Holger Grohganz

Search results

• 2024

  Advancing inflammatory skin disease therapy: Sustained tofacitinib release via electrospun fiber dressings

  Gürtler, A., Maltschik, A. M., Meryem Güler Yildiz, S., Vangelofski, K., Gade, L., Grohganz, H., Rades, T. & Heinz, A., 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 202, 8 p., 114423.

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• Anti-plasticizing effect of water on prilocaine and lidocaine: the role of the hydrogen bonding pattern

  Xu, X., Grohganz, H. & Rades, T., 2024, In: Physical Chemistry Chemical Physics. 26, p. 14149-14159

  Research output: Contribution to journal › Journal article › Research › peer-review

• Coaxial electrospinning of polycaprolactone: A design of experiments approach

  Gürtler, A., Linseisen, I., Grohganz, H. & Heinz, A., 2024, In: European Polymer Journal. 208, 11 p., 112886.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress

  Di, R., Grohganz, H. & Rades, T., 2024, In: Pharmaceutics. 16, 15 p., 67.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• Influence of water and trehalose on α- and β-relaxation of freeze-dried lysozyme formulations

  Vallaster, B., Engelsing, F. & Grohganz, H., 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 194, p. 1-8

  Research output: Contribution to journal › Journal article › Research › peer-review

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  2 Citations (Scopus)

  8 Downloads (Pure)

• Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine

  Xu, X., Rades, T. & Grohganz, H., 2024, In: International Journal of Pharmaceutics. 651, 7 p., 123807.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  3 Citations (Scopus)

  18 Downloads (Pure)

• Salt hydrates as a source to form co-amorphous systems when prepared in the absence of water: Hydrogen bond analysis

  Deng, Y., Liu, S., Jiang, Y., Grohganz, H. & Rades, T., 2024, In: Chemical Engineering Science. 296, 120232.

  Research output: Contribution to journal › Journal article › Research › peer-review

• The interplay between trehalose and dextran as spray drying precursors for cationic liposomes

  Lutta, A., Knopp, M. M., Tollemeto, M., Pedersen, G. K., Schmidt, S. T., Grohganz, H. & Hagner Nielsen, L., 2024, In: International Journal of Pharmaceutics. 652, 10 p., 123798.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  1 Citation (Scopus)

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• Utilizing the allyl-terminated copolymer methoxy(poly(ethylene glycol))-block-poly(jasmine lactone) in the development of amorphous solid dispersions: A comparative study of functionalized and non-functionalized polymer

  Di, R., Bansal, K. K., Rosenholm, J. M., Grohganz, H. & Rades, T., 2024, In: International Journal of Pharmaceutics. 657, 12 p., 124175.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  1 Citation (Scopus)

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• 2023

  Compaction Behavior of Co-Amorphous Systems

  Sørensen, C. M., Rantanen, J. & Grohganz, H., 2023, In: Pharmaceutics. 15, 3, 12 p., 858.

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  7 Citations (Scopus)

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• Considerations on the Kinetic Processes in the Preparation of Ternary Co-Amorphous Systems by Milling

  Wang, Y., Rades, T. & Grohganz, H., 2023, In: Pharmaceutics. 15, 1, 14 p., 172.

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  2 Citations (Scopus)

  28 Downloads (Pure)

• Design of experiments approach on the compaction properties of co-amorphous tablets

  Engelsing, F., Buchart, L. & Grohganz, H., 2023, In: Pharmaceutical Development and Technology. 28, 9, p. 907-914

  Research output: Contribution to journal › Journal article › Research › peer-review

• Interaction of liposomes with bile salts investigated by asymmetric flow field-flow fractionation (AF4): A novel approach for stability assessment of oral drug carriers

  Bohsen, M. S., Tychsen, S. T., Kadhim, A. A. H., Grohganz, H., Treusch, A. H. & Brandl, M., 2023, In: European Journal of Pharmaceutical Sciences. 182, 10 p., 106384.

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  8 Citations (Scopus)

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• Preparation of Co-Amorphous Levofloxacin Systems for Pulmonary Application

  Gabelmann, A., Lehr, C. M. & Grohganz, H., 2023, In: Pharmaceutics. 15, 6, 15 p., 1574.

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  5 Citations (Scopus)

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• Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine

  Xu, X., Rades, T. & Grohganz, H., 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 186, p. 1-6

  Research output: Contribution to journal › Journal article › Research › peer-review

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  5 Citations (Scopus)

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• Wet granulation of co-amorphous indomethacin systems

  Schütz, D., Timmerhaus, A. & Grohganz, H., 2023, In: International Journal of Pharmaceutics. 644, 9 p., 123318.

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• 2022

  Effects of polymer addition on the non-strongly interacting binary co-amorphous system carvedilol-tryptophan

  Wang, Y., Grohganz, H. & Rades, T., 2022, In: International Journal of Pharmaceutics. 617, 9 p., 121625.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  11 Citations (Scopus)

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• Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems

  Liu, J., Hwu, E., Bannow, J., Grohganz, H. & Rades, T., 2022, In: Molecular Pharmaceutics. 19, 4, p. 1183-1190

  Research output: Contribution to journal › Journal article › Research › peer-review

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  7 Citations (Scopus)

  15 Downloads (Pure)

• Influence of Water on Amorphous Lidocaine

  Xu, X., Grohganz, H. & Rades, T., 2022, In: Molecular Pharmaceutics. 19, 9, p. 3199–3205

  Research output: Contribution to journal › Journal article › Research › peer-review

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  5 Citations (Scopus)

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• 2021

  A Multivariate Approach for the Determination of the Optimal Mixing Ratio of the Non-Strong Interacting Co-Amorphous System Carvedilol-Tryptophan

  Di, R., Liu, J., Grohganz, H. & Rades, T., 2021, In: Molecules. 26, 4, 8 p., 801.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  10 Citations (Scopus)

  68 Downloads (Pure)

• Co-Amorphous Drug Formulations in Numbers: Recent Advances in Co-Amorphous Drug Formulations with Focus on Co-Formability, Molar Ratio, Preparation Methods, Physical Stability, In Vitro and In Vivo Performance, and New Formulation Strategies

  Liu, J., Grohganz, H., Lobmann, K., Rades, T. & Hempel, N-J., 2021, In: Pharmaceutics. 13, 3, 43 p., 389.

  Research output: Contribution to journal › Review › Research

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  87 Citations (Scopus)

  54 Downloads (Pure)

• Comparison of co-former performance in co-amorphous formulations: Single amino acids, amino acid physical mixtures, amino acid salts and dipeptides as co-formers

  Wu, W., Grohganz, H., Rades, T. & Loebmann, K., 2021, In: European Journal of Pharmaceutical Sciences. 156, 8 p., 105582.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)

• Predictive identification of co-formers in co-amorphous systems

  Chambers, L. I., Grohganz, H., Palmelund, H., Lobmann, K., Rades, T., Musa, O. M. & Steed, J. W., 2021, In: European Journal of Pharmaceutical Sciences. 157, 9 p., 105636.

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• Screening of novel excipients for freeze-dried protein formulations

  Holm, T. P., Meng-Lund, H., Rantanen, J., Jorgensen, L. & Grohganz, H., 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 160, p. 55-64 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• The influence of moisture on the storage stability of co-amorphous systems

  Liu, J., Rades, T. & Grohganz, H., 2021, In: International Journal of Pharmaceutics. 605, 120802.

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  16 Citations (Scopus)

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• 2020

  Determination of the Optimal Molar Ratio in Amino Acid-Based Coamorphous Systems

  Liu, J., Rades, T. & Grohganz, H., 2020, In: Molecular Pharmaceutics. 17, 4, p. 1335-1342 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  31 Citations (Scopus)

• Formulation of co-amorphous systems from naproxen and naproxen sodium and in situ monitoring of physicochemical state changes during dissolution testing by Raman spectroscopy

  Ueda, H., Peter Bøtker, J., Edinger, M., Löbmann, K., Grohganz, H., Müllertz, A., Rades, T. & Østergaard, J., 2020, In: International Journal of Pharmaceutics. 587, 119662.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Influence of polymer addition on the amorphization, dissolution and physical stability of co-amorphous systems

  Liu, J., Grohganz, H. & Rades, T., 2020, In: International Journal of Pharmaceutics. 588, p. 1-9 9 p., 119768.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)

• Preparation of Co-Amorphous Systems by Freeze-Drying

  Wostry, M., Plappert, H. & Grohganz, H., 2020, In: Pharmaceutics. 12, 10, 12 p., 941.

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  17 Citations (Scopus)

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• 2019

  A co-amorphous form of a substance and a protein

  Mishra, J., Bohr, A., Berg, T. H. A., Löbmann, K., Rades, T., Grohganz, H. & Water, J. J., 2019, Patent No. US201903078886A1

  Research output: Patent

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• Characterising glass transition temperatures and glass dynamics in mesoporous silica-based amorphous drugs

  Kissi, E. O., Ruggiero, M. T., Hempel, N. J., Song, Z., Grohganz, H., Rades, T. & Löbmann, K., 1 Jan 2019, In: Physical Chemistry Chemical Physics. 21, 35, p. 19686-19694 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Co-former selection for co-amorphous drug-amino acid formulations

  Kasten, G., Löbmann, K., Grohganz, H. & Rades, T., 2019, In: International Journal of Pharmaceutics. 557, p. 366-373

  Research output: Contribution to journal › Journal article › Research › peer-review
  86 Citations (Scopus)

• Dipeptides as co-formers in co-amorphous systems

  Wu, W., Löbmann, K., Schnitzkewitz, J., Knuhtsen, A., Pedersen, D. S., Rades, T. & Grohganz, H., 1 Jan 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 134, p. 68-76 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  31 Citations (Scopus)

• Efflux Inhibitor Bicalutamide Increases Oral Bioavailability of the Poorly Soluble Efflux Substrate Docetaxel in Co-Amorphous Anti-Cancer Combination Therapy

  Bohr, A., Nascimento, T. L., Harmankaya, N., Weisser, J. J., Wang, Y., Grohganz, H., Rades, T. & Löbmann, K., 2019, In: Molecules. 24, 2, 13 p., 266.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  19 Citations (Scopus)

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• Exploring the chemical space for freeze-drying excipients

  Meng-Lund, H., Holm, T. P., Poso, A., Jorgensen, L., Rantanen, J. & Grohganz, H., 2019, In: International Journal of Pharmaceutics. 566, p. 254-263 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• Influence of Glass Forming Ability on the Physical Stability of Supersaturated Amorphous Solid Dispersions

  Blaabjerg, L. I., Bulduk, B., Lindenberg, E., Löbmann, K., Rades, T. & Grohganz, H., 1 Jan 2019, In: Journal of Pharmaceutical Sciences. 108, 8, p. 2561-2569

  Research output: Contribution to journal › Journal article › Research › peer-review
  38 Citations (Scopus)

• In situ co-amorphisation in coated tablets – The combination of carvedilol with aspartic acid during immersion in an acidic medium

  Petry, I., Löbmann, K., Grohganz, H., Rades, T. & Leopold, C. S., 10 Mar 2019, In: International Journal of Pharmaceutics. 558, p. 357-366 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations

  Kasten, G., Duarte, Í., Paisana, M., Löbmann, K., Rades, T. & Grohganz, H., 9 Jan 2019, In: Pharmaceutics. 11, 1, 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  19 Citations (Scopus)

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• Transformations between Co-Amorphous and Co-Crystal Systems and Their Influence on the Formation and Physical Stability of Co-Amorphous Systems

  Wu, W., Wang, Y., Löbmann, K., Grohganz, H. & Rades, T., 4 Mar 2019, In: Molecular Pharmaceutics. 16, 3, p. 1294-1304 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  49 Citations (Scopus)

• Using dextran of different molecular weights to achieve faster freeze-drying and improved storage stability of lactate dehydrogenase

  Larsen, B. S., Skytte, J., Svagan, A. J., Meng-Lund, H., Grohganz, H. & Lobmann, K., 2019, In: Pharmaceutical Development and Technology. 24, 3, p. 323-328

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• Whey proteins as stabilizers in amorphous solid dispersions

  Mishra, J., Bohr, A., Rades, T., Grohganz, H. & Löbmann, K., 1 Feb 2019, In: European Journal of Pharmaceutical Sciences. 128, p. 144-151 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)
• 2018

  Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine

  Ueda, H., Wu, W., Lobmann, K., Grohganz, H., Mullertz, A. & Rades, T., May 2018, In: Molecular Pharmaceutics. 15, 5, p. 2036-2044

  Research output: Contribution to journal › Journal article › Research › peer-review
  71 Citations (Scopus)

• Aspartame as a co-former in co-amorphous systems

  Wu, W., Lobmann, K., Schnitzkewitz, J., Knuhtsen, A., Pedersen, D. S., Grohganz, H. & Rades, T., 5 Oct 2018, In: International Journal of Pharmaceutics. 549, 1-2, p. 380-387

  Research output: Contribution to journal › Journal article › Research › peer-review
  40 Citations (Scopus)

• Glass-Transition Temperature of the β-Relaxation as the Major Predictive Parameter for Recrystallization of Neat Amorphous Drugs

  Kissi, E. O., Grohganz, H., Löbmann, K., Ruggiero, M. T., Zeitler, J. A. & Rades, T., 15 Mar 2018, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 122, 10, p. 2803-2808 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  99 Citations (Scopus)

• Influence of preparation technique on co-amorphization of carvedilol with acidic amino acids

  Mishra, J., Lobmann, K., Grohganz, H. & Rades, T., 1 Dec 2018, In: International Journal of Pharmaceutics. 552, 1-2, p. 407-413

  Research output: Contribution to journal › Journal article › Research › peer-review
  36 Citations (Scopus)

• Influence of PVP molecular weight on the microwave assisted in situ amorphization of indomethacin

  Doreth, M., Löbmann, K., Priemel, P., Grohganz, H., Taylor, R., Holm, R., Lopez de Diego, H. & Rades, T., Jan 2018, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 122, p. 62-69

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  31 Citations (Scopus)

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• Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations

  Mishra, J., Rades, T., Löbmann, K. & Grohganz, H., 12 Apr 2018, In: Pharmaceutics. 10, 2, p. 1-13

  Research output: Contribution to journal › Journal article › Research › peer-review

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  26 Citations (Scopus)

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• In situ co-amorphisation of arginine with indomethacin or furosemide during immersion in an acidic medium – A proof of concept study

  Petry, I., Löbmann, K., Grohganz, H., Rades, T. & Leopold, C. S., 1 Dec 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 133, p. 151-160 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• In vitro and in vivo comparison between crystalline and co-amorphous salts of naproxen-arginine

  Kasten, G., Lobo, L., Dengale, S., Grohganz, H., Rades, T. & Löbmann, K., 1 Nov 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 132, p. 192-199 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  38 Citations (Scopus)

• Is there a correlation between the glass forming ability of a drug and its supersaturation propensity?

  Blaabjerg, L. I., Lindenberg, E., Lobmann, K., Grohganz, H. & Rades, T., 1 Mar 2018, In: International Journal of Pharmaceutics. 538, 1-2, p. 243-249

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)