Jan Pravsgaard Christensen

Search results

• 2016

  PB1 as a potential target for increasing the breadth of T-cell mediated immunity to Influenza A

  Uddbäck, I. E. M., Steffensen, M. A., Pedersen, S. R., Nazerai, L., Thomsen, A. R. & Christensen, J. P., 7 Oct 2016, In: Scientific Reports. 6, 11 p., 35033.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  10 Citations (Scopus)

  207 Downloads (Pure)

• Vaccination with Replication Deficient Adenovectors Encoding YF-17D Antigens Induces Long-Lasting Protection from Severe Yellow Fever Virus Infection in Mice

  Bassi, M. R., Larsen, M. A. B., Kongsgaard, M., Rasmussen, M., Buus, S., Buus, A. S., Thomsen, A. R. & Christensen, J. P., Feb 2016, In: PLoS Neglected Tropical Diseases . 10, 2, 17 p., e0004464.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  18 Citations (Scopus)

  229 Downloads (Pure)

• Vaccine Targeting of Subdominant CD8+ T Cell Epitopes Increases the Breadth of the T Cell Response upon Viral Challenge, but May Impair Immediate Virus Control

  Steffensen, M. A., Pedersen, L. H., Jahn, M. L., Nielsen, K. N., Christensen, J. P. & Thomsen, A. R., 15 Mar 2016, In: Journal of Immunology. 196, 6, p. 2666-2676 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)
• 2015

  Adaptive Immunity against Streptococcus pyogenes in Adults Involves Increased IFN-gamma and IgG3 Responses Compared with Children

  Mortensen, R., Nissen, T. N., Blauenfeldt, T., Christensen, J. P., Andersen, P. & Dietrich, J., 15 Aug 2015, In: Journal of Immunology. 195, 4, p. 1657-1664 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  44 Citations (Scopus)

• CD8⁺ T Cells Complement Antibodies in Protecting against Yellow Fever Virus

  Bassi, M. R., Kongsgaard, M., Steffensen, M. A., Fenger, C., Rasmussen, M., Skjødt, K., Finsen, B., Buus, A. S., Buus, S., Christensen, J. P. & Thomsen, A. R., 1 Feb 2015, In: Journal of immunology (Baltimore, Md. : 1950). 194, 3, p. 1141-53 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  65 Citations (Scopus)

• HPV-vaccination: skal/skal ikke

  Translated title of the contribution: In Process CitationThomsen, A. R. & Christensen, J. P., 2015, In: Ugeskrift for Laeger. 177, 18, p. 1692 1 p., V67374.

  Research output: Contribution to journal › Editorial › Research

• Protein energy malnutrition during vaccination has limited influence on vaccine efficacy but abolishes immunity if administered during Mycobacterium tuberculosis infection

  Hoang, T., Agger, E. M., Cassidy, J. P., Christensen, J. P. & Andersen, P., 2015, In: Infection and Immunity. 83, 5, p. 2118-26 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  24 Citations (Scopus)

• Targeting of non-dominant antigens as a vaccine strategy to broaden T-cell responses during chronic viral infection

  Holst, P. J., Jensen, B. A. H., Ragonnaud, E., Thomsen, A. R. & Christensen, J. P., 2015, In: PLOS ONE. 10, 2, 17 p., e0117242.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  15 Citations (Scopus)

  243 Downloads (Pure)
• 2014

  Co-expression of tumor antigen and interleukin-2 from an adenoviral vector augments the efficiency of therapeutic tumor vaccination

  Jensen, B. A. H., Steffensen, M. A., Nørgaard Nielsen, K., Christensen, J. P., Thomsen, A. R. & Holst, P. J., 15 Jul 2014, In: Molecular Therapy. 22, 12

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• IFNγ and perforin cooperate to control infection and prevent fatal pathology during persistent gammaherpesvirus infection in mice

  Bartholdy, C., Høgh-Petersen, M., Storm, P., Holst, P. J., Orskov, C., Christensen, J. P. & Thomsen, A. R., 31 Mar 2014, In: Scandinavian Journal of Immunology. 79, 6, p. 395-403 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Priming of CD8 T Cells by Adenoviral Vectors Is Critically Dependent on B7 and Dendritic Cells but Only Partially Dependent on CD28 Ligation on CD8 T Cells

  Nielsen, K. N., Steffensen, M. A., Christensen, J. P. & Thomsen, A. R., 20 Jun 2014, In: Journal of immunology (Baltimore, Md. : 1950). 193, 3, p. 1223-1232 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Quantification of B16 Melanoma Cells in Lungs Using Triplex Q-PCR - A New Approach to Evaluate Melanoma Cell Metastasis and Tumor Control

  Sorensen, M. R., Pedersen, S. R., Lindkvist, A., Christensen, J. P. & Thomsen, A. R., 2014, In: PLOS ONE. 9, 1, p. 1-9 9 p., e87831.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Suppressors of cytokine signaling 1 and 3 are up-regulated in brain resident cells in response to virus induced inflammation of the CNS via at least two distinctive pathways

  Steffensen, M. A., Fenger, C., Christensen, J. E., Jørgensen, C. K., Bassi, M. R., Christensen, J. P., Finsen, B. & Thomsen, A. R., 24 Sep 2014, In: Journal of Virology. 88, 24, p. 14090-14104 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  14 Citations (Scopus)
• 2013

  Adenovirus-based vaccine against Listeria monocytogenes: extending the concept of invariant chain linkage

  Jensen, S., Steffensen, M. A., Jensen, B. A. H., Schlüter, D., Christensen, J. P. & Thomsen, A. R., 2013, In: Journal of immunology (Baltimore, Md. : 1950). 191, 8, p. 4152-4164 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• Comparing adjuvanted H28 and modified vaccinia virus ankara expressingH28 in a mouse and a non-human primate tuberculosis model

  Billeskov, R., Christensen, J. P., Aagaard, C., Andersen, P. & Dietrich, J., 2013, In: PloS one. 8, 8, p. e72185 12 p., e72185.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)

• Comparison of Vaccine-Induced Effector CD8 T Cell Responses Directed against Self- and Non-Self-Tumor Antigens: Implications for Cancer Immunotherapy

  Pedersen, S. R., Sørensen, M. R., Buus, S., Christensen, J. P. & Thomsen, A. R., 1 Oct 2013, In: Journal of immunology (Baltimore, Md. : 1950). 191, 7, p. 3955-67 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  58 Citations (Scopus)

• Immune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice

  Koch, J., Hau, J., Pravsgaard Christensen, J., Elvang Jensen, H., Bagge Hansen, M. & Rieneck, K., 2013, In: PloS one. 8, 3, p. e59995

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• Qualitative and quantitative analysis of Ad5 vector induced memory CD8 T cells: not as bad as their reputation

  Steffensen, M. A., Holst, P. J., Steengaard, S. S., Jensen, B. A. H., Bartholdy, C., Stryhn, A., Christensen, J. P. & Thomsen, A. R., 27 Mar 2013, In: Journal of Virology. 87, 11, p. 6283-6295 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• Qualitative and quantitative analysis of adenovirus type 5 vector-induced memory CD8 T cells: not as bad as their reputation

  Steffensen, M. A., Holst, P. J., Steengaard, S. S., Jensen, B. A. H., Bartholdy, C., Buus, A. S., Christensen, J. P. & Thomsen, A. R., 2013, In: Journal of Virology. 87, 11, p. 6283-6295 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)

• The availability of a functional tumor targeting T-cell repertoire determines the anti-tumor efficiency of combination therapy with anti-CTLA-4 and anti-4-1BB antibodies

  Jensen, B. A. H., Pedersen, S. R., Christensen, J. P. & Thomsen, A. R., 2013, In: P L o S One. 8, 6, 5 p., e66081.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  13 Citations (Scopus)

  1158 Downloads (Pure)
• 2012

  A cationic vaccine adjuvant based on a saturated quaternary ammonium lipid have different in vivo distribution kinetics and display a distinct CD4 T cell-inducing capacity compared to its unsaturated analog

  Christensen, D., Henriksen-Lacey, M., Kamath, A. T., Lindenstrøm, T., Korsholm, K. S., Christensen, J. P., Rochat, A-F., Lambert, P-H., Andersen, P., Siegrist, C-A., Perrie, Y. & Agger, E. M., Jun 2012, In: Journal of controlled release : official journal of the Controlled Release Society. 160, 3, p. 468-476 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  99 Citations (Scopus)

• A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin

  Egerod, K. L., Engelstoft, M. S., Grunddal, K. V., Nøhr, M. K., Secher, A., Sakata, I., Pedersen, J., Windeløv, J. A., Füchtbauer, E-M., Olsen, J., Sundler, F., Christensen, J. P., Wierup, N., Olsen, J. V., Holst, J. J., Zigman, J. M., Poulsen, S. S. & Schwartz, T. W., 1 Dec 2012, In: Endocrinology. 153, 12, p. 5782-95 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  271 Citations (Scopus)

• Differential Impact of Interferon Regulatory Factor 7 in Initiation of the Type I Interferon Response in the Lymphocytic Choriomeningitis Virus-Infected Central Nervous System versus the Periphery

  Christensen, J. E., Fenger, C., Issazadeh-Navikas, S., Krug, A., Liljestrøm, P., Goriely, S., Paludan, S. R., Finsen, B., Christensen, J. P. & Thomsen, A. R., Jul 2012, In: Journal of Virology. 86, 13, p. 7384-7392 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  16 Citations (Scopus)

• Increased immunogenicity and protective efficacy of influenza M2e fused to a tetramerizing protein

  Andersson, A-M. C., Håkansson, K. O., Jensen, B. A. H., Christensen, D., Andersen, P., Thomsen, A. R. & Christensen, J. P., 2012, In: P L o S One. 7, 10, 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  35 Citations (Scopus)

  2193 Downloads (Pure)

• Pre-existing vector immunity does not prevent replication deficient adenovirus from inducing efficient CD8 T-cell memory and recall responses

  Steffensen, M. A., Jensen, B. A. H., Holst, P. J., Bassi, M. R., Christensen, J. P. & Thomsen, A. R., Apr 2012, In: P L o S One. 7, 4, 14 p., e34884.

  Research output: Contribution to journal › Journal article › Research › peer-review
  23 Citations (Scopus)
• 2011

  Correction: Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosis

  Billeskov, R., Grandal, M. V., Poulsen, C., Christensen, J. P., Winter, N., Vingsbo-Lundberg, C., Hoang, T. T. K. T., Van Deurs, B., Song, Y. H., Aagaard, C., Andersen, P. & Dietrich, J., Mar 2011, In: European Journal of Immunology. 41, 3, p. 873 1 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

• Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain

  Mikkelsen, M., Holst, P. J., Bukh, J., Thomsen, A. R. & Christensen, J. P., 15 Feb 2011, In: Journal of Immunology. 186, 4, p. 2355-64 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  49 Citations (Scopus)

• JNK1, but not JNK2, is required in two mechanistically distinct models of inflammatory arthritis

  Denninger, K., Rasmussen, S. B., Larsen, J. M., Ørskov, C., Seier Poulsen, S., Sørensen, P., Christensen, J. P., Illges, H., Ødum, N. & Labuda, T., 2011, In: American Journal of Pathology. 179, 4, p. 1884-93 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  12 Citations (Scopus)

• Vaccination against lymphocytic choriomeningitis virus infection in MHC class II-deficient mice

  Holst, P. J., Christensen, J. P. & Thomsen, A. R., 2011, In: Journal of Immunology. 186, 7, p. 3997-4007

  Research output: Contribution to journal › Journal article › Research › peer-review
  21 Citations (Scopus)

• Vesicular stomatitis virus infection promotes immune evasion by preventing NKG2D-ligand surface expression

  Jensen, H., Andresen, L., Nielsen, J., Christensen, J. P. & Skov, S., 2011, In: PLoS ONE. 6, 8, 8 p., e23023.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  24 Citations (Scopus)

  1736 Downloads (Pure)
• 2010

  Adenoviral vaccination combined with CD40 stimulation and CTLA-4 blockage can lead to complete tumor regression in a murine melanoma model

  Sørensen, M. R., Holst, P. J., Steffensen, M. A., Christensen, J. P. & Thomsen, A. R., 24 Sep 2010, In: Vaccine. 28, 41, p. 6757-64 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  52 Citations (Scopus)

• Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosis

  Billeskov, R., Grandal, M. V., Poulsen, C., Christensen, J. P., Winther, N., Vingsbo-Lundberg, C., Hoang, T. T. K. T., van Deurs, B., Song, Y-H., Aagaard, C., Andersen, P. & Dietrich, J., 2010, In: European Journal of Immunology.

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• DNA fusion gene vaccines

  Holst, P. J., Bassi, M. R., Thomsen, A. R. & Christensen, J. P., 2010, In: Current Opinion in Molecular Therapeutics. 12, 1, p. 47-54 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  5 Citations (Scopus)

• Quality of the transgene-specific CD8+ T cell response induced by adenoviral vector immunization is critically influenced by virus dose and route of vaccination

  Holst, P. J., Ørskov, C., Thomsen, A. R. & Christensen, J. P., 2010, In: Journal of Immunology. 184, 8, p. 4431-9 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  51 Citations (Scopus)

• The murine gammaherpesvirus-68 chemokine-binding protein M3 inhibits experimental autoimmune encephalomyelitis

  Millward, J. M., Holst, P. J., Høgh-Petersen, M., Thomsen, A. R., Christensen, J. P. & Owens, T., 2010, In: Journal of Neuroimmunology. 224, 1-2, p. 45-50 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus

  Grujic, M., Bartholdy, C., Remy, M., Pinschewer, D. D., Christensen, J. P. & Thomsen, A. R., 1 Aug 2010, In: Journal of Immunology. 185, 3, p. 1730-43 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  26 Citations (Scopus)
• 2009

  CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination

  Elvang, T., Christensen, J. P., Billeskov, R., Thi Kim Thanh Hoang, T., Holst, P., Thomsen, A. R., Andersen, P. & Dietrich, J., 2009, In: PLoS ONE. 4, 4, p. e5139

  Research output: Contribution to journal › Journal article › Research › peer-review
  63 Citations (Scopus)

• CXCR3 Directs Antigen-Specific Effector CD4+ T Cell Migration to the Lung During Parainfluenza Virus Infection

  Kohlmeier, J. E., Cookenham, T., Miller, S. C., Roberts, A. D., Christensen, J. P., Thomsen, A. R. & Woodland, D. L., 2009, In: Journal of Immunology.

  Research output: Contribution to journal › Journal article › Research › peer-review
  101 Citations (Scopus)

• Fulminant lymphocytic choriomeningitis virus-induced inflammation of the CNS involves a cytokine-chemokine-cytokine-chemokine cascade

  Christensen, J. E., Simonsen, S., Fenger, C., Sørensen, M. R., Moos, T., Christensen, J. P., Finsen, B. & Thomsen, A. R., 2009, In: Journal of Immunology. 182, 2, p. 1079-87 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  41 Citations (Scopus)

• Fusion of a viral antigen to invariant chain leads to augmented T-cell immunity and improved protection in gene-gun DNA-vaccinated mice

  Grujic, M., Holst, P. J., Christensen, J. P. & Thomsen, A. R., 2009, In: Journal of General Virology. 90, Pt 2, p. 414-22 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  19 Citations (Scopus)

• Mucosal immunization with recombinant adenoviral vectors expressing murine gammaherpesvirus-68 genes M2 and M3 can reduce latent viral load

  Hoegh-Petersen, M., Thomsen, A. R., Christensen, J. P. & Holst, P. J., 2009, In: Vaccine.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• T-cell intrinsic expression of MyD88 is required for sustained expansion of the virus-specific CD8+ T-cell population in LCMV-infected mice

  Bartholdy, C., Christensen, J. E., Grujic, M., Christensen, J. P. & Thomsen, A. R., 2009, In: Journal of General Virology. 90, Pt 2, p. 423-31 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  23 Citations (Scopus)

• TCR down-regulation controls virus-specific CD8⁺ T cell responses

  Bonefeld, C. M., Haks, M., Nielsen, B., Von Essen, M., Boding, L., Hansen, A. K., Larsen, J. M., Ødum, N., Krimpenfort, P., Kruisbeek, A., Christensen, J. P., Thomsen, A. R. & Geisler, C., 1 Dec 2009, In: Journal of Immunology. 181, 11, p. 7786-7799 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  15 Citations (Scopus)

• The cementless AGC 2000 knee prosthesis: 20-year results in a consecutive series

  Eriksen, J., Christensen, J., Solgaard, S. Ã. & Schrøder, H. M., 2009, In: Acta Orthopaedica Belgica. 75, 2, p. 225-233 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  17 Citations (Scopus)

• Vaccination with an adenoviral vector encoding the tumor antigen directly linked to invariant chain induces potent CD4(+) T-cell-independent CD8(+) T-cell-mediated tumor control

  Sorensen, M. R., Holst, P. J., Pircher, H., Christensen, J. P. & Thomsen, A. R., 2009, In: European Journal of Immunology.

  Research output: Contribution to journal › Journal article › Research › peer-review
  38 Citations (Scopus)
• 2008

  A new anti-tumour vaccination strategy: Adenoviral vector encoding invariant chain linked to the tumour associated antigen

  Sorensen, M. R., Holst, P. J., Christensen, J. P. & Thomsen, A. R., 2008, In: Scandinavian Journal of Immunology. 2, p. 213-213

  Research output: Contribution to journal › Conference abstract in journal › Research

• Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin

  Grujic, M., Christensen, J. P., Sørensen, M. R., Abrink, M., Pejler, G. & Thomsen, A. R., 2008, In: Journal of Immunology. 181, 2, p. 1043-51 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  26 Citations (Scopus)

• Fugleinfluenza og perspektiverne for vaccination mod pandemisk influenza

  Translated title of the contribution: Avian influenza and perspectives on vaccination against pandemic influenzaHolst, P. J., Christensen, J. P. & Thomsen, A. R., 2008, In: Ugeskrift for læger. 170, 48, p. 3953-6 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  1 Citation (Scopus)

• MHC class II-associated invariant chain linkage of antigen dramatically improves cell-mediated immunity induced by adenovirus vaccines

  Holst, P. J., Mandrup Jensen, C. M., Orskov, C., Thomsen, A. R., Christensen, J. P. & Sørensen, M. R., 2008, In: Journal of Immunology. 180, 5, p. 3339-46 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  81 Citations (Scopus)

• Regulation of CXCL10 expression during virus induced CD8(+) T cell mediated inflammation in the central nervous system

  Christensen, J. E., Simonsen, S., Fenger, C., Sorensen, M. R., Christensen, J. P., Finsen, B. & Thomsen, A. R., 2008, In: Scandinavian Journal of Immunology. 2, p. 249-249

  Research output: Contribution to journal › Conference abstract in journal › Research