., Sonnewald, U. & Waagepetersen, H. S., 2011, In: Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 494-503 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  62 Citations (Scopus)

• Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source

  Schousboe, A., Sickmann, H. M., Bak, L. K., Schousboe, I., Jajo, F. S., Faek, S. A. A. & Waagepetersen, H. S., 1 Dec 2011, In: Journal of Neuroscience Research. 89, 12, p. 1926-34 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  43 Citations (Scopus)

• Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

  Leke, R., Bak, L. K., Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Schousboe, A. & Waagepetersen, H. S., 1 Jun 2011, In: Journal of Neurochemistry. 117, 5, p. 824-32 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  39 Citations (Scopus)
• 2010

  A functioning glycolysis is important for maintenance of glutamate transport in cultured astrocytes

  Schousboe, A., Sickmann, H. M., Bak, L. K., Schousboe, I., Bouman, S. D. & Waagepetersen, H. S., 2010, In: Journal of Neurochemistry. s1, p. 288-289

  Research output: Contribution to journal › Conference abstract in journal › Research

• A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures

  Suñol, C., Babot, Z., Cristòfol, R., Sonnewald, U., Waagepetersen, H. S. & Schousboe, A., Sep 2010, In: Neurochemical Research. 35, 9, p. 1384-1390 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Characterization of primary and secondary cultures of astrocytes prepared from mouse cerebral cortex

  Skytt, D. M., Madsen, K. K., Pajecka, K., Schousboe, A. & Waagepetersen, H. S., 2010, In: Neurochemical Research. 35, 12, p. 2043-2052 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Claudin-5 mRNA expression and transendothelial electrical resistance (TEER) correlate in the BCEC/astrocyte blood-brain barrier model

  Helms, H. C. C., Waagepetersen, H. S., Nielsen, C. U. & Brodin, B., 2010. 1 p.

  Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

• Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient

  Schousboe, A., Sickmann, H. M., Walls, A. B., Bak, L. K. & Waagepetersen, H. S., 2010, In: Neurotoxicity Research. 18, 1, p. 94-9 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)

• GABA-syntese - en vigtig brik for kontrol af epilepsi

  Walls, A. B., Schousboe, A. & Waagepetersen, H. S., 2010, In: Lægemiddelforskning. 2010, p. 31-33

  Research output: Contribution to journal › Journal article › Communication

• GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity

  Walls, A. B., Nilsen, L. H., Eyjolfsson, E. M., Vestergaard, H. T., Hansen, S. L., Schousboe, A., Sonnewald, U. & Waagepetersen, H. S., 2010, In: Journal of Neurochemistry. 115, 6, p. 1398–1408

  Research output: Contribution to journal › Journal article › Research › peer-review
  54 Citations (Scopus)

• Glial cell biology: neuronal-glial interaction in nutrition and amino-acid-mediated neurotransmission

  Schousboe, A. & Waagepetersen, H. S., 2010, The newborn brain: Neuroscience and clinical applications. Lagercrantz, H., Hanson, M. A., Ment, L. R. & Peebles, D. M. (eds.). 2 ed. Cambridge: Cambridge University Press, p. 121-128

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

• Hjernens forsvarsmur kortlagt og kopieret

  Helms, H. C., Waagepetersen, H. S., Nielsen, C. U. & Larsen, B. B., 2010, In: Lægemiddelforskning. 2010, p. 22-24

  Research output: Contribution to journal › Journal article › Communication

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