Challenging activity and signaling bias in tachykinin NK1 and NK2 receptors by truncated neuropeptides

Petersen, J. E., Pavlovskyi, A., Madsen, J. J., Schwartz, T. W., Frimurer, T. M. & Olsen, O. H., 2025, In: Journal of Biological Chemistry. 301, 6, 11 p., 108522.

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GLP-1-directed NMDA receptor antagonism for obesity treatment

Petersen, J., Ludwig, M. Q., Juozaityte, V., Ranea-Robles, P., Svendsen, C., Hwang, E., Kristensen, A. W., Fadahunsi, N., Lund, J., Breum, A. W., Mathiesen, C. V., Sachs, L., Moreno-Justicia, R., Rohlfs, R., Ford, J. C., Douros, J. D., Finan, B., Portillo, B., Grose, K. & Petersen, J. E. & 13 others, Trauelsen, M., Feuchtinger, A., DiMarchi, R. D., Schwartz, T. W., Deshmukh, A. S., Thomsen, M. B., Kohlmeier, K. A., Williams, K. W., Pers, T. H., Frølund, B., Strømgaard, K., Klein, A. B. & Clemmensen, C., 2024, In: Nature. 629, 8014, p. 1133–1141

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Molecular determinants of neuropeptide-mediated activation mechanisms in tachykinin NK1 and NK2 receptors

Petersen, J. E., Pavlovskyi, A., Madsen, J. J., Schwartz, T. W., Frimurer, T. M. & Olsen, O. H., 2024, In: The Journal of Biological Chemistry. 300, 12, 13 p., 107948.

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NK2R control of energy expenditure and feeding to treat metabolic diseases

Sass, F., Ma, T., Ekberg, J. H., Kirigiti, M., Ureña, M. G., Dollet, L., Brown, J. M., Basse, A. L., Yacawych, W. T., Burm, H. B., Andersen, M. K., Nielsen, T. S., Tomlinson, A. J., Dmytiyeva, O., Christensen, D. P., Bader, L., Vo, C. T., Wang, Y., Rausch, D. M. & Kristensen, C. K. & 27 others, Gestal-Mato, M., In het Panhuis, W., Sjøberg, K. A., Kernodle, S., Petersen, J. E., Pavlovskyi, A., Sandhu, M., Moltke, I., Jørgensen, M. E., Albrechtsen, A., Grarup, N., Babu, M. M., Rensen, P. C. N., Kooijman, S., Seeley, R. J., Worthmann, A., Heeren, J., Pers, T. H., Hansen, T., Gustafsson, M. B. F., Tang-Christensen, M., Kilpeläinen, T. O., Myers, M. G., Kievit, P., Schwartz, T. W., Hansen, J. B. & Gerhart-Hines, Z., 2024, In: Nature. 635, 8040, p. 987–1000 37 p.

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Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors

Madsen, J. J., Petersen, J. E., Christensen, D. P., Hansen, J. B., Schwartz, T. W., Frimurer, T. M. & Olsen, O. H., 2023, In: Journal of Biological Chemistry. 299, 12, 11 p., 105438.

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Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2

Petersen, J. E., Pedersen, M. H., Dmytriyeva, O., Nellemose, E., Arora, T., Engelstoft, M. S., Asher, W. B., Javitch, J. A., Schwartz, T. W. & Trauelsen, M., 2023, In: Molecular Metabolism. 74, 10 p., 101757.

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Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action

Lückmann, M., Shenol, A., Nissen, T. A. D., Petersen, J. E., Kouvchinov, D., Schwartz, T. W. & Frimurer, T. M., 2022, In: ACS Medicinal Chemistry Letters. 13, 12, p. 1839-1847

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Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

Trauelsen, M., Hiron, T. K., Lin, D., Petersen, J. E., Breton, B., Husted, A. S., Hjorth, S. A., Inoue, A., Frimurer, T. M., Bouvier, M., O'Callaghan, C. A. & Schwartz, T. W., 2021, In: Cell Reports. 35, 11, 15 p., 109246.

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