Jens Juul Holst

Search results

• 2024

  Alpha-cyclodextrin increases glucagon-like peptide-1 secretion in multiple models and improves metabolic status in mice

  Smits, M. M., von Voss, L., Drzazga, A. K., Beaman, E. E., Brethvad, A. O., Holst, J. J. & Rosenkilde, M. M., 2024, In: Food Chemistry. 460, 10 p., 140759.

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• Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge

  Gasbjerg, L. S., Rasmussen, R. S., Dragan, A., Lindquist, P., Melchiorsen, J. U., Stepniewski, T. M., Schiellerup, S., Tordrup, E. K., Gadgaard, S., Kizilkaya, H. S., Willems, S., Zhong, Y., Wang, Y., Wright, S. C., Lauschke, V. M., Hartmann, B., Holst, J. J., Selent, J. & Rosenkilde, M. M., 2024, (E-pub ahead of print) In: British Journal of Pharmacology.

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• Altered Glucagon and GLP-1 Responses to Oral Glucose in Children and Adolescents With Obesity and Insulin Resistance

  Stinson, S. E., Fernández de Retana Alzola, I., Hovendal, E. D. B., Lund, M. A. V., Fonvig, C. E., Holm, L. A., Jonsson, A. E., Frithioff-Bøjsøe, C., Christiansen, M., Pedersen, O., Ängquist, L., Sørensen, T. I. A., Holst, J. J., Hartmann, B., Holm, J-C. & Hansen, T., 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 6, p. 1590-1600 11 p.

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• An Extended Minimal Model of OGTT: estimation of α- and β-cell dysfunction, insulin resistance, and the incretin effect

  Subramanian, V., Bagger, J. I., Harihar, V., Holst, J. J., Knop, F. K. & Vilsbøll, T., 2024, In: American Journal of Physiology - Endocrinology and Metabolism. 326, 2, p. E182-E205

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• Annual Prize Lecture 2024: Endogenous physiological mechanisms as basis for the treatment of obesity and type 2 diabetes

  Holst, J. J., 2024, (E-pub ahead of print) In: Journal of Physiology.

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• Association between recent exposure to continuous glucose monitoring-recorded hypoglycaemia and counterregulatory and symptom responses to subsequent controlled hypoglycaemia in people with type 1 diabetes

  Svensson, C. H., Fabricius, T. W., Verhulst, C. E. M., Kristensen, P. L., Tack, C. J., Heller, S. R., Amiel, S. A., McCrimmon, R. J., Evans, M., Holst, J. J., de Galan, B. E., Pedersen-Bjergaard, U. & Hypo-RESOLVE Consortium, 2024, In: Diabetes, Obesity and Metabolism. 26, 8, p. 3213-3222

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• AT-7687, a novel GIPR peptide antagonist, combined with a GLP-1 agonist, leads to enhanced weight loss and metabolic improvements in cynomolgus monkeys

  Jensen, M. H., Sanni, S. J., Riber, D., Holst, J. J., Rosenkilde, M. M. & Sparre-Ulrich, A. H., 2024, In: Molecular Metabolism. 88, 12 p., 102006.

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• Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial

  Jensen, S. B. K., Sørensen, V., Sandsdal, R. M., Lehmann, E. W., Lundgren, J. R., Juhl, C. R., Janus, C., Ternhamar, T., Stallknecht, B. M., Holst, J. J., Jørgensen, N. R., Jensen, J. E. B., Madsbad, S. & Torekov, S. S., 2024, In: JAMA network open. 7, 6, 13 p., e2416775.

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• Bone remodeling in survivors of pediatric hematopoietic stem cell transplantation: Impact of heavy resistance training

  Krogh, L. M., Nissen, A., Weischendorff, S., Hartmann, B., Andersen, J. L., Holst, J. J., Sørensen, K., Fridh, M. K., Mackey, A. L. & Müller, K., 2024, In: Medical and Pediatric Oncology. Supplement. 71, 9, 10 p., e31159.

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• Canagliflozin or acarbose versus placebo to ameliorate post-bariatric hypoglycaemia - The HypoBar I randomized clinical trial protocol

  Lobato, C. B., Winding, C. T., Bojsen-Møller, K. N., Martinussen, C., Veedfald, S., Holst, J. J., Madsbad, S., Jørgensen, N. B. & Dirksen, C., 2024, In: Diabetic Medicine. 41, 6, 8 p., e15320.

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• Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

  Kizilkaya, H. S., Sørensen, K. V., Madsen, J. S., Lindquist, P., Douros, J. D., Bork-Jensen, J., Berghella, A., Gerlach, P. A., Gasbjerg, L. S., Mokrosiński, J., Mowery, S. A., Knerr, P. J., Finan, B., Campbell, J. E., D’Alessio, D. A., Perez-Tilve, D., Faas, F., Mathiasen, S., Rungby, J., Sørensen, H. T. & 15 others, Vaag, A., Nielsen, J. S., Holm, J. C., Lauenborg, J., Damm, P., Pedersen, O., Linneberg, A., Hartmann, B., Holst, J. J., Hansen, T., Wright, S. C., Lauschke, V. M., Grarup, N., Hauser, A. S. & Rosenkilde, M. M., 2024, In: Nature Metabolism. 6, p. 1268–1281

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• Colesevelam has no acute effect on postprandial GLP-1 levels but abolishes gallbladder refilling

  Gether, I. M., Bahne, E., Nerild, H. H., Rehfeld, J. F., Hartmann, B., Holst, J. J., Vilsbøll, T., Sonne, D. P. & Knop, F. K., 2024, In: European Journal of Endocrinology. 190, 4, p. 314-326 13 p.

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• Counterregulatory hormone and symptom responses to hypoglycaemia in people with type 1 diabetes, insulin-treated type 2 diabetes or without diabetes: the Hypo-RESOLVE hypoglycaemic clamp study

  Fabricius, T. W., Verhulst, C. E. M., Kristensen, P. L., Holst, J. J., Tack, C. J., McCrimmon, R. J., Heller, S. R., Evans, M. L., de Galan, B. E., Pedersen-Bjergaard, U. & Hypo-RESOLVE Consortium, 2024, In: Acta Diabetologica. 61, 5, p. 623-633

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• Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study

  Winther-Sørensen, M., Garcia, S. L., Bartholdy, A., Ottenheijm, M. E., Banasik, K., Brunak, S., Sørensen, C. M., Gluud, L. L., Knop, F. K., Holst, J. J., Rosenkilde, M. M., Jensen, M. K. & Wewer Albrechtsen, N. J., 2024, In: Diabetologia. 67, p. 1602–1615

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• Dietary impact on fasting and stimulated GLP-1 secretion in different metabolic conditions - a narrative review

  Huber, H., Schieren, A., Holst, J. J. & Simon, M-C., 2024, In: The American Journal of Clinical Nutrition. 119, 3, p. 599-627

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• Effect of a 6-Week Carbohydrate-Reduced High-Protein Diet on Levels of FGF21 and GDF15 in People With Type 2 Diabetes

  Richter, M. M., Thomsen, M. N., Skytte, M. J., Kjeldsen, S. A. S., Samkani, A., Frystyk, J., Magkos, F., Holst, J. J., Madsbad, S., Krarup, T., Haugaard, S. B. & Wewer Albrechtsen, N. J., 2024, In: Journal of the Endocrine Society. 8, 4, 11 p., bvae008.

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• Effect of ghrelin on glucose tolerance, gut hormones, appetite, and food intake after sleeve gastrectomy

  Hedbäck, N., Dichman, M. L., Hindsø, M., Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Kristiansen, V. B., Rehfeld, J. F., Hartmann, B., Holst, J. J., Svane, M. S. & Madsbad, S., 2024, In: American journal of physiology. Endocrinology and metabolism. 327, 3, p. E396-E410 15 p.

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• Effect of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on alcohol consumption in alcohol-preferring male vervet monkeys

  Fink-Jensen, A., Wörtwein, G., Klausen, M. K., Holst, J. J., Hartmann, B., Thomsen, M., Ptito, M., Beierschmitt, A. & Palmour, R. M., 2024, (Accepted/In press) In: Psychopharmacology.

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• Effects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial

  Quist, J. S., Pedersen, H. E., Jensen, M. M., Clemmensen, K. K. B., Bjerre, N., Ekblond, T. S., Uldal, S., Størling, J., Wewer Albrechtsen, N. J., Holst, J. J., Torekov, S. S., Nyeland, M. E., Vistisen, D., Jørgensen, M. E., Panda, S., Brock, C., Finlayson, G., Blond, M. B. & Færch, K., 2024, In: The Lancet Healthy Longevity. 5, 5, p. e314-e325 12 p.

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• Effects of a carbohydrate-reduced high-protein diet delivered with meal kits to Danish people with type 2 diabetes: protocol for a 12-month randomised controlled trial

  Kopp, L. H. P., Søgaard-Hansen, C. M., Zachhau, K. M., Bastkjær, R. M., Andersen, B. V., Budtz-Jørgensen, E., Byrne, D. V., Chaaban, N., Holst, J. J., Klindt, T. B., Magkos, F., Ozenne, B., Samkani, A., Skytte, M. J., Madsbad, S., Krarup, T. & Thomsen, M. N., 2024, In: BMJ Open. 14, 8, 12 p., e084686.

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• Effects of a Low-Carbohydrate-High-Protein Pre-Exercise Meal in Type 1 Diabetes—a Randomized Crossover Trial

  Kristensen, K. B., Ranjan, A. G., Mccarthy, O. M., Holst, J. J., Bracken, R. M., Nørgaard, K. & Schmidt, S., 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 1, p. 208–216 9 p.

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• Effects of exogenous GIP and GLP-2 on bone turnover in individuals with type 2 diabetes

  Skov-Jeppesen, K., Christiansen, C. B., Hansen, L. S., Windeløv, J. A., Hedbäck, N., Gasbjerg, L. S., Hindsø, M., Svane, M. S., Madsbad, S., Holst, J. J., Rosenkilde, M. M. & Hartmann, B., 2024, In: The Journal of clinical endocrinology and metabolism. 109, 7, p. 1773–1780

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• Elucidating the glucose-lowering effect of the bile acid sequestrant sevelamer

  Nerild, H. H., Brønden, A., Haddouchi, A. E., Ellegaard, A-M., Hartmann, B., Rehfeld, J. F., Holst, J. J., Sonne, D. P., Vilsbøll, T. & Knop, F. K., 2024, In: Diabetes, Obesity and Metabolism. 26, 4, p. 1252-1263

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• Empagliflozin Normalizes Fasting Hyperglycemia and Improves Postprandial Glucose Tolerance in Totally Pancreatectomized Patients: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

  Baekdal, M., Nielsen, S. W., Hansen, C. P., Storkholm, J. H., van Hall, G., Hartmann, B., Holst, J. J., Vilsbøll, T., Lund, A. & Knop, F. K., 2024, In: Diabetes Care. 47, 1, p. 71-80 10 p.

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• Exercise-induced increase in muscle insulin sensitivity in men is amplified when assessed using a meal test

  Voldstedlund, C. T., Sjøberg, K. A., Schlabs, F. L., Sigvardsen, C. M., Andersen, N. R., Holst, J. J., Hartmann, B., Wojtaszewski, J. F. P., Kiens, B., McConell, G. K. & Richter, E. A., 2024, In: Diabetologia. 67, p. 1386–1398

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• Exogenous glucagon-like peptide 2 counteracts exogenous cholecystokinin-induced gallbladder contraction in healthy men

  Lange, A. H., Hansen, N. L., Pedersen, M. G., Nerild, H. H., Rehfeld, J. F., Hartmann, B., Holst, J. J., Ellegaard, A-M. & Knop, F. K., 2024, (Accepted/In press) In: The Journal of clinical endocrinology and metabolism.

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• Fish-hunting cone snail disrupts prey’s glucose homeostasis with weaponized mimetics of somatostatin and insulin

  Yeung, H. Y., Ramiro, I. B. L., Andersen, D. B., Koch, T. L., Hamilton, A., Bjørn-Yoshimoto, W. E., Espino, S., Vakhrushev, S. Y., Pedersen, K. B., de Haan, N., Hipgrave Ederveen, A. L., Olivera, B. M., Knudsen, J. G., Bräuner-Osborne, H., Schjoldager, K. T., Holst, J. J. & Safavi-Hemami, H., 2024, In: Nature Communications. 15, 1, 16 p., 6408.

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• GIP receptor antagonism eliminates paradoxical growth hormone secretion in some patients with acromegaly

  Jensen, M. H., Gasbjerg, L. S., Skov-Jeppesen, K., Jacobsen, J. C. B., Poulsen, S. S., Zhou, C., Jakubauskaite, R., Poulsen, F. R., Bonde, C., Albarazi, M., Halle, B., Christiansen, C. B., Sanni, S. J., Byberg, S., Hoe, B., Holst, J. J., Dela, F., Rasmussen, A. K., Knop, F. K., Arlien-Søborg, M. C. & 8 others, Melmed, S., Jørgensen, J. O. L., Andersen, M. S., Hartmann, B., Klose, M. C., Feldt-Rasmussen, U., Sparre-Ulrich, A. H. & Rosenkilde, M. M., 2024, (E-pub ahead of print) In: The Journal of clinical endocrinology and metabolism.

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• GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management

  Holst, J. J., 2024, In: Nature Metabolism. 6, p. 1866–1885

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• Glucagon agonism in the treatment of metabolic diseases including type 2 diabetes mellitus and obesity

  Winther, J. B. & Holst, J. J., 2024, In: Diabetes, Obesity and Metabolism. 26, 9, p. 3501-3512

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• Glucagon augments the secretion of FGF21 and GDF15 in MASLD by indirect mechanisms

  Richter, M. M., Kemp, I. M., Heebøll, S., Winther-Sørensen, M., Kjeldsen, S. A. S., Jensen, N. J., Nybing, J. D., Linden, F. H., Høgh-Schmidt, E., Boesen, M. P., Madsbad, S., Schiødt, F. V., Nørgaard, K., Schmidt, S., Gluud, L. L., Haugaard, S. B., Holst, J. J., Nielsen, S., Rungby, J. & Wewer Albrechtsen, N. J., 2024, In: Metabolism: Clinical and Experimental. 156, 13 p., 155915.

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• Glucagon Clearance is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis

  Grøndahl, M. F. G., Lange, A. H., Suppli, M. P., Bagger, J. I., Thing, M., Gluud, L. L., Kofod, D. H., Hornum, M., van Hall, G., Trammell, S. A. J., Grevengoed, T. J., Hartmann, B., Holst, J. J., Vilsbøll, T., Christensen, M. B., Lund, A. B. & Knop, F. K., 2024, In: Diabetes. 73, 10, p. 1641-1647 7 p.

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• Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node

  Lubberding, A. F., Veedfald, S., Achter, J. S., Nissen, S. D., Soattin, L., Sorrentino, A., Torres Vega, E., Linz, B., Eggertsen, C. H. E., Mulvey, J., Toräng, S., Larsen, S. A., Nissen, A., Petersen, L. G., Erbil Bilir, S., Bentzen, B. H., Rosenkilde, M. M., Hartmann, B., Lilleør, T. N. B., Qazi, S. & 6 others, Møller, C. H., Tfelt-Hansen, J., Sattler, S. M., Jespersen, T., Holst, J. J. & Lundby, A., 2024, In: Cardiovascular Research. 120, 12, p. 1427–1441 15 p.

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• Glucagon receptor activation contributes to the development of kidney injury

  Billeschou Bomholt, A., Johansen, C. D., Galsgaard, K. D., Elmelund, E., Winther-Sørensen, M., Holst, J. J., Wewer Albrechtsen, N. J. & Sorensen, C. M., 2024, In: American Journal of Physiology - Renal Physiology. 327, 5, p. F712-F724

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• Glucagon resistance in individuals with obesity and hepatic steatosis can be measured using the GLUSENTIC test and index

  Kjeldsen, S. A. S., Richter, M. M., Jensen, N. J., Nilsson, M. S. D., Heinz, N., Nybing, J. D., Linden, F. H., Høgh-Schmidt, E., Boesen, M. P., Andersen, T. L., Johannesen, H. H., Trammell, S. A. J., Grevengoed, T. J., Madsbad, S., Vilstrup, H., Vinholt Schiødt, F., Møller, A., Rashu, E. B., Nørgaard, K., Schmidt, S. & 5 others, Gluud, L. L., Haugaard, S. B., Holst, J. J., Rungby, J. & Wewer Albrechtsen, N. J., 2024, In: Diabetes. 73, 10, p. 1716–1727 12 p.

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• Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals

  Kliim-Hansen, V., Gether, I. M., Juel, C. T-B., Ellegaard, A-M., Pedersen, M. G., Hartmann, B., Albrechtsen, N. J. W., Holst, J. J., Lund, A. B., Gasbjerg, L. S. & Knop, F. K., 2024, In: Peptides. 179, 5 p., 171242.

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• Glycodeoxycholic acid inhibits primary bile acid synthesis with minor effects on glucose- and lipid homeostasis in humans

  Meessen, E. C. E., Majait, S., Ay, Ü., Olde Damink, S. W., Romijn, J. A., Holst, J. J., Hartmann, B., Kuipers, F., Nieuwdorp, M., Schaap, F. G., Groen, A. K., Kemper, E. M. & Soeters, M. R., 2024, (E-pub ahead of print) In: The Journal of clinical endocrinology and metabolism.

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• Healthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: a post-treatment analysis of a randomised placebo-controlled trial

  Jensen, S. B. K., Blond, M. B., Sandsdal, R. M., Olsen, L. M., Juhl, C. R., Lundgren, J. R., Janus, C., Stallknecht, B. M., Holst, J. J., Madsbad, S. & Torekov, S. S., 2024, In: EClinicalMedicine. 69, 12 p., 102475.

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• Hepatic steatosis and not type 2 diabetes, body mass index, or hepatic fibrosis associates with hyperglucagonemia in individuals with steatotic liver disease

  Kjeldsen, S. A. S., Werge, M. P., Grandt, J., Richter, M. M., Thing, M., Hetland, L. E., Rashu, E. B., Jensen, A-S. H., Winther-Sørensen, M., Kellemann, J. S., Holst, J. J., Junker, A. E., Serizawa, R. R., Vyberg, M., Gluud, L. L. & Wewer Albrechtsen, N. J., 2024, In: American journal of physiology. Gastrointestinal and liver physiology. 327, 4, p. G558-G570 13 p.

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• Impact of Synbiotic Intake on Liver Metabolism in Metabolically Healthy Participants and Its Potential Preventive Effect on Metabolic-Dysfunction-Associated Fatty Liver Disease (MAFLD): A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial

  Mantri, A., Köhlmoos, A., Schelski, D. S., Seel, W., Stoffel-Wagner, B., Krawitz, P., Stehle, P., Holst, J. J., Weber, B., Koban, L., Plassmann, H. & Simon, M. C., 2024, In: Nutrients. 16, 9, 14 p., 1300.

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• Increased gallbladder emptying and reduced GLP-1 response in pregnancy with and without gestational diabetes mellitus

  Gether, I. M., Andersen, E. S., Foghsgaard, S., Ellegaard, A. M., Kelstrup, L., Sonne, D. P., Brønden, A., Gillum, M. P., Holst, J. J., Hartmann, B., Rehfeld, J. F., Vilsbøll, T. & Knop, F. K., 2024, (E-pub ahead of print) In: Diabetes, Obesity and Metabolism.

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• Increased hepatic glucagon sensitivity in totally pancreatectomised patients

  Rix, I., Lund, A. B., Garvey, L. F., Hansen, C. P., Chabanova, E., Hartmann, B., Holst, J. J., Vilsbøll, T., Van Hall, G. & Knop, F. K., 2024, In: European Journal of Endocrinology. 190, 6, p. 446-457 12 p.

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• In-depth phosphoproteomic profiling of the insulin signaling response in heart tissue and cardiomyocytes unveils canonical and specialized regulation

  Achter, J. S., Vega, E. T., Sorrentino, A., Kahnert, K., Galsgaard, K. D., Hernandez-Varas, P., Wierer, M., Holst, J. J., Wojtaszewski, J. F. P., Mills, R. W., Kjøbsted, R. & Lundby, A., 2024, In: Cardiovascular Diabetology. 23, 1, 16 p., 258.

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• Indole-3-carboxyaldehyde does not reverse the intestinal effects of fiber-free diet in mice

  Smits, M. M., Dreyer, S. I. L., Hunt, J. E., Drzazga, A. K., Modvig, I. M., Holst, J. J. & Kissow, H., 2024, In: Frontiers in Endocrinology. 15, 10 p., 1362711.

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• Intraduodenal calcium enhances the effects of L-tryptophan to stimulate gut hormone secretion and suppress energy intake in healthy males: a randomized, crossover, clinical trial

  Anjom-Shoae, J., Fitzgerald, P. CE., Horowitz, M., Mohammadpour, Z., Hall, G. V., Holst, J. J., Rehfeld, J. F., Veedfald, S. & Feinle-Bisset, C., 2024, In: American Journal of Clinical Nutrition. 120, 3, p. 528–539 12 p.

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• In Vivo Inhibition of Dipeptidyl Peptidase 4 Allows Measurement of GLP-1 Secretion in Mice

  Smits, M. M., Galsgaard, K. D., Jepsen, S. L., Albrechtsen, N. W., Hartmann, B. & Holst, J. J., 2024, In: Diabetes. 73, 5, p. 671-681

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• Is low-dose glucagon needed and effective in preventing fasted exercise-induced hypoglycaemia in type 1 diabetes treated with the MiniMed 780G, an automated insulin delivery system?

  Lundemose, S. B., McCarthy, O. M., Christensen, M. B., Laugesen, C., Bracken, R. M., Holst, J. J., Ranjan, A. G. & Nørgaard, K., 2024, (E-pub ahead of print) In: Diabetes, Obesity and Metabolism.

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• Liraglutide enhances insulin secretion and prolongs the remission period in adults with newly diagnosed type 1 diabetes (the NewLira study): A randomized, double-blind, placebo-controlled trial

  Dejgaard, T. F., Frandsen, C. S., Kielgast, U., Størling, J., Overgaard, A. J., Svane, M. S., Olsen, M. H., Thorsteinsson, B., Andersen, H. U., Krarup, T., Holst, J. J. & Madsbad, S., 2024, In: Diabetes, Obesity and Metabolism. 26, 11, p. 4905–4915 11 p.

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• _L-valine is a powerful stimulator of GLP-1 secretion in rodents and stimulates secretion through ATP-sensitive potassium channels and voltage-gated calcium channels

  Modvig, I. M., Smits, M. M., Galsgaard, K. D., Hjørne, A. P., Drzazga, A. K., Rosenkilde, M. M. & Holst, J. J., 2024, In: Nutrition and Diabetes. 14, 11 p., 43.

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• New Lessons from the gut: Studies of the role of gut peptides in weight loss and diabetes resolution after gastric bypass and sleeve gastrectomy

  Holst, J. J., Madsbad, S., Bojsen-Møller, K. N., Dirksen, C. & Svane, M., 2024, In: Peptides. 176, 9 p., 171199.

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