Jette Jacobsen

Search results

• 2025

  Enhancing Buccal Drug Delivery: The Impact of Glycerol in Slot-Die-Coated Pectin Films

  Pantazoglou, E., Tollemeto, M., Ezazi, N. Z., Chang, T. J., Hosta Rigau, L., Jacobsen, J. & Hagner Nielsen, L., 2025, In: Molecular Pharmaceutics. 22, 1, p. 433-445

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2024

  Almen Farmaci

  Mulvad, H. (ed.), Larsen, B. B. (ed.), Jørgensen, L. (ed.) & Jacobsen, J. (ed.), 2024, 5 ed. Samfundslitteratur. 388 p.

  Research output: Book/Report › Book › Education

• Characterizing interregional differences in the rheological properties and composition of rat small intestinal mucus

  Klitgaard, M., Jacobsen, J., Kristensen, M. N., Berthelsen, R. & Müllertz, A., 2024, In: Drug Delivery and Translational Research. 14, p. 3309–3320

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  2 Citations (Scopus)
• 2023

  Assessing acute colitis induced by dextran sulfate sodium in rats and its impact on gastrointestinal fluids

  Klitgaard, M., Kristensen, M. N., Venkatasubramanian, R., Guerra, P., Jacobsen, J., Berthelsen, R., Rades, T. & Müllertz, A., 2023, In: Drug Delivery and Translational Research. 13, p. 1484–1499

  Research output: Contribution to journal › Journal article › Research › peer-review
  2 Citations (Scopus)

• Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery

  Stie, M. B., Öblom, H., Hansen, A. C. N., Jacobsen, J., Chronakis, I. S., Rantanen, J., Nielsen, H. M. & Genina, N., 2023, In: Carbohydrate Polymers. 303, 120429.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  13 Citations (Scopus)

  47 Downloads (Pure)
• 2022

  An Evaluation of the Physicochemical Properties of Preservative-Free 0.005% (w/v) Latanoprost Ophthalmic Solutions, and the Impact on In Vitro Human Conjunctival Goblet Cell Survival

  Freiberg, J. C., Hedengran, A., Heegaard, S., Petrovski, G., Jacobsen, J., Cvenkel, B. & Kolko, M., 2022, In: Journal of Clinical Medicine. 11, 11, 3137.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  8 Citations (Scopus)

  54 Downloads (Pure)

• Generic benzalkonium chloride‐preserved travoprost eye drops are not identical to the branded polyquarternium‐1‐preserved travoprost eye drop: Effect on cultured human conjunctival goblet cells and their physicochemical properties

  Hedengran, A., Freiberg, J. C., Hansen, P. M., Jacobsen, J., Larsen, S. W., Harloff‐helleberg, S., Freude, K., Boix‐lemonche, G., Petrovski, G., Heegaard, S. & Kolko, M., 2022, In: Acta Ophthalmologica. 100, 7, p. 819-827

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  7 Citations (Scopus)

  43 Downloads (Pure)

• Identification of globular protein structures in human whole and parotid saliva

  Hamulic, B., Jacobsen, J., Bar-Shalom, D. & Pedersen, A. M. L., 2022. 1 p.

  Research output: Contribution to conference › Poster › Research › peer-review

  Open Access

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  27 Downloads (Pure)

• Investigating the effect of graphene oxide in chitosan/alginate-based foams on the release and antifungal activity of clotrimazole in vitro

  Huang, J., Jacobsen, J., Genina, N., Larsen, S. W., Nielsen, H. M., Müllertz, A. & Mu, H., 2022, In: European Journal of Pharmaceutical Sciences. 174, 9 p., 106204.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  6 Citations (Scopus)

  38 Downloads (Pure)

• In vitro and ex vivo evaluation of bilayered effervescent microenvironmental pH modifying buccal films with saquinavir

  He, S., Nielsen, C. U., Mu, H. & Jacobsen, J., 2022, In: Journal of Drug Delivery Science and Technology. 78, 7 p., 103954.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  6 Citations (Scopus)

  25 Downloads (Pure)

• Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin

  Stie, M. B., Gätke, J. R., Chronakis, I. S., Jacobsen, J. & Nielsen, H. M., 2022, In: International Journal of Molecular Sciences. 23, 3, 9 p., 1458.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  14 Citations (Scopus)

  45 Downloads (Pure)

• The physicochemical properties of preserved and preservative-free latanoprost eye drops and their impact on human conjunctival goblet cells

  Müllertz, O. A. O., Nagstrup, A. H., Mouhammad, Z. A., Freiberg, J. C., Nagymihály, R., Jacobsen, J., Larsen, S. W., Bair, J. A., Utheim, T. P., Dartt, D. A., Heegaard, S., Petrovski, G. & Kolko, M., 2022, In: Acta Ophthalmologica. 100, S267

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
• 2021

  Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films

  He, S., Jacobsen, J., Nielsen, C. U., Genina, N., Østergaard, J. & Mu, H., 2021, In: European Journal of Pharmaceutical Sciences. 163, 10 p., 105867.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  15 Citations (Scopus)

  49 Downloads (Pure)

• Impact of benzalkonium chloride-preserved and preservative-free latanoprost eye drops on cultured human conjunctival goblet cells upon acute exposure and differences in physicochemical properties of the eye drops

  Mullertz, O., Hedengran, A., Mouhammad, Z. A., Freiberg, J., Nagymihaly, R., Jacobsen, J., Larsen, S. W., Bair, J., Utheim, T., Dartt, D. A., Heegaard, S., Petrovski, G. & Kolko, M., 2021, In: BMJ Open Ophthalmology. 6, 1, 7 p., 000892.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  12 Citations (Scopus)

  47 Downloads (Pure)

• Multi-material 3D printing of programmable and stretchable oromucosal patches for delivery of saquinavir

  He, S., Radeke, C., Jacobsen, J., Lind, J. U. & Mu, H., 2021, In: International Journal of Pharmaceutics. 610, 9 p., 121236.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  15 Citations (Scopus)

  24 Downloads (Pure)

• Predicting in vivo performance of fenofibrate amorphous solid dispersions using in vitro non-sink dissolution and dissolution permeation setup

  Lentz, K. A., Plum, J., Steffansen, B., Arvidsson, P. O., Omkvist, D. H., Pedersen, A. J., Sennbro, C. J., Pedersen, G. P. & Jacobsen, J., 2021, In: International Journal of Pharmaceutics. 610, 8 p., 121174.

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
  9 Citations (Scopus)
• 2020

  Betaxolol Ophthalmic Solution as Alternative Treatment for Patients with Timolol Allergy: A Case Report

  Müllertz, O., Jacobsen, J., Thyssen, J. P., Horwitz, A. & Kolko, M., 2020, In: Reports — Medical Cases, Images, and Videos. 3, 3, 4 p., 21.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  24 Downloads (Pure)

• Characterization of burning mouth syndrome profiles based on response to a local anaesthetic lozenge

  Treldal, C., Petersen, J., Mogensen, S., Therkildsen, C., Jacobsen, J., Andersen, O. & Pedersen, A. M. L., 2020, In: Oral Diseases. 26, 3, p. 656-669 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Electrospun α-lactalbumin nanofibers for site-specific and fast-onset delivery of nicotine in the oral cavity: an in vitro, ex vivo and tissue spatial distribution study

  Kalouta, K., Stie, M. B., Janfelt, C., Chronakis, I. S., Jacobsen, J., Mørck Nielsen, H. & Foderà, V., 2020, In: Molecular Pharmaceutics. 17, 11, p. 4189-4200

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  13 Citations (Scopus)

  27 Downloads (Pure)

• Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

  Eleftheriadis, G. K., Monou, P. K., Bouropoulos, N., Boetker, J., Rantanen, J., Jacobsen, J., Vizirianakis, I. S. & Fatouros, D. G., 2020, In: Journal of Pharmaceutical Sciences. 109, 9, p. 2757-2766

  Research output: Contribution to journal › Journal article › Research › peer-review
  71 Citations (Scopus)

• Graphene oxide as a functional excipient in buccal films for delivery of clotrimazole: effect of molecular interactions on drug release and antifungal activity in vitro

  Huang, J., Jacobsen, J., Larsen, S. W., Genina, N., van de Weert, M., Müllertz, A., Nielsen, H. M. & Mu, H., 2020, In: International Journal of Pharmaceutics. 589, p. 1-9 119811.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Microenvironmental pH modifying films for buccal delivery of saquinavir: Effects of organic acids on pH and drug release in vitro

  He, S., Østergaard, J., Ashna, M., Nielsen, C. U., Jacobsen, J. & Mu, H., 2020, In: International Journal of Pharmaceutics. 585, 10 p., 119567.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)

• Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa

  Stie, M. B., Gätke, J. R., Wan, F., Chronakis, I. S., Jacobsen, J. & Nielsen, H. M., 15 Aug 2020, In: Carbohydrate Polymers. 242, 10 p., 116428.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  48 Citations (Scopus)

  44 Downloads (Pure)

• Waterborne Electrospinning of α-Lactalbumin Generates Tunable and Biocompatible Nanofibers for Drug Delivery

  Stie, M. B., Corezzi, M., Juncos Bombin, A. D., Ajalloueian, F., Attrill, E., Pagliara, S., Jacobsen, J., Chronakis, I. S., Nielsen, H. M. & Foderà, V., 2020, In: ACS Applied Nano Materials. 3, 2, p. 1910–1921

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  28 Citations (Scopus)

  32 Downloads (Pure)
• 2019

  Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers

  Stie, M. B., Jones, M., Sørensen, H. O., Jacobsen, J., Chronakis, I. S. & Nielsen, H. M., 1 Jul 2019, In: Carbohydrate Polymers. 215, p. 253-262

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  35 Citations (Scopus)

  68 Downloads (Pure)

• Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

  Clitherow, K. H., Murdoch, C., Spain, S. G., Handler, A. M., Colley, H. E., Stie, M. B., Nielsen, H. M., Janfelt, C., Hatton, P. V. & Jacobsen, J., Sep 2019, In: Molecular Pharmaceutics. 16, 9, p. 3948-3956

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  32 Citations (Scopus)

  207 Downloads (Pure)

• Polymeric Lids for Microcontainers for Oral Protein Delivery

  Mazzoni, C., Jacobsen, R. D., Mortensen, J., Jørgensen, J. R., Vaut, L., Jacobsen, J., Gundlach, C., Müllertz, A., Nielsen, L. H. & Boisen, A., 2019, In: Macromolecular Bioscience. 19, 5, 1900004.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  17 Citations (Scopus)

  41 Downloads (Pure)

• Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery

  Handler, A. M., Marxen, E., Jacobsen, J. & Janfelt, C., 15 Jan 2019, In: European Journal of Pharmaceutical Sciences. 127, p. 276-281 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)
• 2018

  Analytical aspects of printed oral dosage forms

  Edinger, M., Jacobsen, J., Bar-Shalom, D., Rantanen, J. & Genina, N., 20 Dec 2018, In: International Journal of Pharmaceutics. 553, 1-2, p. 97-108

  Research output: Contribution to journal › Journal article › Research › peer-review
  38 Citations (Scopus)

• Buccal delivery of small molecules - Impact of levulinic acid, oleic acid, sodium dodecyl sulfate and hypotonicity on ex vivo permeability and spatial distribution in mucosa

  Hansen, S. E., Marxen, E., Janfelt, C. & Jacobsen, J., Dec 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 133, p. 250-257

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging

  Marxen, E., Jin, L., Jacobsen, J., Janfelt, C., Hyrup, B. & Nicolazzo, J. A., 21 Feb 2018, In: Pharmaceutical Research. 35, 3, 12 p., 70.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging

  Marxen, E., Jacobsen, J., Hyrup, B. & Janfelt, C., 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526

  Research output: Contribution to journal › Journal article › Research › peer-review
  15 Citations (Scopus)

• Polymer coated liposomes for use in the oral cavity - A study of the in vitro toxicity, effect on cell permeability and interaction with mucin

  Klemetsrud, T., Kjøniksen, A-L., Hiorth, M., Jacobsen, J. & Smistad, G., 2018, In: Journal of Liposome Research. 28, 1, p. 62–73 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  40 Citations (Scopus)
• 2017

  Absorption of Bupivacaine after Administration of a Lozenge as Topical Treatment for Pain from Oral Mucositis

  Mogensen, S., Sverrisdóttir, E., Sveinsdóttir, K., Treldal, C., Jensen, K., Jensen, A. B., Kristensen, C. A., Jacobsen, J., Kreilgaard, M., Petersen, J. & Andersen, O., 2017, In: Basic & Clinical Pharmacology & Toxicology. 120, 1, p. 71-78 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  11 Citations (Scopus)

• Are mucin dispersions a barrier to small molecules in oromucosal drug delivery?

  Marxen, E., Mosgaard, M. D., Pedersen, A. M. L. & Jacobsen, J., 2017.

  Research output: Contribution to conference › Poster › Research › peer-review

• Dissolution enhancement of griseofulvin from griseofulvin-sodium dodecyl sulfate discs investigated by UV imaging

  Madelung, P., Bertelsen, P., Jacobsen, J., Mullertz, A. & Ostergaard, J., Jun 2017, In: Journal of Drug Delivery Science and Technology. 39, p. 516-522 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

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  8 Citations (Scopus)

  84 Downloads (Pure)

• Mucin dispersions as a model for the oromucosal mucus layer in in vitro and ex vivo buccal permeability studies of small molecules

  Marxen, E., Mosgaard, M. D., Pedersen, A. M. L. & Jacobsen, J., 2017, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 121, p. 121-128

  Research output: Contribution to journal › Journal article › Research › peer-review
  27 Citations (Scopus)
• 2016

  Buccal absorption of diazepam is improved when administered in bioadhesive tablets-An in vivo study in conscious Göttingen mini-pigs

  Meng-Lund, E., Jacobsen, J., Müllertz, A., Jørgensen, E. B. & Holm, R., 30 Sep 2016, In: International Journal of Pharmaceutics. 515, 1-2, p. 125-131 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  18 Citations (Scopus)

• Development of a μDissolution-Permeation model with in situ drug concentration monitoring

  Berthelsen, R., Byrialsen, J. P., Holm, R., Jacobsen, J., Abrahamsson, B., Saaby, L., Madelung, P. & Müllertz, A., 1 Oct 2016, In: Journal of Drug Delivery Science and Technology. 35, p. 223-233 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  6 Citations (Scopus)

• Dissolution Model Development: Formulation Effects and Filter Complications

  Berthelsen, R., Holm, R., Jacobsen, J., Kristensen, J., Abrahamsson, B. & Mullertz, A., Feb 2016, In: Dissolution Technologies. 23, 1, p. 6-12 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
  2 Citations (Scopus)

• Effect of a local anesthetic lozenge in relief of symptoms in burning mouth syndrome

  Treldal, C., Jacobsen, C. B., Mogensen, S., Rasmussen, M., Jacobsen, J., Petersen, J., Pedersen, A. M. L. & Andersen, O., Mar 2016, In: Oral Diseases. 22, 2, p. 123-31 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  28 Citations (Scopus)

• Effect of cryoprotectants for maintaining drug permeability barriers in porcine buccal mucosa

  Marxen, E., Axelsen, M. C., Pedersen, A. M. L. & Jacobsen, J., 2016, In: International Journal of Pharmaceutics. 511, 1, p. 599-605 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  29 Citations (Scopus)

• Effect of food intake and co-administration of placebo self-nanoemulsifying drug delivery systems on the absorption of cinnarizine in healthy human volunteers

  Christiansen, M. L., Holm, R., Abrahamsson, B., Jacobsen, J., Kristensen, J., Andersen, J. R. & Müllertz, A., 2016, In: European Journal of Pharmaceutical Sciences. 84, p. 77-82 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  32 Citations (Scopus)

• Polymeric microcontainers improve oral bioavailability of furosemide

  Nielsen, L. H., Melero, A., Keller, S. S., Jacobsen, J., Garrigues, T., Rades, T., Müllertz, A. & Boisen, A., 17 May 2016, In: International Journal of Pharmaceutics. 504, 1-2, p. 98-109 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  61 Citations (Scopus)
• 2015

  Aqueous gel composition and its use

  Bar-Shalom, D., Jacobsen, J., Dalby, K., Pedersen, A. M. L. & Vilmann, P., Oct 2015, Priority date 21 May 2015, Priority No. EP20140169457 20140522

  Research output: Patent

• Can freeze protectants preserve the integrity of permeability barriers in porcine buccal mucosa?

  Marxen, E., Axelsen, M., Pedersen, A. M. L. & Jacobsen, J., Jul 2015.

  Research output: Contribution to conference › Poster › Research › peer-review

• Evaluation of the use of Göttingen minipigs to predict food effects on the oral absorption of drugs in humans

  Christiansen, M. L., Müllertz, A., Garmer, M., Kristensen, J., Jacobsen, J., Abrahamsson, B. & Holm, R., Jan 2015, In: Journal of Pharmaceutical Sciences. 104, 1, p. 135-143 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  17 Citations (Scopus)

• Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

  Berthelsen, R., Holm, R., Jacobsen, J., Kristensen, J., Abrahamsson, B. & Müllertz, A., 6 Apr 2015, In: Molecular Pharmaceutics. 12, 4, p. 1062-1071 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  37 Citations (Scopus)
• 2014

  A mechanistic based approach for enhancing buccal mucoadhesion of chitosan

  Meng-Lund, E., Muff-Westergaard, C., Sander, C., Madelung, P. & Jacobsen, J., 30 Jan 2014, In: International Journal of Pharmaceutics. 461, 1-2, p. 280-5 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
  49 Citations (Scopus)

• Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect

  Meng-Lund, E., Jacobsen, J., Jin, L., Janfelt, C., Holm, R., Müllertz, A. & Nicolazzo, J. A., 15 Feb 2014, In: Journal of Pharmaceutical Sciences. 103, 4, p. 1133-1141 103.

  Research output: Contribution to journal › Journal article › Research › peer-review
  13 Citations (Scopus)