Ian Henry Lambert

Search results

• 2022

  In Vitro Characterization of a Threonine-Ligated Molybdenyl-Sulfide Cluster as a Putative Cyanide Poisoning Antidote: Intracellular Distribution, Effects on Organic Osmolyte Homeostasis, and Induction of Cell Death

  Gretarsdottir, J. M., Lambert, I. H., Sturup, S. & Suman, S. G., 2022, In: ACS Pharmacology and Translational Science. 5, 10, p. 907–918

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  3 Citations (Scopus)
• 2020

  Impact of the histone deacetylase inhibitor trichostatin A on active uptake, volume-sensitive release of taurine, and cell fate in human ovarian cancer cells

  Lambert, I. H., Nielsen, D. & Stürup, S., 2020, In: American journal of physiology. Cell physiology. 318, 3, p. C581-C597

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)
• 2019

  Distribution of platinum between nuclear and cytosolic fractions: can subcellular fractionation be performed quantitatively?

  Dam, C. S., Lambert, I. H., Gammelgaard, B. & Stürup, S., 2019, In: Journal of Pharmaceutical and Biomedical Analysis. 165, p. 82-89 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)
• 2018

  Development and validation of an ICP-MS method for quantification of total carbon and platinum in cell samples and comparison of open-vessel and microwave-assisted acid digestion methods

  Riisom, M., Gammelgaard, B., Lambert, I. H. & Stürup, S., 2018, In: Journal of Pharmaceutical and Biomedical Analysis. 158, p. 144-150 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  27 Citations (Scopus)

• Downregulation of Leucine-Rich Repeat-Containing 8A Limits Proliferation and Increases Sensitivity of Glioblastoma to Temozolomide and Carmustine

  Rubino, S., Bach, M. D., Schober, A. L., Lambert, I. H. & Mongin, A. A., 2018, In: Frontiers in Oncology. 8, 12 p., 142.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  29 Citations (Scopus)

  147 Downloads (Pure)

• Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs

  Lambert, I. H. & Sørensen, B. H., 1 Aug 2018, In: International Journal of Molecular Sciences . 19, 8, p. 1-19 2249.

  Research output: Contribution to journal › Review › Research › peer-review

  Open Access

  File
  16 Citations (Scopus)

  111 Downloads (Pure)

• In vitro evaluation of the enantiomeric R- and S-1,1'-binaphthyl-2,2'-diaminodichlorido-Pt(II) complexes in human Burkitt lymphoma cells: emphasis on cellular accumulation, cytotoxicity, DNA binding, and ability to induce apoptosis

  Sørensen, B. H., Werth, P., Lambert, I. H. & Bednarski, P. J., 2018, In: Metallomics. 10, 2, p. 323-336 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  5 Citations (Scopus)

• Stress-induced modulation of volume-regulated anions channels in human alveolar carcinoma cells

  Bach, M. D., Sørensen, B. H. & Lambert, I. H., 2018, In: Physiological Reports. 6, 19, p. 1-22 e13869.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  11 Citations (Scopus)

  122 Downloads (Pure)
• 2017

  MCT1 and MCT4 expression and lactate flux activity increase during white and brown adipogenesis and impact adipocyte metabolism

  Petersen, C., Nielsen, M. D., Andersen, E. S., Basse, A. L., Isidor, M. S., Markussen, L. K., Viuff, B. M., Lambert, I. H., Hansen, J. B. & Pedersen, S. H. F., 12 Oct 2017, In: Scientific Reports. 7, 1, 13 p., 13101.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  72 Citations (Scopus)

  330 Downloads (Pure)

• Mitigating Cyanide Poisoning

  Suman, S. G., Gretarsdottir, J. M., Lambert, I. H. & Sturup, S., Jul 2017, p. S261-S261.

  Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

• Sliding doors: heteromeric, volume-sensitive osmolyte channels

  Lambert, I. H., 15 Nov 2017, In: The Journal of Physiology. 595, 22, p. 6807-6807 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  1 Citation (Scopus)
• 2016

  Cellular uptake of metallated cobalamins

  Tran, M. T. Q., Stürup, S., Lambert, I. H., Gammelgaard, B., Furger, E. & Alberto, R., 2016, In: Metallomics. 8, 3, p. 298-304 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  17 Citations (Scopus)

  263 Downloads (Pure)

• Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21^Waf1/Cip1 and Caspase-9/-3 activation

  Sørensen, B. H., Nielsen, D., Thorsteinsdottir, U. A., Hoffmann, E. K. & Lambert, I. H., 2016, In: American Journal of Physiology: Cell Physiology. 310, 11, p. C857-C873 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  50 Citations (Scopus)

  201 Downloads (Pure)

• Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells

  Sørensen, B. H., Dam, C. S., Stürup, S. & Lambert, I. H., 2016, In: Journal of Inorganic Biochemistry. 160, p. 287-295 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  49 Citations (Scopus)

• Protolichesterinic acid, isolated from the lichen Cetraria islandica, reduces LRRC8A expression and volume-sensitive release of organic osmolytes in human lung epithelial cancer cells

  Thorsteinsdottir, U. A., Thorsteinsdottir, M. & Lambert, I. H., 2016, In: Phytotherapy Research. 30, 1, p. 97-104 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)
• 2015

  Integrin β₁, osmosensing, and chemoresistance in mouse ehrlich carcinoma cells

  Sørensen, B. H., Rasmussen, L. J. H., Broberg, B. S., Klausen, T. K., Sauter, D. R. P., Lambert, I. H., Aspberg, A. & Hoffmann, E. K., 2015, In: Cellular Physiology and Biochemistry. 36, 1, p. 111-132 22 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  16 Citations (Scopus)

  321 Downloads (Pure)

• In vitro characterization of a novel C,N-cyclometalated benzimidazole Ru(II) complex: stability, intracellular distribution and binding, effects on organic osmolyte homeostasis and induction of apoptosis

  Dam, C. S., Henarejos, S. A. P., Tsolakou, T., Segato, C. A., Gammelgaard, B., Yellol, G. S., Ruiz, J., Lambert, I. H. & Stürup, S., 2015, In: Metallomics. 5, p. 885-895 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Physiological role of taurine - from organism to organelle

  Lambert, I. H., Kristensen, D. M. B., Holm, J. B. & Mortensen, O. H., 2015, In: Acta Physiologica (Print). 213, 1, p. 191-212 22 p.

  Research output: Contribution to journal › Review › Research › peer-review
  260 Citations (Scopus)

• Regulation of p53 in NIH3T3 mouse fibroblasts following hyperosmotic stress

  Lambert, I. H., Enghoff, M. S., Brandi, M-L. & Hoffmann, E. K., 2015, In: Physiological Reports. 3, 6, 9 p., e12412.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  9 Citations (Scopus)

  184 Downloads (Pure)

• Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance

  Hoffmann, E. K., Sørensen, B. H., Sauter, D. R. P. & Lambert, I. H., 2015, In: Channels (Austin). 9, 6, p. 380-396 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  34 Citations (Scopus)
• 2014

  Acquired cisplatin resistance in human ovarian A2780 cancer cells correlates with shift in taurine homeostasis and ability to volume regulate

  Sørensen, B. H., Thorsteinsdottir, U. A. & Lambert, I. H., 2014, In: American Journal of Physiology: Cell Physiology. 307, 12, p. C1071-C1080 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  54 Citations (Scopus)

• Anoctamin 6 differs from VRAC and VSOAC but is involved in apoptosis and supports volume regulation in the presence of Ca²⁺

  Juul, C. A., Grubb, S., Poulsen, K. A., Kyed, T., Hashem, N., Lambert, I. H., Larsen, E. H. & Hoffmann, E. K., 2014, In: Pflügers Archiv - European Journal of Physiology. 466, 10, p. 1899-1910 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
  53 Citations (Scopus)

  790 Downloads (Pure)

• Functions of volume-sensitive and calcium-activated chloride channels

  Hoffmann, E. K., Holm, N. B. & Lambert, I. H., 2014, In: I U B M B Life. 66, 4, p. 257-267 11 p.

  Research output: Contribution to journal › Review › Research › peer-review
  34 Citations (Scopus)

• Ion channels and transporters in the development of drug resistance in cancer cells

  Hoffmann, E. K. & Lambert, I. H., 2014, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1638, 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  92 Citations (Scopus)

• mTOR ensures increased release and reduced uptake of the organic osmolyte taurine under hypoosmotic conditions in mouse fibroblasts

  Lambert, I. H., Jensen, J. V. & Pedersen, P. A., 2014, In: American Journal of Physiology: Cell Physiology. 306, 11, p. C1028-C1040 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)
• 2013

  Double mutation at the putative protein kinase C phosphorylation sites Thr¹⁵¹ plus Thr³²³ in the mouse leukotrieneD₄ receptor eliminates homologous desensitization

  Jørgensen, S. T., Eriksen, H. N., Dausell, J., Jespersen, T., Lambert, I. H. & Hoffmann, E. K., 2013, In: Cellular Physiology and Biochemistry. 31, 2-3, p. 366-378 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase

  Holm, J. B., Grygorczyk, R. & Lambert, I. H., 2013, In: American Journal of Physiology: Cell Physiology. 305, p. C48-C60 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  24 Citations (Scopus)
• 2012

  Downregulation of the taurine transporter TauT during hypo-osmotic stress in NIH3T3 mouse fibroblasts

  Hansen, D. B., Friis, M. B., Hoffmann, E. K. & Lambert, I. H., 2012, In: Journal of Membrane Biology. 245, 2, p. 77-87 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)
• 2011

  Cell Volume Regulation and Signaling in 3T3-L1 Pre-adipocytes and Adipocytes: on the Possible Roles of Caveolae, Insulin Receptors, FAK and ERK1/2

  Eduardsen, K., Larsen, S., Novak, I., Lambert, I. H., Hoffmann, E. K. & Pedersen, S. H. F., 2011, In: Cellular Physiology and Biochemistry. 28, 6, p. 1231-46 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Mechanisms of gemcitabine-resistance in pancreatic cancer cells

  Rasmussen, L. J. H., Ossum, C. G., Tvingsholm, S., Lambert, I. H. & Hoffmann, E. K., 2011, In: Cellular Physiology and Biochemistry. 28, 6, p. 1321-1322 2 p.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Regulation of taurine homeostasis by protein kinase CK₂ in mouse fibroblasts

  Hansen, D. B., Guerra, B., Jacobsen, J. H. & Lambert, I. H., 2011, In: Amino Acids. 40, 4, p. 1091-1106 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  10 Citations (Scopus)

• Regulation of taurine transport systems by protein kinase CK2 in mammalian cells

  Lambert, I. H. & Hansen, D. B., 2011, In: Cellular Physiology and Biochemistry. 28, 6, p. 1099-1110 12 p.

  Research output: Contribution to journal › Review › Research › peer-review
  27 Citations (Scopus)
• 2010

  Activation of the TASK-2 channel after cell swelling is dependent on tyrosine phosphorylation

  Kirkegaard, S. S., Lambert, I. H., Gammeltoft, S. & Hoffmann, E. K., 1 Oct 2010, In: American Journal of Physiology (Consolidated). 299, 4, p. C844-53

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Acute cholesterol depletion leads to net loss of the organic osmolyte taurine in Ehrlich Lettré tumor cells

  Villumsen, K. R., Duelund, L. & Lambert, I. H., 1 Nov 2010, In: Amino Acids. 39, 5, p. 1521-36 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels

  Poulsen, K. A., Andersen, E. C., Hansen, C. F., Klausen, T. K., Hougaard, C., Lambert, I. H. & Hoffmann, E. K., 2010, In: American Journal of Physiology: Cell Physiology. 298, 1, p. C14-25

  Research output: Contribution to journal › Journal article › Research › peer-review
  116 Citations (Scopus)

• Pinpointing differences in cisplatin-induced apoptosis in adherent and non-adherent cancer cells

  Tastesen, H. S., Holm, J. B., Poulsen, K. A., Møller, C., Stürup, S., Hoffmann, E. K. & Lambert, I. H., 1 Jan 2010, In: Cellular Physiology and Biochemistry. 26, 6, p. 809-820 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)

• Stability, accumulation and cytotoxicity of an albumin-cisplatin adduct

  Møller, C., Tastesen, H. S., Gammelgaard, B., Lambert, I. H. & Stürup, S., 1 Dec 2010, In: Metallomics. 2, 12, p. 811-818 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)
• 2009

  HL-1 mouse cardiomyocyte injury and death after simulated ischemia and reperfusion: roles of pH, Ca2+-independent phospholipase A2, and Na+/H+ exchange

  Andersen, A-D., Poulsen, K. A., Lambert, I. H. & Pedersen, S. F., 2009, In: American Journal of Physiology: Cell Physiology. 296, 5, p. C1227-42

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Physiology of cell volume regulation in vertebrates

  Hoffmann, E. K., Lambert, I. H. & Pedersen, S. F., 2009, In: Physiological Reviews. 89, 1, p. 193-277 84 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  1207 Citations (Scopus)

• ROS activate KCl cotransport in nonadherent Ehrlich ascites cells but K⁺ and Cl^- channels in adherent Ehrlich Lettré and NIH3T3 cells

  Lambert, I. H., Klausen, T. K., Bergdahl, A., Hougaard, C. & Hoffmann, E. K., 2009, In: American Journal of Physiology: Cell Physiology. 297, 1, p. C198-C206

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• THE ROLE OF TYROSINE KINASES IN CELL VOLUME REGULATION - WITH EMPHASIS ON TASK-2

  Kirkegaard, S. S., Lambert, I. H., Gammeltoft, S. & Hoffmann, E. K., 2009, In: Journal of Physiological Sciences. Suppl. 1, p. 259-259

  Research output: Contribution to journal › Conference abstract in journal › Research
• 2008

  Casein kinase 2 regulates the active uptake of the organic osmolyte taurine in NIH3T3 mouse fibroblasts

  Jacobsen, J. H., Clement, C. A., Friis, M. B. & Lambert, I. H., 1 Nov 2008, In: Pflügers Archiv - European Journal of Physiology. 457, 2, p. 327-37 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)

• Cell volume regulation: physiology and pathophysiology

  Lambert, I. H., Hoffmann, E. K. & Pedersen, S. H. F., 2008, In: Acta Physiologica (Print Edition). 194, 4, p. 255-82 27 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  81 Citations (Scopus)

• Volume-sensitive NADPH oxidase activity and taurine efflux in NIH3T3 mouse fibroblasts

  Friis, M. B., Vorum, K. G. & Lambert, I. H., 2008, In: American Journal of Physiology: Cell Physiology. 294, 6, p. C1552-65

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)
• 2007

  Activation and inactivation of the volume-sensitive taurine leak pathway in NIH3T3 fibroblasts and Ehrlich Lettre ascites cells.

  Lambert, I. H., 2007, In: American Journal of Physiology: Cell Physiology. 293, 1, p. C390-400

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• Homologous desensitisation of the mouse leukotriene B4 receptor involves protein kinase C-mediated phosphorylation of serine 127.

  Mollerup, J., Eriksen, H. N., Albertsen, J., Wulff, T., Lambert, I. H. & Hoffmann, E. K., 2007, In: Cellular Physiology and Biochemistry. 20, 1-4, p. 143-56 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Induction of group VIA phospholipase A2 activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants.

  Poulsen, K. A., Petersen, S. H. F., Kolko, M. & Lambert, I. H., 2007, In: American Journal of Physiology: Cell Physiology. 293, 5, p. C1605-15

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Role of phospholipase A2 in the induction of drip loss in porcine muscle.

  Poulsen, K. A., Young, J. F., Theil, P., Kolko, M., Oksbjerg, N. & Lambert, I. H., 2007, In: Journal of Agricultural and Food Chemistry. 55, 5, p. 1970-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  9 Citations (Scopus)
• 2006

  12th Acta Physiologica International Symposium "cell volume control in health and disease.".

  Hoffmann, E. K., Lambert, I. H. & Pedersen, S. H. F., 2006, In: Acta Physiologica (Print Edition). 187, 1-2, p. 1-3 2 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  3 Citations (Scopus)

• Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia

  Lambert, I. H., Pedersen, S. F. & Poulsen, K. A., 2006, In: Acta Physiologica (Print Edition). 187, 1-2, p. 75-85

  Research output: Contribution to journal › Journal article › Research › peer-review
  82 Citations (Scopus)