Personal profile
CV
Associate Professor, Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, since may 2011
Assistant Professor, Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, May 2007 April 2011
Associate Professor, Department of Health Sciences, Nord-Trøndelag University College, December 2004 - April 2007
Assistant Professor, Institute of Pharmacy, University of Tromsø, May 2002 - October 2002
Ph.D. Student, Institute of Pharmacy, University of Tromsø, September 1999 - April 2002 and November 2002 - November 2004
Scientific assistant, Institute of Pharmacy, University of Tromsø, February 1999 - August 1999
Registration as pharmacist, December 1998
Pre-registration period, November 1997 - October 1998
Exchange student, University of Utrecht, October 1996 - February 1997
Student of pharmacy, University of Erlangen-Nürnberg, November 1992 - October 1997
Primary fields of research
Research focusses on stabilizing the unstable, thereby addressing two major problems of new pharmacolically actuive substances: structural stability of macromolecules and poor water solubility of small organic molecules.
To address the low water solubility we transfrom drugs to their amorphous counterpart, which is more soluble. However, this form in unstable, which in turn is addressed by the formation of a co-amorphou form, which can posssess increased stability combined with increased solubility.
With reagrd to proteins and peptides, research focusses on an increase of the knowledge base related to freeze-drying.
The application of multivariate analysis, such as principal component analysis, and statisitical design of experiments is an integrated part of our reserach.
Keywords:
Peptides and Proteins in pharmaceutical formulations
Freeze-drying and spray-drying
Co-amorphous systems
Design of experiments, process analytical technology and quality by design
Teaching
Teaching covers the production, composition and quality assurance of solid dosage forms for drugs, such as tablets.
Courses:
Pharmacy 2 - Solid dosage forms
Bachelor project in Pharmacy
In addition, supervision of Master theses
Keywords
- Former Faculty of Pharmaceutical Sciences
Collaborations and top research areas from the last five years
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Phycocyanin oral delivery system obtained by spray-drying with soy proteins for the treatment of inflammatory bowel diseases: in vivo evaluation
Terracina, F., Cicio, A., Puleo, G., Baiamonte, C., Belmonte, B., Merighi, S., D'Anna, T., Montalbano, F., Pizzolanti, G., Serio, R. M., Craparo, E. F., Grohganz, H., Zizzo, M. G. & Licciardi, M., 2026, In: International Journal of Biological Macromolecules. 338, 13 p., 149876.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)9 Downloads (Pure) -
The Role of Pectin in Optimizing Cationic Liposomes for Oral Delivery
Lutta, A., Martinez-Navarrete, M., Tollemeto, M., Andresen, A. K., Pedersen, G. K., Guillot, A. J., Zhang, Z., Grohganz, H., Melero, A., Schmidt, S. T. & Nielsen, L. H., 2026, In: ACS Applied Bio Materials. 9, 6, p. 2815–2826Research output: Contribution to journal › Journal article › Research › peer-review
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A design of experiment approach to identify the most stable composition of a ternary co-amorphous system
Traichel, W., Rades, T. & Grohganz, H., 2025, In: Journal of Drug Delivery Science and Technology. 107, 106834.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile1 Citation (Scopus)25 Downloads (Pure) -
Mechanistic Investigation into Crystallization of Hydrated Co-Amorphous Systems of Flurbiprofen and Lidocaine
Xu, X., Grohganz, H., Knapik-Kowalczuk, J., Paluch, M. & Rades, T., 2025, In: Pharmaceutics. 17, 2, 17 p., 175.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus)27 Downloads (Pure) -
Microfluidic fabrication of pectin-coated liposomes for drug delivery
Lutta, A., Liu, Q., Pedersen, G. K., Dong, M., Grohganz, H., Nielsen, L. H. & Schmidt, S. T., 2025, In: Drug Delivery and Translational Research. 15, p. 2941–2950Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile7 Citations (Scopus)7 Downloads (Pure) -
Advancing inflammatory skin disease therapy: Sustained tofacitinib release via electrospun fiber dressings
Gürtler, A.-L., Maltschik, A. M., Meryem Güler Yildiz, S., Vangelofski, K., Gade, L., Grohganz, H., Rades, T. & Heinz, A., 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 202, 8 p., 114423.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)38 Downloads (Pure) -
Anti-plasticizing effect of water on prilocaine and lidocaine: the role of the hydrogen bonding pattern
Xu, X., Grohganz, H. & Rades, T., 2024, In: Physical Chemistry Chemical Physics. 26, p. 14149-14159Research output: Contribution to journal › Journal article › Research › peer-review
1 Citation (Scopus) -
Coaxial electrospinning of polycaprolactone: A design of experiments approach
Gürtler, A.-L., Linseisen, I., Grohganz, H. & Heinz, A., 2024, In: European Polymer Journal. 208, 11 p., 112886.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile27 Citations (Scopus)66 Downloads (Pure)
Activities
- 1 Lecture and oral contribution
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Bæredygtig medicin - fra Big Pharma til klinik
Nørgaard, L. S. (Speaker) & Grohganz, H. (Speaker)
30 Apr 2024Activity: Presentations, memberships and other activity types › Lecture and oral contribution
Press/Media
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Bæredygtighed ift. lægemidler
Nørgaard, L. S. & Grohganz, H.
22/05/2024
1 item of Media coverage
Press/Media: Press / Media