Research output per year
Research output per year
Personal profile
CV
EDUCATION
- PhD (pharm.), 1995
- MSc (pharm.), 1990
- Apoteksassistent, 1986
EMPLOYMENT
- Associate professor at the Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 2000-
- Assistant professor at the Department of Pharmacy, the Danish University of Pharmaceutical Sciences, 1996-2000
- Research and teaching assistant at the Department of Pharmacy, Royal Danish School of Pharmacy, 1995-1996
- PhD student at the Department of Pharmacy, Royal Danish School of Pharmacy, 1991-1995
- Apoteksassistentelev, Næstved Løve Apotek, 1983-1986
Short presentation
RESEARCH INTERESTS AND EXPERIENCES
The research gains fundamental knowledge about drug delivery in the oral cavity to alleviate local disorders or for systemic drug administration. Elucidation of oromucosal absorption barrier properties and development of biorelevant in vitro methods to study oromucosal toxicity and permeability of drugs and excipients: I) mechanistic understanding of bioadhesivness, drug release and drug absorption, II) in vitro-in vivo correlation of toxicity and permeability of drugs (cell culture, modified Ussing chamber, bioavailability studies in animals); III) development of aqueous gel for alleviation of mucosal disorders or food lubricant
Key words: Oromucosal drug delivery – adhesion – anti-adhesion - biorelevant in vitro models (cell culture, Ussing chamber) - permeability – bioavailability – IVIVC - toxicity of drugs and formulated drugs/excipients – mucus - absorption barrier - absorption enhancement – absorption retardment - surfactants –- lubrication - humectants
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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Almen Farmaci
Mulvad, H. (ed.), Larsen, B. B. (ed.), Jørgensen, L. (ed.) & Jacobsen, J. (ed.), 2024, 5 ed. Samfundslitteratur. 388 p.Research output: Book/Report › Book › Education
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Characterizing interregional differences in the rheological properties and composition of rat small intestinal mucus
Klitgaard, M., Jacobsen, J., Kristensen, M. N., Berthelsen, R. & Müllertz, A., 2024, In: Drug Delivery and Translational Research. 14, p. 3309–3320Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile2 Citations (Scopus) -
Assessing acute colitis induced by dextran sulfate sodium in rats and its impact on gastrointestinal fluids
Klitgaard, M., Kristensen, M. N., Venkatasubramanian, R., Guerra, P., Jacobsen, J., Berthelsen, R., Rades, T. & Müllertz, A., 2023, In: Drug Delivery and Translational Research. 13, p. 1484–1499Research output: Contribution to journal › Journal article › Research › peer-review
2 Citations (Scopus) -
Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery
Stie, M. B., Öblom, H., Hansen, A. C. N., Jacobsen, J., Chronakis, I. S., Rantanen, J., Nielsen, H. M. & Genina, N., 2023, In: Carbohydrate Polymers. 303, 120429.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile12 Citations (Scopus)45 Downloads (Pure) -
An Evaluation of the Physicochemical Properties of Preservative-Free 0.005% (w/v) Latanoprost Ophthalmic Solutions, and the Impact on In Vitro Human Conjunctival Goblet Cell Survival
Freiberg, J. C., Hedengran, A., Heegaard, S., Petrovski, G., Jacobsen, J., Cvenkel, B. & Kolko, M., 2022, In: Journal of Clinical Medicine. 11, 11, 3137.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile8 Citations (Scopus)52 Downloads (Pure) -
Generic benzalkonium chloride‐preserved travoprost eye drops are not identical to the branded polyquarternium‐1‐preserved travoprost eye drop: Effect on cultured human conjunctival goblet cells and their physicochemical properties
Hedengran, A., Freiberg, J. C., Hansen, P. M., Jacobsen, J., Larsen, S. W., Harloff‐helleberg, S., Freude, K., Boix‐lemonche, G., Petrovski, G., Heegaard, S. & Kolko, M., 2022, In: Acta Ophthalmologica. 100, 7, p. 819-827Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile7 Citations (Scopus)36 Downloads (Pure) -
Identification of globular protein structures in human whole and parotid saliva
Hamulic, B., Jacobsen, J., Bar-Shalom, D. & Pedersen, A. M. L., 2022. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
Open AccessFile26 Downloads (Pure) -
Investigating the effect of graphene oxide in chitosan/alginate-based foams on the release and antifungal activity of clotrimazole in vitro
Huang, J., Jacobsen, J., Genina, N., Larsen, S. W., Nielsen, H. M., Müllertz, A. & Mu, H., 2022, In: European Journal of Pharmaceutical Sciences. 174, 9 p., 106204.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile5 Citations (Scopus)37 Downloads (Pure)