Henrik Jessen Jürgensen

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• 2025

  Targeting uPAR with an antibody-drug conjugate suppresses tumor growth and reshapes the immune landscape in pancreatic cancer models

  Metrangolo, V., Blomquist, M. H., Dutta, A., Gårdsvoll, H., Krigslund, O., Nørregaard, K. S., Jürgensen, H. J., Ploug, M., Flick, M. J., Behrendt, N. & Engelholm, L. H., 2025, In: Science Advances. 11, 3, 18 p., eadq0513.

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• 2024

  A proteomics-based survey reveals thrombospondin-4 as a ligand regulated by the mannose receptor in the injured lung

  Nørregaard, K. S., Jürgensen, H. J., Heltberg, S. S., Gårdsvoll, H., Bugge, T. H., Schoof, E. M., Engelholm, L. H. & Behrendt, N., 2024, In: Journal of Biological Chemistry. 300, 5, 13 p., 107284.

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• 2022

  The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1

  Nørregaard, K. S., Jürgensen, H. J., Ingvarsen, S. Z., Heltberg, S. S., Hagensen, C. E., Gårdsvoll, H., Madsen, D. H., Jensen, O. N., Engelholm, L. H. & Behrendt, N., 2022, In: Matrix Biology. 111, p. 307-328 22 p.

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  5 Citations (Scopus)

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• Uncovering mediators of collagen degradation in the tumor microenvironment

  Thorseth, M. L., Carretta, M., Jensen, C., Mølgaard, K., Jürgensen, H. J., Engelholm, L. H., Behrendt, N., Willumsen, N. & Madsen, D. H., 2022, In: Matrix Biology Plus. 13, 100101.

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  22 Citations (Scopus)

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• 2021

  Osteosarcoma and metastasis associated bone degradation—a tale of osteoclast and malignant cell cooperativity

  Nørregaard, K. S., Jürgensen, H. J., Gårdsvoll, H., Engelholm, L. H., Behrendt, N. & Søe, K., 2021, In: International Journal of Molecular Sciences. 22, 13, 6865.

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  35 Citations (Scopus)

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• The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target

  Çakılkaya, P., Sørensen, R. R., Jürgensen, H. J., Krigslund, O., Gårdsvoll, H., Nielsen, C. F., Santoni‐Rugiu, E., Behrendt, N. & Engelholm, L. H., 2021, In: International Journal of Molecular Sciences. 22, 21, 17 p., 11452.

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  4 Citations (Scopus)

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• 2020

  Cellular uptake of collagens and implications for immune cell regulation in disease

  Jürgensen, H. J., Van Putten, S., Nørregaard, K. S., Bugge, T. H., Engelholm, L. H., Behrendt, N. & Madsen, D. H., 2020, In: Cellular and Molecular Life Sciences. 77, 16, p. 3161-3176

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  27 Citations (Scopus)

• The collagen receptor uPARAP/Endo180 regulates collectins through unique structural elements in its FNII domain

  Nørregaard, K. S., Krigslund, O., Behrendt, N., Engelholm, L. H. & Jürgensen, H. J., 2020, In: Journal of Biological Chemistry. 295, 27, p. 9157-9170 15 p.

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  9 Citations (Scopus)

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• Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis

  Ingvarsen, S. Z., Gardsvoll, H., van Putten, S., Norregaard, K. S., Krigslund, O., Meilstrup, J. A., Tran, C., Jurgensen, H. J., Melander, M. C., Nielsen, C. H., Kjaer, A., Bugge, T. H., Engelholm, L. H. & Behrendt, N., 2020, In: Scientific Reports. 10, 1, p. 1-16 19138.

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  16 Citations (Scopus)

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• 2019

  CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets

  Jürgensen, H. J., Silva, L. M., Krigslund, O., Van Putten, S., Madsen, D. H., Behrendt, N., Engelholm, L. H. & Bugge, T. H., 2019, In: Matrix Biology Plus. 1, p. 1-20 100003.

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  23 Citations (Scopus)

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• Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins

  Jürgensen, H. J., Nørregaard, K. S., Sibree, M. M., Santoni‑Rugiu, E., Madsen, D. H., Wassilew, K., Krustrup, D., Garred, P., Bugge, T. H., Engelholm, L. H. & Behrendt, N., 1 Jan 2019, In: Journal of Cell Biology. 218, 1, p. 333-349 17 p.

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  15 Citations (Scopus)
• 2017

  Matriptase zymogen supports epithelial development, homeostasis and regeneration

  Friis, S., Tadeo, D., Le-Gall, S. M., Jurgensen, H. J., Sales, K. U., Camerer, E. & Bugge, T. H., 2017, In: B M C Biology. 15, 17 p., 46.

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  19 Citations (Scopus)

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• The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers

  Nielsen, C. F., van Putten, S. M., Lund, I. K., Melander, M. C., Nørregaard, K. S., Jürgensen, H. J., Reckzeh, K., Christensen, K. R., Ingvarsen, S. Z., Gårdsvoll, H., Jensen, K. E., Hamerlik, P., Engelholm, L. H. & Behrendt, N., 2017, In: OncoTarget. 8, 27, p. 44605-44624 20 p.

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  28 Citations (Scopus)

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• Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

  Madsen, D. H., Jürgensen, H. J., Siersbæk, M. S., Kuczek, D. E., Grey Cloud, L., Liu, S., Behrendt, N., Grøntved, L., Weigert, R. & Bugge, T. H., 26 Dec 2017, In: Cell Reports. 21, 13, p. 3662-3671 10 p.

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  101 Citations (Scopus)

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• 2016

  A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo

  Motley, M. P., Madsen, D. H., Jürgensen, H. J., Spencer, D. E., Szabo, R., Holmbeck, K., Flick, M. J., Lawrence, D. A., Castellino, F. J., Weigert, R. & Bugge, T. H., 2016, In: Blood. 127, 9, p. 1085-1096 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)

• Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding

  Yuan, C., Jürgensen, H. J., Engelholm, L. H., Li, R., Liu, M., Jiang, L., Luo, Z., Behrendt, N. & Huang, M., 1 Aug 2016, In: Biochemical Journal. 473, 15, p. 2359-68 10 p.

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  10 Citations (Scopus)

• Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180

  Engelholm, L. H., Carlsen Melander, E. M., Hald, A., Persson, M., Madsen, D. H., Jürgensen, H. J., Johansson, K., Nielsen, C., Nørregaard, K. S., Ingvarsen, S. Z., Kjaer, A., Trovik, C. S., Lærum, O. D., Bugge, T. H., Eide, J. & Behrendt, N., Jan 2016, In: Journal of Pathology. 238, 1, p. 120-33 14 p.

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  27 Citations (Scopus)
• 2015

  The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)

  Carlsen Melander, E. M., Jürgensen, H. J., Madsen, D. H., Engelholm, L. H. & Behrendt, N., Oct 2015, In: International Journal of Oncology. 47, 4, p. 1177-88 12 p.

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  54 Citations (Scopus)

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• 2014

  Complex Determinants in Specific Members of the Mannose Receptor Family Govern Collagen Endocytosis

  Jürgensen, H. J., Johansson, K., Madsen, D. H., Porse, A., Melander, M. C., Sørensen, K. R., Nielsen, C., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 2014, In: The Journal of Biological Chemistry. 289, 11, p. 7935-7947 13 p.

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  45 Citations (Scopus)
• 2013

  Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis

  Madsen, D. H., Jürgensen, H. J., Ingvarsen, S., Melander, M. C., Albrechtsen, R., Hald, A., Holmbeck, K., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 2013, In: PloS one. 8, 8, p. e71261

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  26 Citations (Scopus)

• Ficolin-1-PTX3 complex formation promotes clearance of altered self-cells and modulates IL-8 production

  Ma, Y. J., Doni, A., Romani, L., Jürgensen, H. J., Behrendt, N., Mantovani, A. & Garred, P., 1 Aug 2013, In: Journal of immunology (Baltimore, Md. : 1950). 191, 3, p. 1324-33 10 p.

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  73 Citations (Scopus)

• M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway

  Madsen, D. H., Leonard, D., Masedunskas, A., Moyer, A., Jürgensen, H. J., Peters, D. E., Amornphimoltham, P., Selvaraj, A., Yamada, S. S., Brenner, D. A., Burgdorf, S., Engelholm, L. H., Behrendt, N., Holmbeck, K., Weigert, R. & Bugge, T. H., 16 Sep 2013, In: Journal of Cell Biology. 202, 6, p. 951-66 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  258 Citations (Scopus)
• 2011

  A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uPARAP/ENDO 180

  Jürgensen, H. J., Madsen, D. H., Ingvarsen, S., Melander, M. C., Gårdsvoll, H., Patthy, L., Engelholm, L. H. & Behrendt, N., 2011, In: Journal of Biological Chemistry. 286, 37, p. 32736-48 13 p.

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  82 Citations (Scopus)

• The non-phagocytic route of collagen uptake: a distinct degradation pathway

  Madsen, D. H., Ingvarsen, S., Jürgensen, H. J., Melander, M. C., Kjøller, L., Moyer, A., Honoré, C., Madsen, M. C., Garred, P., Burgdorf, S., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 29 Jul 2011, In: The Journal of Biological Chemistry. 286, 30, p. 26996-7010 15 p.

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  107 Citations (Scopus)
• 2009

  The collagen receptor uPARAP/Endo180

  Engelholm, L. H., Ingvarsen, S., Jürgensen, H. J., Hillig, T., Madsen, D. H., Nielsen, B. S. & Behrendt, N., 1 Jan 2009, In: Frontiers in Bioscience. 14, p. 2103-14 12 p.

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