Jens D. Mikkelsen

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• 2024

  Binding of the monoacylglycerol lipase (MAGL) radiotracer [³H]T-401 in the rat brain after status epilepticus

  Mikkelsen, J. D., Aripaka, S. S., Egilmez, C. B. & Pazarlar, B. A., 2024, In: Neurochemistry International. 175, 8 p., 105717.

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• Expression of cytokines at baseline correlate/predict in the disc the outcome of surgery after disc degeneration: A 12-month follow-up study

  Aripaka, S. S., Chughtai, S. A., Jørgensen, L. M., Bech-Azeddine, R. & Mikkelsen, J. D., 2024, In: Pain Practice. 24, 8, p. 983-988 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• The effect of antidepressant treatment on blood BDNF levels in depressed patients: A review and methodological recommendations for assessment of BDNF in blood

  Madsen, C. A., Navarro, M. L., Elfving, B., Kessing, L. V., Castrén, E., Mikkelsen, J. D. & Knudsen, G. M., 2024, In: European Neuropsychopharmacology. 87, p. 35-55 21 p.

  Research output: Contribution to journal › Review › Research › peer-review
  2 Citations (Scopus)
• 2023

  Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans: An open-label preliminary investigation

  Burmester, D. R., Madsen, M. K., Szabo, A., Aripaka, S. S., Stenbæk, D. S., Frokjaer, V. G., Elfving, B., Mikkelsen, J. D., Knudsen, G. M. & Fisher, P. M. D., 2023, In: Comprehensive Psychoneuroendocrinology. 13, 7 p., 100163.

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  8 Citations (Scopus)

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• Synaptic vesicle glycoprotein 2A (SV2A) levels in the cerebral cortex in patients with Alzheimer's disease: a radioligand binding study in postmortem brains

  Mikkelsen, J. D., Kaad, S., Aripaka, S. S. & Finsen, B., 2023, In: Neurobiology of Aging. 129, p. 50-57 8 p.

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  10 Citations (Scopus)

• Systemic treatment with a selective TNFR2 agonist alters the central and peripheral immune responses and transiently improves functional outcome after experimental ischemic stroke

  Thougaard, E., Nielsen, P. V., Forsberg, A., Phuong, V., Velasco, A. M., Wlodarczyk, A., Wajant, H., Lang, I., Mikkelsen, J. D., Clausen, B. H., Brambilla, R. & Lambertsen, K. L., 2023, In: Journal of Neuroimmunology. 385, 17 p., 578246.

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• Transient receptor potential (TRP) channels mRNA transcripts in the lumbar intervertebral discs: biomarkers for inflammation, pain, disability, and clinical outcome

  Aripaka, S. S., Bech-Azeddine, R., Jørgensen, L. M. & Mikkelsen, J. D., 2023, In: Molecular and Cellular Biochemistry. 478, 1, p. 121-130 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)
• 2022

  Anti-Inflammatory Effect of Alpha7 Nicotinic Acetylcholine Receptor Modulators on BV2 Cells

  Aripaka, S. S. & Mikkelsen, J. D., 2022, In: Neuroimmunomodulation. 27, 4, p. 194-202 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)

  Pazarlar, B. A., Aripaka, S. S., Petukhov, V., Pinborg, L., Khodosevich, K. & Mikkelsen, J. D., 2022, In: Molecular Brain. 15, 1, 45.

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  10 Citations (Scopus)

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• Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain

  Mikkelsen, J. D., Aripaka, S. S., Bascuñana, P., Bankstahl, M., Bankstahl, J. P. & Pazarlar, B. A., 2022, In: Neuroscience. 499, p. 142-151 10 p.

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  3 Citations (Scopus)

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• Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats

  Thomsen, M., Stoica, A., Christensen, K. V., Fryland, T., Mikkelsen, J. D. & Hansen, J. B., 2022, In: Experimental Neurology. 358, 12 p., 114209.

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  5 Citations (Scopus)

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• Temporal and spatial changes in synaptic vesicle glycoprotein 2A (SV2A) under kainic acid induced epileptogenesis: An autoradiographic study

  Pazarlar, B. A., Madsen, C. A., Oyar, E. Ö., Eğilmez, C. B. & Mikkelsen, J. D., 2022, In: Epilepsy Research. 183, 10 p., 106926.

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  3 Citations (Scopus)

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• 2021

  Low back pain scores correlate with the cytokine mRNA level in lumbar disc biopsies: a study of inflammatory markers in patients undergoing lumbar spinal fusion

  Aripaka, S. S., Bech-Azeddine, R., Jørgensen, L. M., Chughtai, S. A., Gaarde, C., Bendix, T. & Mikkelsen, J. D., 2021, In: European Spine Journal. 30, p. 2967–2974 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• N₁H- and N₁-Substituted Phenylguanidines as alpha 7 Nicotinic Acetylcholine (nACh) Receptor Antagonists: Structure-Activity Relationship Studies

  Alwassil, O., Khatri, S., Schulte, M. K., Aripaka, S. S., Mikkelsen, J. D. & Dukat, M., 2021, In: ACS Chemical Neuroscience. 12, 12, p. 2194-2201 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

  Raval, N. R., Gudmundsen, F., Juhl, M., Andersen, I. V., Speth, N., Videbæk, A., Petersen, I. N., Mikkelsen, J. D., Fisher, P. M. D., Herth, M. M., Plavén-Sigray, P., Knudsen, G. M. & Palner, M., 2021, In: Frontiers in Synaptic Neuroscience. 13, 13 p., 715811.

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  15 Citations (Scopus)

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• 2020

  Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis: [incl. Author Correction]

  Pfisterer, U., Petukhov, V., Demharter, S., Meichsner, J., Thompson, J. J., Batiuk, M. Y., Martinez, A. A., Vasistha, N. A., Thakur, A., Mikkelsen, J., Adorjan, I., Pinborg, L. H., Pers, T. H., von Engelhardt, J., Kharchenko, P. V. & Khodosevich, K., 2020, In: Nature Communications. 11, 1, 19 p., 5038.

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  98 Citations (Scopus)

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• In vitro and in vivo characterization of dibenzothiophene derivatives [¹²⁵I]iodo-ASEM and [¹⁸F]ASEM as radiotracers of homo- And heteromeric α7 nicotinic acetylcholine receptors

  Donat, C. K., Hansen, H. H., Hansen, H. D., Mease, R. C., Horti, A. G., Pomper, M. G., L’Estrade, E. T., Herth, M. M., Peters, D., Knudsen, G. M. & Mikkelsen, J. D., 1 Jan 2020, In: Molecules. 25, 6, 19 p., 1425.

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  8 Citations (Scopus)

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• 2019

  Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons

  Larsen, H. M., Hansen, S. K., Mikkelsen, J. D., Hyttel, P. & Stummann, T. C., 2019, In: Stem Cell Research. 41, 10 p., 101642.

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  17 Citations (Scopus)

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• DNA methylation regulates CHRNA7 transcription and can be modulated by valproate

  Dyrvig, M., Mikkelsen, J. D. & Lichota, J., Jun 2019, In: Neuroscience Letters. 704, p. 145-152

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)
• 2018

  Analysis of gonadotrophin-releasing hormone-1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant-shrew (Elephantulus myurus)

  Medger, K., Bennett, N. C., Chimimba, C. T., Oosthuizen, M. K., Mikkelsen, J. D. & Coen, C. W., 2018, In: The Journal of Comparative Neurology. 526, 15, p. 2388-2405

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons

  Runegaard, A. H., Sørensen, A. T., Fitzpatrick, C. M., Jørgensen, S. H., Petersen, A. V., Hansen, N. W., Weikop, P., Andreasen, J. T., Mikkelsen, J. D., Perrier, J-F., Woldbye, D., Rickhag, M., Wortwein, G. & Gether, U., 2018, In: eNeuro. 5, 3, 26 p., e0345.

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  39 Citations (Scopus)

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• 2017

  Perinatal nicotine treatment induces transient increases in NACHO protein levels in the rat frontal cortex

  Wichern, F., Jensen, M. M., Christensen, D. Z., Mikkelsen, J. D., Gondré-Lewis, M. C. & Thomsen, M. S., 27 Mar 2017, In: Neuroscience. 346, p. 278-283 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  4 Citations (Scopus)

• Roles of RFRP-3 in the daily and seasonal regulation of reproductive activity in female Syrian hamsters

  Henningsen, J. B., Ancel, C., Mikkelsen, J. D., Gauer, F. & Simonneaux, V., 2017, In: Endocrinology. 158, 3, p. 652-663

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  41 Citations (Scopus)

• Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters

  Henningsen, J. B., Ancel, C., Mikkelsen, J. D., Gauer, F. & Simonneaux, V., 1 Mar 2017, In: Endocrinology. 158, 3, p. 652-663 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo

  Hansen, H. H., Weikop, P., Mikkelsen, M. D., Rode, F. & Mikkelsen, J. D., Jan 2017, In: Basic & Clinical Pharmacology & Toxicology Online. 120, 1, p. 46-51 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  7 Citations (Scopus)

• The Preoptic Area and the RFamide-Related Peptide Neuronal System Gate Seasonal Changes in Chemosensory Processing

  Jennings, K. J., Chasles, M., Cho, H., Mikkelsen, J., Bentley, G., Keller, M. & Kriegsfeld, L. J., Nov 2017, In: Integrative and Comparative Biology. 57, 5, p. 1055-1065 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  4 Citations (Scopus)

• The variability of translocator protein signal in brain and blood of genotyped healthy humans using in vivo ¹²³I-CLINDE SPECT imaging: A test-retest study

  Feng, L., Jensen, P., Thomsen, G., Dyssegaard, A., Svarer, C., Knudsen, L. V., Møller, K., Thomsen, C., Mikkelsen, J. D., Guilloteau, D., Knudsen, G. M. & Pinborg, L. H., 2017, In: Journal of Nuclear Medicine. 58, 6, p. 989-995 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)
• 2016

  Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

  Hervig, M. E., Thomsen, M. S., Kalló, I. & Mikkelsen, J. D., 15 Oct 2016, In: Neuroscience. 334, p. 13-25 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Changes in Binding of [¹²³I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury

  Donat, C. K., Gaber, K., Meixensberger, J., Brust, P., Pinborg, L. H., Hansen, H. H. & Mikkelsen, J. D., Jun 2016, In: NeuroMolecular Medicine. 18, 2, p. 158-69 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  22 Citations (Scopus)

• Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease

  Hansen, H. H., Fabricius, K., Barkholt, P., Mikkelsen, J. D., Jelsing, J., Pyke, C., Knudsen, L. B. & Vrang, N., 1 Sep 2016, In: Brain Research. 1646, p. 354-365 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  35 Citations (Scopus)

• Encenicline, an α7 Nicotinic Acetylcholine Receptor Partial Agonist, Reduces Immune Cell Infiltration in the Colon and Improves Experimental Colitis in Mice

  Salaga, M., Blomster, L. V., Piechota-Polańczyk, A., Zielińska, M., Jacenik, D., Cygankiewicz, A. I., Krajewska, W. M., Mikkelsen, J. D. & Fichna, J., Jan 2016, In: Journal of Pharmacology and Experimental Therapeutics. 356, 1, p. 157-69 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)

• Functional interaction between Lypd6 and nicotinic acetylcholine receptors

  Arvaniti, M., Jensen, M. M., Soni, N., Wang, H., Klein, A. B., Thiriet, N., Pinborg, L. H., Muldoon, P. P., Wienecke, J., Imad Damaj, M., Kohlmeier, K. A., Gondré-Lewis, M. C., Mikkelsen, J. D. & Thomsen, M. S., Sep 2016, In: Journal of Neurochemistry. 138, 6, p. 806-820 15 p.

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  29 Citations (Scopus)

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• Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain

  Wu, J., Liu, Q., Tang, P., Mikkelsen, J. D., Shen, J., Whiteaker, P. & Yakel, J. L., Jul 2016, In: Trends in Pharmacological Sciences. 37, 7, p. 562-74 13 p.

  Research output: Contribution to journal › Review › Research › peer-review
  79 Citations (Scopus)

• Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

  Lyukmanova, E. N., Shulepko, M. A., Kudryavtsev, D., Bychkov, M. L., Kulbatskii, D. S., Kasheverov, I. E., Astapova, M. V., Feofanov, A. V., Thomsen, M. S., Mikkelsen, J. D., Shenkarev, Z. O., Tsetlin, V. I., Dolgikh, D. A. & Kirpichnikov, M. P., 2016, In: PLOS ONE. 11, 2, p. 1-14 14 p., e0149733.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  69 Citations (Scopus)

• Lynx1 and Aβ1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes

  Thomsen, M. S., Arvaniti, M., Jensen, M. M., Shulepko, M. A., Dolgikh, D. A., Pinborg, L. H., Härtig, W., Lyukmanova, E. N. & Mikkelsen, J. D., Oct 2016, In: Neurobiology of Aging. 46, p. 13-21 9 p.

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  27 Citations (Scopus)

• Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats

  Bortz, D. M., Upton, B. A., Mikkelsen, J. D. & Bruno, J. P., Dec 2016, In: Neuropharmacology. 111, p. 78-91

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Quantification of the functional expression of the Ca²⁺‐activated K⁺ channel K_Ca3.1 on microglia from adult human neocortical tissue

  Blomster, L. V., Strøbaek, D., Hougaard, C., Klein, J., Pinborg, L. H., Mikkelsen, J. D. & Christophersen, P., Dec 2016, In: Glia. 64, 12, p. 2065-2078 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  19 Citations (Scopus)

• Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression

  Jorgensen, A., Magnusson, P., Hanson, L. G., Kirkegaard, T., Benveniste, H., Lee, H., Svarer, C., Mikkelsen, J. D., Fink-Jensen, A., Knudsen, G. M., Paulson, O. B., Bolwig, T. G. & Jørgensen, M. B., Feb 2016, In: Acta Psychiatrica Scandinavica. 133, 2, p. 154-164 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  92 Citations (Scopus)

• Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster

  Henningsen, J. B., Poirel, V-J., Mikkelsen, J. D., Tsutsui, K., Simonneaux, V. & Gauer, F., 15 Jun 2016, In: Journal of Comparative Neurology. 524, 9, p. 1825-1838 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)
• 2015

  Association Study of CHRNA₇ Promoter Variants with Sensory and Sensorimotor Gating in Schizophrenia Patients and Healthy Controls: A Danish Case-Control Study

  Bertelsen, B., Oranje, B., Melchior, L., Fagerlund, B., Werge, T. M., Mikkelsen, J. D., Tümer, Z. & Glenthøj, B. Y., Dec 2015, In: NeuroMolecular Medicine. 17, 4, p. 423-30 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  20 Citations (Scopus)

• BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels

  Fisher, P. M., Holst, K. K., Adamsen, D., Klein, A. B., Frokjaer, V. G., Jensen, P. S., Svarer, C., Gillings, N., Baare, W. F. C., Mikkelsen, J. D. & Knudsen, G. M., Jan 2015, In: Human Brain Mapping. 36, 1, p. 313–323 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  27 Citations (Scopus)

• High plasma triglyceride levels strongly correlate with low kisspeptin in the arcuate nucleus of male rats

  Overgaard, A., Axel, A. M., Lie, M. E., Hansen, H. H. & Mikkelsen, J. D., Apr 2015, In: Endocrine Regulations. 49, 2, p. 51-7 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  9 Citations (Scopus)

• Ovariectomy Drives Asynchronous Changes in Serotonin Receptor 2A and Transporter Availability in Rats

  Frimer, N. A., Overgaard, A., Lie, M. E. K., Mikkelsen, J. D. & Frokjaer, V. G., 2015, In: Journal of Steroids & Hormonal Science. 6, 3, p. 1-5 5 p., 1000161.

  Research output: Contribution to journal › Journal article › Research › peer-review

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• Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease

  Jensen, M. M., Mikkelsen, J. D., Arvaniti, M., Pinborg, L. H. & Thomsen, M. S., 1 Apr 2015, In: Neurobiology of Aging. 36, 4, p. 1629-1638 10 p.

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  30 Citations (Scopus)

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• Radiosynthesis and in vitro validation of (3)H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand

  Magnussen, J. H., Ettrup, A., Donat, C. K., Peters, D., Pedersen, M. H. F., Knudsen, G. M. & Mikkelsen, J. D., 5 Sep 2015, In: European Journal of Pharmacology. 762, p. 35-41 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  8 Citations (Scopus)

• Role of Serotonin Transporter Changes in Depressive Responses to Sex-Steroid Hormone Manipulation: A Positron Emission Tomography Study

  Frokjaer, V. G., Pinborg, A., Holst, K. K., Overgaard, A., Henningsson, S., Heede, M., Larsen, E. C., Jensen, P. S., Agn, M., Nielsen, A. P., Stenbæk, D. S., da Cunha-Bang, S., Lehel, S., Siebner, H. R., Mikkelsen, J. D., Svarer, C. & Knudsen, K. B. M., 15 Oct 2015, In: Biological Psychiatry. 78, 8, p. 534-43 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  101 Citations (Scopus)

• TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between ¹²³I-CLINDE SPECT, ¹⁸F-FET PET, and Gadolinium-Enhanced MR Imaging

  Jensen, P., Feng, L., Law, I., Svarer, C., Knudsen, G. M., Mikkelsen, J. D., de Nijs, R., Larsen, V. A., Dyssegaard, A., Thomsen, G., Fischer, W., Guilloteau, D. & Pinborg, L. H., Sep 2015, In: Journal of Nuclear Medicine. 56, 9, p. 1386-90 5 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  36 Citations (Scopus)

• α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties

  Thomsen, M. S., Zwart, R., Ursu, D., Jensen, M. M., Pinborg, L. H., Gilmour, G., Wu, J., Sher, E. & Mikkelsen, J. D., 2015, In: PLOS ONE. 10, 6, p. 1-16 16 p., e0130572.

  Research output: Contribution to journal › Journal article › Research › peer-review

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  40 Citations (Scopus)
• 2014

  5-HT_2A and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains

  Klein, A. B., Ultved, L., Adamsen, D., Santini, M. A., Tobeña, A., Fernandez-Teruel, A., Flores, P., Moreno, M., Cardona, D., Knudsen, G. M., Aznar, S. & Mikkelsen, J. D., 28 Mar 2014, In: Neuroscience. 263, p. 36-45 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  61 Citations (Scopus)

• Association of the CHRNA7 promoter variant −86T with Tourette syndrome and comorbid obsessive-compulsive disorder

  Bertelsen, B., Melchior, L., Tümer, Z., Groth, C., Mol Debes, N., Skov, L., Holst, K. K., Fagerlund, B. & Mikkelsen, J. D., 30 Nov 2014, In: Psychiatry Research. 219, 3, p. 710-711 2 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review
  2 Citations (Scopus)