Research output per year
Research output per year
Research output
- 1 - 50 out of 275 results
Search results
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2024
Antimicrobial peptides grafted onto the surface of N-acetylcysteine-chitosan nanoparticles can revitalize drugs against clinical isolates of Mycobacterium tuberculosis
Primo, L. M. D. G., Roque-Borda, C. A., Carnero Canales, C. S., Caruso, I. P., de Lourenço, I. O., Colturato, V. M. M., Sábio, R. M., de Melo, F. A., Vicente, E. F., Chorilli, M., da Silva Barud, H., Barbugli, P. A., Franzyk, H., Hansen, P. R. & Pavan, F. R., 2024, In: Carbohydrate Polymers. 323, 17 p., 121449.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of lipid-polymer hybrid nanoparticles on the biophysical function and lateral structure of pulmonary surfactant: Mechanistic in vitro studies
Xu, Y., Cañadas, O., Alonso, A., Franzyk, H., Thakur, A., Pérez-gil, J. & Foged, C., 2024, In: Journal of Colloid and Interface Science. 654, Part B, p. 1111-1123Research output: Contribution to journal › Journal article › Research › peer-review
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Lipid nanoparticles for local delivery of mRNA to the respiratory tract: Effect of PEG-lipid content and administration route
Ongun, M., Lokras, A. G., Baghel, S., Shi, Z., Schmidt, S. T., Franzyk, H., Rades, T., Sebastiani, F., Thakur, A. & Foged, C., 2024, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 198, 10 p., 114266.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)30 Downloads (Pure) -
Polymyxins with Potent Antibacterial Activity against Colistin-Resistant Pathogens: Fine-Tuning Hydrophobicity with Unnatural Amino Acids
Jørgensen, J. S., Mood, E. H., Knap, A. S. H., Nielsen, S. E., Nielsen, P. E., Żabicka, D., Matias, C., Domraceva, I., Björkling, F. & Franzyk, H., 2024, In: Journal of Medicinal Chemistry. 67, 2, p. 1370–1383Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Recent advances in the development of antimicrobial peptides against ESKAPE pathogens
Roque-Borda, C. A., Primo, L. M. D. G., Franzyk, H., Hansen, P. R. & Pavan, F. R., 2024, In: Heliyon. 10, 11, 15 p., e31958.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)4 Downloads (Pure) -
Studies of antibacterial activity (in vitro and in vivo) and mode of action for des-acyl tridecaptins (DATs)
Couturier, C., Ronzon, Q., Lattanzi, G., Lingard, I., Coyne, S., Cazals, V., Dubarry, N., Yvon, S., Leroi-Geissler, C., Gracia, O. R., Teague, J., Sordello, S., Corbett, D., Bauch, C., Monlong, C., Payne, L., Taillier, T., Fuchs, H., Broenstrup, M., Harrison, P. H. & 10 others, , 2024, In: European Journal of Medicinal Chemistry. 265, 20 p., 116097.Research output: Contribution to journal › Journal article › Research › peer-review
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The Y-ome Conundrum: Insights into Uncharacterized Genes and Approaches for Functional Annotation
Sajid, S., Mashkoor, M., Jørgensen, M. G., Christensen, L. P., Hansen, P. R., Franzyk, H., Mirza, O. & Prabhala, B. K., 2024, In: Molecular and Cellular Biochemistry. 479, p. 1957–1968Research output: Contribution to journal › Review › Research › peer-review
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2023
Elucidating the nanostructure of small interfering RNA-loaded lipidoid-polymer hybrid nanoparticles
Aljabbari, A., Lokras, A. G., Kirkensgaard, J. J. K., Rades, T., Franzyk, H., Thakur, A., Zhang, Y. & Foged, C., 2023, In: Journal of Colloid and Interface Science. 633, p. 907-922Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile10 Citations (Scopus)58 Downloads (Pure) -
Insights into the mechanisms of interaction between inhalable lipid-polymer hybrid nanoparticles and pulmonary surfactant
Xu, Y., Parra-Ortiz, E., Wan, F., Cañadas, O., Garcia-Alvarez, B., Thakur, A., Franzyk, H., Pérez-Gil, J., Malmsten, M. & Foged, C., 2023, In: Journal of Colloid and Interface Science. 633, p. 511-525Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)48 Downloads (Pure) -
Method of manufacturing CAF®09 liposomes affects immune responses induced by adjuvanted subunit proteins
Thakur, A., Wadhwa, A., Lokras, A., Amanda Oest Müllertz, O., Christensen, D., Franzyk, H. & Foged, C., 2023, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 189, p. 84-97Research output: Contribution to journal › Journal article › Research › peer-review
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N-acetylcysteine-chitosan nanoparticles with the Ctx(Ile21)-Ha peptide grafted onto the surface can rescue the susceptibility of pre-extensively resistant Mycobacterium tuberculosis
Roque-Borda, C. A., Primo, L. M. D. G., Vicente, E. F., Barbugli, P. A., Franzyk, H., Hansen, P. R. & Pavan, F. R., 2 Oct 2023. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
Open AccessFile11 Downloads (Pure) -
Optimization of the Hemolysis Assay for the Assessment of Cytotoxicity
Sæbø, I. P., Bjørås, M., Franzyk, H., Helgesen, E. & Booth, J. A., 2023, In: International Journal of Molecular Sciences. 24, 3, 20 p., 2914.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile35 Downloads (Pure) -
Physiological response in E. coli to YdgR overexpression depends on whether the protein has an intact function
Sajid, S., Salas, L. H., Rafiq, M., Lund, T., Jørgensen, M. G., Honoré, B., Christensen, L. P., Hansen, P. R., Franzyk, H., Mirza, O. & Prabhala, B. K., 2023, In: Biochemical and Biophysical Research Communications. 661, p. 42-49Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile20 Downloads (Pure) -
Pulmonary delivery of siRNA-loaded lipid-polymer hybrid nanoparticles: Effect of nanoparticle size
Wadhwa, A., Bobak, T. R., Bohrmann, L., Geczy, R., Sekar, S., Sathyanarayanan, G., Kutter, J. P., Franzyk, H., Foged, C., Saatchi, K. & Häfeli, U. O., 2023, In: OpenNano. 13, 12 p., 100180.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)28 Downloads (Pure) -
Rifampicin-loaded N-acetylcysteine-chitosan nanoparticles surface-grafted with a peptide exhibit potent activity against multidrug-resistant Mycobacterium tuberculosis
Roque-Borda, C. A., Primo, L. M. D. G., Vicente, E. F., Barbugli, P. A., Franzyk, H., Hansen, P. R. & Pavan, F. R., 11 Jun 2023. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
Open AccessFile19 Downloads (Pure) -
Selected strategies to fight pathogenic bacteria
Plotniece, A., Sobolev, A., Supuran, C. T., Carta, F., Björkling, F., Franzyk, H., Yli-Kauhaluoma, J., Augustyns, K., Cos, P., De Vooght, L., Govaerts, M., Aizawa, J., Tammela, P. & Žalubovskis, R., 2023, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 38, 1, 27 p., 2155816.Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile29 Citations (Scopus)13 Downloads (Pure) -
Stereoisomer-Dependent Membrane Association and Capacity for Insulin Delivery Facilitated by Penetratin
Birch, D., Sayers, E. J., Christensen, M. V., Jones, A. T., Franzyk, H. & Nielsen, H. M., 2023, In: Pharmaceutics. 15, 6, 15 p., 1672.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)12 Downloads (Pure) -
Structure-activity study of oncocin: On-resin guanidinylation and incorporation of homoarginine, 4-hydroxyproline or 4,4-difluoroproline residues
Shaikh, A. Y., Björkling, F., Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Kreicberga, A. & Franzyk, H., 2023, In: Bioorganic Chemistry. 141, 11 p., 106876.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)10 Downloads (Pure) -
Substrate space analysis of the bacterial proton-coupled oligopeptide transporter YdgR by cheminformatics
Sajid, S., Nielsen, M. M. K., Khalil, R., Hansen, P. R., Franzyk, H., Jørgensen, M. G., Christensen, L. P., Mirza, O. & Prabhala, B. K., 2023, In: FEMS Microbiology Letters. 370, 9 p., fnad052.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of Cys15 and Cys21 replacement with Ala, Ser and Lys on the anti Mycobacterium tuberculosis activity of antimicrobial peptide B1CTcu5
Roque-Borda, C. A., Costa de Pontes, J. T., Domingos da Silva, L. H., Caroline dos Santos, I. C. D. S., Aparecida Resende, F., Franzyk, H., Hansen, P. R. & Pavan, F. R., 2023.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Open AccessFile17 Downloads (Pure) -
2022
C-locked analogs of the antimicrobial peptide BP214
Andersen, I. K. L., Thomsen, T. T., Rashid, J., Bobak, T. R., Oddo, A., Franzyk, H., Løbner-Olesen, A. & Hansen, P. R., 2022, In: Antibiotics. 11, 8, 10 p., 1080.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Citations (Scopus)41 Downloads (Pure) -
Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review
Hellewell, L., Gilani, N. M., Stanton, C. J., Pelligand, L., Franzyk, H., Guardabassi, L. & Good, L., 2022, In: Future Medicinal Chemistry. 14, 24, p. 1899–1921Research output: Contribution to journal › Review › Research › peer-review
Open AccessFile1 Citation (Scopus)34 Downloads (Pure) -
Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model
Frøslev, P., Franzyk, H., Ozgür, B., Larsen, B. B. & Kristensen, M., 2022, In: European Journal of Pharmaceutical Sciences. 168, 10 p., 106054.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile113 Downloads (Pure) -
Inhalable Composite Microparticles Containing siRNA-Loaded Lipid-Polymer Hybrid Nanoparticles: Saccharides and Leucine Preserve Aerosol Performance and Long-Term Physical Stability
Xu, Y., Turan, E. T., Shi, Z., Franzyk, H., Thakur, A. & Foged, C., 2022, In: Frontiers in Drug Delivery. 2, 15 p., 945459.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile33 Downloads (Pure) -
Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles
Xu, Y., Harinck, L., Lokras, A. G., Gerde, P., Selg, E., Sjöberg, C-O., Franzyk, H., Thakur, A. & Foged, C., 2022, In: International Journal of Pharmaceutics. 621, 14 p., 121758.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile31 Citations (Scopus)27 Downloads (Pure) -
Macrolide Resistance and In Vitro Potentiation by Peptidomimetics in Porcine Clinical Escherichia coli
Ma, Y., Pirolo, M., Subramani, P., Gehring, R., Damborg, P., Franzyk, H. & Guardabassi, L., 2022, In: mSphere. 7, 5, 10 p., e0040222.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile10 Citations (Scopus)22 Downloads (Pure) -
Simultaneous quantification of multiple RNA cargoes co-loaded into nanoparticle-based delivery systems
Lokras, A. G., Chakravarty, A., Rades, T., Christensen, D., Franzyk, H., Thakur, A. & Foged, C., 2022, In: International Journal of Pharmaceutics. 626, 13 p., 122171.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)18 Downloads (Pure) -
Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor Activation.
Viklund, M., Fredriksson, J., Holdfeldt, A., Lind, S., Franzyk, H., Dahlgren, C., Sundqvist, M. & Forsman, H., 2022, In: Journal of Immunology. 208, 7, p. 1632-1641Research output: Contribution to journal › Journal article › Research › peer-review
File2 Citations (Scopus)12 Downloads (Pure) -
2021
Antibiotic Potentiation in Multidrug-Resistant Gram-Negative Pathogenic Bacteria by a Synthetic Peptidomimetic
Mood, E. H., Goltermann, L., Brolin, C., Cavaco, L. M., Nejad, A. J., Yavari, N., Frederiksen, N., Franzyk, H. & Nielsen, P. E., 2021, In: ACS Infectious Diseases. 7, 8, p. 2152–2163Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile27 Downloads (Pure) -
Evaluation of 1H-Triazole-1-[N,N'-Bis(tert-butoxycarbonyl)]carboxamidine in Solution-Phase and On-Resin Guanidinylation
Wester, A., Björkling, F. & Franzyk, H., 2021, In: The Journal of Organic Chemistry. 86, 21, p. 14371–14380Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile3 Citations (Scopus)13 Downloads (Pure) -
Inoculum effect of antimicrobial peptides
Loffredo, M. R., Savini, F., Bobone, S., Casciaro, B., Franzyk, H., Mangoni, M. L. & Stella, L., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 21, 10 p., e2014364118.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile43 Citations (Scopus)36 Downloads (Pure) -
Neuroprotection Against NMDA-Induced Retinal Damage by Philanthotoxin-343 Involves Reduced Nitrosative Stress
Mohamad, M. H. N., Abu, I. F., Fazel, M. F., Agarwal, R., Iezhitsa, I., Juliana, N., Mellor, I. R. & Franzyk, H., 2021, In: Frontiers in Pharmacology. 12, 11 p., 798794.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)15 Downloads (Pure) -
Optimized Synthesis of Fmoc/Boc-Protected PNA Monomers and their Assembly into PNA Oligomers.
Shaikh, A. Y., Björkling, F., Nielsen, P. E. & Franzyk, H., 2021, In: European Journal of Organic Chemistry. 2021, 19, p. 2792-2801 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)18 Downloads (Pure) -
Peptide/β-Peptoid Hybrids with Activity against Vancomycin-Resistant Enterococci: Influence of Hydrophobicity and Structural Features on Antibacterial and Hemolytic Properties
Vestergaard, M., Skive, B., Domraceva, I., Ingmer, H. & Franzyk, H., 2021, In: International Journal of Molecular Sciences. 22, 11, 5617.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile6 Citations (Scopus)44 Downloads (Pure) -
Peptide/β-Peptoid Hybrids with Ultrashort PEG-Like Moieties: Effects on Hydrophobicity, Antibacterial Activity and Hemolytic Properties
Frederiksen, N., Louka, S., Mudaliar, C., Domraceva, I., Kreicberga, A., Pugovics, O., Żabicka, D., Tomczak, M., Wygoda, W., Björkling, F. & Franzyk, H., 2021, In: International Journal of Molecular Sciences. 22, 13, 17 p., 7041.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile17 Downloads (Pure) -
Perfluoro-tert-butanol for selective on-resin detritylation: a mild alternative to traditionally used methods
Wester, A., Hansen, A. M., Hansen, P. R. & Franzyk, H., 2021, In: Amino Acids. 53, p. 1455–1466Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)31 Downloads (Pure) -
Reversal of ABCG2/BCRP-mediated multidrug resistance by 5,3’,5’-trihydroxy-3,6,7,4’-tetramethoxyflavone isolated from the Australian desert plant Eremophila galeata Chinnock
Petersen, M. J., Lund, X. L., Semple, S. J., Buirchell, B., Franzyk, H., Gajhede, M., Kongstad, K. T., Stenvang, J. & Stærk, D., 2021, In: Biomolecules. 11, 10, 19 p., 1534.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)24 Downloads (Pure) -
Targeting Toxins toward Tumors
Franzyk, H. & Christensen, S. B., 2021, In: Molecules. 26, 5, 23 p., 1292.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)78 Downloads (Pure) -
The Effects of Structural Alterations in the Polyamine and Amino Acid Moieties of Philanthotoxins on Nicotinic Acetylcholine Receptor Inhibition in the Locust, Schistocerca gregaria
Luck, V. L., Richards, D. P., Shaikh, A. Y., Franzyk, H. & Mellor, I. R., 2021, In: Molecules (Print Archive Edition). 26, 22, 11 p., 7007.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)11 Downloads (Pure) -
2020
Alternating Cationic-Hydrophobic Peptide/Peptoid Hybrids: Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity
Frederiksen, N., Hansen, P. R., Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Björkling, F. & Franzyk, H., 2020, In: ChemMedChem. 15, 24, p. 2544-2561Research output: Contribution to journal › Journal article › Research › peer-review
27 Citations (Scopus) -
Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens
Malik, A., Ardalani, H., Anam, S., McNair, L. M., Kromphardt, K. J. K., Frandsen, R. J. N., Franzyk, H., Stærk, D. & Kongstad, K. T., 2020, In: Fitoterapia. 142, 8 p., 104522.Research output: Contribution to journal › Journal article › Research › peer-review
42 Citations (Scopus) -
Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis
Sundqvist, M., Holdfeldt, A., Wright, S. C., Møller, T. C., Siaw, E., Jennbacken, K., Franzyk, H., Bouvier, M., Dahlgren, C. & Forsman, H., 2020, In: B B A - Molecular Cell Research. 1867, 12, 13 p., 118849.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile19 Citations (Scopus)19 Downloads (Pure) -
Facile Preparation of PNA-Peptide Conjugates with a Polar Maleimide-Thioether Linkage
Hansen, A. M., Shaikh, A. Y. & Franzyk, H., 2020, Peptide Nucleic Acids: Methods and Protocols. P. E. N. (ed.). Humana Press, p. 97-118 22 p. (Methods in molecular biology (Clifton, N.J.), Vol. 2105).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
1 Citation (Scopus) -
Fluorescent analogues of Human α-Calcitonin Gene-Related Peptide with vasodilator potency
Zhu, J., Pedersen, M. D., Ahmed, L. S., Abdolalizadeh, B., Grell, A-S., Berg, J. O., Thulstrup, P. W., Franzyk, H., Edvinsson, L., Sams, A., Sheykhzade, M. & Hansen, P. R., 2020, In: International Journal of Molecular Sciences (Online). 21, 4, p. 1-15 15 p., 1343.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile9 Citations (Scopus)127 Downloads (Pure) -
Fmoc-Based Assembly of PNA Oligomers: Manual and Microwave-Assisted Automated Synthesis
Shaikh, A. Y., Hansen, A. M. & Franzyk, H., 2020, Peptide Nucleic Acids: Methods and Protocols. P. E. N. (ed.). Humana Press, p. 1-16 16 p. (Methods in molecular biology (Clifton, N.J.), Vol. 2105).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
1 Citation (Scopus) -
In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 Against PMA-Induced Acute Inflammation
Wu, B. C., Skovbakke, S. L., Masoudi, H., Hancock, R. E. W. & Franzyk, H., 2020, In: Frontiers in Immunology. 11, 11 p., 2102.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile13 Citations (Scopus)41 Downloads (Pure) -
Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics
Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M. H., Yli-Kauhaluoma, J., Talman, V., Franzyk, H., Tuominen, R. K. & Christensen, S. B., 2020, In: A C S Medicinal Chemistry Letters. 11, 5, p. 671-677 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Open Access6 Citations (Scopus) -
Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position
Jensen, S. K., Thomsen, T. T., Oddo, A., Franzyk, H., Løbner-Olesen, A. & Hansen, P. R., 2020, In: International Journal of Molecular Sciences . 21, 16, 18 p., 5829.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile16 Citations (Scopus)51 Downloads (Pure) -
Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles
Lokras, A., Thakur, A., Wadhwa, A., Thanki, K., Franzyk, H. & Foged, C., 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 14 p., 601155.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile14 Citations (Scopus)46 Downloads (Pure) -
Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity
Fazel, M. F., Abu, I. F., Mohamad, M. H. N., Agarwal, R., Iezhitsa, I., Bakar, N. S., Juliana, N., Mellor, I. R. & Franzyk, H., 2020, In: PLoS ONE. 15, 7, 14 p., e0236450.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)15 Downloads (Pure)